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The map label for this gene is ycgM [C]

Identifier: 116626887

GI number: 116626887

Start: 9862590

End: 9863348

Strand: Direct

Name: ycgM [C]

Synonym: Acid_7863

Alternate gene names: 116626887

Gene position: 9862590-9863348 (Clockwise)

Preceding gene: 116626886

Following gene: 116626888

Centisome position: 98.97

GC content: 60.61

Gene sequence:

>759_bases
GTGACCAAATTCATTCGCTACCGCACCGCTTCTGGCGTCTCTTACGGCACATTGGAAGGGGACACCGTTCACGAAATCCA
GGGCGGCCTGTTTGACGCCCACACTCCCACCGGCGCCACTCTCAAGCTCTCCGACGTGAAGCTGCTGTATCCCTGCGAAG
CCGGCAAGATACTCGCGGTGGGGCTCAACTACAAGAGTCATCTCGGGAGCCGTCCGCAACCGGCGCACCCGGAGATGTTT
TACAAGCCCATATCGGCGCTGCAGAATCCCGGCGACCCGATCGAACTTCCGCGCGACGCAACCGACGTGCATTCGGAAGG
CGAGATGGTGGTGGTGGTCGGCGGTTACCTGCGCAATGCATCCGTGGATGAGGCGGCGGACGCAGTGTTCGGCGTCACCT
GCGGTAATGATGTCAGCGACCGCTCCTGGCAGCATGGGGAAAAGAAGGATCTGCAATGGTGGCGCGCCAAGGGCTCGGAT
ACCTTCGCCCCGCTCGGCCCCGCCATCGTCAGCGGAGTGGATTACGGGAAGCTGCTGCTCCAGACCCGCATCAACGGGGA
AACCGTCCAAAAACAATTCACCAGTGATTTGATTTTCGACATCCCGACCGTACTGAGCTGGATAAGCGGGTGGGTGACGC
TGTTTCCGGGCGACCTGGTCTATACGGGAACGCCGGGCAACACCAGAAAGATGTCGCCCGGCGATCTAGTCGAGGTCGAA
CTCGAAGGCGTCGGCGTACTGAGCAACCCGGTTAACTGA

Upstream 100 bases:

>100_bases
TCTACGGCATCATCGTCTTTATGTCGGTCGCCACCACTCTGATCGCGCCGCCTCTGTTAAAGGTGGCGTTCCGCGGGAGC
CGCGATACAATATCCAACAC

Downstream 100 bases:

>100_bases
CCTCCACCAGTTCGCTTTCCTCCTGCCGCCGGGCCACTGCGACGGGTGCATTCAGCGGCCGCATGTGCAGGAACCCGTAC
ACCGTCGCGGCGACCAGCGG

Product: fumarylacetoacetate (FAA) hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MTKFIRYRTASGVSYGTLEGDTVHEIQGGLFDAHTPTGATLKLSDVKLLYPCEAGKILAVGLNYKSHLGSRPQPAHPEMF
YKPISALQNPGDPIELPRDATDVHSEGEMVVVVGGYLRNASVDEAADAVFGVTCGNDVSDRSWQHGEKKDLQWWRAKGSD
TFAPLGPAIVSGVDYGKLLLQTRINGETVQKQFTSDLIFDIPTVLSWISGWVTLFPGDLVYTGTPGNTRKMSPGDLVEVE
LEGVGVLSNPVN

Sequences:

>Translated_252_residues
MTKFIRYRTASGVSYGTLEGDTVHEIQGGLFDAHTPTGATLKLSDVKLLYPCEAGKILAVGLNYKSHLGSRPQPAHPEMF
YKPISALQNPGDPIELPRDATDVHSEGEMVVVVGGYLRNASVDEAADAVFGVTCGNDVSDRSWQHGEKKDLQWWRAKGSD
TFAPLGPAIVSGVDYGKLLLQTRINGETVQKQFTSDLIFDIPTVLSWISGWVTLFPGDLVYTGTPGNTRKMSPGDLVEVE
LEGVGVLSNPVN
>Mature_251_residues
TKFIRYRTASGVSYGTLEGDTVHEIQGGLFDAHTPTGATLKLSDVKLLYPCEAGKILAVGLNYKSHLGSRPQPAHPEMFY
KPISALQNPGDPIELPRDATDVHSEGEMVVVVGGYLRNASVDEAADAVFGVTCGNDVSDRSWQHGEKKDLQWWRAKGSDT
FAPLGPAIVSGVDYGKLLLQTRINGETVQKQFTSDLIFDIPTVLSWISGWVTLFPGDLVYTGTPGNTRKMSPGDLVEVEL
EGVGVLSNPVN

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=225, Percent_Identity=36.8888888888889, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI40786394, Length=225, Percent_Identity=36.4444444444444, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI215422413, Length=203, Percent_Identity=33.0049261083744, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI66348062, Length=193, Percent_Identity=32.6424870466321, Blast_Score=91, Evalue=9e-19,
Organism=Homo sapiens, GI13654274, Length=198, Percent_Identity=33.3333333333333, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1787428, Length=202, Percent_Identity=33.6633663366337, Blast_Score=99, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17557057, Length=194, Percent_Identity=35.5670103092784, Blast_Score=101, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6324161, Length=232, Percent_Identity=30.1724137931034, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28572127, Length=220, Percent_Identity=37.7272727272727, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24663695, Length=220, Percent_Identity=32.2727272727273, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28571789, Length=198, Percent_Identity=32.8282828282828, Blast_Score=94, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 27247; Mature: 27116

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKFIRYRTASGVSYGTLEGDTVHEIQGGLFDAHTPTGATLKLSDVKLLYPCEAGKILAV
CCCEEEEECCCCCEEECCCCCCHHHHCCCEEECCCCCCCEEEECCEEEEEECCCCCEEEE
GLNYKSHLGSRPQPAHPEMFYKPISALQNPGDPIELPRDATDVHSEGEMVVVVGGYLRNA
ECCHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCEECCC
SVDEAADAVFGVTCGNDVSDRSWQHGEKKDLQWWRAKGSDTFAPLGPAIVSGVDYGKLLL
CHHHHHHEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHCCCCHHHEEE
QTRINGETVQKQFTSDLIFDIPTVLSWISGWVTLFPGDLVYTGTPGNTRKMSPGDLVEVE
EECCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEECCCCCCCCCCCCCEEEEE
LEGVGVLSNPVN
ECCCEEECCCCC
>Mature Secondary Structure 
TKFIRYRTASGVSYGTLEGDTVHEIQGGLFDAHTPTGATLKLSDVKLLYPCEAGKILAV
CCEEEEECCCCCEEECCCCCCHHHHCCCEEECCCCCCCEEEECCEEEEEECCCCCEEEE
GLNYKSHLGSRPQPAHPEMFYKPISALQNPGDPIELPRDATDVHSEGEMVVVVGGYLRNA
ECCHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCEECCC
SVDEAADAVFGVTCGNDVSDRSWQHGEKKDLQWWRAKGSDTFAPLGPAIVSGVDYGKLLL
CHHHHHHEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHCCCCHHHEEE
QTRINGETVQKQFTSDLIFDIPTVLSWISGWVTLFPGDLVYTGTPGNTRKMSPGDLVEVE
EECCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEECCCCCCCCCCCCCEEEEE
LEGVGVLSNPVN
ECCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]