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The map label for this gene is comA [H]

Identifier: 116690132

GI number: 116690132

Start: 2341793

End: 2344282

Strand: Reverse

Name: comA [H]

Synonym: Bcen2424_2111

Alternate gene names: 116690132

Gene position: 2344282-2341793 (Counterclockwise)

Preceding gene: 116690133

Following gene: 116690131

Centisome position: 67.29

GC content: 73.45

Gene sequence:

>2490_bases
ATGCGCGTGGGGTGGATCGCGTTCGCGCTCGGCGTCGTCGTGCTGCAGCGGCAGGCGGCGTTGCCGGGGGCGGTCGCATG
GACGGTCGGAGCAGCCGTGCTCGCGGGCTGTGCGGCGCTCGGTGTGGGGTGCGTGCGCTGGCCGCGCACGCGTGCGGTCG
TTGCATGCGGATGGATGCTGTGGGCGCTCGCGGCCAGCGTCGCGGGGTTCGGTTATGCGGCGGCACGCGCCGAGTGGCGG
TTGAGCGACAGCCTGCCTGCCGAGTGGGAAGGGCGTGACATCGTCGTCACGGGCGTGATCCGCGGGTTGCCCGTCGTCGA
TGAAACGGGCGCGCGGCTGCTGTTCGCGATCGAATCGAACGATGCAGGGCTCACCCGTTTTCCGCCATTGATCCGGTTGT
CGTGGCGCGCGTATGGCGCAGCCGCGACACGCGACGCGCTTCCCGATTTGCGGGCAGCCCAGCGCTGGCGTTTCGTCGTG
CGTCTCAAGCGTCCGCATGCCGAGGCCAATCCCGGCGTGCGCGACAGCGAGGCGGCGTGGCTCGCCGCGGGCATTCGTGC
GATCGGCTATGTCAGTGCGCCGCGTCGGGCGGTATTGCTCGATGCGCGCGCATCCGGATGGCGTGCATCGATCGATCGGG
TGCGCGACACGCTGCGGGCGCGCATCGGCGACGTGCTCGGTGCTGATGCAGCGCACCGCGGCATCGTCGCCGCGCTGGCG
ATCGGCGACCAGTCGGGCATCGGCGACGACGACTGGCGCGTCCTGCGCAATACGGGCACGAGCCATCTGGTCGCGATTTC
CGGTCTCCATGTCGGGCTGGTCGGCGCGATCGCCGGCTGGCTCGTGTCGATGGTCTGGCGCCGCGTGCGCTGGCGCGCGC
GGGCCGCGACGCTCGTGGTGCCGGCGCCGTACGCGGCCGCGCTTGCCGCGCTGGCTGCCGCCGCGGGCTACGCCGCGCTC
GCCGGTTTCAACGTGCCGGCGCAGCGCGCGTGGTGGATGATCGCGGGCGGCGGCATCGCGTATCTGGCCGGCCGCAGCGT
GCCGACGTCCGCGGTGCTGTGCGCGGCGCTCGGCGGCGTGCTGCTCGCCGATCCGTGGGCCGTGCTGTCGGCCGGGTTCT
GGCTGTCGTTCGGCGCGGTCGCCGTGATCCTGCTGGCCGTCGCCGGCTGGCGCGCGGTGCGCGAGGTCGACGATATCGAT
GAAGCGGGTGCGGAAGGCGGCATGACCGGCCTGCGGAGCCGGTTGCGCGGGTGGGCGACGCGCGGCCGGCACCGCCTCGC
CGAGGCGACGCGCGTGCAGTACGCGGTGACGATCGGGCTCGCGCCGCTCACCGCCGCGTGGTTCGCGCAGGTTTCCCTGT
CGGGCCCGTTCGGCAATGCGTTCGCGATTCCGTGGGTCAGCTCGGTCGTGACGCCGGTCGTGCTGGCCGGCATCGCGTTG
CCGCCGCCGCTCGATGCGGCGGCCTTCCGGCTTGCGCATGCGGCGCTCGCGCCGATGATGACGCTGCTCGGGCACCTGGC
CGACTGGCCGGCCGGCGTGTTCTGGCTGCGCATGCCCGACTGGCCGGTGCTGGCGCTCGCATGCGTGGGCGTCGCGTGGG
CGCTGATGCCGCGCGGCTGGCCGTTGCGCTGGGCGGCGCCGCTCACGTGGCTGCCGCTCGTCGCGCCGGCGCCCGATGCG
CCGCCGCCCGGCGGCTTCCGGATGACCGTGCTCGACGTGGGGCAGGGCGCGGCGGTGCTGGTTGAAACCGCGCGGCGGAC
CTTGCTGTTCGATGCGGGGCCGGGGGCGGAGTCGTCCCATGCCGGTACGCGGATCGTCGCGCCGGCGTTGCGGGCGCGCG
GCATCGCGACGATCGATTCGCTCGTGCTCAGTCATGCGGATGCCGATCACGCGGGCGGCGCACCGGCCGTCTATGCGGCC
GCCGACGTGCGCCAGCTGCTGGCCGGCATTGCGCCGAAGAGCCGGCTGTGGCGCGACGCGGCAGCCGCGGGCGTGGCCGA
CCGGCTGCCGTGCGCGGCCGGGCAGCGCTGGATCTGGGACGGCGTCGCCTTCACGATGCTGTGGCCGCCGGGCGGGGTGG
GCACAGGGTCGTCGAACGGGCAGTCGTGCGTGTTGCGCATCGATGCGGATGGCACGTCCGCGCTGCTGACGGGCGACATC
GATGCGCGCGGCGAACGGCGGCTCGTGAATGACGCGCGCGACGCACTGGCCGCGCAGATCCTGATCGTTCCGCACCACGG
CAGCCGCACGTCGTCGGTCGAGCCTTTCCTCGATTCGGTCGGGCCGCGCGTCGCGGTATTTCCTGTAGGCTATCGCAATC
GTTTCGGGCATCCGCACCGGACCGTGCTGGCCCGCTACGAGGCGCGCGGGATTCCGCTGCCGCGCACCGATCGCGACGGC
GCCGTGCGATTCGACGTCGCGCCGGCCGGCGGCGGGTTTGCCTTCGCGCGCTATCGCGACGAACGGCGCAGGTACTGGAT
GGACCGGTGA

Upstream 100 bases:

>100_bases
ACGCGCTCGCCGCGCTGCCGCGACTCGCACTTTCGTCCGCATAATCGTTGCCGGAAGGCGCCGTATTGGCAGGGTGGCGC
CGGGTCGACGAGGAGGCGGA

Downstream 100 bases:

>100_bases
GCGCGGCGAAGGCCGCCGTATCGGGATGGAAAGTTCGGGGCCGGCGTGCCGTACCGAAGCACGGTCTCGACAGAATATGA
AGCATGGGACTGGCGTGAGA

Product: DNA internalization-related competence protein ComEC/Rec2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 829; Mature: 829

Protein sequence:

>829_residues
MRVGWIAFALGVVVLQRQAALPGAVAWTVGAAVLAGCAALGVGCVRWPRTRAVVACGWMLWALAASVAGFGYAAARAEWR
LSDSLPAEWEGRDIVVTGVIRGLPVVDETGARLLFAIESNDAGLTRFPPLIRLSWRAYGAAATRDALPDLRAAQRWRFVV
RLKRPHAEANPGVRDSEAAWLAAGIRAIGYVSAPRRAVLLDARASGWRASIDRVRDTLRARIGDVLGADAAHRGIVAALA
IGDQSGIGDDDWRVLRNTGTSHLVAISGLHVGLVGAIAGWLVSMVWRRVRWRARAATLVVPAPYAAALAALAAAAGYAAL
AGFNVPAQRAWWMIAGGGIAYLAGRSVPTSAVLCAALGGVLLADPWAVLSAGFWLSFGAVAVILLAVAGWRAVREVDDID
EAGAEGGMTGLRSRLRGWATRGRHRLAEATRVQYAVTIGLAPLTAAWFAQVSLSGPFGNAFAIPWVSSVVTPVVLAGIAL
PPPLDAAAFRLAHAALAPMMTLLGHLADWPAGVFWLRMPDWPVLALACVGVAWALMPRGWPLRWAAPLTWLPLVAPAPDA
PPPGGFRMTVLDVGQGAAVLVETARRTLLFDAGPGAESSHAGTRIVAPALRARGIATIDSLVLSHADADHAGGAPAVYAA
ADVRQLLAGIAPKSRLWRDAAAAGVADRLPCAAGQRWIWDGVAFTMLWPPGGVGTGSSNGQSCVLRIDADGTSALLTGDI
DARGERRLVNDARDALAAQILIVPHHGSRTSSVEPFLDSVGPRVAVFPVGYRNRFGHPHRTVLARYEARGIPLPRTDRDG
AVRFDVAPAGGGFAFARYRDERRRYWMDR

Sequences:

>Translated_829_residues
MRVGWIAFALGVVVLQRQAALPGAVAWTVGAAVLAGCAALGVGCVRWPRTRAVVACGWMLWALAASVAGFGYAAARAEWR
LSDSLPAEWEGRDIVVTGVIRGLPVVDETGARLLFAIESNDAGLTRFPPLIRLSWRAYGAAATRDALPDLRAAQRWRFVV
RLKRPHAEANPGVRDSEAAWLAAGIRAIGYVSAPRRAVLLDARASGWRASIDRVRDTLRARIGDVLGADAAHRGIVAALA
IGDQSGIGDDDWRVLRNTGTSHLVAISGLHVGLVGAIAGWLVSMVWRRVRWRARAATLVVPAPYAAALAALAAAAGYAAL
AGFNVPAQRAWWMIAGGGIAYLAGRSVPTSAVLCAALGGVLLADPWAVLSAGFWLSFGAVAVILLAVAGWRAVREVDDID
EAGAEGGMTGLRSRLRGWATRGRHRLAEATRVQYAVTIGLAPLTAAWFAQVSLSGPFGNAFAIPWVSSVVTPVVLAGIAL
PPPLDAAAFRLAHAALAPMMTLLGHLADWPAGVFWLRMPDWPVLALACVGVAWALMPRGWPLRWAAPLTWLPLVAPAPDA
PPPGGFRMTVLDVGQGAAVLVETARRTLLFDAGPGAESSHAGTRIVAPALRARGIATIDSLVLSHADADHAGGAPAVYAA
ADVRQLLAGIAPKSRLWRDAAAAGVADRLPCAAGQRWIWDGVAFTMLWPPGGVGTGSSNGQSCVLRIDADGTSALLTGDI
DARGERRLVNDARDALAAQILIVPHHGSRTSSVEPFLDSVGPRVAVFPVGYRNRFGHPHRTVLARYEARGIPLPRTDRDG
AVRFDVAPAGGGFAFARYRDERRRYWMDR
>Mature_829_residues
MRVGWIAFALGVVVLQRQAALPGAVAWTVGAAVLAGCAALGVGCVRWPRTRAVVACGWMLWALAASVAGFGYAAARAEWR
LSDSLPAEWEGRDIVVTGVIRGLPVVDETGARLLFAIESNDAGLTRFPPLIRLSWRAYGAAATRDALPDLRAAQRWRFVV
RLKRPHAEANPGVRDSEAAWLAAGIRAIGYVSAPRRAVLLDARASGWRASIDRVRDTLRARIGDVLGADAAHRGIVAALA
IGDQSGIGDDDWRVLRNTGTSHLVAISGLHVGLVGAIAGWLVSMVWRRVRWRARAATLVVPAPYAAALAALAAAAGYAAL
AGFNVPAQRAWWMIAGGGIAYLAGRSVPTSAVLCAALGGVLLADPWAVLSAGFWLSFGAVAVILLAVAGWRAVREVDDID
EAGAEGGMTGLRSRLRGWATRGRHRLAEATRVQYAVTIGLAPLTAAWFAQVSLSGPFGNAFAIPWVSSVVTPVVLAGIAL
PPPLDAAAFRLAHAALAPMMTLLGHLADWPAGVFWLRMPDWPVLALACVGVAWALMPRGWPLRWAAPLTWLPLVAPAPDA
PPPGGFRMTVLDVGQGAAVLVETARRTLLFDAGPGAESSHAGTRIVAPALRARGIATIDSLVLSHADADHAGGAPAVYAA
ADVRQLLAGIAPKSRLWRDAAAAGVADRLPCAAGQRWIWDGVAFTMLWPPGGVGTGSSNGQSCVLRIDADGTSALLTGDI
DARGERRLVNDARDALAAQILIVPHHGSRTSSVEPFLDSVGPRVAVFPVGYRNRFGHPHRTVLARYEARGIPLPRTDRDG
AVRFDVAPAGGGFAFARYRDERRRYWMDR

Specific function: Essential for natural transformation. Could be a transporter involved in DNA uptake [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis ComEC, H.influenzae REC2, and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=737, Percent_Identity=25.6445047489824, Blast_Score=184, Evalue=3e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 87552; Mature: 87552

Theoretical pI: Translated: 11.15; Mature: 11.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVGWIAFALGVVVLQRQAALPGAVAWTVGAAVLAGCAALGVGCVRWPRTRAVVACGWML
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHH
WALAASVAGFGYAAARAEWRLSDSLPAEWEGRDIVVTGVIRGLPVVDETGARLLFAIESN
HHHHHHHHCCCHHHHCCCEEECCCCCCCCCCCEEEEEEHHCCCCCEECCCCEEEEEEECC
DAGLTRFPPLIRLSWRAYGAAATRDALPDLRAAQRWRFVVRLKRPHAEANPGVRDSEAAW
CCCCCCCCCCEEEEHHHHCCHHHHHCCCHHHHHHHEEEEEEEECCCCCCCCCCCCCCHHH
LAAGIRAIGYVSAPRRAVLLDARASGWRASIDRVRDTLRARIGDVLGADAAHRGIVAALA
HHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCEEEEEE
IGDQSGIGDDDWRVLRNTGTSHLVAISGLHVGLVGAIAGWLVSMVWRRVRWRARAATLVV
ECCCCCCCCCHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
PAPYAAALAALAAAAGYAALAGFNVPAQRAWWMIAGGGIAYLAGRSVPTSAVLCAALGGV
CCCHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEEECCCEEEEECCCCCHHHHHHHHHCCH
LLADPWAVLSAGFWLSFGAVAVILLAVAGWRAVREVDDIDEAGAEGGMTGLRSRLRGWAT
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
RGRHRLAEATRVQYAVTIGLAPLTAAWFAQVSLSGPFGNAFAIPWVSSVVTPVVLAGIAL
HHHHHHHHHHHEEEEEEECCHHHHHHHHHEEEECCCCCCEEEHHHHHHHHHHHHHHHCCC
PPPLDAAAFRLAHAALAPMMTLLGHLADWPAGVFWLRMPDWPVLALACVGVAWALMPRGW
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCC
PLRWAAPLTWLPLVAPAPDAPPPGGFRMTVLDVGQGAAVLVETARRTLLFDAGPGAESSH
CCEEECCCCCCCEECCCCCCCCCCCEEEEEEECCCCCCHHHHHHCCEEEEECCCCCCCCC
AGTRIVAPALRARGIATIDSLVLSHADADHAGGAPAVYAAADVRQLLAGIAPKSRLWRDA
CCCEEEHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHH
AAAGVADRLPCAAGQRWIWDGVAFTMLWPPGGVGTGSSNGQSCVLRIDADGTSALLTGDI
HHCCCHHCCCCCCCCCEEECCEEEEEEECCCCCCCCCCCCCEEEEEEECCCCCEEEECCC
DARGERRLVNDARDALAAQILIVPHHGSRTSSVEPFLDSVGPRVAVFPVGYRNRFGHPHR
CCCCCHHHHHHHHHHHEEEEEEEECCCCCCCCCCHHHHCCCCEEEEEECCHHHCCCCCHH
TVLARYEARGIPLPRTDRDGAVRFDVAPAGGGFAFARYRDERRRYWMDR
HHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRVGWIAFALGVVVLQRQAALPGAVAWTVGAAVLAGCAALGVGCVRWPRTRAVVACGWML
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHH
WALAASVAGFGYAAARAEWRLSDSLPAEWEGRDIVVTGVIRGLPVVDETGARLLFAIESN
HHHHHHHHCCCHHHHCCCEEECCCCCCCCCCCEEEEEEHHCCCCCEECCCCEEEEEEECC
DAGLTRFPPLIRLSWRAYGAAATRDALPDLRAAQRWRFVVRLKRPHAEANPGVRDSEAAW
CCCCCCCCCCEEEEHHHHCCHHHHHCCCHHHHHHHEEEEEEEECCCCCCCCCCCCCCHHH
LAAGIRAIGYVSAPRRAVLLDARASGWRASIDRVRDTLRARIGDVLGADAAHRGIVAALA
HHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCEEEEEE
IGDQSGIGDDDWRVLRNTGTSHLVAISGLHVGLVGAIAGWLVSMVWRRVRWRARAATLVV
ECCCCCCCCCHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
PAPYAAALAALAAAAGYAALAGFNVPAQRAWWMIAGGGIAYLAGRSVPTSAVLCAALGGV
CCCHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEEECCCEEEEECCCCCHHHHHHHHHCCH
LLADPWAVLSAGFWLSFGAVAVILLAVAGWRAVREVDDIDEAGAEGGMTGLRSRLRGWAT
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
RGRHRLAEATRVQYAVTIGLAPLTAAWFAQVSLSGPFGNAFAIPWVSSVVTPVVLAGIAL
HHHHHHHHHHHEEEEEEECCHHHHHHHHHEEEECCCCCCEEEHHHHHHHHHHHHHHHCCC
PPPLDAAAFRLAHAALAPMMTLLGHLADWPAGVFWLRMPDWPVLALACVGVAWALMPRGW
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCC
PLRWAAPLTWLPLVAPAPDAPPPGGFRMTVLDVGQGAAVLVETARRTLLFDAGPGAESSH
CCEEECCCCCCCEECCCCCCCCCCCEEEEEEECCCCCCHHHHHHCCEEEEECCCCCCCCC
AGTRIVAPALRARGIATIDSLVLSHADADHAGGAPAVYAAADVRQLLAGIAPKSRLWRDA
CCCEEEHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHH
AAAGVADRLPCAAGQRWIWDGVAFTMLWPPGGVGTGSSNGQSCVLRIDADGTSALLTGDI
HHCCCHHCCCCCCCCCEEECCEEEEEEECCCCCCCCCCCCCEEEEEEECCCCCEEEECCC
DARGERRLVNDARDALAAQILIVPHHGSRTSSVEPFLDSVGPRVAVFPVGYRNRFGHPHR
CCCCCHHHHHHHHHHHEEEEEEEECCCCCCCCCCHHHHCCCCEEEEEECCHHHCCCCCHH
TVLARYEARGIPLPRTDRDGAVRFDVAPAGGGFAFARYRDERRRYWMDR
HHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7934834; 8830266 [H]