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The map label for this gene is ybhO [H]

Identifier: 116690743

GI number: 116690743

Start: 3017901

End: 3019175

Strand: Reverse

Name: ybhO [H]

Synonym: Bcen2424_2723

Alternate gene names: 116690743

Gene position: 3019175-3017901 (Counterclockwise)

Preceding gene: 116690744

Following gene: 116690742

Centisome position: 86.66

GC content: 68.24

Gene sequence:

>1275_bases
ATGAATGCGGAGACCCGCAAGCGCTTCGCGCAATTGCGGCAGATGTTCCTGCAGGAGCGCGGCTCCGCGTCGCGGCTCGC
GTTTACGGCCGGCAACACGGTGCGGCTGTGCGAAACCGGCGGCGAATTCTTCCACGCGCTGATCGAGCGGATCGACGCCG
CCCGCGAGCAGGTGATGCTCGAAACCTACATCTTCTGCGACGACGCGGCCGGCCGCCCGGTGTCGGACGCGCTGATCCGC
GCGGCGCAGCGCGGCGTGCGCGTGCGGGTGATCACCGACGGCATCGGCACCGCGCGCCTGCCGCTGTTCGACACATGGGG
CGAAGCCGGCGTCGAGCACTGCATCTACAATCGCTTCCTGTTCGGCCGCTTCGGCTTCTCGCGCACGCACCGCAAGCTTG
CGGTGATCGATCAGACGACCGCGTTCTGCGGCGGCATCAACATCGTCGACGACTACACGCAGGGCAGCGCGACGCTGCCG
TTTCCGCGCTGGGATTTCGCGGTCGAGATGGCCGGGCCCGCGGTGTCCGACGTGCGCGCCGCGTTCGAGCTGCAGTGGCA
CCGGATCCAGTTCGGCCACAAGCCGTATGCGCAGTACGCGGCCGGGCTGCACGGCGGCGAAGCGTTCCCCGACATGTTCC
GGCGCTGGATGCGCAGCCATCGATGGATCAAGGCCGGCGCGCTGCGGGTCGTGACGGAGCCGAGCGTCGCGTTCGTCGCG
CGCGACAACGTCGTGAACCGCCGCGCGATCGAGAAGGCCTATCTCGCGGCGATCGGCCAGGCGCGCCAGCGCATCCTGCT
CGCGAATCCGTATTTCATGCCGGGCCGCAAGCTGCGCCGCGCGCTGACGGGCGCGGCACGGCGCGGCGTCGACGTGCAGG
TGCTGATCGGCCGCAAGGAGTTCACGGCGCTCGATACGGCCGTGCCGTTCCTGTATCACTCGCTGTTGCGCGCGGGCGTG
CGCGTGGCCGAATACGACAAGACGATCCTGCACGGCAAGGTCGCCGTGATCGACGACAACTGGGCGACGGTCGGCTCGTC
GAATCTGGACGCGCTGAGCCTGATGCTGAACAATGAAGCGAACGTCGTGCTGGTGCGCTACGATGCAGTGACGAATCAGT
TGCGCGACGCGATCGCCACCGCGTTCGCCGAAGGGCGGGAGATCGACGCCGCGCACTATGCCGCCCGCCCGCGCATCGAA
CGGCTGCTGAACTGGCTGGCGTACACCACGTACCGCCTCGTGATGAAGGCGCTGACGGTCGGCGGTTACGACTGA

Upstream 100 bases:

>100_bases
GCGAGGCGGCCGCGCGCTGCTTCTCGCCATCGAACGCCGAGGCGATCCTGCAATTGCCCGCACGCGTGGCCCTCGCGCGT
GCGCCGCACGGCTCGTCCGC

Downstream 100 bases:

>100_bases
CGCCGACTAAGTATTCGCTTCAAAAATCTGTCCGCACGTTCGTGCGGAAAAGCCGCTCCGGTCCCGCCGGAATCGCGCAA
AATAGCGGCTCGGTTAGACA

Product: phospholipase D/transphosphatidylase

Products: cardiolipin; glycerol [C]

Alternate protein names: CL synthase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MNAETRKRFAQLRQMFLQERGSASRLAFTAGNTVRLCETGGEFFHALIERIDAAREQVMLETYIFCDDAAGRPVSDALIR
AAQRGVRVRVITDGIGTARLPLFDTWGEAGVEHCIYNRFLFGRFGFSRTHRKLAVIDQTTAFCGGINIVDDYTQGSATLP
FPRWDFAVEMAGPAVSDVRAAFELQWHRIQFGHKPYAQYAAGLHGGEAFPDMFRRWMRSHRWIKAGALRVVTEPSVAFVA
RDNVVNRRAIEKAYLAAIGQARQRILLANPYFMPGRKLRRALTGAARRGVDVQVLIGRKEFTALDTAVPFLYHSLLRAGV
RVAEYDKTILHGKVAVIDDNWATVGSSNLDALSLMLNNEANVVLVRYDAVTNQLRDAIATAFAEGREIDAAHYAARPRIE
RLLNWLAYTTYRLVMKALTVGGYD

Sequences:

>Translated_424_residues
MNAETRKRFAQLRQMFLQERGSASRLAFTAGNTVRLCETGGEFFHALIERIDAAREQVMLETYIFCDDAAGRPVSDALIR
AAQRGVRVRVITDGIGTARLPLFDTWGEAGVEHCIYNRFLFGRFGFSRTHRKLAVIDQTTAFCGGINIVDDYTQGSATLP
FPRWDFAVEMAGPAVSDVRAAFELQWHRIQFGHKPYAQYAAGLHGGEAFPDMFRRWMRSHRWIKAGALRVVTEPSVAFVA
RDNVVNRRAIEKAYLAAIGQARQRILLANPYFMPGRKLRRALTGAARRGVDVQVLIGRKEFTALDTAVPFLYHSLLRAGV
RVAEYDKTILHGKVAVIDDNWATVGSSNLDALSLMLNNEANVVLVRYDAVTNQLRDAIATAFAEGREIDAAHYAARPRIE
RLLNWLAYTTYRLVMKALTVGGYD
>Mature_424_residues
MNAETRKRFAQLRQMFLQERGSASRLAFTAGNTVRLCETGGEFFHALIERIDAAREQVMLETYIFCDDAAGRPVSDALIR
AAQRGVRVRVITDGIGTARLPLFDTWGEAGVEHCIYNRFLFGRFGFSRTHRKLAVIDQTTAFCGGINIVDDYTQGSATLP
FPRWDFAVEMAGPAVSDVRAAFELQWHRIQFGHKPYAQYAAGLHGGEAFPDMFRRWMRSHRWIKAGALRVVTEPSVAFVA
RDNVVNRRAIEKAYLAAIGQARQRILLANPYFMPGRKLRRALTGAARRGVDVQVLIGRKEFTALDTAVPFLYHSLLRAGV
RVAEYDKTILHGKVAVIDDNWATVGSSNLDALSLMLNNEANVVLVRYDAVTNQLRDAIATAFAEGREIDAAHYAARPRIE
RLLNWLAYTTYRLVMKALTVGGYD

Specific function: Catalyzes, in vitro, the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787007, Length=381, Percent_Identity=38.0577427821522, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1787502, Length=396, Percent_Identity=26.2626262626263, Blast_Score=112, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 47534; Mature: 47534

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAETRKRFAQLRQMFLQERGSASRLAFTAGNTVRLCETGGEFFHALIERIDAAREQVML
CCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
ETYIFCDDAAGRPVSDALIRAAQRGVRVRVITDGIGTARLPLFDTWGEAGVEHCIYNRFL
HHEEEECCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCEECHHHHHHHHHHHHHHH
FGRFGFSRTHRKLAVIDQTTAFCGGINIVDDYTQGSATLPFPRWDFAVEMAGPAVSDVRA
HHHCCCCHHCCEEEEEECHHHHHCCCCEEECCCCCCEECCCCCCCEEEEECCCCHHHHHH
AFELQWHRIQFGHKPYAQYAAGLHGGEAFPDMFRRWMRSHRWIKAGALRVVTEPSVAFVA
HHHHEEEEEECCCCCHHHHHCCCCCCCCCHHHHHHHHHHCCEEECCCEEEEECCCEEEEE
RDNVVNRRAIEKAYLAAIGQARQRILLANPYFMPGRKLRRALTGAARRGVDVQVLIGRKE
CCCHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEECCHH
FTALDTAVPFLYHSLLRAGVRVAEYDKTILHGKVAVIDDNWATVGSSNLDALSLMLNNEA
HHHHHHHHHHHHHHHHHHCCCHHHHCHHHHCCEEEEEECCCCCCCCCCCCEEEEEECCCC
NVVLVRYDAVTNQLRDAIATAFAEGREIDAAHYAARPRIERLLNWLAYTTYRLVMKALTV
CEEEEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC
GGYD
CCCC
>Mature Secondary Structure
MNAETRKRFAQLRQMFLQERGSASRLAFTAGNTVRLCETGGEFFHALIERIDAAREQVML
CCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHH
ETYIFCDDAAGRPVSDALIRAAQRGVRVRVITDGIGTARLPLFDTWGEAGVEHCIYNRFL
HHEEEECCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCEECHHHHHHHHHHHHHHH
FGRFGFSRTHRKLAVIDQTTAFCGGINIVDDYTQGSATLPFPRWDFAVEMAGPAVSDVRA
HHHCCCCHHCCEEEEEECHHHHHCCCCEEECCCCCCEECCCCCCCEEEEECCCCHHHHHH
AFELQWHRIQFGHKPYAQYAAGLHGGEAFPDMFRRWMRSHRWIKAGALRVVTEPSVAFVA
HHHHEEEEEECCCCCHHHHHCCCCCCCCCHHHHHHHHHHCCEEECCCEEEEECCCEEEEE
RDNVVNRRAIEKAYLAAIGQARQRILLANPYFMPGRKLRRALTGAARRGVDVQVLIGRKE
CCCHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEECCHH
FTALDTAVPFLYHSLLRAGVRVAEYDKTILHGKVAVIDDNWATVGSSNLDALSLMLNNEA
HHHHHHHHHHHHHHHHHHCCCHHHHCHHHHCCEEEEEECCCCCCCCCCCCEEEEEECCCC
NVVLVRYDAVTNQLRDAIATAFAEGREIDAAHYAARPRIERLLNWLAYTTYRLVMKALTV
CEEEEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC
GGYD
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 L-1-phosphatidyl-glycerol [C]

Specific reaction: 2 L-1-phosphatidyl-glycerol = cardiolipin + glycerol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]