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The map label for this gene is ywrD [H]

Identifier: 116690693

GI number: 116690693

Start: 2961999

End: 2963639

Strand: Reverse

Name: ywrD [H]

Synonym: Bcen2424_2673

Alternate gene names: 116690693

Gene position: 2963639-2961999 (Counterclockwise)

Preceding gene: 116690696

Following gene: 116690692

Centisome position: 85.07

GC content: 70.26

Gene sequence:

>1641_bases
ATGAGTGGCTTCAACTGGCACAACCCGTATCCGACGACCCGCATTCCGGTGTTCGCGCGCAACGTCGTGTCGACGTCGCA
CCCGCTGGCCGCGCAGGCCGGGCTGCGGATGCTGTGGAAGGGCGGCAACGCGGTGGACGCGGCGCTGGCCGCCGCCGCCG
CGATCACGGTCGTCGAGCCCGTGTCGTGCGGGCTCGGCGGCGATGCATTCGCGCTCGTGTGGGACGGCGAGCGGCTGTCC
GGGCTGAACGCATCGGGCGTCGCGCCGGCCGCCTGGAACGTCGACTACTTCCGCAAGCGCCACGGCGAGGATGCGCGCGG
CATCGCGAACAAGCCGACGCGCGGCTGGGACACCGTCACCGTGCCGGGCGTGATCGCGGGCTGGGAAGCGCTGCACGCAA
AGTTCGGTTCGCTGCCGTTCGCGGATCTGCTCGAGCCGGCGATCGAGATCGCGGAGCGCGGCTATTCGGTGCCGCCGATC
GTCGCGCACAAGTGGGCCGCGGCCGTTCCCGAACTGCAGGACCTGCCGGGCTTCGCCGACACCTTCATGCCGCGCGGCCG
CGCGCCGCTCGTCGGCGAACGCGTGTGCCTGCCCGGTCATGCACGGACGCTGCGCACGCTCGCGAAGGACGGCGCCCGGG
CGTTCTACGAAGGGGCGCTCGCCGAGCGGATCGCCGCCTTCGCGCGCGAAGGCGGCGGCGCGCTGACCGAAGCGGACCTG
CGCGCGTACCGGCCGGAATGGGTCGAGCCGATCGGCAAGCGCTTCGGCCGCCACACGATTCACGAGATCCCGCCGAACGG
GCAGGGCATCGCCGCGCTGATCGCGCTCGGCATCGCCGAGCATGCGGGCGTGACCGAATGGCCGGTCGACTCGGTCGATT
CGCAGCATCTGCAGATCGAGGCGATGAAGCTCGCGTTCGCGGACGTCTATCGCTACGTCGCCGATCCGCGCGCGATGGAG
CTCACGCCCGAACAGATGCTCGACGATGCGTATCTCGCCGAACGCGCGAAGCTGATCGATCGCGCGCGGGCCACACACTT
CGCCGCCGGCCGTCCGCATTCCGGCGGCACGATCTACCTGTCGGCGGCCGACGAGCGCGGGATGATGGTGAGCTTCATCC
AGTCGAACTACATGGGCTTCGGCTCGGGCCTCGTCGTCCCCGGCACGGGCATTGCGCTGCAGAACCGCGGGCACGGCTTC
TCGATGGACCCGGCTTCGCCGAACGTCGTCGCGGGCGGCAAGCGACCGTTCCACACGATCATTCCGGCGTTCGTCACCGA
GGAAGTCGACGGCCGTACCGAGGCCGTGATGAGCTTCGGCGTGATGGGCGGCGACATGCAGCCGCAGGGCCACCTGCAGA
CCATCGTCCGGATGCTCGGCTATGGCCAGCAGCCGCAGGCCGCGTGTTGCGCGCCGCGCTGGAAGGTCAACCGCGACTTC
ACGCTCGACGTCGAGGCGACGATGAACCGCGCGACCGTCGATGGGCTGGCCGCCCGCGGCCATACGATCAAGTCGATCGA
CGATCCTTACATGGATTTCGGCTCGGGGCAGTTCGTCTGGCGCCTCGATCCCGACGATCCGGAGCGCGGCTACGTGGCCG
CGAGCGACAGCCGGCGCGACGGGCTGGCGGCCGGTTTCTGA

Upstream 100 bases:

>100_bases
ATGTGACAAATGAATTTGCGCGATGGCGCTGATCGCGCTGCAATGGCGGATTGCCCGCTCGCGCGGGCACGTTCATTCAG
CTTTCGACGAGGTGGTATCG

Downstream 100 bases:

>100_bases
CGGATCGCTTCCAGCTTCCTATGCAGTTTCCCGGCATCACGGGCGGCCCGACGGCCGCCCGTTTTCATTTGGCGCGGCGC
CTGCCATCGAACGCGCGCAA

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MSGFNWHNPYPTTRIPVFARNVVSTSHPLAAQAGLRMLWKGGNAVDAALAAAAAITVVEPVSCGLGGDAFALVWDGERLS
GLNASGVAPAAWNVDYFRKRHGEDARGIANKPTRGWDTVTVPGVIAGWEALHAKFGSLPFADLLEPAIEIAERGYSVPPI
VAHKWAAAVPELQDLPGFADTFMPRGRAPLVGERVCLPGHARTLRTLAKDGARAFYEGALAERIAAFAREGGGALTEADL
RAYRPEWVEPIGKRFGRHTIHEIPPNGQGIAALIALGIAEHAGVTEWPVDSVDSQHLQIEAMKLAFADVYRYVADPRAME
LTPEQMLDDAYLAERAKLIDRARATHFAAGRPHSGGTIYLSAADERGMMVSFIQSNYMGFGSGLVVPGTGIALQNRGHGF
SMDPASPNVVAGGKRPFHTIIPAFVTEEVDGRTEAVMSFGVMGGDMQPQGHLQTIVRMLGYGQQPQAACCAPRWKVNRDF
TLDVEATMNRATVDGLAARGHTIKSIDDPYMDFGSGQFVWRLDPDDPERGYVAASDSRRDGLAAGF

Sequences:

>Translated_546_residues
MSGFNWHNPYPTTRIPVFARNVVSTSHPLAAQAGLRMLWKGGNAVDAALAAAAAITVVEPVSCGLGGDAFALVWDGERLS
GLNASGVAPAAWNVDYFRKRHGEDARGIANKPTRGWDTVTVPGVIAGWEALHAKFGSLPFADLLEPAIEIAERGYSVPPI
VAHKWAAAVPELQDLPGFADTFMPRGRAPLVGERVCLPGHARTLRTLAKDGARAFYEGALAERIAAFAREGGGALTEADL
RAYRPEWVEPIGKRFGRHTIHEIPPNGQGIAALIALGIAEHAGVTEWPVDSVDSQHLQIEAMKLAFADVYRYVADPRAME
LTPEQMLDDAYLAERAKLIDRARATHFAAGRPHSGGTIYLSAADERGMMVSFIQSNYMGFGSGLVVPGTGIALQNRGHGF
SMDPASPNVVAGGKRPFHTIIPAFVTEEVDGRTEAVMSFGVMGGDMQPQGHLQTIVRMLGYGQQPQAACCAPRWKVNRDF
TLDVEATMNRATVDGLAARGHTIKSIDDPYMDFGSGQFVWRLDPDDPERGYVAASDSRRDGLAAGF
>Mature_545_residues
SGFNWHNPYPTTRIPVFARNVVSTSHPLAAQAGLRMLWKGGNAVDAALAAAAAITVVEPVSCGLGGDAFALVWDGERLSG
LNASGVAPAAWNVDYFRKRHGEDARGIANKPTRGWDTVTVPGVIAGWEALHAKFGSLPFADLLEPAIEIAERGYSVPPIV
AHKWAAAVPELQDLPGFADTFMPRGRAPLVGERVCLPGHARTLRTLAKDGARAFYEGALAERIAAFAREGGGALTEADLR
AYRPEWVEPIGKRFGRHTIHEIPPNGQGIAALIALGIAEHAGVTEWPVDSVDSQHLQIEAMKLAFADVYRYVADPRAMEL
TPEQMLDDAYLAERAKLIDRARATHFAAGRPHSGGTIYLSAADERGMMVSFIQSNYMGFGSGLVVPGTGIALQNRGHGFS
MDPASPNVVAGGKRPFHTIIPAFVTEEVDGRTEAVMSFGVMGGDMQPQGHLQTIVRMLGYGQQPQAACCAPRWKVNRDFT
LDVEATMNRATVDGLAARGHTIKSIDDPYMDFGSGQFVWRLDPDDPERGYVAASDSRRDGLAAGF

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=557, Percent_Identity=27.4685816876122, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI73915090, Length=557, Percent_Identity=27.4685816876122, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI73915096, Length=557, Percent_Identity=27.4685816876122, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI73915094, Length=557, Percent_Identity=27.4685816876122, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI113429324, Length=557, Percent_Identity=26.3913824057451, Blast_Score=139, Evalue=9e-33,
Organism=Homo sapiens, GI113429326, Length=562, Percent_Identity=26.1565836298932, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI109148539, Length=520, Percent_Identity=28.8461538461538, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI153266885, Length=556, Percent_Identity=25, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI153266901, Length=557, Percent_Identity=25.1346499102334, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI153266907, Length=554, Percent_Identity=24.9097472924188, Blast_Score=115, Evalue=1e-25,
Organism=Escherichia coli, GI1789856, Length=560, Percent_Identity=28.9285714285714, Blast_Score=177, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI72000294, Length=513, Percent_Identity=25.9259259259259, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI212646519, Length=513, Percent_Identity=25.9259259259259, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17542894, Length=569, Percent_Identity=25.1318101933216, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17506189, Length=534, Percent_Identity=23.7827715355805, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI193208245, Length=512, Percent_Identity=25.1953125, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI193208247, Length=512, Percent_Identity=25.1953125, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24642670, Length=558, Percent_Identity=26.3440860215054, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24642666, Length=558, Percent_Identity=26.3440860215054, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI161077878, Length=558, Percent_Identity=26.3440860215054, Blast_Score=138, Evalue=9e-33,
Organism=Drosophila melanogaster, GI45551474, Length=558, Percent_Identity=26.3440860215054, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI161077880, Length=558, Percent_Identity=26.3440860215054, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI18859741, Length=531, Percent_Identity=26.7419962335217, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI18859893, Length=430, Percent_Identity=26.9767441860465, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI161077496, Length=517, Percent_Identity=27.0793036750484, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 58686; Mature: 58555

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGFNWHNPYPTTRIPVFARNVVSTSHPLAAQAGLRMLWKGGNAVDAALAAAAAITVVEP
CCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHCHHEEECCCCHHHHHHHHHHHHHEECC
VSCGLGGDAFALVWDGERLSGLNASGVAPAAWNVDYFRKRHGEDARGIANKPTRGWDTVT
CCCCCCCCEEEEEECCCHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCEE
VPGVIAGWEALHAKFGSLPFADLLEPAIEIAERGYSVPPIVAHKWAAAVPELQDLPGFAD
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHCCCCHH
TFMPRGRAPLVGERVCLPGHARTLRTLAKDGARAFYEGALAERIAAFAREGGGALTEADL
HHCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAYRPEWVEPIGKRFGRHTIHEIPPNGQGIAALIALGIAEHAGVTEWPVDSVDSQHLQIE
HHCCCHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHH
AMKLAFADVYRYVADPRAMELTPEQMLDDAYLAERAKLIDRARATHFAAGRPHSGGTIYL
HHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
SAADERGMMVSFIQSNYMGFGSGLVVPGTGIALQNRGHGFSMDPASPNVVAGGKRPFHTI
EECCCCCCCCEEHHHCCCCCCCCEEECCCCEEEECCCCCCCCCCCCCCEEECCCCCHHHH
IPAFVTEEVDGRTEAVMSFGVMGGDMQPQGHLQTIVRMLGYGQQPQAACCAPRWKVNRDF
HHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCE
TLDVEATMNRATVDGLAARGHTIKSIDDPYMDFGSGQFVWRLDPDDPERGYVAASDSRRD
EEEHHHHCCHHHHHHHHHCCCCCCCCCCCHHCCCCCEEEEEECCCCCCCCEEEECCCCCC
GLAAGF
CCCCCC
>Mature Secondary Structure 
SGFNWHNPYPTTRIPVFARNVVSTSHPLAAQAGLRMLWKGGNAVDAALAAAAAITVVEP
CCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHCHHEEECCCCHHHHHHHHHHHHHEECC
VSCGLGGDAFALVWDGERLSGLNASGVAPAAWNVDYFRKRHGEDARGIANKPTRGWDTVT
CCCCCCCCEEEEEECCCHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCEE
VPGVIAGWEALHAKFGSLPFADLLEPAIEIAERGYSVPPIVAHKWAAAVPELQDLPGFAD
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHCCCCHH
TFMPRGRAPLVGERVCLPGHARTLRTLAKDGARAFYEGALAERIAAFAREGGGALTEADL
HHCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAYRPEWVEPIGKRFGRHTIHEIPPNGQGIAALIALGIAEHAGVTEWPVDSVDSQHLQIE
HHCCCHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHH
AMKLAFADVYRYVADPRAMELTPEQMLDDAYLAERAKLIDRARATHFAAGRPHSGGTIYL
HHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
SAADERGMMVSFIQSNYMGFGSGLVVPGTGIALQNRGHGFSMDPASPNVVAGGKRPFHTI
EECCCCCCCCEEHHHCCCCCCCCEEECCCCEEEECCCCCCCCCCCCCCEEECCCCCHHHH
IPAFVTEEVDGRTEAVMSFGVMGGDMQPQGHLQTIVRMLGYGQQPQAACCAPRWKVNRDF
HHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCE
TLDVEATMNRATVDGLAARGHTIKSIDDPYMDFGSGQFVWRLDPDDPERGYVAASDSRRD
EEEHHHHCCHHHHHHHHHCCCCCCCCCCCHHCCCCCEEEEEECCCCCCCCEEEECCCCCC
GLAAGF
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]