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The map label for this gene is hemD [H]

Identifier: 117918842

GI number: 117918842

Start: 445757

End: 446455

Strand: Reverse

Name: hemD [H]

Synonym: Shewana3_0385

Alternate gene names: 117918842

Gene position: 446455-445757 (Counterclockwise)

Preceding gene: 117918843

Following gene: 117918841

Centisome position: 8.98

GC content: 51.65

Gene sequence:

>699_bases
ATGGTCGATGCCTTAACTGAAAAGGGTATCGACCACTGCGTTACTCCGCTCCTCTGTGTTGAGGCAACGCCTCCGCTGCC
ACCTGACACTTCACATCCCCTAGCCGATGTCGATATGGTTATCTGTATCAGCGCCAATGCGGTGAGCTTTGCTGATGCTG
CGTTTAACGTCGATACTGCCCAAGTTAAAGACTGGCCAAGCGTGCCTTATTTCGCCGTGGGTCATGCGACTTGCGAAGCG
CTGCAAGAAAAGGGAATTGAGGCTCTCGAAGCACCGGACGATTGCCAGCAAACGGAAGGCTTGCTGACCCTGCCAGCACT
GCAACATATCCAAGGTAAACATATCACTATCATTCGTGGCGTCGGTGGCCGTGAAGCCCTCGCCGAGCAACTGAATGCTA
GAGGCGCGAAGGTGCGCTATTGGGAAGTCTATCAACGCGCTTGCCCGCCGCTCGATGGTGCCGCTGTTAGTCAACAATGG
CGAGACTTTGGGATAGATACTATCGTCATAACGAGTGGTGAAGTACTGGATAATCTGATTAATCTAGTGCCAAAAGAGTT
ATTTGCATGGCTGCGCTCATGTCATATCATAGTCCCCAGTAACCGAGTAGAAGCTCAAGCTCATGCCTTTGGTATAACCC
AAGTCACCAATGCCAATGCCGCCAACAGCAAAGCCGTGCTAAACGCCCTTAAACTCTAA

Upstream 100 bases:

>100_bases
CTACTCAGCAAAGGCGCCAAAAGCATCCTCGACGCTGTTTACGCAAAAGCCTAAGACGATGAAAGTCTTACTGACGCGCC
CCGAGGGGCGCAATCAGTCC

Downstream 100 bases:

>100_bases
GCGCTATTTAGCCCGATTTTACTCGAATTTCGGCAGTAGCATGATTTTAAGGACTGTTAAATGGATAACAACAAGCACGA
CGCCCAAAGCCCAGAGTCAC

Product: uroporphyrinogen III synthase HEM4

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MVDALTEKGIDHCVTPLLCVEATPPLPPDTSHPLADVDMVICISANAVSFADAAFNVDTAQVKDWPSVPYFAVGHATCEA
LQEKGIEALEAPDDCQQTEGLLTLPALQHIQGKHITIIRGVGGREALAEQLNARGAKVRYWEVYQRACPPLDGAAVSQQW
RDFGIDTIVITSGEVLDNLINLVPKELFAWLRSCHIIVPSNRVEAQAHAFGITQVTNANAANSKAVLNALKL

Sequences:

>Translated_232_residues
MVDALTEKGIDHCVTPLLCVEATPPLPPDTSHPLADVDMVICISANAVSFADAAFNVDTAQVKDWPSVPYFAVGHATCEA
LQEKGIEALEAPDDCQQTEGLLTLPALQHIQGKHITIIRGVGGREALAEQLNARGAKVRYWEVYQRACPPLDGAAVSQQW
RDFGIDTIVITSGEVLDNLINLVPKELFAWLRSCHIIVPSNRVEAQAHAFGITQVTNANAANSKAVLNALKL
>Mature_232_residues
MVDALTEKGIDHCVTPLLCVEATPPLPPDTSHPLADVDMVICISANAVSFADAAFNVDTAQVKDWPSVPYFAVGHATCEA
LQEKGIEALEAPDDCQQTEGLLTLPALQHIQGKHITIIRGVGGREALAEQLNARGAKVRYWEVYQRACPPLDGAAVSQQW
RDFGIDTIVITSGEVLDNLINLVPKELFAWLRSCHIIVPSNRVEAQAHAFGITQVTNANAANSKAVLNALKL

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790236, Length=218, Percent_Identity=35.7798165137615, Blast_Score=130, Evalue=7e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 24995; Mature: 24995

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDALTEKGIDHCVTPLLCVEATPPLPPDTSHPLADVDMVICISANAVSFADAAFNVDTA
CCCCHHHCCHHHHHCHHEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHCCCCHH
QVKDWPSVPYFAVGHATCEALQEKGIEALEAPDDCQQTEGLLTLPALQHIQGKHITIIRG
HCCCCCCCCEEEHHHHHHHHHHHCCCHHHCCCCHHHHHCCEEECHHHHHCCCCEEEEEEC
VGGREALAEQLNARGAKVRYWEVYQRACPPLDGAAVSQQWRDFGIDTIVITSGEVLDNLI
CCCHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECHHHHHHHH
NLVPKELFAWLRSCHIIVPSNRVEAQAHAFGITQVTNANAANSKAVLNALKL
HHHHHHHHHHHHHCEEEECCCCCCHHHHHCCCEEECCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MVDALTEKGIDHCVTPLLCVEATPPLPPDTSHPLADVDMVICISANAVSFADAAFNVDTA
CCCCHHHCCHHHHHCHHEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHCCCCHH
QVKDWPSVPYFAVGHATCEALQEKGIEALEAPDDCQQTEGLLTLPALQHIQGKHITIIRG
HCCCCCCCCEEEHHHHHHHHHHHCCCHHHCCCCHHHHHCCEEECHHHHHCCCCEEEEEEC
VGGREALAEQLNARGAKVRYWEVYQRACPPLDGAAVSQQWRDFGIDTIVITSGEVLDNLI
CCCHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECHHHHHHHH
NLVPKELFAWLRSCHIIVPSNRVEAQAHAFGITQVTNANAANSKAVLNALKL
HHHHHHHHHHHHHCEEEECCCCCCHHHHHCCCEEECCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]