| Definition | Burkholderia cenocepacia HI2424 chromosome 1, complete sequence. |
|---|---|
| Accession | NC_008542 |
| Length | 3,483,902 |
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The map label for this gene is gyrA [H]
Identifier: 116689063
GI number: 116689063
Start: 1152454
End: 1155057
Strand: Direct
Name: gyrA [H]
Synonym: Bcen2424_1040
Alternate gene names: 116689063
Gene position: 1152454-1155057 (Clockwise)
Preceding gene: 116689059
Following gene: 116689064
Centisome position: 33.08
GC content: 64.48
Gene sequence:
>2604_bases ATGGATCAATTCGCCAAAGAGACCCTGCCCACCTCCCTAGAGGAGGAAATGCGCCGTTCGTATCTCGATTACGCGATGAG CGTGATCGTCGGACGTGCCCTCCCGGATGTCCGCGATGGCCTCAAGCCCGTGCACCGGCGCGTATTGTTCGCGATGCACG AACTGAACAACGACTGGAACCGCGCGTACAAGAAGTCGGCGCGTATCGTCGGTGACGTGATCGGTAAATATCACCCTCAC GGCGATACCGCGGTCTACGACACGATCGTGCGGATGGCGCAGGACTTCTCGCTGCGCTACATGCTGATCGACGGGCAGGG CAACTTCGGCTCGATCGACGGCGACAATGCCGCGGCGATGCGTTACACCGAAATTCGCATGGCGAAGATCGGTCACGAGC TGCTCGCCGACATCGACAAGGAAACGGTCGATTTCGAGCCGAACTACGACGGCAACGAAATGCAGCCGTCGGTCCTGCCG TCGCGCATTCCGAACCTGCTGATCAACGGCTCGTCGGGCATCGCGGTCGGCATGGCGACCAACATCCCGCCGCACAACCT GAACGAAGTCGTCGACGCGTGCCAGCACCTGCTCGGCAACCCGGAAGCGACGATCGACGAGCTGATCGAGATCATCCCCG CGCCGGACTTCCCGACGGCCGGCATCATCTACGGCGTCGCCGGCGTGCGCGACGGCTACCGCACCGGGCGCGGCCGCGTC GTGATGCGGGCGGCCACGCACTTCGAGGAGATCGACCGCGGCCAGCGGATGGCGATCATCGTCGACGAGCTGCCGTACCA GGTGAACAAGCGCTCGCTGCTCGAGCGGATCGCCGAGCTCGTCAACGAGAAGAAGCTCGAAGGCATCTCCGACATCCGCG ACGAGTCCGACAAGAGCGGCATGCGCGTCGTGATCGAGCTCAAGCGCGGCGAAGTGCCGGAAGTGGTGCTGAACAACCTG TACAAGGCGACGCAGCTGCAGGACACGTTCGGCATGAACATGGTCGCGCTCGTCGACGGCCAGCCGAAGCTGCTGAACCT GAAGGAAATCCTGCAGTGCTTCCTGTCGCACCGACGCGAAGTGCTGACGCGCCGCACGATCTACGAACTGCGCAAGGCCC GCGAACGCGGCCACGTGCTCGAAGGTCTCGCGGTCGCGCTCGCGAACATCGACGAGTTCATCGCGATCATCAAGGCCGCG CCGACGCCGCCGATCGCGAAGCAGGAACTGATGGCGAAGCCGTGGGATTCGTCGCTCGTGCGCGAGATGCTGACGCGCGC CGAGAGCGAGAACGCGGCGGCCGGCGGTCGTTCCGCGTACCGTCCGGAAGGCCTGAACCCGGCATTCGGGATGCAGACCG ACGGGCTGTACCGCCTGTCCGACACGCAGGCGCAGGAAATCCTGCAGATGCGTCTGCAGCGCCTGACCGGCCTCGAGCAG GACAAGATCATCGGCGAGTACCGCGACGTGATGGCACAGATCGCCGACCTGCTGGACATCCTCGCGCGCCCCGAGCGGAT CACGACGATGATCGGCGACGAGCTGACCTCGGTGAAGGCCGAATTCGGTGATGCGCGCCGCTCGAAGATCGAACTGAACG CGACCGAGCTGAACACCGAGGATCTGATCACGCCGCAGGACATGGTCGTCACGATGTCGCATGCGGGCTACGTGAAGTCG CAGCCGCTGTCCGAGTACCGTGCGCAGAAGCGCGGCGGTCGCGGCAAGCAGGCGACGCAGATGAAGGAAGACGACTGGAT CGAGACGCTCTTCATCGCGAACACGCACGACTACATCCTGTGCTTCTCGAACCGCGGCCGCGTGTACTGGGTCAAGGTCT ATGAAGTGCCGCAGGGCTCGCGCAACTCGCGCGGCCGCCCGATCGTCAACATGTTCCCGCTGCAGGAAGGCGAGAAGATC AACGTCGTGCTGCCGGTCAAGGAATTCTCGGCCGACAAGTTCATCTTCATGGCGACGTCGCTCGGCACCGTGAAGAAGAC GCCGCTCGAAGCGTTCAGCCGCCCGATGAAGAAGGGCATCATCGCGGTCGGCCTCGACGAGGGCGACTACCTGATCGGTG CGTCGATCACCGACGGCGCGCACGACGTGATGCTGTTCTCCGACGCCGGCAAGGCCGTGCGTTTCGACGAGAACGACGTG CGTCCGATGGGGCGCGAGGCGCGCGGCGTGCGCGGCATGCAGCTCGAGGACGGGCAGCAGGTCATCGCGATGCTGGTTGC CGGCAGCGAGGAGCAGACCGTGCTCACCGCAACCGAAAACGGCTACGGCAAGCGCACGCCGATCACCGAGTACACGCGCC ATGGCCGCGGTACGAAGGGTATGATCGCGATCCAGACGTCCGAGCGCAACGGCAAGGTCGTGGCTGCCACGCTCGTCGAC GCCGAGGATCAGATCATGCTGATCACGACGGCCGGCGTGTTGATTCGCACCCGCGTATCCGAGGTTCGCGAGATGGGGCG CGCCACGCAAGGTGTTACACTCATCAGTCTCGATGAGGGCACCAAGCTCTCTGGCCTGCAGCAGATCGCGGAGGCCGAAG AGGGAGAGGGCGAGGCCGACGAGGCGTCGGACGGCGAAGCCTGA
Upstream 100 bases:
>100_bases TGGCGGCTGATGGGCGCATGTTAGAATCTCGCGTTGCGTTGCGCATGCAGCGCCCACGCGAAAGGCGTTCGCCGTCTTCG CTCCGAAACGATACGGATAC
Downstream 100 bases:
>100_bases AGAACGGATGAGACTCTGGCCGCCGCGGGCGAAAAGCGCCGCGGCCGGCGAGCAACCATTCATATTTCCAAAAGGGAGTG ATGATGCAAAAGCAATTCAA
Product: DNA gyrase subunit A
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 867; Mature: 867
Protein sequence:
>867_residues MDQFAKETLPTSLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWNRAYKKSARIVGDVIGKYHPH GDTAVYDTIVRMAQDFSLRYMLIDGQGNFGSIDGDNAAAMRYTEIRMAKIGHELLADIDKETVDFEPNYDGNEMQPSVLP SRIPNLLINGSSGIAVGMATNIPPHNLNEVVDACQHLLGNPEATIDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV VMRAATHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSGMRVVIELKRGEVPEVVLNNL YKATQLQDTFGMNMVALVDGQPKLLNLKEILQCFLSHRREVLTRRTIYELRKARERGHVLEGLAVALANIDEFIAIIKAA PTPPIAKQELMAKPWDSSLVREMLTRAESENAAAGGRSAYRPEGLNPAFGMQTDGLYRLSDTQAQEILQMRLQRLTGLEQ DKIIGEYRDVMAQIADLLDILARPERITTMIGDELTSVKAEFGDARRSKIELNATELNTEDLITPQDMVVTMSHAGYVKS QPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYILCFSNRGRVYWVKVYEVPQGSRNSRGRPIVNMFPLQEGEKI NVVLPVKEFSADKFIFMATSLGTVKKTPLEAFSRPMKKGIIAVGLDEGDYLIGASITDGAHDVMLFSDAGKAVRFDENDV RPMGREARGVRGMQLEDGQQVIAMLVAGSEEQTVLTATENGYGKRTPITEYTRHGRGTKGMIAIQTSERNGKVVAATLVD AEDQIMLITTAGVLIRTRVSEVREMGRATQGVTLISLDEGTKLSGLQQIAEAEEGEGEADEASDGEA
Sequences:
>Translated_867_residues MDQFAKETLPTSLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWNRAYKKSARIVGDVIGKYHPH GDTAVYDTIVRMAQDFSLRYMLIDGQGNFGSIDGDNAAAMRYTEIRMAKIGHELLADIDKETVDFEPNYDGNEMQPSVLP SRIPNLLINGSSGIAVGMATNIPPHNLNEVVDACQHLLGNPEATIDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV VMRAATHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSGMRVVIELKRGEVPEVVLNNL YKATQLQDTFGMNMVALVDGQPKLLNLKEILQCFLSHRREVLTRRTIYELRKARERGHVLEGLAVALANIDEFIAIIKAA PTPPIAKQELMAKPWDSSLVREMLTRAESENAAAGGRSAYRPEGLNPAFGMQTDGLYRLSDTQAQEILQMRLQRLTGLEQ DKIIGEYRDVMAQIADLLDILARPERITTMIGDELTSVKAEFGDARRSKIELNATELNTEDLITPQDMVVTMSHAGYVKS QPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYILCFSNRGRVYWVKVYEVPQGSRNSRGRPIVNMFPLQEGEKI NVVLPVKEFSADKFIFMATSLGTVKKTPLEAFSRPMKKGIIAVGLDEGDYLIGASITDGAHDVMLFSDAGKAVRFDENDV RPMGREARGVRGMQLEDGQQVIAMLVAGSEEQTVLTATENGYGKRTPITEYTRHGRGTKGMIAIQTSERNGKVVAATLVD AEDQIMLITTAGVLIRTRVSEVREMGRATQGVTLISLDEGTKLSGLQQIAEAEEGEGEADEASDGEA >Mature_867_residues MDQFAKETLPTSLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWNRAYKKSARIVGDVIGKYHPH GDTAVYDTIVRMAQDFSLRYMLIDGQGNFGSIDGDNAAAMRYTEIRMAKIGHELLADIDKETVDFEPNYDGNEMQPSVLP SRIPNLLINGSSGIAVGMATNIPPHNLNEVVDACQHLLGNPEATIDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV VMRAATHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSGMRVVIELKRGEVPEVVLNNL YKATQLQDTFGMNMVALVDGQPKLLNLKEILQCFLSHRREVLTRRTIYELRKARERGHVLEGLAVALANIDEFIAIIKAA PTPPIAKQELMAKPWDSSLVREMLTRAESENAAAGGRSAYRPEGLNPAFGMQTDGLYRLSDTQAQEILQMRLQRLTGLEQ DKIIGEYRDVMAQIADLLDILARPERITTMIGDELTSVKAEFGDARRSKIELNATELNTEDLITPQDMVVTMSHAGYVKS QPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYILCFSNRGRVYWVKVYEVPQGSRNSRGRPIVNMFPLQEGEKI NVVLPVKEFSADKFIFMATSLGTVKKTPLEAFSRPMKKGIIAVGLDEGDYLIGASITDGAHDVMLFSDAGKAVRFDENDV RPMGREARGVRGMQLEDGQQVIAMLVAGSEEQTVLTATENGYGKRTPITEYTRHGRGTKGMIAIQTSERNGKVVAATLVD AEDQIMLITTAGVLIRTRVSEVREMGRATQGVTLISLDEGTKLSGLQQIAEAEEGEGEADEASDGEA
Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]
COG id: COG0188
COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]
Homologues:
Organism=Homo sapiens, GI19913406, Length=321, Percent_Identity=26.4797507788162, Blast_Score=94, Evalue=6e-19, Organism=Homo sapiens, GI19913408, Length=379, Percent_Identity=26.1213720316623, Blast_Score=93, Evalue=1e-18, Organism=Escherichia coli, GI1788562, Length=851, Percent_Identity=60.3995299647474, Blast_Score=1045, Evalue=0.0, Organism=Escherichia coli, GI1789396, Length=718, Percent_Identity=35.0974930362117, Blast_Score=392, Evalue=1e-110, Organism=Caenorhabditis elegans, GI17535065, Length=384, Percent_Identity=27.0833333333333, Blast_Score=92, Evalue=9e-19, Organism=Caenorhabditis elegans, GI212645657, Length=380, Percent_Identity=26.3157894736842, Blast_Score=89, Evalue=1e-17, Organism=Caenorhabditis elegans, GI212645845, Length=172, Percent_Identity=31.9767441860465, Blast_Score=72, Evalue=9e-13, Organism=Saccharomyces cerevisiae, GI6324241, Length=352, Percent_Identity=26.7045454545455, Blast_Score=81, Evalue=7e-16, Organism=Drosophila melanogaster, GI17136538, Length=349, Percent_Identity=26.3610315186246, Blast_Score=91, Evalue=4e-18,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR020899 - InterPro: IPR005743 - InterPro: IPR006691 - InterPro: IPR002205 - InterPro: IPR013758 - InterPro: IPR013757 - InterPro: IPR013760 [H]
Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]
EC number: =5.99.1.3 [H]
Molecular weight: Translated: 96302; Mature: 96302
Theoretical pI: Translated: 5.08; Mature: 5.08
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.3 %Cys (Translated Protein) 3.9 %Met (Translated Protein) 4.3 %Cys+Met (Translated Protein) 0.3 %Cys (Mature Protein) 3.9 %Met (Mature Protein) 4.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MDQFAKETLPTSLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWN CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHH RAYKKSARIVGDVIGKYHPHGDTAVYDTIVRMAQDFSLRYMLIDGQGNFGSIDGDNAAAM HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEE RYTEIRMAKIGHELLADIDKETVDFEPNYDGNEMQPSVLPSRIPNLLINGSSGIAVGMAT EHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEECCCCEEEEEEC NIPPHNLNEVVDACQHLLGNPEATIDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCE VMRAATHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSG EEHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC MRVVIELKRGEVPEVVLNNLYKATQLQDTFGMNMVALVDGQPKLLNLKEILQCFLSHRRE CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEECHHHHHHHHHHHHHH VLTRRTIYELRKARERGHVLEGLAVALANIDEFIAIIKAAPTPPIAKQELMAKPWDSSLV HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCHHHH REMLTRAESENAAAGGRSAYRPEGLNPAFGMQTDGLYRLSDTQAQEILQMRLQRLTGLEQ HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCH DKIIGEYRDVMAQIADLLDILARPERITTMIGDELTSVKAEFGDARRSKIELNATELNTE HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHEECCHH DLITPQDMVVTMSHAGYVKSQPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYIL HCCCCCHHEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHCCCCCCCEEEEEEECCCCEEE CFSNRGRVYWVKVYEVPQGSRNSRGRPIVNMFPLQEGEKINVVLPVKEFSADKFIFMATS EECCCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEEEHHHCCCCCEEEEEEC LGTVKKTPLEAFSRPMKKGIIAVGLDEGDYLIGASITDGAHDVMLFSDAGKAVRFDENDV CCCCCCCCHHHHHHHHHCCEEEEEECCCCEEEEEEECCCCCEEEEEECCCCEEECCCCCC RPMGREARGVRGMQLEDGQQVIAMLVAGSEEQTVLTATENGYGKRTPITEYTRHGRGTKG CCCCHHHCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHCCCCCCC MIAIQTSERNGKVVAATLVDAEDQIMLITTAGVLIRTRVSEVREMGRATQGVTLISLDEG EEEEEECCCCCCEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHCCHHCCEEEEEECCC TKLSGLQQIAEAEEGEGEADEASDGEA CCHHHHHHHHHHHCCCCCCCCCCCCCC >Mature Secondary Structure MDQFAKETLPTSLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWN CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHH RAYKKSARIVGDVIGKYHPHGDTAVYDTIVRMAQDFSLRYMLIDGQGNFGSIDGDNAAAM HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEE RYTEIRMAKIGHELLADIDKETVDFEPNYDGNEMQPSVLPSRIPNLLINGSSGIAVGMAT EHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEECCCCEEEEEEC NIPPHNLNEVVDACQHLLGNPEATIDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCE VMRAATHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSG EEHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC MRVVIELKRGEVPEVVLNNLYKATQLQDTFGMNMVALVDGQPKLLNLKEILQCFLSHRRE CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEECHHHHHHHHHHHHHH VLTRRTIYELRKARERGHVLEGLAVALANIDEFIAIIKAAPTPPIAKQELMAKPWDSSLV HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCHHHH REMLTRAESENAAAGGRSAYRPEGLNPAFGMQTDGLYRLSDTQAQEILQMRLQRLTGLEQ HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCH DKIIGEYRDVMAQIADLLDILARPERITTMIGDELTSVKAEFGDARRSKIELNATELNTE HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHEECCHH DLITPQDMVVTMSHAGYVKSQPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYIL HCCCCCHHEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHCCCCCCCEEEEEEECCCCEEE CFSNRGRVYWVKVYEVPQGSRNSRGRPIVNMFPLQEGEKINVVLPVKEFSADKFIFMATS EECCCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEEEHHHCCCCCEEEEEEC LGTVKKTPLEAFSRPMKKGIIAVGLDEGDYLIGASITDGAHDVMLFSDAGKAVRFDENDV CCCCCCCCHHHHHHHHHCCEEEEEECCCCEEEEEEECCCCCEEEEEECCCCEEECCCCCC RPMGREARGVRGMQLEDGQQVIAMLVAGSEEQTVLTATENGYGKRTPITEYTRHGRGTKG CCCCHHHCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHCCCCCCC MIAIQTSERNGKVVAATLVDAEDQIMLITTAGVLIRTRVSEVREMGRATQGVTLISLDEG EEEEEECCCCCCEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHCCHHCCEEEEEECCC TKLSGLQQIAEAEEGEGEADEASDGEA CCHHHHHHHHHHHCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 7811002; 10984043 [H]