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The map label for this gene is folE [H]

Identifier: 116695903

GI number: 116695903

Start: 2221620

End: 2222369

Strand: Direct

Name: folE [H]

Synonym: H16_B1967

Alternate gene names: 116695903

Gene position: 2221620-2222369 (Clockwise)

Preceding gene: 116695902

Following gene: 116695904

Centisome position: 76.28

GC content: 66.13

Gene sequence:

>750_bases
ATGACCAGCAAGGACGCGGCGCACCGCGCGAAGGACAGCAACGCCGGCGACGATGCCGGCCACCCCCACGCCCCCAGCGT
CTCCGCCCGCATCCGCGCACGGCTCGAGGCCGCGCAGGAGCGCTTCCACGCCAACGACAATATTTCGCACCACATCGAGC
CGGGCGAGATGGAGCAGCTTCAGGCCGAAGTGCAGGCGCGCCTGGAGGACGTGCTGCGCGCGCTGGTGATCGACGTCGAC
AACGACCACAACACCCAGGAAACCGCGCGCCGGGTCGCCAAGATGTACCTGAAGGAGATCTTCGCCGGCCGCTACGCCAA
GGCGCCGCCGGTGACCGAGTTCCCCAACGTCGGCCAGCTCAACGAACTGATGATCGTCGGCCCGCTGCGCGTGCGCAGTG
CCTGCTCGCATCACCTGTGCCCGATCATCGGCAAGCTGTGGGTAGGGGTGATGCCGAACCAGCATTCCAACCTGATCGGC
CTGTCCAAGTACGCGCGGCTAGCCGAATGGATCATGTGCCGGCCGCAGATCCAGGAAGAGGCGGTGGCACAGGTCGCCGA
CCTGCTGCAGGAAAAGATGAATCCCGACGGCCTGGCCATCGTGATGGAAGCCGAGCACTTCTGCATGCACTGGCGCGGCG
TGCGCGACACCGATGCCAAGATGACCAACAGCGTGATGCGCGGCTCGTTCCTGAAGGACGACAGCCTGCGCCGCGAGTTC
CTCACGCTGCTGAACCACAACCGCGGCTAG

Upstream 100 bases:

>100_bases
CACCTTGCCATGCCCCGTGCGGGTTGTGAGGCCACGGCATCTGCCATATAGTGAATCCGGCACACCCGCTGCGCAGTCAT
CCATCCCACCACGCATAACC

Downstream 100 bases:

>100_bases
GCCGCACGCCCCGCCCACCAGCCGCCACAACCGAGCGCCACGCCCATGCTAGTCCGCCTGCTCTATGCCAGCCGTGCCCG
CCAGGCCATCGACGCCGCCC

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MTSKDAAHRAKDSNAGDDAGHPHAPSVSARIRARLEAAQERFHANDNISHHIEPGEMEQLQAEVQARLEDVLRALVIDVD
NDHNTQETARRVAKMYLKEIFAGRYAKAPPVTEFPNVGQLNELMIVGPLRVRSACSHHLCPIIGKLWVGVMPNQHSNLIG
LSKYARLAEWIMCRPQIQEEAVAQVADLLQEKMNPDGLAIVMEAEHFCMHWRGVRDTDAKMTNSVMRGSFLKDDSLRREF
LTLLNHNRG

Sequences:

>Translated_249_residues
MTSKDAAHRAKDSNAGDDAGHPHAPSVSARIRARLEAAQERFHANDNISHHIEPGEMEQLQAEVQARLEDVLRALVIDVD
NDHNTQETARRVAKMYLKEIFAGRYAKAPPVTEFPNVGQLNELMIVGPLRVRSACSHHLCPIIGKLWVGVMPNQHSNLIG
LSKYARLAEWIMCRPQIQEEAVAQVADLLQEKMNPDGLAIVMEAEHFCMHWRGVRDTDAKMTNSVMRGSFLKDDSLRREF
LTLLNHNRG
>Mature_248_residues
TSKDAAHRAKDSNAGDDAGHPHAPSVSARIRARLEAAQERFHANDNISHHIEPGEMEQLQAEVQARLEDVLRALVIDVDN
DHNTQETARRVAKMYLKEIFAGRYAKAPPVTEFPNVGQLNELMIVGPLRVRSACSHHLCPIIGKLWVGVMPNQHSNLIGL
SKYARLAEWIMCRPQIQEEAVAQVADLLQEKMNPDGLAIVMEAEHFCMHWRGVRDTDAKMTNSVMRGSFLKDDSLRREFL
TLLNHNRG

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=124, Percent_Identity=41.1290322580645, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI4503949, Length=124, Percent_Identity=41.1290322580645, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI66932970, Length=94, Percent_Identity=36.1702127659575, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI66932972, Length=84, Percent_Identity=39.2857142857143, Blast_Score=68, Evalue=6e-12,
Organism=Escherichia coli, GI1788476, Length=191, Percent_Identity=31.9371727748691, Blast_Score=112, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17560486, Length=125, Percent_Identity=41.6, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321706, Length=125, Percent_Identity=44, Blast_Score=105, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24656782, Length=125, Percent_Identity=38.4, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24656791, Length=125, Percent_Identity=38.4, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24656796, Length=125, Percent_Identity=38.4, Blast_Score=88, Evalue=6e-18,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 28022; Mature: 27891

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSKDAAHRAKDSNAGDDAGHPHAPSVSARIRARLEAAQERFHANDNISHHIEPGEMEQL
CCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
QAEVQARLEDVLRALVIDVDNDHNTQETARRVAKMYLKEIFAGRYAKAPPVTEFPNVGQL
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
NELMIVGPLRVRSACSHHLCPIIGKLWVGVMPNQHSNLIGLSKYARLAEWIMCRPQIQEE
CCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHH
AVAQVADLLQEKMNPDGLAIVMEAEHFCMHWRGVRDTDAKMTNSVMRGSFLKDDSLRREF
HHHHHHHHHHHHCCCCCEEEEECHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHH
LTLLNHNRG
HHHHHCCCC
>Mature Secondary Structure 
TSKDAAHRAKDSNAGDDAGHPHAPSVSARIRARLEAAQERFHANDNISHHIEPGEMEQL
CCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
QAEVQARLEDVLRALVIDVDNDHNTQETARRVAKMYLKEIFAGRYAKAPPVTEFPNVGQL
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
NELMIVGPLRVRSACSHHLCPIIGKLWVGVMPNQHSNLIGLSKYARLAEWIMCRPQIQEE
CCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHH
AVAQVADLLQEKMNPDGLAIVMEAEHFCMHWRGVRDTDAKMTNSVMRGSFLKDDSLRREF
HHHHHHHHHHHHCCCCCEEEEECHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHH
LTLLNHNRG
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA