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The map label for this gene is bfmBAB [H]

Identifier: 116872804

GI number: 116872804

Start: 1376003

End: 1376986

Strand: Direct

Name: bfmBAB [H]

Synonym: lwe1388

Alternate gene names: 116872804

Gene position: 1376003-1376986 (Clockwise)

Preceding gene: 116872803

Following gene: 116872805

Centisome position: 48.9

GC content: 41.87

Gene sequence:

>984_bases
ATGCCAGTCATTTCATATATTGATGCAATAACAATGGCGCTTAAAGAAGAAATGGAGCGCGATGATAAAGTATTTATTTT
AGGGGAAGATGTTGGGAAAAAAGGCGGTGTATTTAAAGCGACTGCTGGTTTATATGATGAGTTTGGTGAAGACCGAGTTC
TCGATACACCACTTGCTGAATCCGCGATTGCCGGAGTCGGAATTGGAGCGGCGATGTATGGTTATCGTCCAGTTGCAGAA
ATGCAGTTTGCTGACTTTATTATGCCAGCTGTAAACCAAATTATTTCAGAAGCTTCCAGAATTCGTTACCGTTCGAACAA
TGATTGGTCATGCCCGTTAGTTATTCGCGCACCTTTTGGCGGCGGGGTTCACGGGGCGCTTTATCATTCTCAGTCGGTCG
AAAAAGTTTTCTTTGGACAACCTGGTTTGAAAATCGTTGTGCCTTCTTCTCCATATGATGCAAAAGGACTTTTAAAAGCA
GCGATTCGCGATAACGACCCAGTACTTTTCTTTGAACATAAACGTGCTTATCGTTTACTAAAAGGCGAAGTGCCAGAAAC
GGATTATATCGTTCCTATTGGCGAGGCAAATGTTGTTCGTGAAGGCGACGATATTACAGTAATTACTTACGGACTTGCTG
TTCAATTTGCCCAACAAGCAGCAGAACGCTTAGCTGCTGAGGGTGTAGAAGCTCATATTCTTGATTTACGGACGATTTAC
CCATTAGATCAAGAAGCAATTATCGAAGCAACGAAAAAAACAGGTAAGGTACTTCTTGTAACAGAAGACAATAAACAAGG
TAGCATCATTAGTGAAGTAGCGGCAATTATTTCAGAGCACTGTTTATTCGATTTAGATGCACCAATTGCAAGACTTGCAG
GTCCTGATACCCCAGCGATGCCTTTTGCGCCAACGATGGAAAAACATTTCATGATTAATCCTGATAAAGTGGCGGATGCA
ATGAAAGAATTAGCGGAATTTTAG

Upstream 100 bases:

>100_bases
GCAACTGATTATGCGGAAAGTGCAGCATACGCTGAACCAGAATCATCTTTACTTTATGTATATGATGAAGAAGCGAATAG
CTGATTAGGAGGGAATTTGA

Downstream 100 bases:

>100_bases
ACCCGTTTTAAATTAAAGGAGTGAAGACCCGTGGCAGTTGAAAAAATCACCATGCCCAAATTAGGGGAAAGTGTAACAGA
AGGAACCATTAGTTCGTGGT

Product: branched-chain alpha-keto acid dehydrogenase E1 subunit (2-oxoisovalerate dehydrogenase beta subunit)

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MPVISYIDAITMALKEEMERDDKVFILGEDVGKKGGVFKATAGLYDEFGEDRVLDTPLAESAIAGVGIGAAMYGYRPVAE
MQFADFIMPAVNQIISEASRIRYRSNNDWSCPLVIRAPFGGGVHGALYHSQSVEKVFFGQPGLKIVVPSSPYDAKGLLKA
AIRDNDPVLFFEHKRAYRLLKGEVPETDYIVPIGEANVVREGDDITVITYGLAVQFAQQAAERLAAEGVEAHILDLRTIY
PLDQEAIIEATKKTGKVLLVTEDNKQGSIISEVAAIISEHCLFDLDAPIARLAGPDTPAMPFAPTMEKHFMINPDKVADA
MKELAEF

Sequences:

>Translated_327_residues
MPVISYIDAITMALKEEMERDDKVFILGEDVGKKGGVFKATAGLYDEFGEDRVLDTPLAESAIAGVGIGAAMYGYRPVAE
MQFADFIMPAVNQIISEASRIRYRSNNDWSCPLVIRAPFGGGVHGALYHSQSVEKVFFGQPGLKIVVPSSPYDAKGLLKA
AIRDNDPVLFFEHKRAYRLLKGEVPETDYIVPIGEANVVREGDDITVITYGLAVQFAQQAAERLAAEGVEAHILDLRTIY
PLDQEAIIEATKKTGKVLLVTEDNKQGSIISEVAAIISEHCLFDLDAPIARLAGPDTPAMPFAPTMEKHFMINPDKVADA
MKELAEF
>Mature_326_residues
PVISYIDAITMALKEEMERDDKVFILGEDVGKKGGVFKATAGLYDEFGEDRVLDTPLAESAIAGVGIGAAMYGYRPVAEM
QFADFIMPAVNQIISEASRIRYRSNNDWSCPLVIRAPFGGGVHGALYHSQSVEKVFFGQPGLKIVVPSSPYDAKGLLKAA
IRDNDPVLFFEHKRAYRLLKGEVPETDYIVPIGEANVVREGDDITVITYGLAVQFAQQAAERLAAEGVEAHILDLRTIYP
LDQEAIIEATKKTGKVLLVTEDNKQGSIISEVAAIISEHCLFDLDAPIARLAGPDTPAMPFAPTMEKHFMINPDKVADAM
KELAEF

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=329, Percent_Identity=41.9452887537994, Blast_Score=269, Evalue=3e-72,
Organism=Homo sapiens, GI34101272, Length=329, Percent_Identity=41.9452887537994, Blast_Score=269, Evalue=3e-72,
Organism=Homo sapiens, GI156564403, Length=310, Percent_Identity=38.7096774193548, Blast_Score=228, Evalue=5e-60,
Organism=Homo sapiens, GI291084858, Length=310, Percent_Identity=37.741935483871, Blast_Score=211, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI17506935, Length=327, Percent_Identity=41.5902140672783, Blast_Score=243, Evalue=9e-65,
Organism=Caenorhabditis elegans, GI17538422, Length=320, Percent_Identity=40.3125, Blast_Score=240, Evalue=9e-64,
Organism=Saccharomyces cerevisiae, GI6319698, Length=326, Percent_Identity=39.2638036809816, Blast_Score=228, Evalue=1e-60,
Organism=Drosophila melanogaster, GI21358145, Length=308, Percent_Identity=41.2337662337662, Blast_Score=243, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24650940, Length=308, Percent_Identity=41.2337662337662, Blast_Score=243, Evalue=1e-64,
Organism=Drosophila melanogaster, GI160714828, Length=326, Percent_Identity=39.2638036809816, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI160714832, Length=326, Percent_Identity=39.2638036809816, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24650943, Length=86, Percent_Identity=46.5116279069767, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24650945, Length=86, Percent_Identity=46.5116279069767, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 35735; Mature: 35604

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVISYIDAITMALKEEMERDDKVFILGEDVGKKGGVFKATAGLYDEFGEDRVLDTPLAE
CCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEHHHHHHHCCCCCEECCCHHH
SAIAGVGIGAAMYGYRPVAEMQFADFIMPAVNQIISEASRIRYRSNNDWSCPLVIRAPFG
HHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCEEEEECCCC
GGVHGALYHSQSVEKVFFGQPGLKIVVPSSPYDAKGLLKAAIRDNDPVLFFEHKRAYRLL
CCCCHHHHCCCCHHHHCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEEECHHHHHHH
KGEVPETDYIVPIGEANVVREGDDITVITYGLAVQFAQQAAERLAAEGVEAHILDLRTIY
CCCCCCCCEEEECCCCCEEECCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEHHEEC
PLDQEAIIEATKKTGKVLLVTEDNKQGSIISEVAAIISEHCLFDLDAPIARLAGPDTPAM
CCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHEECCCCCHHHHCCCCCCCC
PFAPTMEKHFMINPDKVADAMKELAEF
CCCCCCCCCEEECHHHHHHHHHHHHCC
>Mature Secondary Structure 
PVISYIDAITMALKEEMERDDKVFILGEDVGKKGGVFKATAGLYDEFGEDRVLDTPLAE
CHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEHHHHHHHCCCCCEECCCHHH
SAIAGVGIGAAMYGYRPVAEMQFADFIMPAVNQIISEASRIRYRSNNDWSCPLVIRAPFG
HHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCEEEEECCCC
GGVHGALYHSQSVEKVFFGQPGLKIVVPSSPYDAKGLLKAAIRDNDPVLFFEHKRAYRLL
CCCCHHHHCCCCHHHHCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEEECHHHHHHH
KGEVPETDYIVPIGEANVVREGDDITVITYGLAVQFAQQAAERLAAEGVEAHILDLRTIY
CCCCCCCCEEEECCCCCEEECCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEHHEEC
PLDQEAIIEATKKTGKVLLVTEDNKQGSIISEVAAIISEHCLFDLDAPIARLAGPDTPAM
CCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHEECCCCCHHHHCCCCCCCC
PFAPTMEKHFMINPDKVADAMKELAEF
CCCCCCCCCEEECHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]