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The map label for this gene is fabG [C]

Identifier: 116694614

GI number: 116694614

Start: 737597

End: 738481

Strand: Direct

Name: fabG [C]

Synonym: H16_B0663

Alternate gene names: 116694614

Gene position: 737597-738481 (Clockwise)

Preceding gene: 116694613

Following gene: 116694615

Centisome position: 25.33

GC content: 71.98

Gene sequence:

>885_bases
ATGGGAATCTGCGACGCACGCACCGTCATCATCACCGGCGCCGGCGGCGGGCTGGGCCGTGCCTATGCGCTGGCCTTCGC
CGCCGAGGGCGCCAACGTGGTCGTCAACGACATCCGGCGCGAGGCGGCCGAGGCCGTCTGCGCGGAGATCCGTGCAGCCG
GCGCGAAGGCAAAAGCGGCGCTGGCCAGCGCTGACGACATCACGCAGCTGGCCACCGCGCAGCGCATCGTCGATGCCGCG
GTCGAGGCCTTCGGCGAGGTCCACGTGCTGGTCAACAACGCCGGCATCTGCCGCGACCGCATGTTTGTCAGCCTGACCGA
AGCGGACTGGGACGACGTCATGCGCGTGCACCTGCGCGGCCACTTCTGCCTGGCCAACCTGCTCGCCAAACGGTGGCGCG
ATGCCGCCAAGGCCGGCCGCGCCGTCGACGCGCGCATTATCAACACCAGCTCCGGCGCGGGCCTGCAGGGTTCTGTCGGG
CAGTCCAACTACGCCGCCGCCAAGGCCGGCATTGCCGCGCTCACGCTGGTGCAGGCCGCCGAGCTGGGCCGCTATGGCAT
CACCGCCAATGCGCTGGCGCCGGCGGCGCGCACCGGCATGACCGAAGACGTGTTCGCCGACATGATGCGGGCGCCGGCCG
ACGGCTTCGACTACTACGACCCGGCCAACGTCGCGCCGCTGGTGGTGTGGCTGGGCAGCGCCGCCTCCGCGCAGGTCAAC
GGGCGCATGTTCGAGGCGGCCGGCGGCATGGTTTCCGTGGCCGACGGCTGGCGCACCGGACCCAGGACCGACAAGGGATC
GCGCTGGCAGCCGGCCGAACTGGGCGCAGCCGTGGCGGAACTGCTGGCGCAGGCGCAGCCGCCCCAGCCGGTCTACGGCA
GCTGA

Upstream 100 bases:

>100_bases
GAGCTGGAACGCACCCGCGGGCGCTACGGCCTGCAGACCATGTGCGAAGGCGGTGGCCTGGCCAACGTCACCATCATCGA
ACGCTTGTAAGGAGACCGCC

Downstream 100 bases:

>100_bases
GCGCGACGGCCATGGACTTCTCCCTTAGCCTCGAACAGCAGATGGTACGCGACAGCGCGCGCGACTACCTCGCCGCGCAC
AGCGATTCGGCGGCGGTGCG

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MGICDARTVIITGAGGGLGRAYALAFAAEGANVVVNDIRREAAEAVCAEIRAAGAKAKAALASADDITQLATAQRIVDAA
VEAFGEVHVLVNNAGICRDRMFVSLTEADWDDVMRVHLRGHFCLANLLAKRWRDAAKAGRAVDARIINTSSGAGLQGSVG
QSNYAAAKAGIAALTLVQAAELGRYGITANALAPAARTGMTEDVFADMMRAPADGFDYYDPANVAPLVVWLGSAASAQVN
GRMFEAAGGMVSVADGWRTGPRTDKGSRWQPAELGAAVAELLAQAQPPQPVYGS

Sequences:

>Translated_294_residues
MGICDARTVIITGAGGGLGRAYALAFAAEGANVVVNDIRREAAEAVCAEIRAAGAKAKAALASADDITQLATAQRIVDAA
VEAFGEVHVLVNNAGICRDRMFVSLTEADWDDVMRVHLRGHFCLANLLAKRWRDAAKAGRAVDARIINTSSGAGLQGSVG
QSNYAAAKAGIAALTLVQAAELGRYGITANALAPAARTGMTEDVFADMMRAPADGFDYYDPANVAPLVVWLGSAASAQVN
GRMFEAAGGMVSVADGWRTGPRTDKGSRWQPAELGAAVAELLAQAQPPQPVYGS
>Mature_293_residues
GICDARTVIITGAGGGLGRAYALAFAAEGANVVVNDIRREAAEAVCAEIRAAGAKAKAALASADDITQLATAQRIVDAAV
EAFGEVHVLVNNAGICRDRMFVSLTEADWDDVMRVHLRGHFCLANLLAKRWRDAAKAGRAVDARIINTSSGAGLQGSVGQ
SNYAAAKAGIAALTLVQAAELGRYGITANALAPAARTGMTEDVFADMMRAPADGFDYYDPANVAPLVVWLGSAASAQVNG
RMFEAAGGMVSVADGWRTGPRTDKGSRWQPAELGAAVAELLAQAQPPQPVYGS

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=256, Percent_Identity=41.796875, Blast_Score=167, Evalue=9e-42,
Organism=Homo sapiens, GI15277342, Length=252, Percent_Identity=34.1269841269841, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI40807363, Length=204, Percent_Identity=32.843137254902, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4758504, Length=192, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI40254992, Length=243, Percent_Identity=29.2181069958848, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI7705925, Length=262, Percent_Identity=26.7175572519084, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI83715985, Length=229, Percent_Identity=31.8777292576419, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI66933014, Length=262, Percent_Identity=27.8625954198473, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787335, Length=265, Percent_Identity=31.6981132075472, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1789208, Length=253, Percent_Identity=30.0395256916996, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1790717, Length=257, Percent_Identity=31.5175097276265, Blast_Score=100, Evalue=8e-23,
Organism=Escherichia coli, GI87082160, Length=255, Percent_Identity=31.3725490196078, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI87082100, Length=283, Percent_Identity=30.3886925795053, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1787905, Length=254, Percent_Identity=31.1023622047244, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1789057, Length=269, Percent_Identity=29.368029739777, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788459, Length=253, Percent_Identity=27.6679841897233, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI2367175, Length=248, Percent_Identity=32.6612903225806, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787526, Length=257, Percent_Identity=26.0700389105058, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1789378, Length=254, Percent_Identity=27.9527559055118, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17568967, Length=254, Percent_Identity=37.7952755905512, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17555706, Length=252, Percent_Identity=32.9365079365079, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI25147288, Length=249, Percent_Identity=30.1204819277108, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17562904, Length=207, Percent_Identity=30.9178743961353, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17562908, Length=216, Percent_Identity=28.7037037037037, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17562906, Length=219, Percent_Identity=29.2237442922374, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17564282, Length=209, Percent_Identity=29.1866028708134, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17560220, Length=266, Percent_Identity=25.5639097744361, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17560150, Length=193, Percent_Identity=28.4974093264249, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=213, Percent_Identity=28.169014084507, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=193, Percent_Identity=27.979274611399, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17508895, Length=164, Percent_Identity=29.8780487804878, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562910, Length=272, Percent_Identity=25.7352941176471, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI115534694, Length=252, Percent_Identity=26.5873015873016, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71982365, Length=203, Percent_Identity=30.5418719211823, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193203117, Length=184, Percent_Identity=29.3478260869565, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71994600, Length=251, Percent_Identity=25.4980079681275, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=184, Percent_Identity=29.3478260869565, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17531453, Length=264, Percent_Identity=25, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=250, Percent_Identity=24.4, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560332, Length=261, Percent_Identity=28.3524904214559, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562990, Length=262, Percent_Identity=24.0458015267176, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=262, Percent_Identity=25.5725190839695, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=252, Percent_Identity=40.8730158730159, Blast_Score=166, Evalue=4e-42,
Organism=Drosophila melanogaster, GI18859837, Length=254, Percent_Identity=38.9763779527559, Blast_Score=154, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24639444, Length=257, Percent_Identity=31.5175097276265, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24644339, Length=211, Percent_Identity=29.8578199052133, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI23397609, Length=253, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28571526, Length=211, Percent_Identity=28.436018957346, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24649181, Length=165, Percent_Identity=32.1212121212121, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24643142, Length=262, Percent_Identity=25.9541984732824, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21357673, Length=203, Percent_Identity=30.0492610837438, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 30401; Mature: 30269

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGICDARTVIITGAGGGLGRAYALAFAAEGANVVVNDIRREAAEAVCAEIRAAGAKAKAA
CCCCCCEEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LASADDITQLATAQRIVDAAVEAFGEVHVLVNNAGICRDRMFVSLTEADWDDVMRVHLRG
HHCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHCC
HFCLANLLAKRWRDAAKAGRAVDARIINTSSGAGLQGSVGQSNYAAAKAGIAALTLVQAA
HHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
ELGRYGITANALAPAARTGMTEDVFADMMRAPADGFDYYDPANVAPLVVWLGSAASAQVN
HHCCCCCCHHHHCHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
GRMFEAAGGMVSVADGWRTGPRTDKGSRWQPAELGAAVAELLAQAQPPQPVYGS
CEEEECCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
GICDARTVIITGAGGGLGRAYALAFAAEGANVVVNDIRREAAEAVCAEIRAAGAKAKAA
CCCCCEEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LASADDITQLATAQRIVDAAVEAFGEVHVLVNNAGICRDRMFVSLTEADWDDVMRVHLRG
HHCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHCC
HFCLANLLAKRWRDAAKAGRAVDARIINTSSGAGLQGSVGQSNYAAAKAGIAALTLVQAA
HHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
ELGRYGITANALAPAARTGMTEDVFADMMRAPADGFDYYDPANVAPLVVWLGSAASAQVN
HHCCCCCCHHHHCHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
GRMFEAAGGMVSVADGWRTGPRTDKGSRWQPAELGAAVAELLAQAQPPQPVYGS
CEEEECCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]