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The map label for this gene is bioA [H]

Identifier: 116690949

GI number: 116690949

Start: 3240095

End: 3241474

Strand: Direct

Name: bioA [H]

Synonym: Bcen2424_2931

Alternate gene names: 116690949

Gene position: 3240095-3241474 (Clockwise)

Preceding gene: 116690948

Following gene: 116690950

Centisome position: 93.0

GC content: 70.65

Gene sequence:

>1380_bases
ATGCCGCGCGGTCGTTTTACCCCCGGAGTCGCCTTGAGTACGCCAGCCACCGACGACTGGGTCGCGCGCAGCCTGCGCGC
GGTCTGGCATCCCTGCACCCAGATGAAGCATCACGAGCGCCTGCCGCTCGTCCCCGTCGCGCGCGGCGCGGGCCTGTGGC
TGTACGACCGTGACGGCCGCCGCTACTTCGACGCGATCAGCTCCTGGTGGGTCAACCTGTTCGGCCATGCGAACCCGGAC
ATCAACGCGGCGCTGAAGGACCAGCTCGACACGCTCGAGCACGCGATGCTCGCCGGCTGCACGCACGAACCCGCGATCGA
GCTCGCCGAACGGCTGCACGCGCTCACCGCGCGCACGCTCGGCCATGCGTTCTTCGCATCCGACGGCGCGTCGGCCGTCG
AGATCGCGCTGAAGATGAGCTTCCACGCGTGGCGCAACCGCGGCCGCGCGAACAAGCAGGAATTCGTCTGCGTCGCGAAC
AGCTATCACGGCGAGACGATCGGCGCGCTCGGCGTGACCGACGTCGCGCTGTTCAAGGATGCGTACGACCCGCTGATCCG
CCACGCGCACGTGGTCGCGTCGCCCGATGCGCGCGGCGCGCTGCCGGGCGAGACGGCCGCCGACGTCGCGGGCCGCGCGC
TCGCGGACGTGCGGCGCCTGTTCGTCGAACGCGGCGACCGGATCGCCGCGCTGATCGTCGAGCCGCTCGTGCAGTGCGCG
GCCGGCATGGCAATGCACGATCCGTCGTACGTGCGCGGGCTGCGCGCGCTGTGCGACGAATTCGGCGTGCACCTGATCGC
CGACGAGATCGCGGTCGGGTGCGGGCGCACCGGCACCTTCTTCGCGTGCGAGCAGGCGGGCGTCTGGCCCGATTTCATGT
GCCTGTCGAAAGGGATCAGCGGCGGCTATCTGCCGCTGTCGCTGGTGCTCACGCGCGACGACGTGTTCGCGGCGTTCTAC
GACGACGACACGACGCGCGGCTTTCTGCACTCGCATTCGTACACCGGCAACCCGCTCGCGTGCCGCGCGGCCGTTGCGAC
GCTCGACCTGTTCGCGCGCGACGACGTGCTCGCGAGCAATGCCCGCAAATCGGCGACGCTGCGCGCGGCGCTCGCGCCGC
TCGACGCGCACCGCCAAGTGCGCCACCTGCGCGAGCGCGGCACGCTGTTCGCGTTCGACGTCACGCTCGACGGCGACGCT
GCGCGCGGCTTCTCGCGACGTTTCTTCGAACACGCGCTCGAACGCGAGCTGCTGCTGCGCCCGATCGGCACGACCGTGTA
CCTGATGCCGCCGTACGTGATGAGCGACGACGACATCGCGTGGCTCGCGCAGCGCACGCGCGACACGCTCGACGCGACGC
TGGAGGACCTCGGCCGATGA

Upstream 100 bases:

>100_bases
GCCCAGCAAGGCTGTGCGGCGTTTGTAACCGCTAGTGCAACCTCCGGCGGAACACGCTAATCTCTGCGCGTTTCGTGTCC
CGCCGCGCGGCATCCCGTCG

Downstream 100 bases:

>100_bases
GCCTGCTCGACACCCTGCAACGCGGCCTCGCCGACCTCGACGCGCAAGGGCTGCGCCGCGTGCGCCGCATCGCCGACACC
GCGTGCGACGCGCGCATGAT

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MPRGRFTPGVALSTPATDDWVARSLRAVWHPCTQMKHHERLPLVPVARGAGLWLYDRDGRRYFDAISSWWVNLFGHANPD
INAALKDQLDTLEHAMLAGCTHEPAIELAERLHALTARTLGHAFFASDGASAVEIALKMSFHAWRNRGRANKQEFVCVAN
SYHGETIGALGVTDVALFKDAYDPLIRHAHVVASPDARGALPGETAADVAGRALADVRRLFVERGDRIAALIVEPLVQCA
AGMAMHDPSYVRGLRALCDEFGVHLIADEIAVGCGRTGTFFACEQAGVWPDFMCLSKGISGGYLPLSLVLTRDDVFAAFY
DDDTTRGFLHSHSYTGNPLACRAAVATLDLFARDDVLASNARKSATLRAALAPLDAHRQVRHLRERGTLFAFDVTLDGDA
ARGFSRRFFEHALERELLLRPIGTTVYLMPPYVMSDDDIAWLAQRTRDTLDATLEDLGR

Sequences:

>Translated_459_residues
MPRGRFTPGVALSTPATDDWVARSLRAVWHPCTQMKHHERLPLVPVARGAGLWLYDRDGRRYFDAISSWWVNLFGHANPD
INAALKDQLDTLEHAMLAGCTHEPAIELAERLHALTARTLGHAFFASDGASAVEIALKMSFHAWRNRGRANKQEFVCVAN
SYHGETIGALGVTDVALFKDAYDPLIRHAHVVASPDARGALPGETAADVAGRALADVRRLFVERGDRIAALIVEPLVQCA
AGMAMHDPSYVRGLRALCDEFGVHLIADEIAVGCGRTGTFFACEQAGVWPDFMCLSKGISGGYLPLSLVLTRDDVFAAFY
DDDTTRGFLHSHSYTGNPLACRAAVATLDLFARDDVLASNARKSATLRAALAPLDAHRQVRHLRERGTLFAFDVTLDGDA
ARGFSRRFFEHALERELLLRPIGTTVYLMPPYVMSDDDIAWLAQRTRDTLDATLEDLGR
>Mature_458_residues
PRGRFTPGVALSTPATDDWVARSLRAVWHPCTQMKHHERLPLVPVARGAGLWLYDRDGRRYFDAISSWWVNLFGHANPDI
NAALKDQLDTLEHAMLAGCTHEPAIELAERLHALTARTLGHAFFASDGASAVEIALKMSFHAWRNRGRANKQEFVCVANS
YHGETIGALGVTDVALFKDAYDPLIRHAHVVASPDARGALPGETAADVAGRALADVRRLFVERGDRIAALIVEPLVQCAA
GMAMHDPSYVRGLRALCDEFGVHLIADEIAVGCGRTGTFFACEQAGVWPDFMCLSKGISGGYLPLSLVLTRDDVFAAFYD
DDTTRGFLHSHSYTGNPLACRAAVATLDLFARDDVLASNARKSATLRAALAPLDAHRQVRHLRERGTLFAFDVTLDGDAA
RGFSRRFFEHALERELLLRPIGTTVYLMPPYVMSDDDIAWLAQRTRDTLDATLEDLGR

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=432, Percent_Identity=31.25, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI37574042, Length=428, Percent_Identity=24.0654205607477, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI13994255, Length=376, Percent_Identity=25, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI284507298, Length=319, Percent_Identity=31.3479623824451, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI226442705, Length=428, Percent_Identity=24.0654205607477, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI226442709, Length=398, Percent_Identity=24.1206030150754, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI24119277, Length=433, Percent_Identity=24.2494226327945, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI1786991, Length=445, Percent_Identity=37.3033707865169, Blast_Score=261, Evalue=6e-71,
Organism=Escherichia coli, GI145693181, Length=410, Percent_Identity=30.2439024390244, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1789016, Length=403, Percent_Identity=30.0248138957816, Blast_Score=151, Evalue=7e-38,
Organism=Escherichia coli, GI1789759, Length=405, Percent_Identity=28.1481481481481, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI1788044, Length=401, Percent_Identity=28.1795511221945, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1787560, Length=412, Percent_Identity=29.6116504854369, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1786349, Length=398, Percent_Identity=27.3869346733668, Blast_Score=102, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI25144271, Length=433, Percent_Identity=25.635103926097, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI32564660, Length=425, Percent_Identity=24.7058823529412, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI25144274, Length=236, Percent_Identity=28.3898305084746, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71992977, Length=371, Percent_Identity=23.7196765498652, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324386, Length=470, Percent_Identity=27.8723404255319, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6323470, Length=459, Percent_Identity=27.8867102396514, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6324432, Length=371, Percent_Identity=27.2237196765499, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI21357415, Length=419, Percent_Identity=27.6849642004773, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI161085790, Length=381, Percent_Identity=25.9842519685039, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28574759, Length=381, Percent_Identity=25.9842519685039, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI21356575, Length=316, Percent_Identity=24.6835443037975, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 50443; Mature: 50312

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00436 PEROXIDASE_2 ; PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRGRFTPGVALSTPATDDWVARSLRAVWHPCTQMKHHERLPLVPVARGAGLWLYDRDGR
CCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEEEECCCH
RYFDAISSWWVNLFGHANPDINAALKDQLDTLEHAMLAGCTHEPAIELAERLHALTARTL
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
GHAFFASDGASAVEIALKMSFHAWRNRGRANKQEFVCVANSYHGETIGALGVTDVALFKD
HHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEECCCCHHHHHHHHH
AYDPLIRHAHVVASPDARGALPGETAADVAGRALADVRRLFVERGDRIAALIVEPLVQCA
HHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
AGMAMHDPSYVRGLRALCDEFGVHLIADEIAVGCGRTGTFFACEQAGVWPDFMCLSKGIS
CCCCCCCHHHHHHHHHHHHHHCCEEEHHHHHHCCCCCCCEEEECCCCCCHHHHHHHCCCC
GGYLPLSLVLTRDDVFAAFYDDDTTRGFLHSHSYTGNPLACRAAVATLDLFARDDVLASN
CCCEEEEEEEECCCEEEEEECCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHCC
ARKSATLRAALAPLDAHRQVRHLRERGTLFAFDVTLDGDAARGFSRRFFEHALERELLLR
CHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
PIGTTVYLMPPYVMSDDDIAWLAQRTRDTLDATLEDLGR
CCCCEEEEECCEEECCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PRGRFTPGVALSTPATDDWVARSLRAVWHPCTQMKHHERLPLVPVARGAGLWLYDRDGR
CCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEEEECCCH
RYFDAISSWWVNLFGHANPDINAALKDQLDTLEHAMLAGCTHEPAIELAERLHALTARTL
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
GHAFFASDGASAVEIALKMSFHAWRNRGRANKQEFVCVANSYHGETIGALGVTDVALFKD
HHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEECCCCHHHHHHHHH
AYDPLIRHAHVVASPDARGALPGETAADVAGRALADVRRLFVERGDRIAALIVEPLVQCA
HHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
AGMAMHDPSYVRGLRALCDEFGVHLIADEIAVGCGRTGTFFACEQAGVWPDFMCLSKGIS
CCCCCCCHHHHHHHHHHHHHHCCEEEHHHHHHCCCCCCCEEEECCCCCCHHHHHHHCCCC
GGYLPLSLVLTRDDVFAAFYDDDTTRGFLHSHSYTGNPLACRAAVATLDLFARDDVLASN
CCCEEEEEEEECCCEEEEEECCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHCC
ARKSATLRAALAPLDAHRQVRHLRERGTLFAFDVTLDGDAARGFSRRFFEHALERELLLR
CHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
PIGTTVYLMPPYVMSDDDIAWLAQRTRDTLDATLEDLGR
CCCCEEEEECCEEECCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]