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The map label for this gene is uvrC [H]

Identifier: 116689165

GI number: 116689165

Start: 1253784

End: 1255829

Strand: Direct

Name: uvrC [H]

Synonym: Bcen2424_1143

Alternate gene names: 116689165

Gene position: 1253784-1255829 (Clockwise)

Preceding gene: 116689161

Following gene: 116689166

Centisome position: 35.99

GC content: 67.89

Gene sequence:

>2046_bases
ATGACATCCCCAGAAGCCTCCGCTACTCCGTTCGAACCGAAGAAGATCCTTGCGCAGTTGCCGCACATGCCGGGCGTCTA
TCGCTATTACGACACGACGGGCGCCGTCCTCTACGTCGGCAAGGCGCGCGACCTGAAAAAGCGCGTGTCGAGTTATTTCA
CGAAGACGCAACTGTCGCCGCGCATCGCGATGATGGTCACGCGCATCGCGCGCATCGAAACGACCGTCACGCGCTCGGAA
GCCGAGGCGCTGCTGCTCGAGAACAACCTGATCAAGGCGCTCGCGCCGCGCTACAACATCCTGTTTCGCGACGACAAGTC
GTATCCGTACCTGAAGCTCACCGCGCACCGCTTTCCGCGGATGGCCTACTACCGCGGCTCGGTCGACAAGCAGAACCAGT
ACTTCGGGCCGTTCCCGAGCGCGTGGGCCGTGCGCGAGAGCATCCAGATCCTGCAGCGCGTGTTCCAGTTGCGCACCTGC
GAGGATTCGGTCTTCAACAACCGCACGCGGCCGTGCCTGCTGCATCAGATCGGGCGTTGCACGGCGCCGTGCGTGGGCGC
GATCTCCGAAGAGGATTACGCGGTCGACGTGTCGAACGCCGCGCGCTTCCTGCTCGGCCGGCAGTCCGAAGTGATGAAGG
AGCTCGAGCAGAAGATGCACGCGTTCGCGGCCGAGCTGAAATTCGAGCAGGCGGCGGCCGTGCGCAACCAGATGAGCTCG
CTTGCGACGGTGCTGCACCAGCAGGCGATCGAGGTCGGCAGCGACAGCGACGTCGACATCCTGGCCGTCGTCGCGCAGGG
CGGACGCGTGTGCGTGAACCTCGCGATGGTGCGCGGCGGCCGGCACCTCGGCGACAAGGCGTATTTCCCGACGCACGTCG
AAAGTGCGCTGACGCTCGCCGAAGGCGGTCTCGGGGAAGAGGTCGAGCCGGCGGAGGCGGTCGATGCGACGGCCGACGCG
CCGGTCGACACGGTGCCCGATCAGCCTGCGGAAGAGGCGGGCAGCGCGCGCGGCGCGGCGGCAGCGTCGGTCGAGGCCGA
GGTGCTCGACGCATTCATCGCGCAGCACTATCTCGGCAACCGCGTGCCGCCGGTGCTCGTCGTCAGCCATGCGCCCGCGA
GTCGCGACCTGCTGGAGCTGCTGTCCGAGCAGGCCGGTCACAAGGTGTCGCTGGTGCGGCAGCCGCAGGGACAGCGGCGC
GCGTGGCTGTCGATGGCCGAGCAGAACGCACGGCTCGCGCTCGCGCGGCTGCTGTCCGAGCAGGGCTCGCAGCAGGCGCG
CACGCGCGCGCTGGCGGACACGCTCAGCTACGACAGCGACGATCTCGCGACGCTGCGGATCGAGTGCTTCGACATCAGCC
ATACGATGGGCGAGGCGACGCAGGCATCGTGTGTCGTTTATCACCATCACAAGATGCAGTCGAGCGAATACCGCCGCTAC
AACATCACGGGCATCACGCCGGGCGACGATTACGCGGCGATGCGGCAGGTGCTCACGCGCCGCTACGAGAAGATGGTCGA
GCAGGCCGCGCAGGCGGCGGCCGTCGACGAAGCGGCCGGCATCGACGGCGAGTCGACCCGCCAGGCCGAGGCGTCGAGCC
TGCTGCCGAACATCGTGCTGATCGACGGCGGCAAGGGTCAGGTCGAGATCGCGCGGCAGGTGTTCACCGAGCTCGGCCTC
GACACGTCGATGCTGGTCGGCGTCGCGAAAGGCGAGGGGCGCAAGGTCGGCCTCGAGACACTGGTGTTCGCGGACGGCCG
CGCGCCGCTCGAACTCGGCAAGGAGAGCGCCGCGCTGATGCTCGTCGCGCAGATTCGCGACGAGGCGCACCGTTTCGCGA
TCACCGGCATGCGGGCGAAGCGGGCGAAGGCTCGCCAGACGTCGCGGCTCGAGGAGCTCGAAGGCGTCGGTGCGAAGCGT
CGGCAGCGGCTGCTCGCGCGCTTCGGCGGGTTGCGCGGCGTGGTGGCTGCGAGTGTCGAGGAACTGGCGAGCGTCGAGGG
CATTTCGCACGCGCTCGCCGAGCAGATCTACAAGCAGCTTCACTGA

Upstream 100 bases:

>100_bases
GGGGGCAGCGGTGGTGCGTGGCATCGAAGCGGGCCGGTGAATGCTCTAAACTGGCGATTCTAATAGACCCGTTCCGCGTT
ACAAGGCGCCCGGATCACGC

Downstream 100 bases:

>100_bases
CGCGGCCGTGCGGCCGGCTCGTTGCCAGCGTTCTTGTGGCAGGCCGGTCGACACGGCACAATTGCGAATCCTTTACTGTC
CCGCATGCCATGCCGTTCAA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 681; Mature: 680

Protein sequence:

>681_residues
MTSPEASATPFEPKKILAQLPHMPGVYRYYDTTGAVLYVGKARDLKKRVSSYFTKTQLSPRIAMMVTRIARIETTVTRSE
AEALLLENNLIKALAPRYNILFRDDKSYPYLKLTAHRFPRMAYYRGSVDKQNQYFGPFPSAWAVRESIQILQRVFQLRTC
EDSVFNNRTRPCLLHQIGRCTAPCVGAISEEDYAVDVSNAARFLLGRQSEVMKELEQKMHAFAAELKFEQAAAVRNQMSS
LATVLHQQAIEVGSDSDVDILAVVAQGGRVCVNLAMVRGGRHLGDKAYFPTHVESALTLAEGGLGEEVEPAEAVDATADA
PVDTVPDQPAEEAGSARGAAAASVEAEVLDAFIAQHYLGNRVPPVLVVSHAPASRDLLELLSEQAGHKVSLVRQPQGQRR
AWLSMAEQNARLALARLLSEQGSQQARTRALADTLSYDSDDLATLRIECFDISHTMGEATQASCVVYHHHKMQSSEYRRY
NITGITPGDDYAAMRQVLTRRYEKMVEQAAQAAAVDEAAGIDGESTRQAEASSLLPNIVLIDGGKGQVEIARQVFTELGL
DTSMLVGVAKGEGRKVGLETLVFADGRAPLELGKESAALMLVAQIRDEAHRFAITGMRAKRAKARQTSRLEELEGVGAKR
RQRLLARFGGLRGVVAASVEELASVEGISHALAEQIYKQLH

Sequences:

>Translated_681_residues
MTSPEASATPFEPKKILAQLPHMPGVYRYYDTTGAVLYVGKARDLKKRVSSYFTKTQLSPRIAMMVTRIARIETTVTRSE
AEALLLENNLIKALAPRYNILFRDDKSYPYLKLTAHRFPRMAYYRGSVDKQNQYFGPFPSAWAVRESIQILQRVFQLRTC
EDSVFNNRTRPCLLHQIGRCTAPCVGAISEEDYAVDVSNAARFLLGRQSEVMKELEQKMHAFAAELKFEQAAAVRNQMSS
LATVLHQQAIEVGSDSDVDILAVVAQGGRVCVNLAMVRGGRHLGDKAYFPTHVESALTLAEGGLGEEVEPAEAVDATADA
PVDTVPDQPAEEAGSARGAAAASVEAEVLDAFIAQHYLGNRVPPVLVVSHAPASRDLLELLSEQAGHKVSLVRQPQGQRR
AWLSMAEQNARLALARLLSEQGSQQARTRALADTLSYDSDDLATLRIECFDISHTMGEATQASCVVYHHHKMQSSEYRRY
NITGITPGDDYAAMRQVLTRRYEKMVEQAAQAAAVDEAAGIDGESTRQAEASSLLPNIVLIDGGKGQVEIARQVFTELGL
DTSMLVGVAKGEGRKVGLETLVFADGRAPLELGKESAALMLVAQIRDEAHRFAITGMRAKRAKARQTSRLEELEGVGAKR
RQRLLARFGGLRGVVAASVEELASVEGISHALAEQIYKQLH
>Mature_680_residues
TSPEASATPFEPKKILAQLPHMPGVYRYYDTTGAVLYVGKARDLKKRVSSYFTKTQLSPRIAMMVTRIARIETTVTRSEA
EALLLENNLIKALAPRYNILFRDDKSYPYLKLTAHRFPRMAYYRGSVDKQNQYFGPFPSAWAVRESIQILQRVFQLRTCE
DSVFNNRTRPCLLHQIGRCTAPCVGAISEEDYAVDVSNAARFLLGRQSEVMKELEQKMHAFAAELKFEQAAAVRNQMSSL
ATVLHQQAIEVGSDSDVDILAVVAQGGRVCVNLAMVRGGRHLGDKAYFPTHVESALTLAEGGLGEEVEPAEAVDATADAP
VDTVPDQPAEEAGSARGAAAASVEAEVLDAFIAQHYLGNRVPPVLVVSHAPASRDLLELLSEQAGHKVSLVRQPQGQRRA
WLSMAEQNARLALARLLSEQGSQQARTRALADTLSYDSDDLATLRIECFDISHTMGEATQASCVVYHHHKMQSSEYRRYN
ITGITPGDDYAAMRQVLTRRYEKMVEQAAQAAAVDEAAGIDGESTRQAEASSLLPNIVLIDGGKGQVEIARQVFTELGLD
TSMLVGVAKGEGRKVGLETLVFADGRAPLELGKESAALMLVAQIRDEAHRFAITGMRAKRAKARQTSRLEELEGVGAKRR
QRLLARFGGLRGVVAASVEELASVEGISHALAEQIYKQLH

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=680, Percent_Identity=42.5, Blast_Score=513, Evalue=1e-146,
Organism=Escherichia coli, GI1788037, Length=207, Percent_Identity=28.5024154589372, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 74630; Mature: 74499

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPEASATPFEPKKILAQLPHMPGVYRYYDTTGAVLYVGKARDLKKRVSSYFTKTQLSP
CCCCCCCCCCCCHHHHHHHCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHCCCH
RIAMMVTRIARIETTVTRSEAEALLLENNLIKALAPRYNILFRDDKSYPYLKLTAHRFPR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEHHHCCC
MAYYRGSVDKQNQYFGPFPSAWAVRESIQILQRVFQLRTCEDSVFNNRTRPCLLHQIGRC
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
TAPCVGAISEEDYAVDVSNAARFLLGRQSEVMKELEQKMHAFAAELKFEQAAAVRNQMSS
CCCHHCCCCCCCCEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LATVLHQQAIEVGSDSDVDILAVVAQGGRVCVNLAMVRGGRHLGDKAYFPTHVESALTLA
HHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEHHHHCCCCCCCCCCCCHHHHHHHHHH
EGGLGEEVEPAEAVDATADAPVDTVPDQPAEEAGSARGAAAASVEAEVLDAFIAQHYLGN
CCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
RVPPVLVVSHAPASRDLLELLSEQAGHKVSLVRQPQGQRRAWLSMAEQNARLALARLLSE
CCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
QGSQQARTRALADTLSYDSDDLATLRIECFDISHTMGEATQASCVVYHHHKMQSSEYRRY
CCHHHHHHHHHHHHHCCCCCCCEEEEEEEEECHHHHCCCCCCEEEEEEHHHCCCCCCCEE
NITGITPGDDYAAMRQVLTRRYEKMVEQAAQAAAVDEAAGIDGESTRQAEASSLLPNIVL
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEE
IDGGKGQVEIARQVFTELGLDTSMLVGVAKGEGRKVGLETLVFADGRAPLELGKESAALM
EECCCCHHHHHHHHHHHHCCCHHHEEEEECCCCCEECCEEEEEECCCCCHHHCCCHHHHH
LVAQIRDEAHRFAITGMRAKRAKARQTSRLEELEGVGAKRRQRLLARFGGLRGVVAASVE
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHH
ELASVEGISHALAEQIYKQLH
HHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSPEASATPFEPKKILAQLPHMPGVYRYYDTTGAVLYVGKARDLKKRVSSYFTKTQLSP
CCCCCCCCCCCHHHHHHHCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHCCCH
RIAMMVTRIARIETTVTRSEAEALLLENNLIKALAPRYNILFRDDKSYPYLKLTAHRFPR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEHHHCCC
MAYYRGSVDKQNQYFGPFPSAWAVRESIQILQRVFQLRTCEDSVFNNRTRPCLLHQIGRC
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
TAPCVGAISEEDYAVDVSNAARFLLGRQSEVMKELEQKMHAFAAELKFEQAAAVRNQMSS
CCCHHCCCCCCCCEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LATVLHQQAIEVGSDSDVDILAVVAQGGRVCVNLAMVRGGRHLGDKAYFPTHVESALTLA
HHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEHHHHCCCCCCCCCCCCHHHHHHHHHH
EGGLGEEVEPAEAVDATADAPVDTVPDQPAEEAGSARGAAAASVEAEVLDAFIAQHYLGN
CCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
RVPPVLVVSHAPASRDLLELLSEQAGHKVSLVRQPQGQRRAWLSMAEQNARLALARLLSE
CCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
QGSQQARTRALADTLSYDSDDLATLRIECFDISHTMGEATQASCVVYHHHKMQSSEYRRY
CCHHHHHHHHHHHHHCCCCCCCEEEEEEEEECHHHHCCCCCCEEEEEEHHHCCCCCCCEE
NITGITPGDDYAAMRQVLTRRYEKMVEQAAQAAAVDEAAGIDGESTRQAEASSLLPNIVL
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEE
IDGGKGQVEIARQVFTELGLDTSMLVGVAKGEGRKVGLETLVFADGRAPLELGKESAALM
EECCCCHHHHHHHHHHHHCCCHHHEEEEECCCCCEECCEEEEEECCCCCHHHCCCHHHHH
LVAQIRDEAHRFAITGMRAKRAKARQTSRLEELEGVGAKRRQRLLARFGGLRGVVAASVE
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHH
ELASVEGISHALAEQIYKQLH
HHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA