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The map label for this gene is napA [H]

Identifier: 116626886

GI number: 116626886

Start: 9861424

End: 9862593

Strand: Direct

Name: napA [H]

Synonym: Acid_7862

Alternate gene names: 116626886

Gene position: 9861424-9862593 (Clockwise)

Preceding gene: 116626885

Following gene: 116626887

Centisome position: 98.95

GC content: 62.82

Gene sequence:

>1170_bases
ATGGACCCTGCGGCCCAGATACCGCTGGCTATGCTGCTGGTCTTCGCCTCCGCGAAGATCATGGCGGAGATCTTCGAGCG
CCTGGGGCAGCCCGGAATCGTCGGCGAGATTCTCGCCGGGGTACTCATCGGTCCGCACGTGCTCGGCTGGCTGGCGCCCA
GCGAGTTTCTGCGTACACTATCCGATCTCGGGGTGATGTTCCTGCTGTTCCGCGTCGGGTTGGAGATCAGGTCCTCCGAG
TTGATGAAGGTTTCCGGCATTGGTTTTCTGGTCGCTCTTGCCGGTATCGTCCTGCCTTTCCTCACCGGCTGGGGAATCTC
CACACTGTGGGGCGAGCCACAGTTGGAGAGCATCTTTACCGGCGCCGCCATGGTGGCAACCAGCGTCGGCATCACCGCGC
AGGTGCTGGCTGCGCGCGGATTGTTAAGCACTCGCGCGGCGCGGATCATCCTGGCAGCCGCCGTGATCGATGACGTGCTC
GGCCTGCTGGTGCTGGCTTTGGTCAGCGGCCTGGCAAAGGGGGCGATCAACTATCTCGATCTTGCCATCACCGCGGCGCT
TGCCATCGGCTTCACCGTATTCGTGGCGCAGTTCGGCACGCGCACTGTCCGGCGGATGATGCCAAAGATGAACGCGCGGA
TGCGGCTGGTGGAATCCGAGTTCGCCCTCGCCATGACATTGCTGTTCGCGCTCTCCCTTTTGGCGGTATATGCCGGTGTA
GCGGCGATCGTGGGCGCGTTCCTGGCGGGCATGGCCCTCTCCGAGACCGCTGAGGGACGCCTCAAGGAACTAACTAATGG
CGTGGCGGAACTGCTGGTGCCGTTCTTTCTGGTCGGCATCGGCTTGAATTTCGACGTTACGGCCTTTGCGGGCGGTCGCA
ATCTCGCTCTTGCCGCTACCATCGTCGCCGGCGCGGTGTTGTCAAAGTTCATCGGCTGCGGCCTGGGCGCGATTTCCATG
GGGCGCACCGACGCGGTACGCGTTGGCGTAGGCATGATTCCACGCGGCGAGGTCGGCATGGTCGTGGCGCAGATCGGGCT
CAACATGGGTGTGATGGCGCACAGCGTCTACGGCATCATCGTCTTTATGTCGGTCGCCACCACTCTGATCGCGCCGCCTC
TGTTAAAGGTGGCGTTCCGCGGGAGCCGCGATACAATATCCAACACGTGA

Upstream 100 bases:

>100_bases
AGCGGGCTCCGACGCCCCCACATCGCCGGTGTTGTTCGCCGCTCAGGTTCCCGGGCAACACTAGACCGAGCGCCCATACC
GCAGACCTGATAATGAAGTT

Downstream 100 bases:

>100_bases
CCAAATTCATTCGCTACCGCACCGCTTCTGGCGTCTCTTACGGCACATTGGAAGGGGACACCGTTCACGAAATCCAGGGC
GGCCTGTTTGACGCCCACAC

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MDPAAQIPLAMLLVFASAKIMAEIFERLGQPGIVGEILAGVLIGPHVLGWLAPSEFLRTLSDLGVMFLLFRVGLEIRSSE
LMKVSGIGFLVALAGIVLPFLTGWGISTLWGEPQLESIFTGAAMVATSVGITAQVLAARGLLSTRAARIILAAAVIDDVL
GLLVLALVSGLAKGAINYLDLAITAALAIGFTVFVAQFGTRTVRRMMPKMNARMRLVESEFALAMTLLFALSLLAVYAGV
AAIVGAFLAGMALSETAEGRLKELTNGVAELLVPFFLVGIGLNFDVTAFAGGRNLALAATIVAGAVLSKFIGCGLGAISM
GRTDAVRVGVGMIPRGEVGMVVAQIGLNMGVMAHSVYGIIVFMSVATTLIAPPLLKVAFRGSRDTISNT

Sequences:

>Translated_389_residues
MDPAAQIPLAMLLVFASAKIMAEIFERLGQPGIVGEILAGVLIGPHVLGWLAPSEFLRTLSDLGVMFLLFRVGLEIRSSE
LMKVSGIGFLVALAGIVLPFLTGWGISTLWGEPQLESIFTGAAMVATSVGITAQVLAARGLLSTRAARIILAAAVIDDVL
GLLVLALVSGLAKGAINYLDLAITAALAIGFTVFVAQFGTRTVRRMMPKMNARMRLVESEFALAMTLLFALSLLAVYAGV
AAIVGAFLAGMALSETAEGRLKELTNGVAELLVPFFLVGIGLNFDVTAFAGGRNLALAATIVAGAVLSKFIGCGLGAISM
GRTDAVRVGVGMIPRGEVGMVVAQIGLNMGVMAHSVYGIIVFMSVATTLIAPPLLKVAFRGSRDTISNT
>Mature_389_residues
MDPAAQIPLAMLLVFASAKIMAEIFERLGQPGIVGEILAGVLIGPHVLGWLAPSEFLRTLSDLGVMFLLFRVGLEIRSSE
LMKVSGIGFLVALAGIVLPFLTGWGISTLWGEPQLESIFTGAAMVATSVGITAQVLAARGLLSTRAARIILAAAVIDDVL
GLLVLALVSGLAKGAINYLDLAITAALAIGFTVFVAQFGTRTVRRMMPKMNARMRLVESEFALAMTLLFALSLLAVYAGV
AAIVGAFLAGMALSETAEGRLKELTNGVAELLVPFFLVGIGLNFDVTAFAGGRNLALAATIVAGAVLSKFIGCGLGAISM
GRTDAVRVGVGMIPRGEVGMVVAQIGLNMGVMAHSVYGIIVFMSVATTLIAPPLLKVAFRGSRDTISNT

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1786685, Length=274, Percent_Identity=29.1970802919708, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1786232, Length=284, Percent_Identity=28.169014084507, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322367, Length=403, Percent_Identity=25.8064516129032, Blast_Score=102, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 40404; Mature: 40404

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPAAQIPLAMLLVFASAKIMAEIFERLGQPGIVGEILAGVLIGPHVLGWLAPSEFLRTL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SDLGVMFLLFRVGLEIRSSELMKVSGIGFLVALAGIVLPFLTGWGISTLWGEPQLESIFT
HHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHH
GAAMVATSVGITAQVLAARGLLSTRAARIILAAAVIDDVLGLLVLALVSGLAKGAINYLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAITAALAIGFTVFVAQFGTRTVRRMMPKMNARMRLVESEFALAMTLLFALSLLAVYAGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAIVGAFLAGMALSETAEGRLKELTNGVAELLVPFFLVGIGLNFDVTAFAGGRNLALAAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHH
IVAGAVLSKFIGCGLGAISMGRTDAVRVGVGMIPRGEVGMVVAQIGLNMGVMAHSVYGII
HHHHHHHHHHHHCCCCHHCCCCCHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHH
VFMSVATTLIAPPLLKVAFRGSRDTISNT
HHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MDPAAQIPLAMLLVFASAKIMAEIFERLGQPGIVGEILAGVLIGPHVLGWLAPSEFLRTL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SDLGVMFLLFRVGLEIRSSELMKVSGIGFLVALAGIVLPFLTGWGISTLWGEPQLESIFT
HHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHH
GAAMVATSVGITAQVLAARGLLSTRAARIILAAAVIDDVLGLLVLALVSGLAKGAINYLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAITAALAIGFTVFVAQFGTRTVRRMMPKMNARMRLVESEFALAMTLLFALSLLAVYAGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAIVGAFLAGMALSETAEGRLKELTNGVAELLVPFFLVGIGLNFDVTAFAGGRNLALAAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHH
IVAGAVLSKFIGCGLGAISMGRTDAVRVGVGMIPRGEVGMVVAQIGLNMGVMAHSVYGII
HHHHHHHHHHHHCCCCHHCCCCCHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHH
VFMSVATTLIAPPLLKVAFRGSRDTISNT
HHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]