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The map label for this gene is ilvA [H]

Identifier: 116694571

GI number: 116694571

Start: 691967

End: 692887

Strand: Direct

Name: ilvA [H]

Synonym: H16_B0620

Alternate gene names: 116694571

Gene position: 691967-692887 (Clockwise)

Preceding gene: 116694568

Following gene: 116694572

Centisome position: 23.76

GC content: 65.47

Gene sequence:

>921_bases
ATGACGCTTCACATCAGCACACCTTTTGTACAGTCCCAGCCCAATTCGCGGCGGCTCGGCAAACCGGTCTGGCTAAAGAT
GGAAGCCGCACAGCCGTCCGGGTCTTTCAAGCTTCGGGGTGTCGGAGCCTTGTGTGAAGCGCGGCACGCCGCGGGCGTAC
AGCGATTCGTTGCATCTTCAGGCGGAAATGCCGGGCTTGCGGCAGCCTATTGCGGACGCGAACTCGGCGTTCCCGTGGTG
GTGGTGGTACCGGAGAGCACACCATCGCGAGCGCGCGACCTGATCCGCCTGGAGGGCTCGGAGTTGATCGTGCGCGGAGG
CACATGGGCGGAAGCGCACGAGTTTGCACTGTCCCTGATCGGGCCACGCGATGCCTTCGTGCACCCGTTCGACGATCCGC
TCATCTGGCAGGGGCACGCCACGCTGGTGGACGAGATCGCGGCATCCGGGCCGAAGCCAGGCGCCATCGTTCTTGCCGTG
GGCGGTGGTGGCCTGCTGTGCGGCGTGCTGGAGGGGCTTCAGCGGAATGGCTGGTCCGACGTGCCTGTGATCGCGGTAGA
AACCGACGGTGCGGACTGCTACGCCCGCTCGGTTGCCGAAGGCAGGCCGGTCGAACTCGCACAGATCACCAGCGTGGCGA
CGTCGCTTGGCGCCAGGCGGCCGTGTGATGGCGCGCTCCGATGGGCGCAGCGTCACGAGATCCACAGCGTCGTTGTGTCA
GACAAACAGGCGGTGGAGGCAGCGATAAGGCTTCTTGACGAACACCGCGTCCTGGTTGAGCCGGCATGCGGCGCAGCCTT
GGCGGCATTGGATTGCGACACCCCGGTGCTGCAGGCGGCGTCCAGCATTGCCGTGGTGGTATGTGGCGGGGCCACGGTGA
CGGCACAGCAACTGCTTGACTTTGCTGCAAGGCTGGACTGA

Upstream 100 bases:

>100_bases
GCTACCTAAATAACATTGGTTTGCATAGCTTCCTGCGACTACGATGGCGCAGCTTCCCGCGTTGCGGGGACGGCTCGCTT
TCCACATTTCGCTACCAAAC

Downstream 100 bases:

>100_bases
GCGGGCTTAAGGTAGCAATTTGGTAAGCTCGGCTACCCGCCGGCGAGATTCGCCCGAATTACCTGGTTCCGGGGATGCCC
CTCACGGCCGATTTCTGTCA

Product: L-Serine dehydratase, putative

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MTLHISTPFVQSQPNSRRLGKPVWLKMEAAQPSGSFKLRGVGALCEARHAAGVQRFVASSGGNAGLAAAYCGRELGVPVV
VVVPESTPSRARDLIRLEGSELIVRGGTWAEAHEFALSLIGPRDAFVHPFDDPLIWQGHATLVDEIAASGPKPGAIVLAV
GGGGLLCGVLEGLQRNGWSDVPVIAVETDGADCYARSVAEGRPVELAQITSVATSLGARRPCDGALRWAQRHEIHSVVVS
DKQAVEAAIRLLDEHRVLVEPACGAALAALDCDTPVLQAASSIAVVVCGGATVTAQQLLDFAARLD

Sequences:

>Translated_306_residues
MTLHISTPFVQSQPNSRRLGKPVWLKMEAAQPSGSFKLRGVGALCEARHAAGVQRFVASSGGNAGLAAAYCGRELGVPVV
VVVPESTPSRARDLIRLEGSELIVRGGTWAEAHEFALSLIGPRDAFVHPFDDPLIWQGHATLVDEIAASGPKPGAIVLAV
GGGGLLCGVLEGLQRNGWSDVPVIAVETDGADCYARSVAEGRPVELAQITSVATSLGARRPCDGALRWAQRHEIHSVVVS
DKQAVEAAIRLLDEHRVLVEPACGAALAALDCDTPVLQAASSIAVVVCGGATVTAQQLLDFAARLD
>Mature_305_residues
TLHISTPFVQSQPNSRRLGKPVWLKMEAAQPSGSFKLRGVGALCEARHAAGVQRFVASSGGNAGLAAAYCGRELGVPVVV
VVPESTPSRARDLIRLEGSELIVRGGTWAEAHEFALSLIGPRDAFVHPFDDPLIWQGHATLVDEIAASGPKPGAIVLAVG
GGGLLCGVLEGLQRNGWSDVPVIAVETDGADCYARSVAEGRPVELAQITSVATSLGARRPCDGALRWAQRHEIHSVVVSD
KQAVEAAIRLLDEHRVLVEPACGAALAALDCDTPVLQAASSIAVVVCGGATVTAQQLLDFAARLD

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI33469958, Length=314, Percent_Identity=46.1783439490446, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI19923959, Length=317, Percent_Identity=47.0031545741325, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI11345492, Length=282, Percent_Identity=25.531914893617, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1790207, Length=270, Percent_Identity=30.7407407407407, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71991565, Length=295, Percent_Identity=27.1186440677966, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17537387, Length=150, Percent_Identity=34.6666666666667, Blast_Score=68, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6319788, Length=305, Percent_Identity=38.3606557377049, Blast_Score=205, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6322024, Length=203, Percent_Identity=36.9458128078818, Blast_Score=135, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6320930, Length=296, Percent_Identity=28.0405405405405, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6322023, Length=121, Percent_Identity=36.3636363636364, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21355833, Length=288, Percent_Identity=29.1666666666667, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 31921; Mature: 31790

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLHISTPFVQSQPNSRRLGKPVWLKMEAAQPSGSFKLRGVGALCEARHAAGVQRFVASS
CEEEECCCHHCCCCCCCCCCCCEEEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCC
GGNAGLAAAYCGRELGVPVVVVVPESTPSRARDLIRLEGSELIVRGGTWAEAHEFALSLI
CCCCCHHHHHCCHHCCCCEEEEECCCCCHHHHHHEEECCCEEEEECCCCHHHHHHHHHHC
GPRDAFVHPFDDPLIWQGHATLVDEIAASGPKPGAIVLAVGGGGLLCGVLEGLQRNGWSD
CCCCCCCCCCCCCEEECCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCC
VPVIAVETDGADCYARSVAEGRPVELAQITSVATSLGARRPCDGALRWAQRHEIHSVVVS
CCEEEEECCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEC
DKQAVEAAIRLLDEHRVLVEPACGAALAALDCDTPVLQAASSIAVVVCGGATVTAQQLLD
CHHHHHHHHHHHHCCCEEEECCCCCEEEEECCCCHHHHCCCCEEEEEECCCHHHHHHHHH
FAARLD
HHHHCC
>Mature Secondary Structure 
TLHISTPFVQSQPNSRRLGKPVWLKMEAAQPSGSFKLRGVGALCEARHAAGVQRFVASS
EEEECCCHHCCCCCCCCCCCCEEEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCC
GGNAGLAAAYCGRELGVPVVVVVPESTPSRARDLIRLEGSELIVRGGTWAEAHEFALSLI
CCCCCHHHHHCCHHCCCCEEEEECCCCCHHHHHHEEECCCEEEEECCCCHHHHHHHHHHC
GPRDAFVHPFDDPLIWQGHATLVDEIAASGPKPGAIVLAVGGGGLLCGVLEGLQRNGWSD
CCCCCCCCCCCCCEEECCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCC
VPVIAVETDGADCYARSVAEGRPVELAQITSVATSLGARRPCDGALRWAQRHEIHSVVVS
CCEEEEECCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEC
DKQAVEAAIRLLDEHRVLVEPACGAALAALDCDTPVLQAASSIAVVVCGGATVTAQQLLD
CHHHHHHHHHHHHCCCEEEECCCCCEEEEECCCCHHHHCCCCEEEEEECCCHHHHHHHHH
FAARLD
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]