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The map label for this gene is ilvA [H]

Identifier: 116690756

GI number: 116690756

Start: 3033300

End: 3034823

Strand: Direct

Name: ilvA [H]

Synonym: Bcen2424_2736

Alternate gene names: 116690756

Gene position: 3033300-3034823 (Clockwise)

Preceding gene: 116690737

Following gene: 116690757

Centisome position: 87.07

GC content: 66.93

Gene sequence:

>1524_bases
ATGGCATCCCACGATTACCTGAAGAAAATCCTCACCGCGCGCGTCTACGACGTCGCGATCGAGACGGAACTCGAACCGGC
CCGCAACCTGTCGGCCCGGCTGCGCAACGCCGTTTACCTGAAGCGCGAGGACAACCAGCCGGTGTTCTCGTTCAAGCTGC
GCGGCGCATACAACAAGATGGCGCACATTCCGGTGGACGCGCTCGCGCGCGGCGTGATTACCGCGTCGGCCGGCAACCAC
GCGCAGGGCGTTGCGTTCTCGGCGGCCCGGATGGGCGTCAAGGCCGTGATCGTCGTACCGGTCACGACGCCGCAGGTGAA
GGTCGACGCGGTGCGCGCGCACGGCGGCCCGAGCGTCGAGGTGATCCAGGCGGGCGAATCGTACAGCGATGCGTACGCGC
ACGCGGTCAAGGTCCAGCAGGAGCGCGACCTCACGTTCGTCCACCCGTTCGACGATCCGTACGTGATCGCCGGCCAGGGC
ACGATCGCGATGGAAATCCTGCGCCAGCACCAGGGCCCGATCCACGCGGTCTTCGTGCCGATCGGCGGCGGCGGACTCGC
GTCCGGCGTCGCCGCGTACGTGAAGGCGGTGCGCCCGGAGATCAAGGTGATCGGCGTGCAGGCCGAGGATTCGTGCGCGA
TGGCGCAGTCGCTGGACGCGGGCGAGCGCATCGAGCTGAGCGAAGTCGGCCTGTTCGCGGACGGCACCGCGGTAAAGCTC
GTCGGCGAGGAAACCTTCCGGCTGTGCCGCGAATTCCTGGACGGCGTCGTGACCGTCAACACCGACGCACTGTGCGCGGC
GATCAAGGACGTGTTCCAGGACACGCGCAGCGTGCTCGAGCCGTCCGGCGCGCTCGCGGTCGCGGGTGCGAAGCTGTATG
CGGAACGCGAAGGCATCGAGAACCAGACGCTCGTCGCGGTCACGTCCGGCGCGAACATGAATTTCGACCGGATGCGCTTC
GTCGCCGAGCGCGCCGAGGTCGGCGAAGCGCGCGAAGCCGTGTTCGCGGTCACGATTCCCGAGGAACGCGGCAGCTTCAA
GCGCTTCTGCTCGCTCGTCGGCGATCGCAACGTCACCGAGTTCAACTACCGGATCGCCGACGAGAAGTCCGCGCACATCT
TCGTCGGCGTGCAGATCAAGCGCCGCGGCGAATCGGCGGAGATCGCCGCGAACTTCGAGTCGCACGGCTTCAAGAGCGTC
GACCTGACGCACGACGAGCTGTCGAAGGAACACATCCGCTACATGGTCGGCGGCCGCTCGCCGCTCGCGCTCGACGAGCG
CCTGTTCCGCTTCGAATTCCCGGAACGGCCGGGCGCGCTGATGAAGTTCCTGTCGTCGATGGCGCCGGACTGGAACATCA
GCCTGTTCCACTACCGCAACCAGGGCGCGGACTACAGCTCGATCCTCGTCGGGCTGCAGGTGCCGCAGGCCGATCGCGCC
GAATTCGAACGCTTCCTCGCGGCACTCGGCTACCCGTATGTCGAAGAGAGCGCCAACCCGGCTTACCGCCTCTTCCTGTC
GTAA

Upstream 100 bases:

>100_bases
GCTCACAGCCGCCCGCCCGGCATGCCGCTTGCGTGCGGGCGGACCCTTGGCGCTATCATTGACCCTTTACCGTCTGCATC
CGCACTGCCCGCGAGCGCCC

Downstream 100 bases:

>100_bases
AGGCTTCGTGCAATGAATCCCGAACATTCCCCGCTCGGCAAGGCCACCGTCTACGCGGCGCAGTACGACGCGTCGCTGCT
GTTCCCGATCCCGCGCGCCG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MASHDYLKKILTARVYDVAIETELEPARNLSARLRNAVYLKREDNQPVFSFKLRGAYNKMAHIPVDALARGVITASAGNH
AQGVAFSAARMGVKAVIVVPVTTPQVKVDAVRAHGGPSVEVIQAGESYSDAYAHAVKVQQERDLTFVHPFDDPYVIAGQG
TIAMEILRQHQGPIHAVFVPIGGGGLASGVAAYVKAVRPEIKVIGVQAEDSCAMAQSLDAGERIELSEVGLFADGTAVKL
VGEETFRLCREFLDGVVTVNTDALCAAIKDVFQDTRSVLEPSGALAVAGAKLYAEREGIENQTLVAVTSGANMNFDRMRF
VAERAEVGEAREAVFAVTIPEERGSFKRFCSLVGDRNVTEFNYRIADEKSAHIFVGVQIKRRGESAEIAANFESHGFKSV
DLTHDELSKEHIRYMVGGRSPLALDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQADRA
EFERFLAALGYPYVEESANPAYRLFLS

Sequences:

>Translated_507_residues
MASHDYLKKILTARVYDVAIETELEPARNLSARLRNAVYLKREDNQPVFSFKLRGAYNKMAHIPVDALARGVITASAGNH
AQGVAFSAARMGVKAVIVVPVTTPQVKVDAVRAHGGPSVEVIQAGESYSDAYAHAVKVQQERDLTFVHPFDDPYVIAGQG
TIAMEILRQHQGPIHAVFVPIGGGGLASGVAAYVKAVRPEIKVIGVQAEDSCAMAQSLDAGERIELSEVGLFADGTAVKL
VGEETFRLCREFLDGVVTVNTDALCAAIKDVFQDTRSVLEPSGALAVAGAKLYAEREGIENQTLVAVTSGANMNFDRMRF
VAERAEVGEAREAVFAVTIPEERGSFKRFCSLVGDRNVTEFNYRIADEKSAHIFVGVQIKRRGESAEIAANFESHGFKSV
DLTHDELSKEHIRYMVGGRSPLALDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQADRA
EFERFLAALGYPYVEESANPAYRLFLS
>Mature_506_residues
ASHDYLKKILTARVYDVAIETELEPARNLSARLRNAVYLKREDNQPVFSFKLRGAYNKMAHIPVDALARGVITASAGNHA
QGVAFSAARMGVKAVIVVPVTTPQVKVDAVRAHGGPSVEVIQAGESYSDAYAHAVKVQQERDLTFVHPFDDPYVIAGQGT
IAMEILRQHQGPIHAVFVPIGGGGLASGVAAYVKAVRPEIKVIGVQAEDSCAMAQSLDAGERIELSEVGLFADGTAVKLV
GEETFRLCREFLDGVVTVNTDALCAAIKDVFQDTRSVLEPSGALAVAGAKLYAEREGIENQTLVAVTSGANMNFDRMRFV
AERAEVGEAREAVFAVTIPEERGSFKRFCSLVGDRNVTEFNYRIADEKSAHIFVGVQIKRRGESAEIAANFESHGFKSVD
LTHDELSKEHIRYMVGGRSPLALDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQADRAE
FERFLAALGYPYVEESANPAYRLFLS

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=298, Percent_Identity=33.8926174496644, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI33469958, Length=318, Percent_Identity=26.7295597484277, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1790207, Length=504, Percent_Identity=53.968253968254, Blast_Score=520, Evalue=1e-149,
Organism=Escherichia coli, GI1789505, Length=311, Percent_Identity=36.3344051446945, Blast_Score=166, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI71991565, Length=325, Percent_Identity=29.5384615384615, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17537387, Length=342, Percent_Identity=30.9941520467836, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17508781, Length=292, Percent_Identity=27.7397260273973, Blast_Score=116, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320930, Length=517, Percent_Identity=47.5822050290135, Blast_Score=461, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6322631, Length=304, Percent_Identity=33.5526315789474, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6319788, Length=269, Percent_Identity=25.2788104089219, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355833, Length=316, Percent_Identity=30.0632911392405, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24645328, Length=255, Percent_Identity=29.0196078431373, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 55477; Mature: 55345

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASHDYLKKILTARVYDVAIETELEPARNLSARLRNAVYLKREDNQPVFSFKLRGAYNKM
CCCHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHEEEEEECCCCCEEEEEECCCCCCH
AHIPVDALARGVITASAGNHAQGVAFSAARMGVKAVIVVPVTTPQVKVDAVRAHGGPSVE
HCCCHHHHHCCEEEECCCCCCCCEEEHHHHCCEEEEEEEECCCCCEEEEEEECCCCCCEE
VIQAGESYSDAYAHAVKVQQERDLTFVHPFDDPYVIAGQGTIAMEILRQHQGPIHAVFVP
EEECCCCCHHHHHHHHEEECCCCEEEECCCCCCEEEECCCHHHHHHHHHCCCCEEEEEEE
IGGGGLASGVAAYVKAVRPEIKVIGVQAEDSCAMAQSLDAGERIELSEVGLFADGTAVKL
ECCCHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHCCCCCEEEHHHCCEEECCCEEEE
VGEETFRLCREFLDGVVTVNTDALCAAIKDVFQDTRSVLEPSGALAVAGAKLYAEREGIE
ECHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHCCCC
NQTLVAVTSGANMNFDRMRFVAERAEVGEAREAVFAVTIPEERGSFKRFCSLVGDRNVTE
CCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECHHCCCHHHHHHHHCCCCEEE
FNYRIADEKSAHIFVGVQIKRRGESAEIAANFESHGFKSVDLTHDELSKEHIRYMVGGRS
EEEEECCCCCCEEEEEEEEEECCCCCEEEECHHHCCCEEECCCHHHHHHHHHHEEECCCC
PLALDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQADRA
CCHHHHHHHEECCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHEEEEEECCCCCHH
EFERFLAALGYPYVEESANPAYRLFLS
HHHHHHHHHCCCHHHCCCCCEEEEEEC
>Mature Secondary Structure 
ASHDYLKKILTARVYDVAIETELEPARNLSARLRNAVYLKREDNQPVFSFKLRGAYNKM
CCHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHEEEEEECCCCCEEEEEECCCCCCH
AHIPVDALARGVITASAGNHAQGVAFSAARMGVKAVIVVPVTTPQVKVDAVRAHGGPSVE
HCCCHHHHHCCEEEECCCCCCCCEEEHHHHCCEEEEEEEECCCCCEEEEEEECCCCCCEE
VIQAGESYSDAYAHAVKVQQERDLTFVHPFDDPYVIAGQGTIAMEILRQHQGPIHAVFVP
EEECCCCCHHHHHHHHEEECCCCEEEECCCCCCEEEECCCHHHHHHHHHCCCCEEEEEEE
IGGGGLASGVAAYVKAVRPEIKVIGVQAEDSCAMAQSLDAGERIELSEVGLFADGTAVKL
ECCCHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHCCCCCEEEHHHCCEEECCCEEEE
VGEETFRLCREFLDGVVTVNTDALCAAIKDVFQDTRSVLEPSGALAVAGAKLYAEREGIE
ECHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHCCCC
NQTLVAVTSGANMNFDRMRFVAERAEVGEAREAVFAVTIPEERGSFKRFCSLVGDRNVTE
CCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECHHCCCHHHHHHHHCCCCEEE
FNYRIADEKSAHIFVGVQIKRRGESAEIAANFESHGFKSVDLTHDELSKEHIRYMVGGRS
EEEEECCCCCCEEEEEEEEEECCCCCEEEECHHHCCCEEECCCHHHHHHHHHHEEECCCC
PLALDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQADRA
CCHHHHHHHEECCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHEEEEEECCCCCHH
EFERFLAALGYPYVEESANPAYRLFLS
HHHHHHHHHCCCHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA