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The map label for this gene is hemC [H]

Identifier: 117918843

GI number: 117918843

Start: 446502

End: 447434

Strand: Reverse

Name: hemC [H]

Synonym: Shewana3_0386

Alternate gene names: 117918843

Gene position: 447434-446502 (Counterclockwise)

Preceding gene: 117918845

Following gene: 117918842

Centisome position: 9.0

GC content: 53.16

Gene sequence:

>933_bases
ATGTCTGAAAACCGCATACGTATCGCTACCCGCAAGAGTCCGCTGGCCATGTGGCAAGCAGAATTTGTTAAAGCAGAATT
AGAACGCGTTCACCCAGGTATCGTGGTGGAGCTATTGCCAATGAGCACTAAGGGCGATGTTATCTTAGACACCCCATTAG
CTAAGGTTGGTGGTAAGGGCCTATTCGTAAAAGAACTCGAAGTCGCCATGCTGGAAGACCAAGCCGATATCGCGGTGCAC
TCGATGAAAGACGTGCCAGTGGATTTCCCCGAAGGCTTAGGACTGGAAGTGATTTGTGAGCGCGAAGATCCGCGCGACGC
CTTTGTGTCTAACCTTTATAAGTCAATCAGTGAGTTGCCACTTGGCGCCACAGTCGGCACCTCAAGCCTACGTCGTCAGT
GCCAGCTGCGCGCCTCACGCCCAGACCTGATTATCAAAGATCTGCGTGGCAACGTCGGTACTCGCCTCGCGAAACTCGAT
AACGGCGAATACGATGCGATTATCCTGGCTGCTGCAGGTTTAATCCGCCTGAAATTGTCTGAGCGTATCGCCAGCTTTAT
CTCTGCGGAAGAATCCTTACCCGCCAACGGACAAGGCGCTGTCGGTATCGAGTGCCGCACTAACGATGAACGCGTAAAAG
CACTCCTAGCACCTTTAGAACACTTAGAGACTCGCTACCGCGTGATCGCCGAGCGCGCCATGAATACTCGCCTCGAAGGC
GGCTGCCAAGTACCTATTGGTGCCTTTGCCGAAATCCACGGTGATGAGATGACACTGCGCGGCCTCGTAGGTAACCCAGA
TGGTAGCGAAATCATCGAAGGCGTGATTACAGGTCCAAAGACCGAAGCAACGAAACTCGGTGTGGCCCTGGCTGAAGAAC
TACTCAGCAAAGGCGCCAAAAGCATCCTCGACGCTGTTTACGCAAAAGCCTAA

Upstream 100 bases:

>100_bases
TAGAACGCCGCCGACTTCAAAGAATCGATACGCCTTCCTTACATTCACGAATAGCCAATGTTAGCATTGGCGCAACTAAG
ATCTCGGATGGAAACTAGGC

Downstream 100 bases:

>100_bases
GACGATGAAAGTCTTACTGACGCGCCCCGAGGGGCGCAATCAGTCCATGGTCGATGCCTTAACTGAAAAGGGTATCGACC
ACTGCGTTACTCCGCTCCTC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MSENRIRIATRKSPLAMWQAEFVKAELERVHPGIVVELLPMSTKGDVILDTPLAKVGGKGLFVKELEVAMLEDQADIAVH
SMKDVPVDFPEGLGLEVICEREDPRDAFVSNLYKSISELPLGATVGTSSLRRQCQLRASRPDLIIKDLRGNVGTRLAKLD
NGEYDAIILAAAGLIRLKLSERIASFISAEESLPANGQGAVGIECRTNDERVKALLAPLEHLETRYRVIAERAMNTRLEG
GCQVPIGAFAEIHGDEMTLRGLVGNPDGSEIIEGVITGPKTEATKLGVALAEELLSKGAKSILDAVYAKA

Sequences:

>Translated_310_residues
MSENRIRIATRKSPLAMWQAEFVKAELERVHPGIVVELLPMSTKGDVILDTPLAKVGGKGLFVKELEVAMLEDQADIAVH
SMKDVPVDFPEGLGLEVICEREDPRDAFVSNLYKSISELPLGATVGTSSLRRQCQLRASRPDLIIKDLRGNVGTRLAKLD
NGEYDAIILAAAGLIRLKLSERIASFISAEESLPANGQGAVGIECRTNDERVKALLAPLEHLETRYRVIAERAMNTRLEG
GCQVPIGAFAEIHGDEMTLRGLVGNPDGSEIIEGVITGPKTEATKLGVALAEELLSKGAKSILDAVYAKA
>Mature_309_residues
SENRIRIATRKSPLAMWQAEFVKAELERVHPGIVVELLPMSTKGDVILDTPLAKVGGKGLFVKELEVAMLEDQADIAVHS
MKDVPVDFPEGLGLEVICEREDPRDAFVSNLYKSISELPLGATVGTSSLRRQCQLRASRPDLIIKDLRGNVGTRLAKLDN
GEYDAIILAAAGLIRLKLSERIASFISAEESLPANGQGAVGIECRTNDERVKALLAPLEHLETRYRVIAERAMNTRLEGG
CQVPIGAFAEIHGDEMTLRGLVGNPDGSEIIEGVITGPKTEATKLGVALAEELLSKGAKSILDAVYAKA

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=332, Percent_Identity=41.8674698795181, Blast_Score=235, Evalue=3e-62,
Organism=Homo sapiens, GI20149500, Length=332, Percent_Identity=41.8674698795181, Blast_Score=235, Evalue=4e-62,
Organism=Escherichia coli, GI48994974, Length=307, Percent_Identity=69.7068403908795, Blast_Score=426, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6319996, Length=321, Percent_Identity=38.3177570093458, Blast_Score=196, Evalue=3e-51,
Organism=Drosophila melanogaster, GI20130425, Length=261, Percent_Identity=41.7624521072797, Blast_Score=204, Evalue=6e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33472; Mature: 33341

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENRIRIATRKSPLAMWQAEFVKAELERVHPGIVVELLPMSTKGDVILDTPLAKVGGKG
CCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCHHHHCCCC
LFVKELEVAMLEDQADIAVHSMKDVPVDFPEGLGLEVICEREDPRDAFVSNLYKSISELP
EEHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCC
LGATVGTSSLRRQCQLRASRPDLIIKDLRGNVGTRLAKLDNGEYDAIILAAAGLIRLKLS
CCCCCCHHHHHHHHHHCCCCCCEEHHHHCCCHHHEEEECCCCCCCEEEEEHHHHHHHHHH
ERIASFISAEESLPANGQGAVGIECRTNDERVKALLAPLEHLETRYRVIAERAMNTRLEG
HHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GCQVPIGAFAEIHGDEMTLRGLVGNPDGSEIIEGVITGPKTEATKLGVALAEELLSKGAK
CCCCCCCHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
SILDAVYAKA
HHHHHHHHCC
>Mature Secondary Structure 
SENRIRIATRKSPLAMWQAEFVKAELERVHPGIVVELLPMSTKGDVILDTPLAKVGGKG
CCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCHHHHCCCC
LFVKELEVAMLEDQADIAVHSMKDVPVDFPEGLGLEVICEREDPRDAFVSNLYKSISELP
EEHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCC
LGATVGTSSLRRQCQLRASRPDLIIKDLRGNVGTRLAKLDNGEYDAIILAAAGLIRLKLS
CCCCCCHHHHHHHHHHCCCCCCEEHHHHCCCHHHEEEECCCCCCCEEEEEHHHHHHHHHH
ERIASFISAEESLPANGQGAVGIECRTNDERVKALLAPLEHLETRYRVIAERAMNTRLEG
HHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GCQVPIGAFAEIHGDEMTLRGLVGNPDGSEIIEGVITGPKTEATKLGVALAEELLSKGAK
CCCCCCCHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
SILDAVYAKA
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA