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The map label for this gene is paaJ [H]

Identifier: 116694613

GI number: 116694613

Start: 736435

End: 737586

Strand: Direct

Name: paaJ [H]

Synonym: H16_B0662

Alternate gene names: 116694613

Gene position: 736435-737586 (Clockwise)

Preceding gene: 116694612

Following gene: 116694614

Centisome position: 25.29

GC content: 69.53

Gene sequence:

>1152_bases
ATGAAAGACGCCTATATCGTTGATGCCCTGCGCACGCCCACCGGGCGCCGCAAGGGCGGACTGTCGCACATGCACGGCGC
CGACCTGGGCGGCTTCGTGCTGGCCGAGCTGGTGCGCCGCAACGGCATTCCCGCCGAGGATTATGACGACGTGGTGTTCG
GCTGCGTCGACACCATCGGCCCGCTGGCCGGCAATATCGCCCGCAGCGCGTGGCTGGCCGCCGGCCTGCCGCTGACGGTG
CCGGGCGTGACCGTGGACCGCCAGTGCGGCTCGTCGCAGCAGGCCGTGCACTTTGCCGCGCAGGCAGTGATGAGCGGCAC
GCAGGACGTGGTGATCGCCGGCGGCGTGCAGACCATGACCCAGATCCCGATCTCGTCGGCCATGCTGGCCGGGCAGGCAC
TGGGCTTTGCCGACCCGTTCTCGGGCAGCAAGGGCTGGCAGACGCGCTTTGGCGATGCGCCGGTGTCGCAGTTCCATGCG
GCGCAGCGCATTGCCGATCACTGGAAGCTGTCGCGCGAGGCCATGGAAGCCTACGCGCTGGCAAGCCATCAGCGCGCCGC
CGCGGCCATCGAAGGCGGCCGCTTTGCGCGCGAGATCGTGCCGTGCGCAGGCGTGAAGCATGACGAGACCCCGCGCCCCG
ATACCACGCTGGCCAGGATGGCTGCGCTGGAACCGCTGATGCCCGGCAGTTCGCTGACTGCGGCTGTGTCCAGCCAGACC
GCCGATGCCGCCGCCGCGCTGCTGATCGTCTCGGAAGACGCGCTCAAGCGCTACCAGCTCAAGCCGCGTGCGCGCATCGC
GCATATGAGCGTGCTGGGCGACGACCCGCTGTGGATGCTGACCGCGCCGATCCCTGCAACCAGACGCGCACTGGAGCGCA
GCGGCCTGCGCCTGGCCGATATCGACGTGGTCGAGATCAATGAAGCGTTCGCCTCGGTGGCGATGGCATGGCTGGCCGAA
ACCGGCTACGCGGCCGAGCGCACCAACCCCAACGGCGGCGCCATCGCACTGGGCCACCCGCTGGGCGCCACCGGCGCGCG
CCTGATGACCACGCTGCTGCATGAGCTGGAACGCACCCGCGGGCGCTACGGCCTGCAGACCATGTGCGAAGGCGGTGGCC
TGGCCAACGTCACCATCATCGAACGCTTGTAA

Upstream 100 bases:

>100_bases
GTGCCTTCCACAAGGCGCGCATGGGCGCGCACATCCTTGACGGCGTGCATGAGATCGGCGCCGGCGCCACCTTCGCCTGA
ATCCAAAGAGAACCAAGACC

Downstream 100 bases:

>100_bases
GGAGACCGCCATGGGAATCTGCGACGCACGCACCGTCATCATCACCGGCGCCGGCGGCGGGCTGGGCCGTGCCTATGCGC
TGGCCTTCGCCGCCGAGGGC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: 3-oxoadipyl-CoA thiolase [H]

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MKDAYIVDALRTPTGRRKGGLSHMHGADLGGFVLAELVRRNGIPAEDYDDVVFGCVDTIGPLAGNIARSAWLAAGLPLTV
PGVTVDRQCGSSQQAVHFAAQAVMSGTQDVVIAGGVQTMTQIPISSAMLAGQALGFADPFSGSKGWQTRFGDAPVSQFHA
AQRIADHWKLSREAMEAYALASHQRAAAAIEGGRFAREIVPCAGVKHDETPRPDTTLARMAALEPLMPGSSLTAAVSSQT
ADAAAALLIVSEDALKRYQLKPRARIAHMSVLGDDPLWMLTAPIPATRRALERSGLRLADIDVVEINEAFASVAMAWLAE
TGYAAERTNPNGGAIALGHPLGATGARLMTTLLHELERTRGRYGLQTMCEGGGLANVTIIERL

Sequences:

>Translated_383_residues
MKDAYIVDALRTPTGRRKGGLSHMHGADLGGFVLAELVRRNGIPAEDYDDVVFGCVDTIGPLAGNIARSAWLAAGLPLTV
PGVTVDRQCGSSQQAVHFAAQAVMSGTQDVVIAGGVQTMTQIPISSAMLAGQALGFADPFSGSKGWQTRFGDAPVSQFHA
AQRIADHWKLSREAMEAYALASHQRAAAAIEGGRFAREIVPCAGVKHDETPRPDTTLARMAALEPLMPGSSLTAAVSSQT
ADAAAALLIVSEDALKRYQLKPRARIAHMSVLGDDPLWMLTAPIPATRRALERSGLRLADIDVVEINEAFASVAMAWLAE
TGYAAERTNPNGGAIALGHPLGATGARLMTTLLHELERTRGRYGLQTMCEGGGLANVTIIERL
>Mature_383_residues
MKDAYIVDALRTPTGRRKGGLSHMHGADLGGFVLAELVRRNGIPAEDYDDVVFGCVDTIGPLAGNIARSAWLAAGLPLTV
PGVTVDRQCGSSQQAVHFAAQAVMSGTQDVVIAGGVQTMTQIPISSAMLAGQALGFADPFSGSKGWQTRFGDAPVSQFHA
AQRIADHWKLSREAMEAYALASHQRAAAAIEGGRFAREIVPCAGVKHDETPRPDTTLARMAALEPLMPGSSLTAAVSSQT
ADAAAALLIVSEDALKRYQLKPRARIAHMSVLGDDPLWMLTAPIPATRRALERSGLRLADIDVVEINEAFASVAMAWLAE
TGYAAERTNPNGGAIALGHPLGATGARLMTTLLHELERTRGRYGLQTMCEGGGLANVTIIERL

Specific function: Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=394, Percent_Identity=36.0406091370558, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI167614485, Length=391, Percent_Identity=35.0383631713555, Blast_Score=211, Evalue=7e-55,
Organism=Homo sapiens, GI4557237, Length=400, Percent_Identity=32.5, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI4501853, Length=397, Percent_Identity=34.2569269521411, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI4504327, Length=432, Percent_Identity=32.1759259259259, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI194353979, Length=384, Percent_Identity=28.6458333333333, Blast_Score=125, Evalue=9e-29,
Organism=Escherichia coli, GI1787663, Length=403, Percent_Identity=43.1761786600496, Blast_Score=284, Evalue=6e-78,
Organism=Escherichia coli, GI87082165, Length=398, Percent_Identity=39.6984924623116, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=39.5989974937343, Blast_Score=252, Evalue=2e-68,
Organism=Escherichia coli, GI1788554, Length=400, Percent_Identity=38, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI1788683, Length=413, Percent_Identity=31.9612590799031, Blast_Score=156, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI133906874, Length=394, Percent_Identity=36.2944162436548, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17535921, Length=395, Percent_Identity=29.620253164557, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI25147385, Length=400, Percent_Identity=30.25, Blast_Score=177, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=29.8823529411765, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17535917, Length=387, Percent_Identity=28.1653746770026, Blast_Score=143, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6325229, Length=405, Percent_Identity=32.8395061728395, Blast_Score=183, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6322031, Length=385, Percent_Identity=31.4285714285714, Blast_Score=163, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24655093, Length=398, Percent_Identity=36.1809045226131, Blast_Score=231, Evalue=7e-61,
Organism=Drosophila melanogaster, GI17648125, Length=393, Percent_Identity=34.3511450381679, Blast_Score=208, Evalue=5e-54,
Organism=Drosophila melanogaster, GI24640423, Length=401, Percent_Identity=30.4239401496259, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=30.5882352941176, Blast_Score=151, Evalue=8e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012793
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.174 [H]

Molecular weight: Translated: 40437; Mature: 40437

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDAYIVDALRTPTGRRKGGLSHMHGADLGGFVLAELVRRNGIPAEDYDDVVFGCVDTIG
CCCCEEEHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
PLAGNIARSAWLAAGLPLTVPGVTVDRQCGSSQQAVHFAAQAVMSGTQDVVIAGGVQTMT
HHHHHHHHHHHHHCCCCEECCCCEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCHHHHH
QIPISSAMLAGQALGFADPFSGSKGWQTRFGDAPVSQFHAAQRIADHWKLSREAMEAYAL
HCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ASHQRAAAAIEGGRFAREIVPCAGVKHDETPRPDTTLARMAALEPLMPGSSLTAAVSSQT
HHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHCCC
ADAAAALLIVSEDALKRYQLKPRARIAHMSVLGDDPLWMLTAPIPATRRALERSGLRLAD
HHHHEEEEEECHHHHHHHCCCCHHHEEEEEEECCCCEEEEECCCHHHHHHHHHCCCEEEE
IDVVEINEAFASVAMAWLAETGYAAERTNPNGGAIALGHPLGATGARLMTTLLHELERTR
EEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHC
GRYGLQTMCEGGGLANVTIIERL
CCCCHHHHHCCCCEEEEEEEECC
>Mature Secondary Structure
MKDAYIVDALRTPTGRRKGGLSHMHGADLGGFVLAELVRRNGIPAEDYDDVVFGCVDTIG
CCCCEEEHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
PLAGNIARSAWLAAGLPLTVPGVTVDRQCGSSQQAVHFAAQAVMSGTQDVVIAGGVQTMT
HHHHHHHHHHHHHCCCCEECCCCEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCHHHHH
QIPISSAMLAGQALGFADPFSGSKGWQTRFGDAPVSQFHAAQRIADHWKLSREAMEAYAL
HCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ASHQRAAAAIEGGRFAREIVPCAGVKHDETPRPDTTLARMAALEPLMPGSSLTAAVSSQT
HHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHCCC
ADAAAALLIVSEDALKRYQLKPRARIAHMSVLGDDPLWMLTAPIPATRRALERSGLRLAD
HHHHEEEEEECHHHHHHHCCCCHHHEEEEEEECCCCEEEEECCCHHHHHHHHHCCCEEEE
IDVVEINEAFASVAMAWLAETGYAAERTNPNGGAIALGHPLGATGARLMTTLLHELERTR
EEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHC
GRYGLQTMCEGGGLANVTIIERL
CCCCHHHHHCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 10766858 [H]