Click here to switch to the map view.

The map label for this gene is clpX [H]

Identifier: 116872701

GI number: 116872701

Start: 1274886

End: 1276145

Strand: Direct

Name: clpX [H]

Synonym: lwe1285

Alternate gene names: 116872701

Gene position: 1274886-1276145 (Clockwise)

Preceding gene: 116872700

Following gene: 116872702

Centisome position: 45.3

GC content: 36.27

Gene sequence:

>1260_bases
TTGTTTAAATTTAACGATGAAAAAGGCCAACTTAAATGCTCCTTTTGCGGAAAGACTCAAGATCAAGTACGTAAATTAGT
GGCTGGTCCAGGTGTTTATATTTGTGATGAATGTATCGAGCTTTGTAATGAAATTATTGAAGAAGAGCTAGGTATTTCTG
AATTTGTTGATTTTGGAGAAGTACCAAAACCACAAGAAATTCGTCATATATTAAGTGATTATGTTATTGGTCAAGAGCGT
GCAAAAAAAGCACTAGCTGTGGCAGTTTACAATCACTACAAACGAATTAATTCCAATGAAACAAAAGAAGAAGAAGTAGA
ACTCTCAAAAAGTAACATTTGTTTAATTGGTCCAACAGGTAGTGGTAAAACACTTCTTGCTCAAACATTAGCGCGAATTC
TTAATGTTCCATTTGCGATTGCAGATGCGACTTCACTTACAGAAGCTGGTTATGTTGGGGAAGATGTAGAAAATATTCTT
CTTAAACTTATCCAATCAGCTGACTACGATGTAGAAAAAGCAGAAAAAGGTATCATTTATATTGATGAAATCGACAAAGT
TGCTCGCAAATCTGAAAATCCATCTATTACTAGAGATGTTTCAGGAGAAGGCGTACAACAAGCTTTACTGAAAATTTTGG
AAGGTACTGTCGCAAGTGTTCCTCCTCAAGGTGGTAGAAAGCACCCTCATCAAGAACTAATTCAAATCGATACTGGGAAT
ATTCTATTTATCGTCGGTGGCGCATTTGATGGAATCGAACAAATCGTAAAAAATCGAATGGGCGAAAAAGTCATTGGATT
TGGTACTGATAACGCGAAACTTAAAGAAGATGAAACCTATCTATCTCGCGTTGTTCCAGAAGATTTACTTAAATTCGGTT
TAATTCCTGAATTTATTGGTCGTTTGCCAGTTATCGCAACACTGGAACAATTGGATGAAGCGGCACTCGTTTCTATTTTG
ACAGAACCTAAAAATGCTTTAGTCAAACAATATAAACGTATGTTGGAGCTGGATGATGTAGAACTTGAATTCGAACCGAC
TGCTTTAATTGAAATCGCCAAAGAAGCAATTGAACGTAAAACAGGAGCGCGTGGTCTTCGTTCTATCATTGAACAGATTA
TGTTAGAAGTTATGTTCGAAATTCCTTCTCGAGATGATATTACTAAATGTATTATTACGGAGAAAGCAGCTCGCGGAGAA
GAAGAACCACAATTGCAATTAGAGGATGGTTCTATAATCCCAATTAAAACATCTGCATGA

Upstream 100 bases:

>100_bases
CAGATGATTGGCATTTCTAATAAACAAATGATATTATTAACACACATAGGAGATGAAAAATCGCCTATATGCAACATACC
TATGCGAAGGGGTGAATATT

Downstream 100 bases:

>100_bases
TTCTGAATGCGCGTCGTTATTGGCGCGCATTTTTTCTGTCAAACCAGCTTGTTTCATTACACCATCTGGTGGGTTTCGTG
CTATACTTTAGTAATATTAA

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MFKFNDEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCNEIIEEELGISEFVDFGEVPKPQEIRHILSDYVIGQER
AKKALAVAVYNHYKRINSNETKEEEVELSKSNICLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENIL
LKLIQSADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVASVPPQGGRKHPHQELIQIDTGN
ILFIVGGAFDGIEQIVKNRMGEKVIGFGTDNAKLKEDETYLSRVVPEDLLKFGLIPEFIGRLPVIATLEQLDEAALVSIL
TEPKNALVKQYKRMLELDDVELEFEPTALIEIAKEAIERKTGARGLRSIIEQIMLEVMFEIPSRDDITKCIITEKAARGE
EEPQLQLEDGSIIPIKTSA

Sequences:

>Translated_419_residues
MFKFNDEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCNEIIEEELGISEFVDFGEVPKPQEIRHILSDYVIGQER
AKKALAVAVYNHYKRINSNETKEEEVELSKSNICLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENIL
LKLIQSADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVASVPPQGGRKHPHQELIQIDTGN
ILFIVGGAFDGIEQIVKNRMGEKVIGFGTDNAKLKEDETYLSRVVPEDLLKFGLIPEFIGRLPVIATLEQLDEAALVSIL
TEPKNALVKQYKRMLELDDVELEFEPTALIEIAKEAIERKTGARGLRSIIEQIMLEVMFEIPSRDDITKCIITEKAARGE
EEPQLQLEDGSIIPIKTSA
>Mature_419_residues
MFKFNDEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCNEIIEEELGISEFVDFGEVPKPQEIRHILSDYVIGQER
AKKALAVAVYNHYKRINSNETKEEEVELSKSNICLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENIL
LKLIQSADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVASVPPQGGRKHPHQELIQIDTGN
ILFIVGGAFDGIEQIVKNRMGEKVIGFGTDNAKLKEDETYLSRVVPEDLLKFGLIPEFIGRLPVIATLEQLDEAALVSIL
TEPKNALVKQYKRMLELDDVELEFEPTALIEIAKEAIERKTGARGLRSIIEQIMLEVMFEIPSRDDITKCIITEKAARGE
EEPQLQLEDGSIIPIKTSA

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP [H]

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family [H]

Homologues:

Organism=Homo sapiens, GI7242140, Length=331, Percent_Identity=48.036253776435, Blast_Score=308, Evalue=6e-84,
Organism=Escherichia coli, GI1786642, Length=410, Percent_Identity=62.1951219512195, Blast_Score=511, Evalue=1e-146,
Organism=Escherichia coli, GI1790366, Length=104, Percent_Identity=43.2692307692308, Blast_Score=92, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71982908, Length=339, Percent_Identity=44.8377581120944, Blast_Score=285, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI71982905, Length=339, Percent_Identity=44.8377581120944, Blast_Score=284, Evalue=5e-77,
Organism=Caenorhabditis elegans, GI71988663, Length=399, Percent_Identity=39.3483709273183, Blast_Score=261, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI71988660, Length=253, Percent_Identity=39.5256916996047, Blast_Score=173, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6319704, Length=440, Percent_Identity=37.2727272727273, Blast_Score=256, Evalue=4e-69,
Organism=Drosophila melanogaster, GI24648291, Length=325, Percent_Identity=47.3846153846154, Blast_Score=298, Evalue=4e-81,
Organism=Drosophila melanogaster, GI24648289, Length=325, Percent_Identity=47.3846153846154, Blast_Score=298, Evalue=5e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603 [H]

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX [H]

EC number: NA

Molecular weight: Translated: 46427; Mature: 46427

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKFNDEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCNEIIEEELGISEFVDFGE
CCCCCCCCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCC
VPKPQEIRHILSDYVIGQERAKKALAVAVYNHYKRINSNETKEEEVELSKSNICLIGPTG
CCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEECCC
SGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILLKLIQSADYDVEKAEKGIIY
CCHHHHHHHHHHHHCCCHHHHCCHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHCCCEEE
IDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVASVPPQGGRKHPHQELIQIDTGN
EHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCHHHCCCCCCCCCCCHHHHEEECCCC
ILFIVGGAFDGIEQIVKNRMGEKVIGFGTDNAKLKEDETYLSRVVPEDLLKFGLIPEFIG
EEEEECCCHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHCHHHHHHHCCCHHHHC
RLPVIATLEQLDEAALVSILTEPKNALVKQYKRMLELDDVELEFEPTALIEIAKEAIERK
CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHH
TGARGLRSIIEQIMLEVMFEIPSRDDITKCIITEKAARGEEEPQLQLEDGSIIPIKTSA
HCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCEEEEECCC
>Mature Secondary Structure
MFKFNDEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCNEIIEEELGISEFVDFGE
CCCCCCCCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCC
VPKPQEIRHILSDYVIGQERAKKALAVAVYNHYKRINSNETKEEEVELSKSNICLIGPTG
CCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEECCC
SGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILLKLIQSADYDVEKAEKGIIY
CCHHHHHHHHHHHHCCCHHHHCCHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHCCCEEE
IDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVASVPPQGGRKHPHQELIQIDTGN
EHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCHHHCCCCCCCCCCCHHHHEEECCCC
ILFIVGGAFDGIEQIVKNRMGEKVIGFGTDNAKLKEDETYLSRVVPEDLLKFGLIPEFIG
EEEEECCCHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHCHHHHHHHCCCHHHHC
RLPVIATLEQLDEAALVSILTEPKNALVKQYKRMLELDDVELEFEPTALIEIAKEAIERK
CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHH
TGARGLRSIIEQIMLEVMFEIPSRDDITKCIITEKAARGEEEPQLQLEDGSIIPIKTSA
HCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]