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The map label for this gene is kynA

Identifier: 116690599

GI number: 116690599

Start: 2853602

End: 2854537

Strand: Direct

Name: kynA

Synonym: Bcen2424_2579

Alternate gene names: 116690599

Gene position: 2853602-2854537 (Clockwise)

Preceding gene: 116690598

Following gene: 116690604

Centisome position: 81.91

GC content: 66.88

Gene sequence:

>936_bases
ATGCAGCCCCCCGGCGGCGACGCGCCGGCAGGCTGCCCGTTCTCGGGCGCACGCGCCGCACAACCGGCGCAAGCCCCGCA
CGAAGCCCCGCACGTGCCGGGCGAGGCCGACGCTCAAGCCGGCTGGCACAACGCGCAGCTCGATTTCTCGAAGTCGATGA
GCTACGGCGACTACCTGTCGCTGAATTCGATCCTCGACGCGCAGCATCCGCTGTCGCCCGATCACAACGAGATGCTGTTC
ATCATCCAGCATCAGACGAGCGAGCTGTGGATGAAGCTTGCGCTGTTCGAATTGCGCGGCGCGCTCGATGCGGTGCGCAC
CGACGCGCTGCCGCCGGCGTTCAAGATGCTCGCACGCGTGTCGCGCATCCTCGAGCAACTGGTGCAGGCGTGGAACGTGC
TGTCGACGATGACGCCGTCCGAGTATTCGGCGATGCGCCCGTACCTCGGCCAGTCGTCCGGCTTCCAGTCGTACCAGTAT
CGTCAGCTCGAATTCCTGCTCGGCAACAAGAACGCGCAGATGCTGCAGCCGCATGCGCACCGGCCCGACATCCTCGAACA
GGTGCGCGCGACGCTCGAGGCGCCGTCGTTCTACGATGAAGTCGTGCGACTGCTCGCGCGGCGCGGCTTCCCGATCGCGG
CAGAGCGGCTGGAGCGCGACTGGACCCAGCCGACGCGGCACGACGAGACGGTCGAGGCCGCGTGGCTCGAGGTCTATCGT
CATCCGCAGCAGCACTGGGAGCTGTACGAGATGGCCGAGGAACTCGTCGATCTCGAGGATGCGTTCCGCCAGTGGCGCTT
CCGTCACGTGACGACGGTCGAGCGCATCATCGGCTTCAAGCAGGGCACCGGCGGCACGAGCGGCGCGCCGTACCTGCGCA
AGATGCTCGACGTCGTGCTATTCCCCGAGCTCTGGCACGTGCGCACCACGCTGTAA

Upstream 100 bases:

>100_bases
CGGTTTTGCGCGGCGCGCCGCCGTTGCATGCCGCAGCTGCATGCGAAGCGCGCCACGCGTTCGTCATTCAAATCTGGAGA
TAGTCGTGAATTCTGGTCAT

Downstream 100 bases:

>100_bases
CGCACGCCACGCGCCCGCCGTCACGACGATCACGACGACGTGCGGGCGAGCGCCTCCCCTTCGCGCGGCTGCGCCGCCGC
GCGCGACAGCCGCGGAATGT

Product: tryptophan 2,3-dioxygenase

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MQPPGGDAPAGCPFSGARAAQPAQAPHEAPHVPGEADAQAGWHNAQLDFSKSMSYGDYLSLNSILDAQHPLSPDHNEMLF
IIQHQTSELWMKLALFELRGALDAVRTDALPPAFKMLARVSRILEQLVQAWNVLSTMTPSEYSAMRPYLGQSSGFQSYQY
RQLEFLLGNKNAQMLQPHAHRPDILEQVRATLEAPSFYDEVVRLLARRGFPIAAERLERDWTQPTRHDETVEAAWLEVYR
HPQQHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDVVLFPELWHVRTTL

Sequences:

>Translated_311_residues
MQPPGGDAPAGCPFSGARAAQPAQAPHEAPHVPGEADAQAGWHNAQLDFSKSMSYGDYLSLNSILDAQHPLSPDHNEMLF
IIQHQTSELWMKLALFELRGALDAVRTDALPPAFKMLARVSRILEQLVQAWNVLSTMTPSEYSAMRPYLGQSSGFQSYQY
RQLEFLLGNKNAQMLQPHAHRPDILEQVRATLEAPSFYDEVVRLLARRGFPIAAERLERDWTQPTRHDETVEAAWLEVYR
HPQQHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDVVLFPELWHVRTTL
>Mature_311_residues
MQPPGGDAPAGCPFSGARAAQPAQAPHEAPHVPGEADAQAGWHNAQLDFSKSMSYGDYLSLNSILDAQHPLSPDHNEMLF
IIQHQTSELWMKLALFELRGALDAVRTDALPPAFKMLARVSRILEQLVQAWNVLSTMTPSEYSAMRPYLGQSSGFQSYQY
RQLEFLLGNKNAQMLQPHAHRPDILEQVRATLEAPSFYDEVVRLLARRGFPIAAERLERDWTQPTRHDETVEAAWLEVYR
HPQQHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDVVLFPELWHVRTTL

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family

Homologues:

Organism=Homo sapiens, GI5032165, Length=171, Percent_Identity=36.2573099415205, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17552370, Length=376, Percent_Identity=26.5957446808511, Blast_Score=111, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI32564651, Length=181, Percent_Identity=31.4917127071823, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17530891, Length=331, Percent_Identity=31.1178247734139, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): T23O_BURCA (Q1BU34)

Other databases:

- EMBL:   CP000378
- RefSeq:   YP_621844.1
- ProteinModelPortal:   Q1BU34
- SMR:   Q1BU34
- STRING:   Q1BU34
- GeneID:   4092501
- GenomeReviews:   CP000378_GR
- KEGG:   bcn:Bcen_1968
- eggNOG:   COG3483
- HOGENOM:   HBG647485
- OMA:   QWSVLAT
- ProtClustDB:   CLSK930429
- BioCyc:   BCEN331271:BCEN_1968-MONOMER
- InterPro:   IPR017485
- InterPro:   IPR004981
- PANTHER:   PTHR10138
- TIGRFAMs:   TIGR03036

Pfam domain/function: PF03301 Trp_dioxygenase

EC number: =1.13.11.11

Molecular weight: Translated: 35456; Mature: 35456

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: BINDING 142-142 BINDING 146-146 BINDING 153-153 BINDING 283-283

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPPGGDAPAGCPFSGARAAQPAQAPHEAPHVPGEADAQAGWHNAQLDFSKSMSYGDYLS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCHHH
LNSILDAQHPLSPDHNEMLFIIQHQTSELWMKLALFELRGALDAVRTDALPPAFKMLARV
HHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
SRILEQLVQAWNVLSTMTPSEYSAMRPYLGQSSGFQSYQYRQLEFLLGNKNAQMLQPHAH
HHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHCCCCCC
RPDILEQVRATLEAPSFYDEVVRLLARRGFPIAAERLERDWTQPTRHDETVEAAWLEVYR
CCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
HPQQHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDVVL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
FPELWHVRTTL
HHHHHHHHHCC
>Mature Secondary Structure
MQPPGGDAPAGCPFSGARAAQPAQAPHEAPHVPGEADAQAGWHNAQLDFSKSMSYGDYLS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCHHH
LNSILDAQHPLSPDHNEMLFIIQHQTSELWMKLALFELRGALDAVRTDALPPAFKMLARV
HHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
SRILEQLVQAWNVLSTMTPSEYSAMRPYLGQSSGFQSYQYRQLEFLLGNKNAQMLQPHAH
HHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHCCCCCC
RPDILEQVRATLEAPSFYDEVVRLLARRGFPIAAERLERDWTQPTRHDETVEAAWLEVYR
CCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
HPQQHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDVVL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
FPELWHVRTTL
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA