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The map label for this gene is gcvP2 [H]

Identifier: 116872781

GI number: 116872781

Start: 1354309

End: 1355775

Strand: Direct

Name: gcvP2 [H]

Synonym: lwe1365

Alternate gene names: 116872781

Gene position: 1354309-1355775 (Clockwise)

Preceding gene: 116872780

Following gene: 116872785

Centisome position: 48.13

GC content: 38.31

Gene sequence:

>1467_bases
ATGAATTTAGAAGAAACAATGCCATTAGTATTTGAACGCTCTATTCCAGGAAGAATTGGTTTTAGTTTGCCAGAAAGTGA
TGTGCCAGAAACAAAGGCTAGTGATTTTTTTGAGGAAGCTTATCTTCGTTCTACTCCAGCAGATTTACCCGAATTAAGTG
AGCTTGAAATTATGCGTCATTATACCAATTTATCCAATCATAACTTTGGCGTAGATTCTGGTTTTTATCCGCTTGGTTCT
TGTACGATGAAATATAATCCAAAAATCAATGAAAAAGTAGCTAGGTTCCCCGGTTTTGCCAACATTCACCCTAATCAACC
GGAAAGTTCAGTACAAGGCGCGCTTGAGCTGTTATATGATTTACAGACTAGTTTAGTTGAAATTACAGGTATGGATGAAG
TGACATTACAACCAGCTGCTGGAGCACATGGAGAATGGACAGGGTTGATGCTTATTCGTGCGTTCCATGAAAAAAATGGC
GACACGAAACGTACAAAAGTTATCATTCCAGATTCTGCTCATGGTACAAATCCGGCATCTGCGGCTGTTGCAGGCTTTGA
TGTAGTGACAGTTAAATCCAATGAAAAAGGTCTTGTGGATGTAGCTGATTTGAAAAAAGTAGTTGGTGAGGACACAGCAG
CACTAATGCTTACAAACCCAAATACACTTGGTCTGTTTGAAAAAGATATTGTGGAAATGGCAGAAATTGTTCATGCGGCA
GGTGGTAAATTGTATTATGATGGTGCCAACTTAAATGCAATTATGGCGAAAGTTAGACCAGGAGACATGGGTTTTGATGT
AGTACATTTAAACCTTCACAAAACTTTCACAGGTCCTCATGGAGGCGGTGGCCCAGGTTCAGGACCCATCGGTGTGAAAA
AAGAATTAATTCCATTTTTACCTACACCAGTGCTTACGAAAAAAGAAGATGCTTACACATTTGATTACAATTATCCTGAT
TCTATTGGACGTGTGAAGCCATACTATGGTAATTTTGGTATAAATGTGCGCGCATATACTTACATCCGCACTATGGGACC
AGATGGTTTGAAATTAGTGACGGAATATGCCGTGTTAAATGCTAATTATATGATGCGCAAATTACAAGCGGCGTATGATT
TGCCATTTGATCAAGTTTGCAAACATGAATTTGTTTTAAGTGGCAATAGACAGAAAAAACTCGGCGTCCGTACAATTGAT
ATTGCGAAACGTTTATTAGATCATAATTTCCATCCACCAACTGTTTATTTCCCATTAATCGTTGGGGAAGCAATTATGAT
TGAACCAACTGAAACAGAATCTAAGGAAACACTTGATTCGTTTATTGATACAATGTTAAAAATTGCTAAAGAAGCAGAAG
AGAATCCTGAAATCGTTCAAGAAGCGCCGCATAGTACGTATGTAAAACGACTAGATGAAACGCGGGCTGCTAGAAAACCT
GTTTTAAGATATCAAAAAGAAGTATAA

Upstream 100 bases:

>100_bases
TTTACGATACTAAATACGAAAAACATATGCTTGTAGCGGTAACTGAAATGCGTACTAAAGAGGAAATTGATGCCTTTGTG
GCGAGCTTGGAGGGTGTAAA

Downstream 100 bases:

>100_bases
AAAAATCCTTGTCATGAATTTTCATGACAAGGATTTTTTTATTTTGCTTTAGTTTTTCCTGTCCATTTACGGAAGCCGCC
TTTTAGCTGATAAACATCTT

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MNLEETMPLVFERSIPGRIGFSLPESDVPETKASDFFEEAYLRSTPADLPELSELEIMRHYTNLSNHNFGVDSGFYPLGS
CTMKYNPKINEKVARFPGFANIHPNQPESSVQGALELLYDLQTSLVEITGMDEVTLQPAAGAHGEWTGLMLIRAFHEKNG
DTKRTKVIIPDSAHGTNPASAAVAGFDVVTVKSNEKGLVDVADLKKVVGEDTAALMLTNPNTLGLFEKDIVEMAEIVHAA
GGKLYYDGANLNAIMAKVRPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPIGVKKELIPFLPTPVLTKKEDAYTFDYNYPD
SIGRVKPYYGNFGINVRAYTYIRTMGPDGLKLVTEYAVLNANYMMRKLQAAYDLPFDQVCKHEFVLSGNRQKKLGVRTID
IAKRLLDHNFHPPTVYFPLIVGEAIMIEPTETESKETLDSFIDTMLKIAKEAEENPEIVQEAPHSTYVKRLDETRAARKP
VLRYQKEV

Sequences:

>Translated_488_residues
MNLEETMPLVFERSIPGRIGFSLPESDVPETKASDFFEEAYLRSTPADLPELSELEIMRHYTNLSNHNFGVDSGFYPLGS
CTMKYNPKINEKVARFPGFANIHPNQPESSVQGALELLYDLQTSLVEITGMDEVTLQPAAGAHGEWTGLMLIRAFHEKNG
DTKRTKVIIPDSAHGTNPASAAVAGFDVVTVKSNEKGLVDVADLKKVVGEDTAALMLTNPNTLGLFEKDIVEMAEIVHAA
GGKLYYDGANLNAIMAKVRPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPIGVKKELIPFLPTPVLTKKEDAYTFDYNYPD
SIGRVKPYYGNFGINVRAYTYIRTMGPDGLKLVTEYAVLNANYMMRKLQAAYDLPFDQVCKHEFVLSGNRQKKLGVRTID
IAKRLLDHNFHPPTVYFPLIVGEAIMIEPTETESKETLDSFIDTMLKIAKEAEENPEIVQEAPHSTYVKRLDETRAARKP
VLRYQKEV
>Mature_488_residues
MNLEETMPLVFERSIPGRIGFSLPESDVPETKASDFFEEAYLRSTPADLPELSELEIMRHYTNLSNHNFGVDSGFYPLGS
CTMKYNPKINEKVARFPGFANIHPNQPESSVQGALELLYDLQTSLVEITGMDEVTLQPAAGAHGEWTGLMLIRAFHEKNG
DTKRTKVIIPDSAHGTNPASAAVAGFDVVTVKSNEKGLVDVADLKKVVGEDTAALMLTNPNTLGLFEKDIVEMAEIVHAA
GGKLYYDGANLNAIMAKVRPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPIGVKKELIPFLPTPVLTKKEDAYTFDYNYPD
SIGRVKPYYGNFGINVRAYTYIRTMGPDGLKLVTEYAVLNANYMMRKLQAAYDLPFDQVCKHEFVLSGNRQKKLGVRTID
IAKRLLDHNFHPPTVYFPLIVGEAIMIEPTETESKETLDSFIDTMLKIAKEAEENPEIVQEAPHSTYVKRLDETRAARKP
VLRYQKEV

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=432, Percent_Identity=43.287037037037, Blast_Score=297, Evalue=1e-80,
Organism=Escherichia coli, GI1789269, Length=430, Percent_Identity=41.8604651162791, Blast_Score=291, Evalue=9e-80,
Organism=Caenorhabditis elegans, GI17535605, Length=437, Percent_Identity=40.5034324942792, Blast_Score=284, Evalue=6e-77,
Organism=Caenorhabditis elegans, GI32564013, Length=370, Percent_Identity=42.972972972973, Blast_Score=261, Evalue=8e-70,
Organism=Saccharomyces cerevisiae, GI6323843, Length=464, Percent_Identity=42.0258620689655, Blast_Score=322, Evalue=1e-88,
Organism=Drosophila melanogaster, GI24645648, Length=414, Percent_Identity=41.7874396135266, Blast_Score=291, Evalue=6e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 54071; Mature: 54071

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLEETMPLVFERSIPGRIGFSLPESDVPETKASDFFEEAYLRSTPADLPELSELEIMRH
CCCHHHCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
YTNLSNHNFGVDSGFYPLGSCTMKYNPKINEKVARFPGFANIHPNQPESSVQGALELLYD
HHCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
LQTSLVEITGMDEVTLQPAAGAHGEWTGLMLIRAFHEKNGDTKRTKVIIPDSAHGTNPAS
HHHHHEEECCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHH
AAVAGFDVVTVKSNEKGLVDVADLKKVVGEDTAALMLTNPNTLGLFEKDIVEMAEIVHAA
HHEECEEEEEEECCCCCCEEHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHC
GGKLYYDGANLNAIMAKVRPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPIGVKKELIPFL
CCEEEECCCCCEEEEEEECCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHCC
PTPVLTKKEDAYTFDYNYPDSIGRVKPYYGNFGINVRAYTYIRTMGPDGLKLVTEYAVLN
CCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHH
ANYMMRKLQAAYDLPFDQVCKHEFVLSGNRQKKLGVRTIDIAKRLLDHNFHPPTVYFPLI
HHHHHHHHHHHHCCCHHHHHCHHHEECCCCCHHCCCCHHHHHHHHHHCCCCCCEEEEHHH
VGEAIMIEPTETESKETLDSFIDTMLKIAKEAEENPEIVQEAPHSTYVKRLDETRAARKP
HCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHH
VLRYQKEV
HHHHHCCC
>Mature Secondary Structure
MNLEETMPLVFERSIPGRIGFSLPESDVPETKASDFFEEAYLRSTPADLPELSELEIMRH
CCCHHHCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
YTNLSNHNFGVDSGFYPLGSCTMKYNPKINEKVARFPGFANIHPNQPESSVQGALELLYD
HHCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
LQTSLVEITGMDEVTLQPAAGAHGEWTGLMLIRAFHEKNGDTKRTKVIIPDSAHGTNPAS
HHHHHEEECCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHH
AAVAGFDVVTVKSNEKGLVDVADLKKVVGEDTAALMLTNPNTLGLFEKDIVEMAEIVHAA
HHEECEEEEEEECCCCCCEEHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHC
GGKLYYDGANLNAIMAKVRPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPIGVKKELIPFL
CCEEEECCCCCEEEEEEECCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHCC
PTPVLTKKEDAYTFDYNYPDSIGRVKPYYGNFGINVRAYTYIRTMGPDGLKLVTEYAVLN
CCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHH
ANYMMRKLQAAYDLPFDQVCKHEFVLSGNRQKKLGVRTIDIAKRLLDHNFHPPTVYFPLI
HHHHHHHHHHHHCCCHHHHHCHHHEECCCCCHHCCCCHHHHHHHHHHCCCCCCEEEEHHH
VGEAIMIEPTETESKETLDSFIDTMLKIAKEAEENPEIVQEAPHSTYVKRLDETRAARKP
HCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHH
VLRYQKEV
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]