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The map label for this gene is bioF [H]

Identifier: 116690950

GI number: 116690950

Start: 3241471

End: 3242691

Strand: Direct

Name: bioF [H]

Synonym: Bcen2424_2932

Alternate gene names: 116690950

Gene position: 3241471-3242691 (Clockwise)

Preceding gene: 116690949

Following gene: 116690951

Centisome position: 93.04

GC content: 72.73

Gene sequence:

>1221_bases
ATGAGCCTGCTCGACACCCTGCAACGCGGCCTCGCCGACCTCGACGCGCAAGGGCTGCGCCGCGTGCGCCGCATCGCCGA
CACCGCGTGCGACGCGCGCATGATCGTGAACCGCCGCGAGATCGTCGGCTTCGCGAGCAACGACTACCTCGGCCTCGCCG
CGCATCCGGCGCTCGTCGCCGCGTTCGCGGAAGGCGCGCAGCGCTACGGCGCCGGCAGCGGCGGCTCGCACCTGCTCGGC
GGCCATTCGCGCGCGCACGCCAGACTGGAAGACGAACTCGCGGGCTTCGCGGGCGGCTTCTCCGATGCGCCGCGCGCGCT
GTACTTCAGCACCGGCTACATGGCGAACCTCGCCGCGATGACGGCGCTCGCCGGCAAGGGCGCGACGATCTTCTCCGATG
CGCTGAACCACGCGTCGCTGATCGACGGCATGCGGCTGTCGCGCGCGAACGTGCAGGTCTATCCGCACGCCGATACGGCC
GCGCTCGCCGCGCTGCTCGACGCATCGGAGGCCGAAACGAAGCTGATCGTCAGCGACACAGTGTTCAGCATGGACGGCGA
CATCGCGCCGCTCGCCGAACTCGTCGCGCTGGCCGAACGCCACGGCGCGTGGCTCGTCATCGACGACGCGCACGGCTTCG
GCGTGCTCGGCCCGCAGGGTCGCGGTGCGCTCGCGGCCGCCGCGCTGCGCTCGCCGCATCTCGTGTACGTCGGTACGCTC
GGCAAGGCGGCCGGCGTCGCCGGCGCGTTCGTGATCGCGCATGAAACCGTGATCGAATGGCTGATCCAGCGCGCGCGCAG
CTACATCTTCACGACCGCCGCGCCGCCGGCCGTCGCGCATGCCGTGTCGGCAAGCCTCAAGGTGATCGCGGGCGACGAAG
GCGACGCGCGCCGCGCGCACCTCGCCGCGCTGATCGAACGCACGCGCGCGCTGCTGCGCAACACGCGCTGGCAGCCGGTC
GATTCGCACACGGCCGTGCAGCCGCTCGTGATCGGCAGCAACGACGCGACGCTCGCGGCGATGCGCGCGCTCGACGCGCA
CGGCCTGTGGGTGCCCGCGATCCGGCCGCCGACGGTGCCGGCCGGCACGTCGCGGCTGCGCGTGTCGCTGTCGGCCGCGC
ATTCGTTCGACGATCTCGCCAGGCTCGAAGCCGCGTTGATCGAGGCCAGCGAGGCGGCCGCGGCCTCCGTTGGAGCGGCC
CGGCAGGAGGCAGCAGCATGA

Upstream 100 bases:

>100_bases
TGTACCTGATGCCGCCGTACGTGATGAGCGACGACGACATCGCGTGGCTCGCGCAGCGCACGCGCGACACGCTCGACGCG
ACGCTGGAGGACCTCGGCCG

Downstream 100 bases:

>100_bases
CCGCTCCGCTCTCCGTCTTCGTCACCGGCACCGACACCGAGATCGGCAAGACCTTCGTGTCGGCCGCGATGCTGCACGGC
TTCGCGCGGCACGGGCTGCG

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MSLLDTLQRGLADLDAQGLRRVRRIADTACDARMIVNRREIVGFASNDYLGLAAHPALVAAFAEGAQRYGAGSGGSHLLG
GHSRAHARLEDELAGFAGGFSDAPRALYFSTGYMANLAAMTALAGKGATIFSDALNHASLIDGMRLSRANVQVYPHADTA
ALAALLDASEAETKLIVSDTVFSMDGDIAPLAELVALAERHGAWLVIDDAHGFGVLGPQGRGALAAAALRSPHLVYVGTL
GKAAGVAGAFVIAHETVIEWLIQRARSYIFTTAAPPAVAHAVSASLKVIAGDEGDARRAHLAALIERTRALLRNTRWQPV
DSHTAVQPLVIGSNDATLAAMRALDAHGLWVPAIRPPTVPAGTSRLRVSLSAAHSFDDLARLEAALIEASEAAAASVGAA
RQEAAA

Sequences:

>Translated_406_residues
MSLLDTLQRGLADLDAQGLRRVRRIADTACDARMIVNRREIVGFASNDYLGLAAHPALVAAFAEGAQRYGAGSGGSHLLG
GHSRAHARLEDELAGFAGGFSDAPRALYFSTGYMANLAAMTALAGKGATIFSDALNHASLIDGMRLSRANVQVYPHADTA
ALAALLDASEAETKLIVSDTVFSMDGDIAPLAELVALAERHGAWLVIDDAHGFGVLGPQGRGALAAAALRSPHLVYVGTL
GKAAGVAGAFVIAHETVIEWLIQRARSYIFTTAAPPAVAHAVSASLKVIAGDEGDARRAHLAALIERTRALLRNTRWQPV
DSHTAVQPLVIGSNDATLAAMRALDAHGLWVPAIRPPTVPAGTSRLRVSLSAAHSFDDLARLEAALIEASEAAAASVGAA
RQEAAA
>Mature_405_residues
SLLDTLQRGLADLDAQGLRRVRRIADTACDARMIVNRREIVGFASNDYLGLAAHPALVAAFAEGAQRYGAGSGGSHLLGG
HSRAHARLEDELAGFAGGFSDAPRALYFSTGYMANLAAMTALAGKGATIFSDALNHASLIDGMRLSRANVQVYPHADTAA
LAALLDASEAETKLIVSDTVFSMDGDIAPLAELVALAERHGAWLVIDDAHGFGVLGPQGRGALAAAALRSPHLVYVGTLG
KAAGVAGAFVIAHETVIEWLIQRARSYIFTTAAPPAVAHAVSASLKVIAGDEGDARRAHLAALIERTRALLRNTRWQPVD
SHTAVQPLVIGSNDATLAAMRALDAHGLWVPAIRPPTVPAGTSRLRVSLSAAHSFDDLARLEAALIEASEAAAASVGAAR
QEAAA

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=395, Percent_Identity=33.4177215189873, Blast_Score=198, Evalue=7e-51,
Organism=Homo sapiens, GI284448556, Length=364, Percent_Identity=34.0659340659341, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI83977440, Length=411, Percent_Identity=32.6034063260341, Blast_Score=191, Evalue=8e-49,
Organism=Homo sapiens, GI83977442, Length=411, Percent_Identity=32.8467153284672, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI83977444, Length=411, Percent_Identity=32.6034063260341, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI4502025, Length=355, Percent_Identity=31.830985915493, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI40316939, Length=355, Percent_Identity=31.830985915493, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI4758668, Length=369, Percent_Identity=30.0813008130081, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI119220554, Length=374, Percent_Identity=29.9465240641711, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI5454084, Length=274, Percent_Identity=27.3722627737226, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1786993, Length=349, Percent_Identity=45.8452722063037, Blast_Score=280, Evalue=8e-77,
Organism=Escherichia coli, GI1790046, Length=374, Percent_Identity=36.096256684492, Blast_Score=198, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI71994529, Length=355, Percent_Identity=34.3661971830986, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI32566772, Length=378, Percent_Identity=27.7777777777778, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17560914, Length=366, Percent_Identity=26.5027322404372, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17560912, Length=366, Percent_Identity=26.5027322404372, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71982625, Length=287, Percent_Identity=25.4355400696864, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71982617, Length=287, Percent_Identity=25.4355400696864, Blast_Score=91, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320438, Length=410, Percent_Identity=29.5121951219512, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6320267, Length=363, Percent_Identity=28.3746556473829, Blast_Score=123, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6323954, Length=273, Percent_Identity=27.1062271062271, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24662918, Length=396, Percent_Identity=32.8282828282828, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI17137420, Length=358, Percent_Identity=30.7262569832402, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI17136286, Length=356, Percent_Identity=25.8426966292135, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24653280, Length=325, Percent_Identity=24.9230769230769, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24653276, Length=325, Percent_Identity=24.9230769230769, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24653278, Length=325, Percent_Identity=24.9230769230769, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022834
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 42165; Mature: 42034

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLDTLQRGLADLDAQGLRRVRRIADTACDARMIVNRREIVGFASNDYLGLAAHPALVA
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHCHHHHEEECCCCCEEEEHHHHHHH
AFAEGAQRYGAGSGGSHLLGGHSRAHARLEDELAGFAGGFSDAPRALYFSTGYMANLAAM
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHH
TALAGKGATIFSDALNHASLIDGMRLSRANVQVYPHADTAALAALLDASEAETKLIVSDT
HHHCCCCCHHHHHHHHHHHHHCCCEEECCCEEEEECCCHHHHHHHHCCCCCCCEEEEEEE
VFSMDGDIAPLAELVALAERHGAWLVIDDAHGFGVLGPQGRGALAAAALRSPHLVYVGTL
EEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHCCCCEEEEECC
GKAAGVAGAFVIAHETVIEWLIQRARSYIFTTAAPPAVAHAVSASLKVIAGDEGDARRAH
CCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHCCEEEEECCCCCHHHHH
LAALIERTRALLRNTRWQPVDSHTAVQPLVIGSNDATLAAMRALDAHGLWVPAIRPPTVP
HHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCEEECCCCCCCCC
AGTSRLRVSLSAAHSFDDLARLEAALIEASEAAAASVGAARQEAAA
CCCCEEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLLDTLQRGLADLDAQGLRRVRRIADTACDARMIVNRREIVGFASNDYLGLAAHPALVA
CHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHCHHHHEEECCCCCEEEEHHHHHHH
AFAEGAQRYGAGSGGSHLLGGHSRAHARLEDELAGFAGGFSDAPRALYFSTGYMANLAAM
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHH
TALAGKGATIFSDALNHASLIDGMRLSRANVQVYPHADTAALAALLDASEAETKLIVSDT
HHHCCCCCHHHHHHHHHHHHHCCCEEECCCEEEEECCCHHHHHHHHCCCCCCCEEEEEEE
VFSMDGDIAPLAELVALAERHGAWLVIDDAHGFGVLGPQGRGALAAAALRSPHLVYVGTL
EEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHCCCCEEEEECC
GKAAGVAGAFVIAHETVIEWLIQRARSYIFTTAAPPAVAHAVSASLKVIAGDEGDARRAH
CCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHCCEEEEECCCCCHHHHH
LAALIERTRALLRNTRWQPVDSHTAVQPLVIGSNDATLAAMRALDAHGLWVPAIRPPTVP
HHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCEEECCCCCCCCC
AGTSRLRVSLSAAHSFDDLARLEAALIEASEAAAASVGAARQEAAA
CCCCEEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA