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The map label for this gene is hemL [H]

Identifier: 116688984

GI number: 116688984

Start: 1067247

End: 1068530

Strand: Reverse

Name: hemL [H]

Synonym: Bcen2424_0961

Alternate gene names: 116688984

Gene position: 1068530-1067247 (Counterclockwise)

Preceding gene: 116688985

Following gene: 116688983

Centisome position: 30.67

GC content: 69.31

Gene sequence:

>1284_bases
ATGTCCAACAATCAGATCCTCTTCGAACGCGCCCAGAAGACCATTCCGGGCGGCGTCAACTCGCCGGTGCGCGCCTTCCG
CTCGGTCGGCGGCACGCCGCGCTTCGTCGCGCGCGCACAAGGCCCGTATTTCTGGGATGCCGACGGCAAGCAGTACATCG
ACTACATCGGCTCGTGGGGCCCGATGATCGTCGGCCACGTCCATCCGGAAGTGCTGTCGGCCGTGCAGAACGTGCTCGCC
GACGGCTTCTCGTTCGGCGCGCCGACCGAAGCCGAGATCGAGATCGCCGAGGAAATCTGCAAGCTCGTGCCGTCGATCGA
GCAGGTGCGGATGGTGTCGAGCGGCACCGAGGCGACGATGAGCGCACTGCGTCTCGCGCGCGGCTTCACGGGCCGCAGCC
GCATCGTCAAGTTCGAGGGCTGCTACCACGGCCACGCGGACAGCCTGCTGGTCAAGGCCGGCTCGGGCCTGCTGACGTTC
GGCAACCCGACGTCGGCCGGCGTGCCCGCCGACATCGCGAAGCACACGACCGTCCTCGAATACAACAACGTCGCCGCGCT
GGAAGAAGCGTTCGGCGCGTTCGGCGACGAGATCGCCGCGGTAATCGTCGAGCCGGTCGCCGGCAACATGAACCTCGTGC
GCGGCACGCCCGAATTCCTGAACGCGCTGCGCGCGCTGTGCACGAAGCACGGCGCCGTGCTGATCTTCGACGAGGTGATG
TGCGGGTTCCGCGTCGCGCTCGGCGGCGCGCAGACGTACTACGGGATCGCGGCCGACCTCACCTGCCTCGGCAAGGTGAT
CGGCGGCGGGATGCCGGCCGCCGCGTTCGGCGGCCGCCGCGACATCATGGCCCACCTCGCGCCGCTCGGCGGCGTCTATC
AGGCCGGCACGCTGTCGGGCAATCCGATCGCGGTCGCCGCGGGCTTGAAGACGCTGCAACTGATCCAGGCGCCGGGCTTC
TACGACGCGCTCACCGCGCAGACGAAGCGGCTCGCCGACGGCCTTGCGGCGGAAGCACGCGCGGCCGGCGTGCCGTTCGC
GGCCGACTCGATCGGCGCGATGTTCGGCCTGTACTTCGCCGAGCGCGTGCCGGGCAGCTTCGCGGAAGTCACCAAGAGCA
ACGTCGAGCGATTCAACCGCTTCTTCCACCTGATGCTCGACGAGGGCGTGTACTTCGCGCCGTCCGCGTACGAAGCCGGC
TTCGTGTCGAGCACGCACGACGACGCGGTGATCGACGCGACGCTCGCGGCCGCGCGCCGCGCGTTCGCGGCACTCGCCGC
CTGA

Upstream 100 bases:

>100_bases
GGCTTGCCGCGCGCGTCTCCGGTACAATCAGACGATCGTTCCGCCCAGGCGCCGCGGCCCGTGCACAGGCCCCCGCGCCC
TTCTCTCGCAGGTTTCGCTC

Downstream 100 bases:

>100_bases
CCCGGGGCCGCGCGCATGTTCTCGGATACCGATTTCGCCCACATGCAGCGCGCGCTCGCGCTCGCGGCGCGCGGCATGTA
CACGACCGCGCCGAATCCGC

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MSNNQILFERAQKTIPGGVNSPVRAFRSVGGTPRFVARAQGPYFWDADGKQYIDYIGSWGPMIVGHVHPEVLSAVQNVLA
DGFSFGAPTEAEIEIAEEICKLVPSIEQVRMVSSGTEATMSALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTF
GNPTSAGVPADIAKHTTVLEYNNVAALEEAFGAFGDEIAAVIVEPVAGNMNLVRGTPEFLNALRALCTKHGAVLIFDEVM
CGFRVALGGAQTYYGIAADLTCLGKVIGGGMPAAAFGGRRDIMAHLAPLGGVYQAGTLSGNPIAVAAGLKTLQLIQAPGF
YDALTAQTKRLADGLAAEARAAGVPFAADSIGAMFGLYFAERVPGSFAEVTKSNVERFNRFFHLMLDEGVYFAPSAYEAG
FVSSTHDDAVIDATLAAARRAFAALAA

Sequences:

>Translated_427_residues
MSNNQILFERAQKTIPGGVNSPVRAFRSVGGTPRFVARAQGPYFWDADGKQYIDYIGSWGPMIVGHVHPEVLSAVQNVLA
DGFSFGAPTEAEIEIAEEICKLVPSIEQVRMVSSGTEATMSALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTF
GNPTSAGVPADIAKHTTVLEYNNVAALEEAFGAFGDEIAAVIVEPVAGNMNLVRGTPEFLNALRALCTKHGAVLIFDEVM
CGFRVALGGAQTYYGIAADLTCLGKVIGGGMPAAAFGGRRDIMAHLAPLGGVYQAGTLSGNPIAVAAGLKTLQLIQAPGF
YDALTAQTKRLADGLAAEARAAGVPFAADSIGAMFGLYFAERVPGSFAEVTKSNVERFNRFFHLMLDEGVYFAPSAYEAG
FVSSTHDDAVIDATLAAARRAFAALAA
>Mature_426_residues
SNNQILFERAQKTIPGGVNSPVRAFRSVGGTPRFVARAQGPYFWDADGKQYIDYIGSWGPMIVGHVHPEVLSAVQNVLAD
GFSFGAPTEAEIEIAEEICKLVPSIEQVRMVSSGTEATMSALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTFG
NPTSAGVPADIAKHTTVLEYNNVAALEEAFGAFGDEIAAVIVEPVAGNMNLVRGTPEFLNALRALCTKHGAVLIFDEVMC
GFRVALGGAQTYYGIAADLTCLGKVIGGGMPAAAFGGRRDIMAHLAPLGGVYQAGTLSGNPIAVAAGLKTLQLIQAPGFY
DALTAQTKRLADGLAAEARAAGVPFAADSIGAMFGLYFAERVPGSFAEVTKSNVERFNRFFHLMLDEGVYFAPSAYEAGF
VSSTHDDAVIDATLAAARRAFAALAA

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=291, Percent_Identity=28.1786941580756, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI284507298, Length=209, Percent_Identity=28.7081339712919, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1786349, Length=427, Percent_Identity=60.655737704918, Blast_Score=530, Evalue=1e-152,
Organism=Escherichia coli, GI1789016, Length=379, Percent_Identity=32.1899736147757, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1789759, Length=311, Percent_Identity=28.9389067524116, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1788044, Length=351, Percent_Identity=29.9145299145299, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1787560, Length=359, Percent_Identity=29.8050139275766, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI145693181, Length=341, Percent_Identity=30.4985337243402, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1786991, Length=385, Percent_Identity=26.7532467532467, Blast_Score=95, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI25144271, Length=363, Percent_Identity=25.068870523416, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71992977, Length=338, Percent_Identity=25.7396449704142, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI32564660, Length=363, Percent_Identity=23.1404958677686, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI25144274, Length=210, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323470, Length=348, Percent_Identity=27.0114942528736, Blast_Score=97, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6324432, Length=342, Percent_Identity=26.3157894736842, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21357415, Length=298, Percent_Identity=25.8389261744966, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21356575, Length=358, Percent_Identity=24.8603351955307, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 44866; Mature: 44734

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNNQILFERAQKTIPGGVNSPVRAFRSVGGTPRFVARAQGPYFWDADGKQYIDYIGSWG
CCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEECCCCEEECCCCHHHHHHHCCCC
PMIVGHVHPEVLSAVQNVLADGFSFGAPTEAEIEIAEEICKLVPSIEQVRMVSSGTEATM
CEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCHHHHH
SALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTFGNPTSAGVPADIAKHTTVLE
HHHHHHHCCCCCCCEEEEECCCCCCCCCEEEECCCCEEEECCCCCCCCCHHHHHCCEEEE
YNNVAALEEAFGAFGDEIAAVIVEPVAGNMNLVRGTPEFLNALRALCTKHGAVLIFDEVM
ECCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHCCCEEEEHHHH
CGFRVALGGAQTYYGIAADLTCLGKVIGGGMPAAAFGGRRDIMAHLAPLGGVYQAGTLSG
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHCCCCCEECCCCCC
NPIAVAAGLKTLQLIQAPGFYDALTAQTKRLADGLAAEARAAGVPFAADSIGAMFGLYFA
CCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ERVPGSFAEVTKSNVERFNRFFHLMLDEGVYFAPSAYEAGFVSSTHDDAVIDATLAAARR
HHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
AFAALAA
HHHHHCC
>Mature Secondary Structure 
SNNQILFERAQKTIPGGVNSPVRAFRSVGGTPRFVARAQGPYFWDADGKQYIDYIGSWG
CCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEECCCCEEECCCCHHHHHHHCCCC
PMIVGHVHPEVLSAVQNVLADGFSFGAPTEAEIEIAEEICKLVPSIEQVRMVSSGTEATM
CEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCHHHHH
SALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTFGNPTSAGVPADIAKHTTVLE
HHHHHHHCCCCCCCEEEEECCCCCCCCCEEEECCCCEEEECCCCCCCCCHHHHHCCEEEE
YNNVAALEEAFGAFGDEIAAVIVEPVAGNMNLVRGTPEFLNALRALCTKHGAVLIFDEVM
ECCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHCCCEEEEHHHH
CGFRVALGGAQTYYGIAADLTCLGKVIGGGMPAAAFGGRRDIMAHLAPLGGVYQAGTLSG
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHCCCCCEECCCCCC
NPIAVAAGLKTLQLIQAPGFYDALTAQTKRLADGLAAEARAAGVPFAADSIGAMFGLYFA
CCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ERVPGSFAEVTKSNVERFNRFFHLMLDEGVYFAPSAYEAGFVSSTHDDAVIDATLAAARR
HHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
AFAALAA
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA