Click here to switch to the map view.

The map label for this gene is degS [H]

Identifier: 117919141

GI number: 117919141

Start: 804742

End: 805824

Strand: Reverse

Name: degS [H]

Synonym: Shewana3_0689

Alternate gene names: 117919141

Gene position: 805824-804742 (Counterclockwise)

Preceding gene: 117919142

Following gene: 117919137

Centisome position: 16.21

GC content: 49.22

Gene sequence:

>1083_bases
ATGACAATAAAAGAAACCCTGTTATATCTCGGTAAAGCCGTGCTCTTCGGCCTTATCATGGCGGCCATGTTTTTGTTAGT
TACACACTACTTCGACAATAAGAATCTCGGCAGCTCGTTACTGCAAAACCGGGGTAATAACACGGTCGAACTCTCCTTTG
CTAAGGCCGTACGCCGCGCCGCTCCTGCCGTAGTCAATATTTATAGCTTAAGTATTGATCAGAACCGTCCGCTAAACTCT
GGCTCCCTCCAAGGCCTAGGCTCAGGGGTGATCATGAGCAAAGAAGGCTATATTCTCACGAATTATCATGTGATTAAAAA
AGCTGATGAAATTGTGGTCGCCCTGCAGGATGGCCGCAAATTCACCTCGGAAGTCGTCGGTTTTGATCCAGAAACCGATC
TTTCAGTGCTTAAGATCGAAGGCGATAATCTTCCTACGGTGCCAGTCAATCTCGACAGCCCACCGCAGGTTGGGGATGTG
GTATTAGCGATTGGTAACCCTTATAACCTCGGCCAAACCATTACCCAAGGCATTATCAGCGCCACGGGTCGTAACGGCTT
AAGTTCTGGTTATTTAGACTTCTTACAGACAGATGCTGCAATTAACGCCGGTAACTCAGGCGGCGCCTTAATCGACACTA
ACGGTAGCCTGATTGGTATCAACACCGCCGCCTTCCAAGTGGGCGGTGAAGGTGGCGGCCACGGGATTAACTTCGCGATC
CCGATTAAACTGGCCCACAGCATTATGGGTAAACTGATTAAAAATGGTCGAGTGATCCGTGGTGCCTTAGGGATATCTGG
CGAACCGATTAACCCTGTTGTGGCGCAAATCCTCAACCTACCCGATTTACGTGGGGTATTAGTCACAGGCGTCGATCCTA
ATGGCCCTGCGGCACGGGCGCATCTACAACCAAGGGATGTGATCATCAAATACGATGGCGAAGATGTGCCAGGGGTCGAA
ATGCTGATGGATAGAATTGCCGAAACTACGCCCGGCAAGAAAATCATGATGACGGTTATCCGCCAAGGCAAAGAGCAAGT
ATTGCCGGTGATTATCGATGAAAAGGTCGTCGTCGATAATTAA

Upstream 100 bases:

>100_bases
CAATTATCAGATGCGGATCAGCATAGGGAACGCGGGTTCCCTATGCTTTAACTTGTTAAACATGTTAATCTAACTCACCT
TTTTCAATACTTAGCCTGCC

Downstream 100 bases:

>100_bases
GCTCAGTAAGCTACCTTGATTAATCTCAGAATGAGGCATGTATAGAACCTCATTCTGAGCCATCCTAAAATCACCTATTA
CTTCATCCCTCAATTAGCAA

Product: DegS serine peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MTIKETLLYLGKAVLFGLIMAAMFLLVTHYFDNKNLGSSLLQNRGNNTVELSFAKAVRRAAPAVVNIYSLSIDQNRPLNS
GSLQGLGSGVIMSKEGYILTNYHVIKKADEIVVALQDGRKFTSEVVGFDPETDLSVLKIEGDNLPTVPVNLDSPPQVGDV
VLAIGNPYNLGQTITQGIISATGRNGLSSGYLDFLQTDAAINAGNSGGALIDTNGSLIGINTAAFQVGGEGGGHGINFAI
PIKLAHSIMGKLIKNGRVIRGALGISGEPINPVVAQILNLPDLRGVLVTGVDPNGPAARAHLQPRDVIIKYDGEDVPGVE
MLMDRIAETTPGKKIMMTVIRQGKEQVLPVIIDEKVVVDN

Sequences:

>Translated_360_residues
MTIKETLLYLGKAVLFGLIMAAMFLLVTHYFDNKNLGSSLLQNRGNNTVELSFAKAVRRAAPAVVNIYSLSIDQNRPLNS
GSLQGLGSGVIMSKEGYILTNYHVIKKADEIVVALQDGRKFTSEVVGFDPETDLSVLKIEGDNLPTVPVNLDSPPQVGDV
VLAIGNPYNLGQTITQGIISATGRNGLSSGYLDFLQTDAAINAGNSGGALIDTNGSLIGINTAAFQVGGEGGGHGINFAI
PIKLAHSIMGKLIKNGRVIRGALGISGEPINPVVAQILNLPDLRGVLVTGVDPNGPAARAHLQPRDVIIKYDGEDVPGVE
MLMDRIAETTPGKKIMMTVIRQGKEQVLPVIIDEKVVVDN
>Mature_359_residues
TIKETLLYLGKAVLFGLIMAAMFLLVTHYFDNKNLGSSLLQNRGNNTVELSFAKAVRRAAPAVVNIYSLSIDQNRPLNSG
SLQGLGSGVIMSKEGYILTNYHVIKKADEIVVALQDGRKFTSEVVGFDPETDLSVLKIEGDNLPTVPVNLDSPPQVGDVV
LAIGNPYNLGQTITQGIISATGRNGLSSGYLDFLQTDAAINAGNSGGALIDTNGSLIGINTAAFQVGGEGGGHGINFAIP
IKLAHSIMGKLIKNGRVIRGALGISGEPINPVVAQILNLPDLRGVLVTGVDPNGPAARAHLQPRDVIIKYDGEDVPGVEM
LMDRIAETTPGKKIMMTVIRQGKEQVLPVIIDEKVVVDN

Specific function: Senses the OMP signal triggered by the accumulation of unassembled porins in the envelope and then initiates rseA degradation by cleaving it in its periplasmic domain, making it an attractive substrate for subsequent cleavage by rseP [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=329, Percent_Identity=31.6109422492401, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI4506141, Length=321, Percent_Identity=30.5295950155763, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI7019477, Length=314, Percent_Identity=32.1656050955414, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI24308541, Length=326, Percent_Identity=30.3680981595092, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1789630, Length=351, Percent_Identity=49.8575498575499, Blast_Score=291, Evalue=4e-80,
Organism=Escherichia coli, GI1789629, Length=274, Percent_Identity=42.7007299270073, Blast_Score=205, Evalue=3e-54,
Organism=Escherichia coli, GI1786356, Length=263, Percent_Identity=42.2053231939163, Blast_Score=199, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24646839, Length=290, Percent_Identity=32.0689655172414, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011783
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 38110; Mature: 37978

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKETLLYLGKAVLFGLIMAAMFLLVTHYFDNKNLGSSLLQNRGNNTVELSFAKAVRRA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEEEHHHHHHHHH
APAVVNIYSLSIDQNRPLNSGSLQGLGSGVIMSKEGYILTNYHVIKKADEIVVALQDGRK
CCCEEEEEEEEECCCCCCCCCCCCCCCCCEEEECCCEEEEEEHEEECCCEEEEEEECCCH
FTSEVVGFDPETDLSVLKIEGDNLPTVPVNLDSPPQVGDVVLAIGNPYNLGQTITQGIIS
HHHHHCCCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHH
ATGRNGLSSGYLDFLQTDAAINAGNSGGALIDTNGSLIGINTAAFQVGGEGGGHGINFAI
HCCCCCCCHHHHHHHHCCCEEECCCCCCEEEECCCCEEEEEHEEEEECCCCCCCCEEEEE
PIKLAHSIMGKLIKNGRVIRGALGISGEPINPVVAQILNLPDLRGVLVTGVDPNGPAARA
HHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHCCCCCCCEEEECCCCCCCCCCC
HLQPRDVIIKYDGEDVPGVEMLMDRIAETTPGKKIMMTVIRQGKEQVLPVIIDEKVVVDN
CCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCHHHCCCEEECCEEEECC
>Mature Secondary Structure 
TIKETLLYLGKAVLFGLIMAAMFLLVTHYFDNKNLGSSLLQNRGNNTVELSFAKAVRRA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEEEHHHHHHHHH
APAVVNIYSLSIDQNRPLNSGSLQGLGSGVIMSKEGYILTNYHVIKKADEIVVALQDGRK
CCCEEEEEEEEECCCCCCCCCCCCCCCCCEEEECCCEEEEEEHEEECCCEEEEEEECCCH
FTSEVVGFDPETDLSVLKIEGDNLPTVPVNLDSPPQVGDVVLAIGNPYNLGQTITQGIIS
HHHHHCCCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHH
ATGRNGLSSGYLDFLQTDAAINAGNSGGALIDTNGSLIGINTAAFQVGGEGGGHGINFAI
HCCCCCCCHHHHHHHHCCCEEECCCCCCEEEECCCCEEEEEHEEEEECCCCCCCCEEEEE
PIKLAHSIMGKLIKNGRVIRGALGISGEPINPVVAQILNLPDLRGVLVTGVDPNGPAARA
HHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHCCCCCCCEEEECCCCCCCCCCC
HLQPRDVIIKYDGEDVPGVEMLMDRIAETTPGKKIMMTVIRQGKEQVLPVIIDEKVVVDN
CCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCHHHCCCEEECCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]