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The map label for this gene is pdxA [H]

Identifier: 116694273

GI number: 116694273

Start: 356964

End: 357965

Strand: Direct

Name: pdxA [H]

Synonym: H16_B0319

Alternate gene names: 116694273

Gene position: 356964-357965 (Clockwise)

Preceding gene: 116694272

Following gene: 116694274

Centisome position: 12.26

GC content: 69.06

Gene sequence:

>1002_bases
ATGAGCGACTACCTCCCCGTCATCGGTATCACCATGGGCGATGCCACAGGCATCGGCCCCGAAGTCATCGTCAAGAGCCT
CGCGCATGACAGCGTTCGTGCGCAATGCCGCCCGCTCGTCATCGGCGACGTGCGCCGGCTGGAAGTGGCCGGCCGGCTCG
TCGGCTCCCCGCTCAAGCTGCGCGCCATCCAGGCCCCGGAGGAAGCGCGCTTCCAGTCCGGCACCATCGACTGCATCGAC
CTGGGCCTGATCCCGGAAGGCCTGCCCTTCGGCAAGCTGTCCGCCGTCGCCGGTGATGCCGCCTTCCGCTACATCGAGCG
CGCGGTGGCGCTCACCCGCGACGAGAAGATCGATGCGATCTGCACAGCGCCGCTGAACAAGGAAGCCCTGCACGCGGGGG
GTCACAAGTTTCCCGGCCACACGGAAATGCTGGCGTACCTGACCGGCACCCCGGAGGTGTCGATGATGCTGGTGGCGCCG
AAGCTGCGCGTGATCCACGTCACCACGCACATCGGCCTGCTCGACGCCATCCGCAAGATCGAGCCGGGGCTGGTCCAGCG
CACCATTGAGCGCGGCCATCAGACGCTGCAGCGCGCTGGCATTGCAGCGCCGCGTATCGGCGTGTGCGGCATCAATCCGC
ACGCCGGCGAGAACGGCCTGTTCGGCCACGGCGAGGAGGAGGAAAAAATCATCCCGGCGGTCGAGGCCTTGCGCGCGCGC
GGCCGGGACGTGGAAGGTCCGCTGCCCGCCGACACGCTGTTCTATCGCGCCGGCCGCGGCGACTTCGATCTGGTGGTGGC
GATGTACCACGACCAGGGCCACGGGCCGGTCAAGGTGCTCGGCCTGGAGGCCGGCGTCAACATCACGGTGGGCCTGCCGG
TCATCCGCACGTCGGTTGATCACGGCACCGCCTTCGACATCGCCGGCAAGGGGATCGCCGACGAACGCAGCCTGCTGGAG
GCGCTGCGCCAGGGCGCTGAGCTGGCCACGCGCCGCGCCTGA

Upstream 100 bases:

>100_bases
CTCCGAGGCCGCCCTGTGGCATGCCTGGCAGGCTATGACTGAATCCCGCGCGCCGTCAGCCTGACGGCGCGCCGCGCCAC
ACTCGACAAGAGACACATCA

Downstream 100 bases:

>100_bases
GCCATCGGCGTACGCCGGGGCTGCCGGCTCCTGTAAGATCGGGGATCGTTGAGGATCCCCCATTTTCATTTCGCCTGCCA
TGAAAGCCGCCGACCGCCGC

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MSDYLPVIGITMGDATGIGPEVIVKSLAHDSVRAQCRPLVIGDVRRLEVAGRLVGSPLKLRAIQAPEEARFQSGTIDCID
LGLIPEGLPFGKLSAVAGDAAFRYIERAVALTRDEKIDAICTAPLNKEALHAGGHKFPGHTEMLAYLTGTPEVSMMLVAP
KLRVIHVTTHIGLLDAIRKIEPGLVQRTIERGHQTLQRAGIAAPRIGVCGINPHAGENGLFGHGEEEEKIIPAVEALRAR
GRDVEGPLPADTLFYRAGRGDFDLVVAMYHDQGHGPVKVLGLEAGVNITVGLPVIRTSVDHGTAFDIAGKGIADERSLLE
ALRQGAELATRRA

Sequences:

>Translated_333_residues
MSDYLPVIGITMGDATGIGPEVIVKSLAHDSVRAQCRPLVIGDVRRLEVAGRLVGSPLKLRAIQAPEEARFQSGTIDCID
LGLIPEGLPFGKLSAVAGDAAFRYIERAVALTRDEKIDAICTAPLNKEALHAGGHKFPGHTEMLAYLTGTPEVSMMLVAP
KLRVIHVTTHIGLLDAIRKIEPGLVQRTIERGHQTLQRAGIAAPRIGVCGINPHAGENGLFGHGEEEEKIIPAVEALRAR
GRDVEGPLPADTLFYRAGRGDFDLVVAMYHDQGHGPVKVLGLEAGVNITVGLPVIRTSVDHGTAFDIAGKGIADERSLLE
ALRQGAELATRRA
>Mature_332_residues
SDYLPVIGITMGDATGIGPEVIVKSLAHDSVRAQCRPLVIGDVRRLEVAGRLVGSPLKLRAIQAPEEARFQSGTIDCIDL
GLIPEGLPFGKLSAVAGDAAFRYIERAVALTRDEKIDAICTAPLNKEALHAGGHKFPGHTEMLAYLTGTPEVSMMLVAPK
LRVIHVTTHIGLLDAIRKIEPGLVQRTIERGHQTLQRAGIAAPRIGVCGINPHAGENGLFGHGEEEEKIIPAVEALRARG
RDVEGPLPADTLFYRAGRGDFDLVVAMYHDQGHGPVKVLGLEAGVNITVGLPVIRTSVDHGTAFDIAGKGIADERSLLEA
LRQGAELATRRA

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=316, Percent_Identity=40.5063291139241, Blast_Score=190, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 35492; Mature: 35360

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDYLPVIGITMGDATGIGPEVIVKSLAHDSVRAQCRPLVIGDVRRLEVAGRLVGSPLKL
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHCCCEEE
RAIQAPEEARFQSGTIDCIDLGLIPEGLPFGKLSAVAGDAAFRYIERAVALTRDEKIDAI
EEECCCHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
CTAPLNKEALHAGGHKFPGHTEMLAYLTGTPEVSMMLVAPKLRVIHVTTHIGLLDAIRKI
EECCCCHHHHHCCCCCCCCCCEEEEEEECCCCEEEEEEECCEEEEEEEHHHHHHHHHHHC
EPGLVQRTIERGHQTLQRAGIAAPRIGVCGINPHAGENGLFGHGEEEEKIIPAVEALRAR
CHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
GRDVEGPLPADTLFYRAGRGDFDLVVAMYHDQGHGPVKVLGLEAGVNITVGLPVIRTSVD
CCCCCCCCCHHHHEEECCCCCEEEEEEEEECCCCCCEEEEEEECCCEEEECCCEEEECCC
HGTAFDIAGKGIADERSLLEALRQGAELATRRA
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDYLPVIGITMGDATGIGPEVIVKSLAHDSVRAQCRPLVIGDVRRLEVAGRLVGSPLKL
CCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHCCCEEE
RAIQAPEEARFQSGTIDCIDLGLIPEGLPFGKLSAVAGDAAFRYIERAVALTRDEKIDAI
EEECCCHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
CTAPLNKEALHAGGHKFPGHTEMLAYLTGTPEVSMMLVAPKLRVIHVTTHIGLLDAIRKI
EECCCCHHHHHCCCCCCCCCCEEEEEEECCCCEEEEEEECCEEEEEEEHHHHHHHHHHHC
EPGLVQRTIERGHQTLQRAGIAAPRIGVCGINPHAGENGLFGHGEEEEKIIPAVEALRAR
CHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
GRDVEGPLPADTLFYRAGRGDFDLVVAMYHDQGHGPVKVLGLEAGVNITVGLPVIRTSVD
CCCCCCCCCHHHHEEECCCCCEEEEEEEEECCCCCCEEEEEEECCCEEEECCCEEEECCC
HGTAFDIAGKGIADERSLLEALRQGAELATRRA
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]