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The map label for this gene is ribB [H]

Identifier: 117919547

GI number: 117919547

Start: 1292284

End: 1293387

Strand: Direct

Name: ribB [H]

Synonym: Shewana3_1098

Alternate gene names: 117919547

Gene position: 1292284-1293387 (Clockwise)

Preceding gene: 117919546

Following gene: 117919548

Centisome position: 25.99

GC content: 50.27

Gene sequence:

>1104_bases
ATGGCGCTGCACAGTATAGAAGAGATCATCGAGGATATTCGTCAAGGCAAAATGGTTATTTTGATGGATGACGAAGACAG
AGAAAACGAAGGCGACCTGATTATGGCGGCCGAGCTGGTGACGCCTGAAGCGATTAACTTTATGGCGAAATACGGCCGTG
GACTTATCTGCCAAACGATGACTAAGGCCCGTTGTCAGCAGCTAAACCTGCCCTTGATGGTGACTAATAACAATGCGCAG
TTCTCGACTAACTTTACGGTATCGATTGAAGCGGCAGAAGGTGTAACCACCGGGATTTCGGCCCACGATCGCGCTGTAAC
GGTAAAAGCTGCCGTGGCTAAAGATGCCAAGGCATCGGATTTAGTACAACCTGGTCATATCTTCCCATTAATGGCGCAGG
ACGGCGGCGTGTTAACCCGCGCAGGTCACACGGAAGCGGGTTGTGATTTAGCCCGTTTAGCAGGACTTGAGCCATCGGGG
GTGATTGTTGAGATCCTCAATGAAGACGGCACTATGGCTCGTCGCCCCGATTTAGAGATTTTCTCTGAATTACACGGGAT
TAAAATCGGCACTATTGCGGCGCTTATCGAATACCGCAACACCAAAGAAACCACTGTCGTGCGCGAAGCCAAATGTAAAC
TGCCAACCCGCTTTGGCGAGTTCGACATGGTGACCTTTAGGGATACTATCGACAATCAACTGCACTTTGCCTTAGTGAAG
GGCGAGGTGAAACCGGATTGTTTAGTGCGCGTACACTTACAAAATACCTTCAACGATTTACTCCACTCAGAGCGCGATCA
GCAGCGTAGCTGGCCGCTTGAAAAAGCCATGGAGCGCATTTCTGCCGAAGGTGGAGTGTTGGTGCTACTGGGCAATCAAG
AGCATACCTGTGAAATTCTCTCTAAAGTCAAAGCCTTTGAAGCAGAAGATCAAGGTCAAGCGCCAGCCTCTGCAAAATGG
CAAGGCACTTCACGCCGCGTGGGTGTAGGTTCGCAAATCCTTGCCAGCCTTGGGGTAACCAAAATGCGTCTCTTGAGTTC
GCCTAAGCGTTATCACTCGCTCTCTGGCTTTGGGCTTGAAGTGACTGAATACGTAGCGGAGTAA

Upstream 100 bases:

>100_bases
GAAATGTTAGCCCGTGCTGGCTTTGTGCGTTAGGGCACTGGCACTTAGCTCACTTAGGTATAGAATTTCATAACAACAGT
AAAATCATAAAGGTCCTACA

Downstream 100 bases:

>100_bases
CAGGCCGAGCTTGTTAGACGTTGCACTAAGGTAAAATTAATCATTTGTATAATTTGCATAGGGCTGTGGGCGATTGACTG
TGGTATCATGTCGCCACTTT

Product: GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: DHBP synthase [H]

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MALHSIEEIIEDIRQGKMVILMDDEDRENEGDLIMAAELVTPEAINFMAKYGRGLICQTMTKARCQQLNLPLMVTNNNAQ
FSTNFTVSIEAAEGVTTGISAHDRAVTVKAAVAKDAKASDLVQPGHIFPLMAQDGGVLTRAGHTEAGCDLARLAGLEPSG
VIVEILNEDGTMARRPDLEIFSELHGIKIGTIAALIEYRNTKETTVVREAKCKLPTRFGEFDMVTFRDTIDNQLHFALVK
GEVKPDCLVRVHLQNTFNDLLHSERDQQRSWPLEKAMERISAEGGVLVLLGNQEHTCEILSKVKAFEAEDQGQAPASAKW
QGTSRRVGVGSQILASLGVTKMRLLSSPKRYHSLSGFGLEVTEYVAE

Sequences:

>Translated_367_residues
MALHSIEEIIEDIRQGKMVILMDDEDRENEGDLIMAAELVTPEAINFMAKYGRGLICQTMTKARCQQLNLPLMVTNNNAQ
FSTNFTVSIEAAEGVTTGISAHDRAVTVKAAVAKDAKASDLVQPGHIFPLMAQDGGVLTRAGHTEAGCDLARLAGLEPSG
VIVEILNEDGTMARRPDLEIFSELHGIKIGTIAALIEYRNTKETTVVREAKCKLPTRFGEFDMVTFRDTIDNQLHFALVK
GEVKPDCLVRVHLQNTFNDLLHSERDQQRSWPLEKAMERISAEGGVLVLLGNQEHTCEILSKVKAFEAEDQGQAPASAKW
QGTSRRVGVGSQILASLGVTKMRLLSSPKRYHSLSGFGLEVTEYVAE
>Mature_366_residues
ALHSIEEIIEDIRQGKMVILMDDEDRENEGDLIMAAELVTPEAINFMAKYGRGLICQTMTKARCQQLNLPLMVTNNNAQF
STNFTVSIEAAEGVTTGISAHDRAVTVKAAVAKDAKASDLVQPGHIFPLMAQDGGVLTRAGHTEAGCDLARLAGLEPSGV
IVEILNEDGTMARRPDLEIFSELHGIKIGTIAALIEYRNTKETTVVREAKCKLPTRFGEFDMVTFRDTIDNQLHFALVKG
EVKPDCLVRVHLQNTFNDLLHSERDQQRSWPLEKAMERISAEGGVLVLLGNQEHTCEILSKVKAFEAEDQGQAPASAKWQ
GTSRRVGVGSQILASLGVTKMRLLSSPKRYHSLSGFGLEVTEYVAE

Specific function: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=198, Percent_Identity=52.5252525252525, Blast_Score=217, Evalue=8e-58,
Organism=Escherichia coli, GI1787533, Length=166, Percent_Identity=32.5301204819277, Blast_Score=69, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6320695, Length=201, Percent_Identity=45.771144278607, Blast_Score=182, Evalue=9e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12 [H]

Molecular weight: Translated: 40288; Mature: 40156

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALHSIEEIIEDIRQGKMVILMDDEDRENEGDLIMAAELVTPEAINFMAKYGRGLICQTM
CCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCEEEHHH
TKARCQQLNLPLMVTNNNAQFSTNFTVSIEAAEGVTTGISAHDRAVTVKAAVAKDAKASD
HHHHHHHCCCCEEEECCCCEEEEEEEEEEEECCCCCCCCCCCCCEEEEEEHHHCCCCHHH
LVQPGHIFPLMAQDGGVLTRAGHTEAGCDLARLAGLEPSGVIVEILNEDGTMARRPDLEI
CCCCCCEEEEEECCCCEEEECCCCCCCCCHHHHCCCCCCCEEEEEECCCCCCCCCCCHHH
FSELHGIKIGTIAALIEYRNTKETTVVREAKCKLPTRFGEFDMVTFRDTIDNQLHFALVK
HHHHCCCCHHHHHHHHHHCCCCHHHEEHHHHCCCCCCCCCEEEEEECCCCCCCEEEEEEE
GEVKPDCLVRVHLQNTFNDLLHSERDQQRSWPLEKAMERISAEGGVLVLLGNQEHTCEIL
CCCCCCEEEEEEEHHHHHHHHHCHHHHHHCCCHHHHHHHHCCCCCEEEEECCCCHHHHHH
SKVKAFEAEDQGQAPASAKWQGTSRRVGVGSQILASLGVTKMRLLSSPKRYHSLSGFGLE
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCHHHHHHHCCCHHHHCCCCCCCH
VTEYVAE
HHHHHCC
>Mature Secondary Structure 
ALHSIEEIIEDIRQGKMVILMDDEDRENEGDLIMAAELVTPEAINFMAKYGRGLICQTM
CHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCEEEHHH
TKARCQQLNLPLMVTNNNAQFSTNFTVSIEAAEGVTTGISAHDRAVTVKAAVAKDAKASD
HHHHHHHCCCCEEEECCCCEEEEEEEEEEEECCCCCCCCCCCCCEEEEEEHHHCCCCHHH
LVQPGHIFPLMAQDGGVLTRAGHTEAGCDLARLAGLEPSGVIVEILNEDGTMARRPDLEI
CCCCCCEEEEEECCCCEEEECCCCCCCCCHHHHCCCCCCCEEEEEECCCCCCCCCCCHHH
FSELHGIKIGTIAALIEYRNTKETTVVREAKCKLPTRFGEFDMVTFRDTIDNQLHFALVK
HHHHCCCCHHHHHHHHHHCCCCHHHEEHHHHCCCCCCCCCEEEEEECCCCCCCEEEEEEE
GEVKPDCLVRVHLQNTFNDLLHSERDQQRSWPLEKAMERISAEGGVLVLLGNQEHTCEIL
CCCCCCEEEEEEEHHHHHHHHHCHHHHHHCCCHHHHHHHHCCCCCEEEEECCCCHHHHHH
SKVKAFEAEDQGQAPASAKWQGTSRRVGVGSQILASLGVTKMRLLSSPKRYHSLSGFGLE
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCHHHHHHHCCCHHHHCCCCCCCH
VTEYVAE
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1339274 [H]