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The map label for this gene is gcvT [H]

Identifier: 116872779

GI number: 116872779

Start: 1351863

End: 1352951

Strand: Direct

Name: gcvT [H]

Synonym: lwe1363

Alternate gene names: 116872779

Gene position: 1351863-1352951 (Clockwise)

Preceding gene: 116872771

Following gene: 116872780

Centisome position: 48.04

GC content: 36.55

Gene sequence:

>1089_bases
ATGACAGAATTACTAAAAACACCGATTCATCCACTTTATGCAAAATACGGTGCGAAAACCATTGATTTTGGTGGATGGGA
TTTACCAGTACAATTTGCTGGGATAAAAGCAGAACATGAAGCCGTGCGAACAGATGCAGGGTTGTTTGACGTGTCTCATA
TGGGAGAAATTTTAGTGAAAGGTCCTGACAGTACTTCTTATTTACAGTATTTACTATCCAACGACATAGAGAAAATAAAA
ATTGGAAAAGCGCAATACAACATCATGTGTTATGAAAATGGTGGAACCGTGGATGATTTAGTAGTATATAAAAAATCAGA
AACAGAATACATACTTGTCGTCAATGCGGCAAATACAGAAAAAGATTTTGAATGGATGGTACAAAACGTTCGGGGAGATG
TGACAGTTACTAATGTTTCTGCGGAATATGGTCAATTAGCGCTTCAAGGTCCAAGTGCAGAAAAAATCCTTTCGAAGTTG
ACGGATGTAGATTTAAGTTCTATAAGCTTCTTTGGATTCATAGAAGACGTAGAGGTAGCCGGAGTAAAAACAATTATTTC
TAGAAGTGGCTATACTGGAGAAGATGGTTTTGAAATTTATATGGCAAGCGCAGATGCTGGAAAAGTATTTGAAGCTATTT
TGGCAGAAGGGGTAGCGCCAATTGGTTTAGGTGCTCGTGATACGTTGCGCCTAGAAGCGGTGCTAGCTTTATATGGTCAA
GAATTAAGTAAGGATATTACACCACTTGAAGCAGGTCTGAATTTTGCTGTGAAATTAAAAAAAGAAGCAGATTTTATTGG
TAAGGAAGCGCTTATCAAACAAAAAGAAGCTGGACTCACAAGAAAATTAGTTGGTATTGAATTAATCGAACGTGGTATTC
CTCGTCACGATTATCCAGTGTTTTTAAATGATAAAGAAGTTGGAATTGTTACTTCAGGTACACAATCCCCAACATTTGGA
ACCAATATAGGTTTAGCTTTAATAGATACAGCTTATGCAGAATTAGGTCAAGAGTTAGAAGTGGGTATAAGAAATAAAAA
AGTCAAAGCAAAAATAGTACAAACACCATTTTATAAACGCGCAAAGTAA

Upstream 100 bases:

>100_bases
AAGGATGTTTACGGGACGCAACTCTGGAGTCATTTTTATGTCACGACAGGGCTTATGAATCATATAAGCCTTTTTGTTAT
GTGAAAAGGAGGATATAATT

Downstream 100 bases:

>100_bases
AAGGAGGAAATAATATGGCAAAACATCGTTATTTACCAATGACAGAACAAGATGAAAAGGAAATGCTTGATGTAATAGGG
GTTAAATCAATTGATGACTT

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MTELLKTPIHPLYAKYGAKTIDFGGWDLPVQFAGIKAEHEAVRTDAGLFDVSHMGEILVKGPDSTSYLQYLLSNDIEKIK
IGKAQYNIMCYENGGTVDDLVVYKKSETEYILVVNAANTEKDFEWMVQNVRGDVTVTNVSAEYGQLALQGPSAEKILSKL
TDVDLSSISFFGFIEDVEVAGVKTIISRSGYTGEDGFEIYMASADAGKVFEAILAEGVAPIGLGARDTLRLEAVLALYGQ
ELSKDITPLEAGLNFAVKLKKEADFIGKEALIKQKEAGLTRKLVGIELIERGIPRHDYPVFLNDKEVGIVTSGTQSPTFG
TNIGLALIDTAYAELGQELEVGIRNKKVKAKIVQTPFYKRAK

Sequences:

>Translated_362_residues
MTELLKTPIHPLYAKYGAKTIDFGGWDLPVQFAGIKAEHEAVRTDAGLFDVSHMGEILVKGPDSTSYLQYLLSNDIEKIK
IGKAQYNIMCYENGGTVDDLVVYKKSETEYILVVNAANTEKDFEWMVQNVRGDVTVTNVSAEYGQLALQGPSAEKILSKL
TDVDLSSISFFGFIEDVEVAGVKTIISRSGYTGEDGFEIYMASADAGKVFEAILAEGVAPIGLGARDTLRLEAVLALYGQ
ELSKDITPLEAGLNFAVKLKKEADFIGKEALIKQKEAGLTRKLVGIELIERGIPRHDYPVFLNDKEVGIVTSGTQSPTFG
TNIGLALIDTAYAELGQELEVGIRNKKVKAKIVQTPFYKRAK
>Mature_361_residues
TELLKTPIHPLYAKYGAKTIDFGGWDLPVQFAGIKAEHEAVRTDAGLFDVSHMGEILVKGPDSTSYLQYLLSNDIEKIKI
GKAQYNIMCYENGGTVDDLVVYKKSETEYILVVNAANTEKDFEWMVQNVRGDVTVTNVSAEYGQLALQGPSAEKILSKLT
DVDLSSISFFGFIEDVEVAGVKTIISRSGYTGEDGFEIYMASADAGKVFEAILAEGVAPIGLGARDTLRLEAVLALYGQE
LSKDITPLEAGLNFAVKLKKEADFIGKEALIKQKEAGLTRKLVGIELIERGIPRHDYPVFLNDKEVGIVTSGTQSPTFGT
NIGLALIDTAYAELGQELEVGIRNKKVKAKIVQTPFYKRAK

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=369, Percent_Identity=33.6043360433604, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI257796258, Length=353, Percent_Identity=33.7110481586402, Blast_Score=181, Evalue=6e-46,
Organism=Homo sapiens, GI24797151, Length=336, Percent_Identity=33.9285714285714, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI257796254, Length=362, Percent_Identity=30.6629834254144, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI257796256, Length=311, Percent_Identity=33.1189710610932, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI197927446, Length=282, Percent_Identity=29.4326241134752, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI21361378, Length=282, Percent_Identity=29.4326241134752, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI194306651, Length=325, Percent_Identity=25.8461538461538, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1789272, Length=368, Percent_Identity=39.4021739130435, Blast_Score=253, Evalue=9e-69,
Organism=Caenorhabditis elegans, GI17560118, Length=362, Percent_Identity=35.0828729281768, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI32563613, Length=351, Percent_Identity=27.6353276353276, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71994045, Length=340, Percent_Identity=27.6470588235294, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71994052, Length=340, Percent_Identity=27.6470588235294, Blast_Score=123, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320222, Length=389, Percent_Identity=35.73264781491, Blast_Score=197, Evalue=3e-51,
Organism=Drosophila melanogaster, GI20129441, Length=372, Percent_Identity=35.752688172043, Blast_Score=204, Evalue=7e-53,
Organism=Drosophila melanogaster, GI28571104, Length=348, Percent_Identity=30.1724137931034, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI20130091, Length=367, Percent_Identity=25.8855585831063, Blast_Score=101, Evalue=7e-22,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 39560; Mature: 39429

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELLKTPIHPLYAKYGAKTIDFGGWDLPVQFAGIKAEHEAVRTDAGLFDVSHMGEILVK
CCCHHHCCCHHHHHHHCCCEEECCCCCCEEEEECCCCHHHHHHCCCCEEEHHCCCCEEEE
GPDSTSYLQYLLSNDIEKIKIGKAQYNIMCYENGGTVDDLVVYKKSETEYILVVNAANTE
CCCHHHHHHHHHHCCCCEEEECCEEEEEEEECCCCCEEEEEEEEECCCCEEEEEECCCCC
KDFEWMVQNVRGDVTVTNVSAEYGQLALQGPSAEKILSKLTDVDLSSISFFGFIEDVEVA
HHHHHHHHHCCCCEEEEECCCCCCEEEECCCCHHHHHHHHHCCCHHHEEEEEEHHHHHHH
GVKTIISRSGYTGEDGFEIYMASADAGKVFEAILAEGVAPIGLGARDTLRLEAVLALYGQ
HHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
ELSKDITPLEAGLNFAVKLKKEADFIGKEALIKQKEAGLTRKLVGIELIERGIPRHDYPV
HHHCCCCHHHHCCCEEEEEECHHHHCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCE
FLNDKEVGIVTSGTQSPTFGTNIGLALIDTAYAELGQELEVGIRNKKVKAKIVQTPFYKR
EECCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCHHCCCCCCCEEEEEEECCCCCCC
AK
CC
>Mature Secondary Structure 
TELLKTPIHPLYAKYGAKTIDFGGWDLPVQFAGIKAEHEAVRTDAGLFDVSHMGEILVK
CCHHHCCCHHHHHHHCCCEEECCCCCCEEEEECCCCHHHHHHCCCCEEEHHCCCCEEEE
GPDSTSYLQYLLSNDIEKIKIGKAQYNIMCYENGGTVDDLVVYKKSETEYILVVNAANTE
CCCHHHHHHHHHHCCCCEEEECCEEEEEEEECCCCCEEEEEEEEECCCCEEEEEECCCCC
KDFEWMVQNVRGDVTVTNVSAEYGQLALQGPSAEKILSKLTDVDLSSISFFGFIEDVEVA
HHHHHHHHHCCCCEEEEECCCCCCEEEECCCCHHHHHHHHHCCCHHHEEEEEEHHHHHHH
GVKTIISRSGYTGEDGFEIYMASADAGKVFEAILAEGVAPIGLGARDTLRLEAVLALYGQ
HHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
ELSKDITPLEAGLNFAVKLKKEADFIGKEALIKQKEAGLTRKLVGIELIERGIPRHDYPV
HHHCCCCHHHHCCCEEEEEECHHHHCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCE
FLNDKEVGIVTSGTQSPTFGTNIGLALIDTAYAELGQELEVGIRNKKVKAKIVQTPFYKR
EECCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCHHCCCCCCCEEEEEEECCCCCCC
AK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]