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The map label for this gene is hisQ [H]

Identifier: 116690425

GI number: 116690425

Start: 2666982

End: 2667671

Strand: Direct

Name: hisQ [H]

Synonym: Bcen2424_2405

Alternate gene names: 116690425

Gene position: 2666982-2667671 (Clockwise)

Preceding gene: 116690424

Following gene: 116690426

Centisome position: 76.55

GC content: 64.78

Gene sequence:

>690_bases
ATGTTTCTACAAGGCTACGGCCCGCTGATCCTCGCCGGCACCTGGCAAACCGTCAAACTGGCGGTGCTTTCGCTTGCGCT
GTCGTTCCTGCTGGGGCTGCTCGGCGCCGGCGCGAAGCTGTCGCGCAACCGCGTGACGAACGGCGTCGGCACCGTCTACA
CGACGCTGATCCGCGGCGTACCCGATCTCGTGCTGATGCTGCTGCTGTTCTACAGCCTGCAGATCTGGCTGAACATGGCG
ACCGACGCGCTCGGCTGGGACCAGATCGACATCGACCCGTTCCTCGCCGGCGTGCTCGTGCTCGGCTTCATCTACGGCGC
GTACTTCACCGAGACGTTCCGCGGCGCGTTCCTGTCGGTGCCGCGCGGCCAGCTCGAGGCCGGCAGCGCCTACGGGATGA
CGAACTGGCAGGTGTTCACGCGGATCATGTTCCCGCAGATGATGCGCTTCGCGCTGCCGGGCATCGGCAACAACTGGCAG
GTGCTCGTGAAGTCGACCGCGCTCGTGTCGATCATCGGCCTGGCCGACGTCGTGAAGGCGTCGCAGGACGCCGGCAAGGG
CACGCTGCGGTTCTTCTTCTTCACGCTGATCGCGGGAGCGGTCTACCTCGCCATCACGACGATCTCGAACTTCGTGCTGA
TGTGGCTCGAAAAGCGCTACTCGACCGGTGTCCGCAAGGCTGACCTATGA

Upstream 100 bases:

>100_bases
CGGACGGTCATGATACGCACGGGGCGTTCCGCGCAGCTTGGCGGGCGCGTCTTTCGCGGCGCACGACGTGCACCGTCAGG
GACCACACCAGGGACCACAT

Downstream 100 bases:

>100_bases
TCGAACTCATCCAAGAATACTGGCGCAACTATCTGTACACCGACGGCTATCGCATCACCGGTGTCGCGATCACGCTGTGG
CTGCTGGTCGTGTCGATCGG

Product: polar amino acid ABC transporter, inner membrane subunit

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MFLQGYGPLILAGTWQTVKLAVLSLALSFLLGLLGAGAKLSRNRVTNGVGTVYTTLIRGVPDLVLMLLLFYSLQIWLNMA
TDALGWDQIDIDPFLAGVLVLGFIYGAYFTETFRGAFLSVPRGQLEAGSAYGMTNWQVFTRIMFPQMMRFALPGIGNNWQ
VLVKSTALVSIIGLADVVKASQDAGKGTLRFFFFTLIAGAVYLAITTISNFVLMWLEKRYSTGVRKADL

Sequences:

>Translated_229_residues
MFLQGYGPLILAGTWQTVKLAVLSLALSFLLGLLGAGAKLSRNRVTNGVGTVYTTLIRGVPDLVLMLLLFYSLQIWLNMA
TDALGWDQIDIDPFLAGVLVLGFIYGAYFTETFRGAFLSVPRGQLEAGSAYGMTNWQVFTRIMFPQMMRFALPGIGNNWQ
VLVKSTALVSIIGLADVVKASQDAGKGTLRFFFFTLIAGAVYLAITTISNFVLMWLEKRYSTGVRKADL
>Mature_229_residues
MFLQGYGPLILAGTWQTVKLAVLSLALSFLLGLLGAGAKLSRNRVTNGVGTVYTTLIRGVPDLVLMLLLFYSLQIWLNMA
TDALGWDQIDIDPFLAGVLVLGFIYGAYFTETFRGAFLSVPRGQLEAGSAYGMTNWQVFTRIMFPQMMRFALPGIGNNWQ
VLVKSTALVSIIGLADVVKASQDAGKGTLRFFFFTLIAGAVYLAITTISNFVLMWLEKRYSTGVRKADL

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4215

COG function: function code E; ABC-type arginine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788646, Length=227, Percent_Identity=62.1145374449339, Blast_Score=291, Evalue=2e-80,
Organism=Escherichia coli, GI1787087, Length=225, Percent_Identity=35.5555555555556, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1787030, Length=212, Percent_Identity=32.0754716981132, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1788226, Length=221, Percent_Identity=28.0542986425339, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788645, Length=212, Percent_Identity=30.188679245283, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1786874, Length=182, Percent_Identity=30.7692307692308, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1786873, Length=212, Percent_Identity=28.3018867924528, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87082239, Length=214, Percent_Identity=27.1028037383178, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787086, Length=214, Percent_Identity=26.1682242990654, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 25114; Mature: 25114

Theoretical pI: Translated: 10.08; Mature: 10.08

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLQGYGPLILAGTWQTVKLAVLSLALSFLLGLLGAGAKLSRNRVTNGVGTVYTTLIRGV
CCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHCC
PDLVLMLLLFYSLQIWLNMATDALGWDQIDIDPFLAGVLVLGFIYGAYFTETFRGAFLSV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRGQLEAGSAYGMTNWQVFTRIMFPQMMRFALPGIGNNWQVLVKSTALVSIIGLADVVKA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHEEHHHHHHHHHHHHHHHHH
SQDAGKGTLRFFFFTLIAGAVYLAITTISNFVLMWLEKRYSTGVRKADL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MFLQGYGPLILAGTWQTVKLAVLSLALSFLLGLLGAGAKLSRNRVTNGVGTVYTTLIRGV
CCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHCC
PDLVLMLLLFYSLQIWLNMATDALGWDQIDIDPFLAGVLVLGFIYGAYFTETFRGAFLSV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRGQLEAGSAYGMTNWQVFTRIMFPQMMRFALPGIGNNWQVLVKSTALVSIIGLADVVKA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHEEHHHHHHHHHHHHHHHHH
SQDAGKGTLRFFFFTLIAGAVYLAITTISNFVLMWLEKRYSTGVRKADL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]