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The map label for this gene is sipZ [H]

Identifier: 116872704

GI number: 116872704

Start: 1277536

End: 1278078

Strand: Direct

Name: sipZ [H]

Synonym: lwe1288

Alternate gene names: 116872704

Gene position: 1277536-1278078 (Clockwise)

Preceding gene: 116872703

Following gene: 116872705

Centisome position: 45.4

GC content: 34.25

Gene sequence:

>543_bases
TTGAAAGAAAAGAATTTAAAACGGTTATGGTCTTGGATTTGGGCGGCAGTTTTAGCAGTATTAATAGCTGTTATAATCCG
TTTTTATTTGTTTGTGCCAATTCTTGTTGATGGAATTTCAATGATGCCCACACTTCATAATGATGATCGAGTGATTATTA
ATCGCTTCGGACATGTAGACCGTTTTGATGTGATTGTTTTTCGTGAAAAAGATGGAAAAGAATACATAAAGCGAGTAATT
GGTTTGCCGGGAGATACTGTTGAATATAAAGCAGATCAACTCTACATTAACGGAAAAAAATATGATGAACCATATTTAGA
TACATACAAGAAAAAGCTGAAAGATGGCTATTTAACAGATGATTACAGTTCTAAAGATCAACTGAATGGTGGCAAAATTC
CAGAAAATACGTATTTTGTTTTAGGCGATAACCGGAGAGCCAGTAAAGATAGCAGAATAATTGGTCCAATTCCTTTAAGC
AAAGTATTAGGAACGACACCAATTTGTTATTGGCCGATTAAAGACGCCAAACTTATAGATTAG

Upstream 100 bases:

>100_bases
TGGAAGTCCGTGAAAGTTTTTTTCACGGCTTTCTCTATTAAATGAAAGATTTTTCGTTTATAATAAGACTGTTAGTAAAA
AAATAGGGCGGTGCAGTTTT

Downstream 100 bases:

>100_bases
GAGTATATGATGACAATTCAATGGTTTCCAGGTCATATGGCCAAAGCTCGTCGTGAGGTAACAGAAAAATTAAAATTAGT
GGATGTGATTTTTGAATTAG

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 180; Mature: 180

Protein sequence:

>180_residues
MKEKNLKRLWSWIWAAVLAVLIAVIIRFYLFVPILVDGISMMPTLHNDDRVIINRFGHVDRFDVIVFREKDGKEYIKRVI
GLPGDTVEYKADQLYINGKKYDEPYLDTYKKKLKDGYLTDDYSSKDQLNGGKIPENTYFVLGDNRRASKDSRIIGPIPLS
KVLGTTPICYWPIKDAKLID

Sequences:

>Translated_180_residues
MKEKNLKRLWSWIWAAVLAVLIAVIIRFYLFVPILVDGISMMPTLHNDDRVIINRFGHVDRFDVIVFREKDGKEYIKRVI
GLPGDTVEYKADQLYINGKKYDEPYLDTYKKKLKDGYLTDDYSSKDQLNGGKIPENTYFVLGDNRRASKDSRIIGPIPLS
KVLGTTPICYWPIKDAKLID
>Mature_180_residues
MKEKNLKRLWSWIWAAVLAVLIAVIIRFYLFVPILVDGISMMPTLHNDDRVIINRFGHVDRFDVIVFREKDGKEYIKRVI
GLPGDTVEYKADQLYINGKKYDEPYLDTYKKKLKDGYLTDDYSSKDQLNGGKIPENTYFVLGDNRRASKDSRIIGPIPLS
KVLGTTPICYWPIKDAKLID

Specific function: Not essential for cell viability, but required for efficient secretion of many proteins [H]

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 20847; Mature: 20847

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEKNLKRLWSWIWAAVLAVLIAVIIRFYLFVPILVDGISMMPTLHNDDRVIINRFGHVD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
RFDVIVFREKDGKEYIKRVIGLPGDTVEYKADQLYINGKKYDEPYLDTYKKKLKDGYLTD
EEEEEEEECCCCHHHHHHHHCCCCCCEEEECCEEEECCCCCCCHHHHHHHHHHHCCCCCC
DYSSKDQLNGGKIPENTYFVLGDNRRASKDSRIIGPIPLSKVLGTTPICYWPIKDAKLID
CCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEECCCCHHHHHCCCCEEEECCCCCCCCC
>Mature Secondary Structure
MKEKNLKRLWSWIWAAVLAVLIAVIIRFYLFVPILVDGISMMPTLHNDDRVIINRFGHVD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
RFDVIVFREKDGKEYIKRVIGLPGDTVEYKADQLYINGKKYDEPYLDTYKKKLKDGYLTD
EEEEEEEECCCCHHHHHHHHCCCCCCEEEECCEEEECCCCCCCHHHHHHHHHHHCCCCCC
DYSSKDQLNGGKIPENTYFVLGDNRRASKDSRIIGPIPLSKVLGTTPICYWPIKDAKLID
CCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEECCCCHHHHHCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1639057; 7934829; 7876097; 9384377; 8951809; 9823656 [H]