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The map label for this gene is pntAA [H]

Identifier: 116688723

GI number: 116688723

Start: 779896

End: 781035

Strand: Direct

Name: pntAA [H]

Synonym: Bcen2424_0700

Alternate gene names: 116688723

Gene position: 779896-781035 (Clockwise)

Preceding gene: 116688719

Following gene: 116688724

Centisome position: 22.39

GC content: 68.86

Gene sequence:

>1140_bases
ATGCATATTGGAGTGCCTGCTGAAACGCGGGCCAACGAGGCGCGCGTGGCTGCGACGCCGGAAACCGTGAAGAAATACGC
GGCGGCCGGCCATCGGGTCAGTATCGCGAAAGGGGCCGGCAGTGCAGCCAGCTATCCCGATGAAGCCTATGTGGCCGCCG
GCGCAGAATTGACCGACCAGTCGGCCGCTTTCGCCGCCGACCTCGTGCTGAAGGTCCAGGCGCCCACCGACGCCGAATTG
CCGTTGCTCAAGCGCGGCGCCGTGCTGGTTGGCATGCTCGAGCCGTTCAACGGCGAGCAGGCGGCGCAACTCGCCGCGGC
CGGCGTGACCGGTTTCGCGCTCGAGGCCGCGCCGCGCACGACTCGCGCGCAGAGTCTCGACGTGCTGTCGTCGCAGGCGA
ACATCGCCGGCTACAAGGCCGTGCTGGTGGCCGCGTCGCTGTATCCGCGCTTCATGCCGATGCTGATGACGGCCGCGGGC
ACCGTGAAGGCGGCGCGCGTGCTGATTCTCGGCGCGGGCGTCGCGGGCCTGCAGGCGATCGCGACCGCGAAGCGGCTGGG
CGCGGTGATCGAGGCGTCCGACGTGCGGCCGGCCGTGAAGGAACAGATCGAGTCGCTCGGTGCGAAATTCCTCGACGTGC
CGTTCGAAACCGACGAAGAGCGCGAAGCCGCGCAGGGTGTCGGCGGCTATGCACGCCCGATGCCGCCGTCGTGGCTCGGC
CGCCAGGCCGCGCTCGTGCACGAACGCGCGAAGCAGGCCGACATCGTGATCACCACCGCGCTGATTCCCGGCCGCCCGGC
GCCGACGCTGATCTCGGTCGACACCGCGCAGTCGATGAAGCCCGGCTCGGTGCTCGTCGATCTCGCGGCCGGCCGCGGCC
CGGAAATCGACGGCCGCAAGGGCGGCAACTGCCCGCTGACCGTCGCCGATCAGGTGATCGTGCACAACGGCGTGACGATC
GCCGGCTACACGAACCTCGCGTCGATGGTCGCGTCGGACGCGTCGGCACTGTACGCACGCAACCTGCTCGACTTCCTGAA
GCTGATCGTCACGAAGGAAGGCACGCTGAACATCGACCTGACCGACGACATCGTCGCCGCGACGCTGCTGTGCCGCGACG
GCGAAGTCACGCGTAAATAA

Upstream 100 bases:

>100_bases
GAAAGCCGTTGCTCGTGAGCCGGTAAGTCAGCCTGTCCGGCTCGTTGCGCAGTAAAGAACGCAAGAAAAGAAATACTGAC
AATGACTGGAGGAACTGACG

Downstream 100 bases:

>100_bases
CGGAGGAGACCATGGAAGTCATCAATCACACGGTGATCAACGTGATCATCTTCGTGCTGGCGGTGTACGTCGGCTACCAC
GTCGTCTGGAACGTCACGCC

Product: NAD(P) transhydrogenase subunit alpha

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MHIGVPAETRANEARVAATPETVKKYAAAGHRVSIAKGAGSAASYPDEAYVAAGAELTDQSAAFAADLVLKVQAPTDAEL
PLLKRGAVLVGMLEPFNGEQAAQLAAAGVTGFALEAAPRTTRAQSLDVLSSQANIAGYKAVLVAASLYPRFMPMLMTAAG
TVKAARVLILGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPFETDEEREAAQGVGGYARPMPPSWLG
RQAALVHERAKQADIVITTALIPGRPAPTLISVDTAQSMKPGSVLVDLAAGRGPEIDGRKGGNCPLTVADQVIVHNGVTI
AGYTNLASMVASDASALYARNLLDFLKLIVTKEGTLNIDLTDDIVAATLLCRDGEVTRK

Sequences:

>Translated_379_residues
MHIGVPAETRANEARVAATPETVKKYAAAGHRVSIAKGAGSAASYPDEAYVAAGAELTDQSAAFAADLVLKVQAPTDAEL
PLLKRGAVLVGMLEPFNGEQAAQLAAAGVTGFALEAAPRTTRAQSLDVLSSQANIAGYKAVLVAASLYPRFMPMLMTAAG
TVKAARVLILGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPFETDEEREAAQGVGGYARPMPPSWLG
RQAALVHERAKQADIVITTALIPGRPAPTLISVDTAQSMKPGSVLVDLAAGRGPEIDGRKGGNCPLTVADQVIVHNGVTI
AGYTNLASMVASDASALYARNLLDFLKLIVTKEGTLNIDLTDDIVAATLLCRDGEVTRK
>Mature_379_residues
MHIGVPAETRANEARVAATPETVKKYAAAGHRVSIAKGAGSAASYPDEAYVAAGAELTDQSAAFAADLVLKVQAPTDAEL
PLLKRGAVLVGMLEPFNGEQAAQLAAAGVTGFALEAAPRTTRAQSLDVLSSQANIAGYKAVLVAASLYPRFMPMLMTAAG
TVKAARVLILGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPFETDEEREAAQGVGGYARPMPPSWLG
RQAALVHERAKQADIVITTALIPGRPAPTLISVDTAQSMKPGSVLVDLAAGRGPEIDGRKGGNCPLTVADQVIVHNGVTI
AGYTNLASMVASDASALYARNLLDFLKLIVTKEGTLNIDLTDDIVAATLLCRDGEVTRK

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=391, Percent_Identity=39.1304347826087, Blast_Score=251, Evalue=7e-67,
Organism=Homo sapiens, GI122939153, Length=391, Percent_Identity=39.1304347826087, Blast_Score=251, Evalue=7e-67,
Organism=Escherichia coli, GI1787887, Length=380, Percent_Identity=44.7368421052632, Blast_Score=308, Evalue=4e-85,
Organism=Caenorhabditis elegans, GI17550456, Length=379, Percent_Identity=41.4248021108179, Blast_Score=268, Evalue=3e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 39182; Mature: 39182

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIGVPAETRANEARVAATPETVKKYAAAGHRVSIAKGAGSAASYPDEAYVAAGAELTDQ
CCCCCCCCCCCCCCEEECCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEEECCCCCCCC
SAAFAADLVLKVQAPTDAELPLLKRGAVLVGMLEPFNGEQAAQLAAAGVTGFALEAAPRT
HHHHEEEEEEEEECCCCCCCCHHHCCCEEEEEECCCCCHHHHHHHHCCCCCEEEECCCCC
TRAQSLDVLSSQANIAGYKAVLVAASLYPRFMPMLMTAAGTVKAARVLILGAGVAGLQAI
CHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHEEEEEEECCHHHHHHH
ATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPFETDEEREAAQGVGGYARPMPPSWLG
HHHHHHHHEEECCCCCHHHHHHHHHHCCCEEECCCCCCHHHHHHHCCCCCCCCCCHHHHC
RQAALVHERAKQADIVITTALIPGRPAPTLISVDTAQSMKPGSVLVDLAAGRGPEIDGRK
HHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCCC
GGNCPLTVADQVIVHNGVTIAGYTNLASMVASDASALYARNLLDFLKLIVTKEGTLNIDL
CCCCCEEEECEEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
TDDIVAATLLCRDGEVTRK
CHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MHIGVPAETRANEARVAATPETVKKYAAAGHRVSIAKGAGSAASYPDEAYVAAGAELTDQ
CCCCCCCCCCCCCCEEECCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEEECCCCCCCC
SAAFAADLVLKVQAPTDAELPLLKRGAVLVGMLEPFNGEQAAQLAAAGVTGFALEAAPRT
HHHHEEEEEEEEECCCCCCCCHHHCCCEEEEEECCCCCHHHHHHHHCCCCCEEEECCCCC
TRAQSLDVLSSQANIAGYKAVLVAASLYPRFMPMLMTAAGTVKAARVLILGAGVAGLQAI
CHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHEEEEEEECCHHHHHHH
ATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPFETDEEREAAQGVGGYARPMPPSWLG
HHHHHHHHEEECCCCCHHHHHHHHHHCCCEEECCCCCCHHHHHHHCCCCCCCCCCHHHHC
RQAALVHERAKQADIVITTALIPGRPAPTLISVDTAQSMKPGSVLVDLAAGRGPEIDGRK
HHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCCC
GGNCPLTVADQVIVHNGVTIAGYTNLASMVASDASALYARNLLDFLKLIVTKEGTLNIDL
CCCCCEEEECEEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
TDDIVAATLLCRDGEVTRK
CHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]