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The map label for this gene is kynU [H]

Identifier: 116690598

GI number: 116690598

Start: 2852244

End: 2853500

Strand: Direct

Name: kynU [H]

Synonym: Bcen2424_2578

Alternate gene names: 116690598

Gene position: 2852244-2853500 (Clockwise)

Preceding gene: 116690597

Following gene: 116690599

Centisome position: 81.87

GC content: 70.8

Gene sequence:

>1257_bases
ATGATGATCAAGACCCGTGAAGATGCGCTCGCGCTCGACCGCGACGACCCGCTGGCCCCGCTGCGCGACCAGTTCGCGCT
GCCCGACGGCGTGATCTACCTCGACGGCAACTCGCTCGGCGCGCAGCCGCGCGCATCGGCCGCCCGCGCGCAGCAGGTGA
TCGGCGCCGAGTGGGGCGAAGGCCTGATCCGCAGCTGGAACACCGCCGGCTGGTTCGCGCTGCCGCGCCGCCTCGGCGAC
AAGCTTGCGACGCTGATCGGCGGCGCGCCCGGCGAAACGGTCGTGACCGACACCATCTCGATCAACCTGTTCAAGCTGCT
GTCGGCGATGCTGCGCCACCAGGCGGAGCGCGCGCCCGAGCGCCGGGTGATCGTGTCGGAGCGCTCGAATTTCCCGACCG
ACCTGTATATCGCGCAGGGGCTGATCGAGCAGCTCGGCGGCGGCTACGAGCTGCGCCTGATCGACGATCCGGCCGACCTG
CCCGGCGCGCTCGGCGCGGACACGGCCGTCGCGATGATCACGCACGTGAACTACCGCACCGGCTACATGCACGACATGCC
GGCCGTCACGCAGCTGGTGCACGACGCCGGCGCGCTGATGCTGTGGGATCTCGCGCACTCGGCCGGCGCGGTGCCGGTCG
ACCTGAACGGCGCGCGCGCGGACGGCGCGGTCGGCTGCACGTACAAGTACCTGAACGGCGGCCCCGGCTCGCCCGCGTTC
GTGTGGGTGCCGCAACGCCATCTCGCGCATTTCTCGCAGCCGCTGTCCGGCTGGTGGGGCCACCGCGCGCCGTTCGCGAT
GCAGCCGGGCTTCGCGCCCGATCCGGGCATCGCGCGCTTCCTGTGCGGCACGCAGCCGATCGTGTCGATGTCGATGGTCG
AATGCGGGCTCGACGTGTTCCTGCAGACCGACATGGACGCGATCCGCCGCAAGTCGCTCGCGCTGACCGACGCGTTCATC
GCGCTCGTCGAAGCGCGCTGCGCGGGCCTGTCGCTGAAGCTCGTCACGCCGCGCGCGCATCACCAGCGCGGCTCGCAGGC
GAGCTTCGAGCATCCGCACGGCTACGAAGTGATGCAGGCGCTGATCGCGCGCGGCGTGATTGGCGACTACCGCGAGCCGT
ACGTGCTGCGCTTCGGCTTCACGCCGCTCTATACGCGCTTCGCCGACGTGTGGGATGCGGTCGAGACGCTGCGCGACATC
CTCGCCACCGACGCGTGGAAGGCACCCGAGTTCGCCGAACGCGGCGCGGTGACCTGA

Upstream 100 bases:

>100_bases
GCCGCTCAAATTCGCGACACTCGACGCGAGCCCCGTGCGCGCGGTGCTGCGCGCGCTGCCCGCGCACGCTTCCTGATTAC
CCGACCTACGACCCCACATC

Downstream 100 bases:

>100_bases
CCGGTTTTGCGCGGCGCGCCGCCGTTGCATGCCGCAGCTGCATGCGAAGCGCGCCACGCGTTCGTCATTCAAATCTGGAG
ATAGTCGTGAATTCTGGTCA

Product: kynureninase

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MMIKTREDALALDRDDPLAPLRDQFALPDGVIYLDGNSLGAQPRASAARAQQVIGAEWGEGLIRSWNTAGWFALPRRLGD
KLATLIGGAPGETVVTDTISINLFKLLSAMLRHQAERAPERRVIVSERSNFPTDLYIAQGLIEQLGGGYELRLIDDPADL
PGALGADTAVAMITHVNYRTGYMHDMPAVTQLVHDAGALMLWDLAHSAGAVPVDLNGARADGAVGCTYKYLNGGPGSPAF
VWVPQRHLAHFSQPLSGWWGHRAPFAMQPGFAPDPGIARFLCGTQPIVSMSMVECGLDVFLQTDMDAIRRKSLALTDAFI
ALVEARCAGLSLKLVTPRAHHQRGSQASFEHPHGYEVMQALIARGVIGDYREPYVLRFGFTPLYTRFADVWDAVETLRDI
LATDAWKAPEFAERGAVT

Sequences:

>Translated_418_residues
MMIKTREDALALDRDDPLAPLRDQFALPDGVIYLDGNSLGAQPRASAARAQQVIGAEWGEGLIRSWNTAGWFALPRRLGD
KLATLIGGAPGETVVTDTISINLFKLLSAMLRHQAERAPERRVIVSERSNFPTDLYIAQGLIEQLGGGYELRLIDDPADL
PGALGADTAVAMITHVNYRTGYMHDMPAVTQLVHDAGALMLWDLAHSAGAVPVDLNGARADGAVGCTYKYLNGGPGSPAF
VWVPQRHLAHFSQPLSGWWGHRAPFAMQPGFAPDPGIARFLCGTQPIVSMSMVECGLDVFLQTDMDAIRRKSLALTDAFI
ALVEARCAGLSLKLVTPRAHHQRGSQASFEHPHGYEVMQALIARGVIGDYREPYVLRFGFTPLYTRFADVWDAVETLRDI
LATDAWKAPEFAERGAVT
>Mature_418_residues
MMIKTREDALALDRDDPLAPLRDQFALPDGVIYLDGNSLGAQPRASAARAQQVIGAEWGEGLIRSWNTAGWFALPRRLGD
KLATLIGGAPGETVVTDTISINLFKLLSAMLRHQAERAPERRVIVSERSNFPTDLYIAQGLIEQLGGGYELRLIDDPADL
PGALGADTAVAMITHVNYRTGYMHDMPAVTQLVHDAGALMLWDLAHSAGAVPVDLNGARADGAVGCTYKYLNGGPGSPAF
VWVPQRHLAHFSQPLSGWWGHRAPFAMQPGFAPDPGIARFLCGTQPIVSMSMVECGLDVFLQTDMDAIRRKSLALTDAFI
ALVEARCAGLSLKLVTPRAHHQRGSQASFEHPHGYEVMQALIARGVIGDYREPYVLRFGFTPLYTRFADVWDAVETLRDI
LATDAWKAPEFAERGAVT

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=444, Percent_Identity=28.3783783783784, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI74101437, Length=285, Percent_Identity=26.6666666666667, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17550466, Length=430, Percent_Identity=26.9767441860465, Blast_Score=148, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6323261, Length=456, Percent_Identity=29.1666666666667, Blast_Score=145, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 45524; Mature: 45524

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMIKTREDALALDRDDPLAPLRDQFALPDGVIYLDGNSLGAQPRASAARAQQVIGAEWGE
CCCCCCCCCCEECCCCCCCCHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCC
GLIRSWNTAGWFALPRRLGDKLATLIGGAPGETVVTDTISINLFKLLSAMLRHQAERAPE
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCC
RRVIVSERSNFPTDLYIAQGLIEQLGGGYELRLIDDPADLPGALGADTAVAMITHVNYRT
CEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCC
GYMHDMPAVTQLVHDAGALMLWDLAHSAGAVPVDLNGARADGAVGCTYKYLNGGPGSPAF
CCCCCHHHHHHHHHHCCHHEEEHHHHCCCCCEEECCCCCCCCCCEEEEEECCCCCCCCEE
VWVPQRHLAHFSQPLSGWWGHRAPFAMQPGFAPDPGIARFLCGTQPIVSMSMVECGLDVF
EECCHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHCHHHH
LQTDMDAIRRKSLALTDAFIALVEARCAGLSLKLVTPRAHHQRGSQASFEHPHGYEVMQA
HHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCCCCCCCCCHHHHHH
LIARGVIGDYREPYVLRFGFTPLYTRFADVWDAVETLRDILATDAWKAPEFAERGAVT
HHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCC
>Mature Secondary Structure
MMIKTREDALALDRDDPLAPLRDQFALPDGVIYLDGNSLGAQPRASAARAQQVIGAEWGE
CCCCCCCCCCEECCCCCCCCHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCC
GLIRSWNTAGWFALPRRLGDKLATLIGGAPGETVVTDTISINLFKLLSAMLRHQAERAPE
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCC
RRVIVSERSNFPTDLYIAQGLIEQLGGGYELRLIDDPADLPGALGADTAVAMITHVNYRT
CEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCC
GYMHDMPAVTQLVHDAGALMLWDLAHSAGAVPVDLNGARADGAVGCTYKYLNGGPGSPAF
CCCCCHHHHHHHHHHCCHHEEEHHHHCCCCCEEECCCCCCCCCCEEEEEECCCCCCCCEE
VWVPQRHLAHFSQPLSGWWGHRAPFAMQPGFAPDPGIARFLCGTQPIVSMSMVECGLDVF
EECCHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHCHHHH
LQTDMDAIRRKSLALTDAFIALVEARCAGLSLKLVTPRAHHQRGSQASFEHPHGYEVMQA
HHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCCCCCCCCCHHHHHH
LIARGVIGDYREPYVLRFGFTPLYTRFADVWDAVETLRDILATDAWKAPEFAERGAVT
HHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA