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The map label for this gene is thrB [H]

Identifier: 117919589

GI number: 117919589

Start: 1345289

End: 1346227

Strand: Direct

Name: thrB [H]

Synonym: Shewana3_1140

Alternate gene names: 117919589

Gene position: 1345289-1346227 (Clockwise)

Preceding gene: 117919588

Following gene: 117919590

Centisome position: 27.06

GC content: 53.35

Gene sequence:

>939_bases
ATGAGTTTGACCGTTTACGCTCCCGCCTCTATGGGTAATGTGGGTGTGGGCTTTGATTTATTGGGCGCAGCACTTGCGCC
CATCGATGGCAGTTTATTGGGCGATAGAGTCACAATTGCGGCTGCGGATGCGGGGGTGAGCCTCACTCAAGTGGGAGCGT
GGGCGCATAAGTTACCCAGCAATCCTGAGGAGAATATCGTCCATCAATGCGCGGTGTTTTTCTTGAAAGCCCTTGGAAAA
GAAAACCAAGGCGTGGCATTAACCCTAGAAAAAAACTTGCCCGTCGGCAGTGGCTTAGGTTCGAGCGCCAGTTCTGTGGT
TGCAGCGCTTTACGCGCTTAACGAGCATTTTGAGCGTCCATACGATAAGCAAGCGCTACTCGAACTCATGGGCGAGTTTG
AGGGCAAGATCAGCGGTAGCGTGCATTACGACAACGTCGCGCCCTGTTATTTGGGCGGCATGCAGCTGATGCTAAATGTG
CCTGGCGCTATCTGTGAGCCGATTCCCAGTTTTAAACAATGGTATTGGGTGGTGGCGTATCCTGGGATTTCACTCTCAAC
GGCAATGATGCGTAAACTCATGCCAGAACAATACGATAAGTCGGTGGCCATCGATTTTGGGCGTTATTTGAGTGCCTTTG
TACACGCCTCTTATCAGCAAAACGCCAAGCTTGCGATTCAAGTCTTGAAGGATGTGCTGGCCGAACCTTACCGCGCAGCG
GCGATACCGGGTTATGACAATGCCAGGGCGGCGCTCGCCGAATTAGGCATGTTAACCACTGGCATCTCGGGCAGTGGGCC
AACGCTGTTTTCGGTGACAGACAATCTTGTGACCGCTAACGCCGCCAAGGCGTGGTTAGAGGCTCATTATCTGACTGAAG
CGGGGGGCTTTGCCCATGTGTGCCGCCTCGATGAGCAAGGTACGCGCCGAGTCGATTAA

Upstream 100 bases:

>100_bases
CTTTTGTATTACGTGGATACGGTGCGGGTACAGAAGTGACAGCGGCCGGCGCCTTTGCCGATGTATTAAGAACCTTAAAT
TGGACTCGTGAGGTGAGTGT

Downstream 100 bases:

>100_bases
TTTTCTTACTTTTAAAAGCATTAAGCCCAAGCCTAACGGCTTGGCACTGATAAGGTCGAGTGAGCATGGAACTATATAAT
TTAAAACACCCTTCGCAGAA

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MSLTVYAPASMGNVGVGFDLLGAALAPIDGSLLGDRVTIAAADAGVSLTQVGAWAHKLPSNPEENIVHQCAVFFLKALGK
ENQGVALTLEKNLPVGSGLGSSASSVVAALYALNEHFERPYDKQALLELMGEFEGKISGSVHYDNVAPCYLGGMQLMLNV
PGAICEPIPSFKQWYWVVAYPGISLSTAMMRKLMPEQYDKSVAIDFGRYLSAFVHASYQQNAKLAIQVLKDVLAEPYRAA
AIPGYDNARAALAELGMLTTGISGSGPTLFSVTDNLVTANAAKAWLEAHYLTEAGGFAHVCRLDEQGTRRVD

Sequences:

>Translated_312_residues
MSLTVYAPASMGNVGVGFDLLGAALAPIDGSLLGDRVTIAAADAGVSLTQVGAWAHKLPSNPEENIVHQCAVFFLKALGK
ENQGVALTLEKNLPVGSGLGSSASSVVAALYALNEHFERPYDKQALLELMGEFEGKISGSVHYDNVAPCYLGGMQLMLNV
PGAICEPIPSFKQWYWVVAYPGISLSTAMMRKLMPEQYDKSVAIDFGRYLSAFVHASYQQNAKLAIQVLKDVLAEPYRAA
AIPGYDNARAALAELGMLTTGISGSGPTLFSVTDNLVTANAAKAWLEAHYLTEAGGFAHVCRLDEQGTRRVD
>Mature_311_residues
SLTVYAPASMGNVGVGFDLLGAALAPIDGSLLGDRVTIAAADAGVSLTQVGAWAHKLPSNPEENIVHQCAVFFLKALGKE
NQGVALTLEKNLPVGSGLGSSASSVVAALYALNEHFERPYDKQALLELMGEFEGKISGSVHYDNVAPCYLGGMQLMLNVP
GAICEPIPSFKQWYWVVAYPGISLSTAMMRKLMPEQYDKSVAIDFGRYLSAFVHASYQQNAKLAIQVLKDVLAEPYRAAA
IPGYDNARAALAELGMLTTGISGSGPTLFSVTDNLVTANAAKAWLEAHYLTEAGGFAHVCRLDEQGTRRVD

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=307, Percent_Identity=55.0488599348534, Blast_Score=350, Evalue=9e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 33200; Mature: 33069

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTVYAPASMGNVGVGFDLLGAALAPIDGSLLGDRVTIAAADAGVSLTQVGAWAHKLPS
CCEEEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCC
NPEENIVHQCAVFFLKALGKENQGVALTLEKNLPVGSGLGSSASSVVAALYALNEHFERP
CCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
YDKQALLELMGEFEGKISGSVHYDNVAPCYLGGMQLMLNVPGAICEPIPSFKQWYWVVAY
CCHHHHHHHHHHHCCCCCCCEECCCCCHHHHCCHHHHHCCCCHHHCCCCCHHHEEEEEEE
PGISLSTAMMRKLMPEQYDKSVAIDFGRYLSAFVHASYQQNAKLAIQVLKDVLAEPYRAA
CCCCHHHHHHHHHCHHHHCCCEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHC
AIPGYDNARAALAELGMLTTGISGSGPTLFSVTDNLVTANAAKAWLEAHYLTEAGGFAHV
CCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEE
CRLDEQGTRRVD
EECCCCCCCCCC
>Mature Secondary Structure 
SLTVYAPASMGNVGVGFDLLGAALAPIDGSLLGDRVTIAAADAGVSLTQVGAWAHKLPS
CEEEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCC
NPEENIVHQCAVFFLKALGKENQGVALTLEKNLPVGSGLGSSASSVVAALYALNEHFERP
CCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
YDKQALLELMGEFEGKISGSVHYDNVAPCYLGGMQLMLNVPGAICEPIPSFKQWYWVVAY
CCHHHHHHHHHHHCCCCCCCEECCCCCHHHHCCHHHHHCCCCHHHCCCCCHHHEEEEEEE
PGISLSTAMMRKLMPEQYDKSVAIDFGRYLSAFVHASYQQNAKLAIQVLKDVLAEPYRAA
CCCCHHHHHHHHHCHHHHCCCEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHC
AIPGYDNARAALAELGMLTTGISGSGPTLFSVTDNLVTANAAKAWLEAHYLTEAGGFAHV
CCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEE
CRLDEQGTRRVD
EECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA