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The map label for this gene is gcvP1 [H]

Identifier: 116872780

GI number: 116872780

Start: 1352966

End: 1354312

Strand: Direct

Name: gcvP1 [H]

Synonym: lwe1364

Alternate gene names: 116872780

Gene position: 1352966-1354312 (Clockwise)

Preceding gene: 116872779

Following gene: 116872781

Centisome position: 48.08

GC content: 36.97

Gene sequence:

>1347_bases
ATGGCAAAACATCGTTATTTACCAATGACAGAACAAGATGAAAAGGAAATGCTTGATGTAATAGGGGTTAAATCAATTGA
TGACTTATTTCAAGATATTCCAGAAAAAATTAGATTTAAGCGAGATTATGATTTAAAACCAGCAAAATCTGAACCAGCCT
TATTACGTGAATTGTCTAAACTTGCTTCTAAAAATGCCAATACAGCAGAATATGCATCTTTTTTAGGTGCAGGGGTTTAT
AGTCACTATATCCCTACAGTGGTAGATCATGTTATTTCTCGTTCTGAATTCTATACTGCTTATACCCCTTATCAGCCGGA
AATTTCGCAAGGAGAACTGCAAGCGATTTTTGAATTTCAAACAATGATTGCGGAATTAACTGGTATGGATTTAGCTAATT
CATCGATGTATGATGGCGGGACAGCCCTTGCAGAAGCAGCTATGTTAGCAAGTGGCCATACAAAACGTAAAAAAATCCTT
ATTTCAGGAGCTGTTCACCCAGAAAGCTCTAATGTATTAAAAACATATGCTACTGGTCAACATATCGAAGTAGAAGTGAT
TCCAGAAATAGATGGGAAAACTGATATGGATGCGCTAAAAAAAGCTCTTTCAGAGGATATCGCTGGTTTTGTCGTACAGT
ATCCAAACTTTTATGGTCAAGTTGAGCCTTTAGCAGAATTAGAAAAACTGATTCATGAAAATAATTCGTTACTATTAGTT
TCCAGTAATCCATTATCTCTTGGCTTACTTACACCACCAGGAGAGTTTGGTGCCGATATTGTTGTTGGGGATTCTCAAGT
GTTTGGTATACCAGAATCGTTTGGTGGTCCGCACTGTGGATTTTTTGCAGTAACAAATAAATTAATGCGTAAAGTTCCTG
GACGTTTAGTTGGAGAGACAGTGGACGAAAATGGAAAACGTGGTTATGTGTTGACTTTACAAGCGCGCGAACAACATATT
CGTCGTGATAAAGCTACATCAAATATTTGCTCGAACCAAGCTCTAAACGCATTAGCTTCCTCGGTTGCAATGGCGACGCT
TGGTAAAACAGGTCTAATAGAAATGGCAAAACAAAACCTAGATAAATCGCATTACGCAAAACAAAAATTCCGTGAAAATG
GTTTTGAAGTATTATTTTCAGATGGTTTTTTCAATGAGTTTGTCGTTAAACTCTCAAAACCAATTAAAGAAGTAAATGAA
TCGCTTTTAGATGAGGGGATTATTGGTGGGTATGATTTGGGTTTTTACGATACTAAATACGAAAAACATATGCTTGTAGC
GGTAACTGAAATGCGTACTAAAGAGGAAATTGATGCCTTTGTGGCGAGCTTGGAGGGTGTAAAATGA

Upstream 100 bases:

>100_bases
TAGGTCAAGAGTTAGAAGTGGGTATAAGAAATAAAAAAGTCAAAGCAAAAATAGTACAAACACCATTTTATAAACGCGCA
AAGTAAAAGGAGGAAATAAT

Downstream 100 bases:

>100_bases
ATTTAGAAGAAACAATGCCATTAGTATTTGAACGCTCTATTCCAGGAAGAATTGGTTTTAGTTTGCCAGAAAGTGATGTG
CCAGAAACAAAGGCTAGTGA

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MAKHRYLPMTEQDEKEMLDVIGVKSIDDLFQDIPEKIRFKRDYDLKPAKSEPALLRELSKLASKNANTAEYASFLGAGVY
SHYIPTVVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQTMIAELTGMDLANSSMYDGGTALAEAAMLASGHTKRKKIL
ISGAVHPESSNVLKTYATGQHIEVEVIPEIDGKTDMDALKKALSEDIAGFVVQYPNFYGQVEPLAELEKLIHENNSLLLV
SSNPLSLGLLTPPGEFGADIVVGDSQVFGIPESFGGPHCGFFAVTNKLMRKVPGRLVGETVDENGKRGYVLTLQAREQHI
RRDKATSNICSNQALNALASSVAMATLGKTGLIEMAKQNLDKSHYAKQKFRENGFEVLFSDGFFNEFVVKLSKPIKEVNE
SLLDEGIIGGYDLGFYDTKYEKHMLVAVTEMRTKEEIDAFVASLEGVK

Sequences:

>Translated_448_residues
MAKHRYLPMTEQDEKEMLDVIGVKSIDDLFQDIPEKIRFKRDYDLKPAKSEPALLRELSKLASKNANTAEYASFLGAGVY
SHYIPTVVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQTMIAELTGMDLANSSMYDGGTALAEAAMLASGHTKRKKIL
ISGAVHPESSNVLKTYATGQHIEVEVIPEIDGKTDMDALKKALSEDIAGFVVQYPNFYGQVEPLAELEKLIHENNSLLLV
SSNPLSLGLLTPPGEFGADIVVGDSQVFGIPESFGGPHCGFFAVTNKLMRKVPGRLVGETVDENGKRGYVLTLQAREQHI
RRDKATSNICSNQALNALASSVAMATLGKTGLIEMAKQNLDKSHYAKQKFRENGFEVLFSDGFFNEFVVKLSKPIKEVNE
SLLDEGIIGGYDLGFYDTKYEKHMLVAVTEMRTKEEIDAFVASLEGVK
>Mature_447_residues
AKHRYLPMTEQDEKEMLDVIGVKSIDDLFQDIPEKIRFKRDYDLKPAKSEPALLRELSKLASKNANTAEYASFLGAGVYS
HYIPTVVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQTMIAELTGMDLANSSMYDGGTALAEAAMLASGHTKRKKILI
SGAVHPESSNVLKTYATGQHIEVEVIPEIDGKTDMDALKKALSEDIAGFVVQYPNFYGQVEPLAELEKLIHENNSLLLVS
SNPLSLGLLTPPGEFGADIVVGDSQVFGIPESFGGPHCGFFAVTNKLMRKVPGRLVGETVDENGKRGYVLTLQAREQHIR
RDKATSNICSNQALNALASSVAMATLGKTGLIEMAKQNLDKSHYAKQKFRENGFEVLFSDGFFNEFVVKLSKPIKEVNES
LLDEGIIGGYDLGFYDTKYEKHMLVAVTEMRTKEEIDAFVASLEGVK

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=420, Percent_Identity=39.2857142857143, Blast_Score=292, Evalue=3e-79,
Organism=Escherichia coli, GI1789269, Length=359, Percent_Identity=34.8189415041783, Blast_Score=201, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI17535605, Length=394, Percent_Identity=39.3401015228426, Blast_Score=268, Evalue=5e-72,
Organism=Saccharomyces cerevisiae, GI6323843, Length=419, Percent_Identity=38.6634844868735, Blast_Score=270, Evalue=3e-73,
Organism=Drosophila melanogaster, GI24645648, Length=389, Percent_Identity=40.1028277634961, Blast_Score=285, Evalue=4e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 49502; Mature: 49371

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKHRYLPMTEQDEKEMLDVIGVKSIDDLFQDIPEKIRFKRDYDLKPAKSEPALLRELSK
CCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
LASKNANTAEYASFLGAGVYSHYIPTVVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQ
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCEEEECCCCCCCCCCHHHHHHHHH
TMIAELTGMDLANSSMYDGGTALAEAAMLASGHTKRKKILISGAVHPESSNVLKTYATGQ
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEEECCCC
HIEVEVIPEIDGKTDMDALKKALSEDIAGFVVQYPNFYGQVEPLAELEKLIHENNSLLLV
EEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEE
SSNPLSLGLLTPPGEFGADIVVGDSQVFGIPESFGGPHCGFFAVTNKLMRKVPGRLVGET
ECCCCEEEEECCCCCCCCEEEECCCEEECCCHHCCCCCCHHHHHHHHHHHHCCHHHHCCC
VDENGKRGYVLTLQAREQHIRRDKATSNICSNQALNALASSVAMATLGKTGLIEMAKQNL
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
DKSHYAKQKFRENGFEVLFSDGFFNEFVVKLSKPIKEVNESLLDEGIIGGYDLGFYDTKY
CHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
EKHMLVAVTEMRTKEEIDAFVASLEGVK
CCEEEEEHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AKHRYLPMTEQDEKEMLDVIGVKSIDDLFQDIPEKIRFKRDYDLKPAKSEPALLRELSK
CCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
LASKNANTAEYASFLGAGVYSHYIPTVVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQ
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCEEEECCCCCCCCCCHHHHHHHHH
TMIAELTGMDLANSSMYDGGTALAEAAMLASGHTKRKKILISGAVHPESSNVLKTYATGQ
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEEECCCC
HIEVEVIPEIDGKTDMDALKKALSEDIAGFVVQYPNFYGQVEPLAELEKLIHENNSLLLV
EEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEE
SSNPLSLGLLTPPGEFGADIVVGDSQVFGIPESFGGPHCGFFAVTNKLMRKVPGRLVGET
ECCCCEEEEECCCCCCCCEEEECCCEEECCCHHCCCCCCHHHHHHHHHHHHCCHHHHCCC
VDENGKRGYVLTLQAREQHIRRDKATSNICSNQALNALASSVAMATLGKTGLIEMAKQNL
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
DKSHYAKQKFRENGFEVLFSDGFFNEFVVKLSKPIKEVNESLLDEGIIGGYDLGFYDTKY
CHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
EKHMLVAVTEMRTKEEIDAFVASLEGVK
CCEEEEEHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]