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The map label for this gene is dppA [H]

Identifier: 116871559

GI number: 116871559

Start: 139732

End: 140550

Strand: Direct

Name: dppA [H]

Synonym: lwe0139

Alternate gene names: 116871559

Gene position: 139732-140550 (Clockwise)

Preceding gene: 116871558

Following gene: 116871560

Centisome position: 4.97

GC content: 37.48

Gene sequence:

>819_bases
ATGAAACTTTGGATTTCAGTAGATATGGAAGGGATAAATGGTCTTCCAGATGATACTTTTGTTGATTCTAGTATGCGAAA
TTATACTAGAGGACAAAAAATCATGACAGAAGAAACAAATTGGGTAGTGGAAGAAGCGCTTAAAGCAGGTTACGATGATA
TTTTAGTTAATGATAGTCATTCAAAAATGAATAATATTTTGCTAGAAGAATTACATGAAGAAGCAAGACTTATCACAGGT
GATGTAAAGCCATTTTCGATGGTGCAAGGTTTAGATGAGAGTGCGGAAGCGGCGGTTTTTATAGGTTATCATTCACGTGC
TGGAAAGCCTGGAGTGATGAGCCATTCAATGACTTCGGGAGTGCGAAATTTTTATATTAATGATATTGCGATAGGAGAAT
TTGGCTTGAATGCCTACGTTGCTGGTGCTTTCGGTGTTCCTGTAATTCTTGTTGCGGGTGATGATTTTATCGCTAGTGAA
GCAAAAGAGCTAATACCTGGAATCGAGACAGCTATAGTGAAAGAAGCAGTTTCACGTTCCTCCGCGATTGCGTTTTCTAA
AGCAAAAGCTGAAAAAATTATTCGCGAAAAAGTAAAGATTGCTCTGAAAGATAAGAAAGCTGCACCTCTTATACCACCAG
AAAATCCTGTTCTGAAAATTGAGTTCTGTAATTATGGTCAAGCAGAATGGGCAGCATTAGTTCCAAAAACAAAAATCATT
GATGAAACTACTGTCATGTTTGAAGCAGAAGACATCTTTGAAGCGTATCAAGCAATGGTTGCAATGACTGAACTTGCTAT
GAAATGCGCTTTTTCATAA

Upstream 100 bases:

>100_bases
GTAATTTGAAAAAAGATACAGTAAAAGGAATTGTTCATCATAACTTTGGGACAAGCTTTTCCTATAAAGGTGCTTACGTA
GAGTAGAAGGAGAGAGTGAA

Downstream 100 bases:

>100_bases
AATAAAATCACAGCCAAATATTCTTTGTCTCTACAAAGAACATTTTGGCTGTTTTTTGTTCTCAAAAATATGGCTATTAT
AAAATGGATTGCTCAAATCC

Product: D-alanyl-aminopeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MKLWISVDMEGINGLPDDTFVDSSMRNYTRGQKIMTEETNWVVEEALKAGYDDILVNDSHSKMNNILLEELHEEARLITG
DVKPFSMVQGLDESAEAAVFIGYHSRAGKPGVMSHSMTSGVRNFYINDIAIGEFGLNAYVAGAFGVPVILVAGDDFIASE
AKELIPGIETAIVKEAVSRSSAIAFSKAKAEKIIREKVKIALKDKKAAPLIPPENPVLKIEFCNYGQAEWAALVPKTKII
DETTVMFEAEDIFEAYQAMVAMTELAMKCAFS

Sequences:

>Translated_272_residues
MKLWISVDMEGINGLPDDTFVDSSMRNYTRGQKIMTEETNWVVEEALKAGYDDILVNDSHSKMNNILLEELHEEARLITG
DVKPFSMVQGLDESAEAAVFIGYHSRAGKPGVMSHSMTSGVRNFYINDIAIGEFGLNAYVAGAFGVPVILVAGDDFIASE
AKELIPGIETAIVKEAVSRSSAIAFSKAKAEKIIREKVKIALKDKKAAPLIPPENPVLKIEFCNYGQAEWAALVPKTKII
DETTVMFEAEDIFEAYQAMVAMTELAMKCAFS
>Mature_272_residues
MKLWISVDMEGINGLPDDTFVDSSMRNYTRGQKIMTEETNWVVEEALKAGYDDILVNDSHSKMNNILLEELHEEARLITG
DVKPFSMVQGLDESAEAAVFIGYHSRAGKPGVMSHSMTSGVRNFYINDIAIGEFGLNAYVAGAFGVPVILVAGDDFIASE
AKELIPGIETAIVKEAVSRSSAIAFSKAKAEKIIREKVKIALKDKKAAPLIPPENPVLKIEFCNYGQAEWAALVPKTKII
DETTVMFEAEDIFEAYQAMVAMTELAMKCAFS

Specific function: Hydrolyzes N-terminal residues in D-amino acid containing peptides. Among the tested substrates, the highest activities are with D-Ala-D-Ala and D-Ala-Gly-Gly. The physiological role is not clear [H]

COG id: COG2362

COG function: function code E; D-aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M55 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007035 [H]

Pfam domain/function: PF04951 Peptidase_M55 [H]

EC number: NA

Molecular weight: Translated: 29852; Mature: 29852

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLWISVDMEGINGLPDDTFVDSSMRNYTRGQKIMTEETNWVVEEALKAGYDDILVNDSH
CEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHCCCCCEEEECCH
SKMNNILLEELHEEARLITGDVKPFSMVQGLDESAEAAVFIGYHSRAGKPGVMSHSMTSG
HHHHHHHHHHHHHHHHEEECCCCHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHH
VRNFYINDIAIGEFGLNAYVAGAFGVPVILVAGDDFIASEAKELIPGIETAIVKEAVSRS
HHHHEECEEEEECCCCCCEEEECCCCCEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHH
SAIAFSKAKAEKIIREKVKIALKDKKAAPLIPPENPVLKIEFCNYGQAEWAALVPKTKII
HHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCEEEEEECCCCCCHHHHHCCCCHHC
DETTVMFEAEDIFEAYQAMVAMTELAMKCAFS
CCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLWISVDMEGINGLPDDTFVDSSMRNYTRGQKIMTEETNWVVEEALKAGYDDILVNDSH
CEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHCCCCCEEEECCH
SKMNNILLEELHEEARLITGDVKPFSMVQGLDESAEAAVFIGYHSRAGKPGVMSHSMTSG
HHHHHHHHHHHHHHHHEEECCCCHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHH
VRNFYINDIAIGEFGLNAYVAGAFGVPVILVAGDDFIASEAKELIPGIETAIVKEAVSRS
HHHHEECEEEEECCCCCCEEEECCCCCEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHH
SAIAFSKAKAEKIIREKVKIALKDKKAAPLIPPENPVLKIEFCNYGQAEWAALVPKTKII
HHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCEEEEEECCCCCCHHHHHCCCCHHC
DETTVMFEAEDIFEAYQAMVAMTELAMKCAFS
CCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1766370; 9384377 [H]