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The map label for this gene is phbA [H]

Identifier: 116690792

GI number: 116690792

Start: 3067379

End: 3068560

Strand: Reverse

Name: phbA [H]

Synonym: Bcen2424_2772

Alternate gene names: 116690792

Gene position: 3068560-3067379 (Counterclockwise)

Preceding gene: 116690793

Following gene: 116690791

Centisome position: 88.08

GC content: 70.39

Gene sequence:

>1182_bases
ATGACGGATGTAGTGATCGTATCGGCCGCGCGGACCGCGGTCGGCAAATTCGGCGGCTCGCTCGCGAAGATTGCGGCGCC
CGAACTGGGCGCGACGGTGATCCGCGCGGTGCTGGAGCGTGCGGGCGTGAAGCCCGAGCAGGTCAGCGAAGTGATCATGG
GCCAGGTGCTGACGGCCGGCTCCGGGCAGAACCCGGCGCGGCAGTCGCTGATCAAGGCGGGGCTGCCCACGGCCGTGCCG
GGGATGACGATCAACAAGGTGTGCGGCTCGGGCCTGAAGGCCGTGATGCTGGCGGCGAACGCGATCATCGCGGGCGACGC
GGAGATCGTGGTCGCGGGCGGCCAGGAGAACATGAGCGCGTCGCCGCACGTGCTGCCGGGCTCGCGCGACGGCTTCCGGA
TGGGCGACGCGAAGCTGGTCGACACGATGATCGTCGACGGCTTGTGGGACGTGTACAACCAGTACCACATGGGCATCACG
GCGGAGAACGTCGCGAAGGAATACGGGATCACGCGCGAAGAGCAGGACGCGTTCGCGGCGCTGTCGCAGAACAAGGCGGA
AGCCGCGCAGAAGGCCGGGCGCTTCGACGACGAGATCGTGCCGGTGTCGATTCCGCAACGCAAGGGCGAGCCGCTGCAGT
TCGCGACCGACGAGTTCGTGCGTCACGGCGTGACGGCGGAGTCGCTCGCCGGGCTGAAGCCGGCGTTCTCGAAGGACGGC
TCGGTGACGGCGGCGAACGCGTCGGGGCTGAACGACGGCGCGGCGGCGGTGCTGGTGATGTCGGCGCAGAAGGCGGCGGC
GCTGGGCCTGACGCCGCTGGCGCGAATCAAGGCGTACGCGAACGCGGGCGTGGACCCGAGCGTGATGGGCATGGGCCCGG
TGCCGGCGTCGCGCCGGGCGCTGGAGCGCGCGGGCTGGACGCCGGGCGACCTGGACCTGATGGAGATCAACGAAGCGTTC
GCGGCGCAGGCGCTGGCGGTGCACAAGCAGATGGGCTGGGACACGTCGAAGGTGAACGTGAACGGCGGGGCGATCGCGAT
CGGCCATCCGATCGGCGCGTCGGGCTGCCGGATTCTGGTGACGCTGCTGCACGAGATGGCCAAGCGCGACGCGAAGCGCG
GGCTGGCGTCGCTGTGCATCGGCGGCGGGATGGGCGTCGCGCTTGCGGTCGAGCGCGTCTGA

Upstream 100 bases:

>100_bases
ACCGCGATTGCGCCGGTTGGCGCGGCGCGTGCCATCGTCACGTGTGATCGCCTCGTGCCGGCGTCACGACGACAAACTGA
TTTCGATGCAGGGATTGAAC

Downstream 100 bases:

>100_bases
GCGGCGGCTGACGACACGGTTCGCTCGCGGCGTGGGCCAGCGCCGCGGGCGAGCCAGGCGGTTTTCGCGCAAGACAGGCA
GTCAATAACACGCGCGAGGT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTDVVIVSAARTAVGKFGGSLAKIAAPELGATVIRAVLERAGVKPEQVSEVIMGQVLTAGSGQNPARQSLIKAGLPTAVP
GMTINKVCGSGLKAVMLAANAIIAGDAEIVVAGGQENMSASPHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGIT
AENVAKEYGITREEQDAFAALSQNKAEAAQKAGRFDDEIVPVSIPQRKGEPLQFATDEFVRHGVTAESLAGLKPAFSKDG
SVTAANASGLNDGAAAVLVMSAQKAAALGLTPLARIKAYANAGVDPSVMGMGPVPASRRALERAGWTPGDLDLMEINEAF
AAQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMAKRDAKRGLASLCIGGGMGVALAVERV

Sequences:

>Translated_393_residues
MTDVVIVSAARTAVGKFGGSLAKIAAPELGATVIRAVLERAGVKPEQVSEVIMGQVLTAGSGQNPARQSLIKAGLPTAVP
GMTINKVCGSGLKAVMLAANAIIAGDAEIVVAGGQENMSASPHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGIT
AENVAKEYGITREEQDAFAALSQNKAEAAQKAGRFDDEIVPVSIPQRKGEPLQFATDEFVRHGVTAESLAGLKPAFSKDG
SVTAANASGLNDGAAAVLVMSAQKAAALGLTPLARIKAYANAGVDPSVMGMGPVPASRRALERAGWTPGDLDLMEINEAF
AAQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMAKRDAKRGLASLCIGGGMGVALAVERV
>Mature_392_residues
TDVVIVSAARTAVGKFGGSLAKIAAPELGATVIRAVLERAGVKPEQVSEVIMGQVLTAGSGQNPARQSLIKAGLPTAVPG
MTINKVCGSGLKAVMLAANAIIAGDAEIVVAGGQENMSASPHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGITA
ENVAKEYGITREEQDAFAALSQNKAEAAQKAGRFDDEIVPVSIPQRKGEPLQFATDEFVRHGVTAESLAGLKPAFSKDGS
VTAANASGLNDGAAAVLVMSAQKAAALGLTPLARIKAYANAGVDPSVMGMGPVPASRRALERAGWTPGDLDLMEINEAFA
AQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMAKRDAKRGLASLCIGGGMGVALAVERV

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=56.5217391304348, Blast_Score=443, Evalue=1e-124,
Organism=Homo sapiens, GI4557237, Length=394, Percent_Identity=44.9238578680203, Blast_Score=325, Evalue=6e-89,
Organism=Homo sapiens, GI167614485, Length=390, Percent_Identity=44.3589743589744, Blast_Score=321, Evalue=6e-88,
Organism=Homo sapiens, GI4501853, Length=396, Percent_Identity=43.1818181818182, Blast_Score=272, Evalue=4e-73,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=31.3679245283019, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI194353979, Length=393, Percent_Identity=31.8066157760814, Blast_Score=159, Evalue=4e-39,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=62.2448979591837, Blast_Score=488, Evalue=1e-139,
Organism=Escherichia coli, GI1788554, Length=394, Percent_Identity=60.6598984771574, Blast_Score=452, Evalue=1e-128,
Organism=Escherichia coli, GI1787663, Length=405, Percent_Identity=45.679012345679, Blast_Score=322, Evalue=2e-89,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=43, Blast_Score=277, Evalue=8e-76,
Organism=Escherichia coli, GI1788683, Length=409, Percent_Identity=34.2298288508557, Blast_Score=197, Evalue=8e-52,
Organism=Caenorhabditis elegans, GI133906874, Length=391, Percent_Identity=46.5473145780051, Blast_Score=334, Evalue=4e-92,
Organism=Caenorhabditis elegans, GI25147385, Length=388, Percent_Identity=42.2680412371134, Blast_Score=301, Evalue=4e-82,
Organism=Caenorhabditis elegans, GI17535921, Length=397, Percent_Identity=41.8136020151133, Blast_Score=281, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=32.3155216284987, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17551802, Length=428, Percent_Identity=31.7757009345794, Blast_Score=182, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6325229, Length=398, Percent_Identity=42.2110552763819, Blast_Score=291, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6322031, Length=399, Percent_Identity=40.1002506265664, Blast_Score=237, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24655093, Length=393, Percent_Identity=57.5063613231552, Blast_Score=451, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24640423, Length=394, Percent_Identity=46.1928934010152, Blast_Score=325, Evalue=3e-89,
Organism=Drosophila melanogaster, GI17648125, Length=392, Percent_Identity=45.1530612244898, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=31.2941176470588, Blast_Score=177, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40409; Mature: 40278

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDVVIVSAARTAVGKFGGSLAKIAAPELGATVIRAVLERAGVKPEQVSEVIMGQVLTAG
CCCEEEEEHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
SGQNPARQSLIKAGLPTAVPGMTINKVCGSGLKAVMLAANAIIAGDAEIVVAGGQENMSA
CCCCHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHEEECCCEEEEECCCCCCCC
SPHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGITAENVAKEYGITREEQDAFAA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHH
LSQNKAEAAQKAGRFDDEIVPVSIPQRKGEPLQFATDEFVRHGVTAESLAGLKPAFSKDG
HHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCHHHHHCCCCCCCCCC
SVTAANASGLNDGAAAVLVMSAQKAAALGLTPLARIKAYANAGVDPSVMGMGPVPASRRA
CEEECCCCCCCCCCEEEEEEECHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
LERAGWTPGDLDLMEINEAFAAQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILV
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCHHHHHHH
TLLHEMAKRDAKRGLASLCIGGGMGVALAVERV
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
>Mature Secondary Structure 
TDVVIVSAARTAVGKFGGSLAKIAAPELGATVIRAVLERAGVKPEQVSEVIMGQVLTAG
CCEEEEEHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
SGQNPARQSLIKAGLPTAVPGMTINKVCGSGLKAVMLAANAIIAGDAEIVVAGGQENMSA
CCCCHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHEEECCCEEEEECCCCCCCC
SPHVLPGSRDGFRMGDAKLVDTMIVDGLWDVYNQYHMGITAENVAKEYGITREEQDAFAA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHH
LSQNKAEAAQKAGRFDDEIVPVSIPQRKGEPLQFATDEFVRHGVTAESLAGLKPAFSKDG
HHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCHHHHHCCCCCCCCCC
SVTAANASGLNDGAAAVLVMSAQKAAALGLTPLARIKAYANAGVDPSVMGMGPVPASRRA
CEEECCCCCCCCCCEEEEEEECHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
LERAGWTPGDLDLMEINEAFAAQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILV
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCHHHHHHH
TLLHEMAKRDAKRGLASLCIGGGMGVALAVERV
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2670935; 2670936 [H]