Click here to switch to the map view.

The map label for this gene is mutL

Identifier: 116626082

GI number: 116626082

Start: 8852933

End: 8854915

Strand: Reverse

Name: mutL

Synonym: Acid_7040

Alternate gene names: 116626082

Gene position: 8854915-8852933 (Counterclockwise)

Preceding gene: 116626090

Following gene: 116626079

Centisome position: 88.85

GC content: 64.55

Gene sequence:

>1983_bases
ATGGGCCGCATCCGAATTCTTCCCGATCAGGTCGCCAATAAAATCGCCGCGGGCGAAGTGGTGGAGCGTCCGGCGTCCGT
AGTCAAGGAACTGTTGGAGAACTCGCTCGACGCGGGCGCCACGGAAGTGCGCGTGGAGGTGGAGGCCGGCGGGCGCCGCC
TGATCCGCATTGTGGACGATGGCTTCGGCATGCTGCGCGACGACGCGCTGCTCGCTTTTGAACGCCACGCGACCAGCAAA
CTACGCGACGTCAAGGATCTGCTCTCCATCGCCACGCTCGGTTTCCGCGGCGAAGCGCTGCCCTCCATCGCGTCGGTCTC
GCGGCTGCTGCTGGAGACGCGGTCGATGGAAGAGCCCACCGGCACGCGCATCGAAATCGCGGGTGGAAAGATGCTGCGCT
GCGAGGAGGCGGCGCTCGGCGGCGGCACCGTGATCACGGTCCGCGACCTGTTCTACAACGTGCCCGCACGGCGCAAATTC
CTGCGCACGGAACCGACTGAACTGGCGCACATCGCGTCGCTGGTGACGCACTACAGCCTGGCGCATCCCGACAAGAGTTT
TCGCCTCAGCACCGGGCCGACGGAGTTGCTGGGGGTCACGCCGGTGGCGTCCATGAAGGAGCGGGTGTACCAGGTTTTCG
GCAGCCAGATATTGGACGAGCTGGTGGAGATCGGTGTGCGCGAGCGTGATCTATTCCTGCCGCCGCCCAGCGTACCGCCC
TCGCAGGCGATCGCGGAGTACCGCAGCACGGAGCCCGAAGATCCGCCCTTCCGCCGCTTCCGTCTCACCGGTTTTTTTTC
GCGGCCGCAGATTCAGAAATCGAATCGCAATTCGATCTACATTTTCGTCAACGGGCGCCTGATCCGGGACCGGCTGGTGC
TGCACGCGCTCTCCTCCGCGTATCACAACCTGATGCCGGCTTCGGCCTATCCTTTCGCACTGCTGTTCCTGGAGTGCGAC
GCCGAAGAGGTGGATGTCAACGTGCATCCCTCGAAGACCGAGGTGCGGTTCCGCCACGGATCGTTCCTGCACGATTTTAT
CCGCGACAGCATTCGCGAGCGGCTGATGGAGAGCCGTCCGGCGCCGACGTTTTCGCCGGTTCCGATGGCCGCGCCGCCGG
CCCAACAGGGTGCACAGTTGCCGTATTCGGAATTCAGCCAGATGCTGGAGAACGAACAGCAGGCGGCGTCGGAGATGGCG
GAGCCTGCGATTGCCGGTGAACCTGCGATGCCGGAATTCAATCTGCGAGCGACGGCGCCGCCTACGCCGCGGCTGGATTT
CAGCGCGCCGCCGATCGAAGTCGCGCCCGGTCCGCCGCCTTCGGGGAAGCTCTCGCGACGGCTCGACATGCACGGCGAAT
TTCCGCTGGAGGCAATTCCCGCGCCCGAGATGTCGCTCTCCGCGCTCAGCGACCTGCGGCCGCTGGGACAGATCCACGAG
AGCTTCATCATCGCCGCGGGACGCGACGGCTTGTGGATCATCGACCAGCACGTGGCCCATGAGCGCATTCTCTTCGAACA
AGTGCTCAAGCAGCGCGCCGCCGGCCGGGTGGAGACGCAGCGCCTGCTGATGCCGATGATCCTGCAACTCAGCGCGGAGC
AACAGATCGATTACGCGCGCATCGCCGACGAATTGCACGCCTCGGGCTTCGAGACCGAGCCCTTCGGCAATCGGACGATC
GCGGTGAAAGCCGCGCCAGCCGCCGTGGGGCCGCAGGATCTGGAGCGCATCCTCTTTGAGATCCTGGAGATCGCCGAGAA
CGAGATGCGGACCAACTCACTCGACGATCTGCGACGCAACATCTGCGCGTCGATCGCTTGCCGGGCTGCGATCAAGATCA
ACATGCGCCTGGATCTCGCCAAGATGGAATGGCTGCTGCGCGCGCTCGCCGCCACCGATTGTCCCATGAGCTGCCCACAC
GGCCGCCCCATCGCGATGCACTACTCCACGCGAGAGATATTGAAGGCGTTCCACAGGATTTGA

Upstream 100 bases:

>100_bases
GTTTTCGCAGATTGCGAGCAAACAGATGCACAGTAGTACACTGCGGCACGGCACGAACTGAAATCAGTGCGGGGTCGGGT
TATAGTGGGAATTCCTTCCC

Downstream 100 bases:

>100_bases
GGCAACCGTGCTCATTCTATTTCGTCGCCCGGAACGGGAGTGTTCCCACGGCCAGCTCGTTTTAATATCCGTTTTGCCTT
GACCACATTGCCGCGTTCCG

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 660; Mature: 659

Protein sequence:

>660_residues
MGRIRILPDQVANKIAAGEVVERPASVVKELLENSLDAGATEVRVEVEAGGRRLIRIVDDGFGMLRDDALLAFERHATSK
LRDVKDLLSIATLGFRGEALPSIASVSRLLLETRSMEEPTGTRIEIAGGKMLRCEEAALGGGTVITVRDLFYNVPARRKF
LRTEPTELAHIASLVTHYSLAHPDKSFRLSTGPTELLGVTPVASMKERVYQVFGSQILDELVEIGVRERDLFLPPPSVPP
SQAIAEYRSTEPEDPPFRRFRLTGFFSRPQIQKSNRNSIYIFVNGRLIRDRLVLHALSSAYHNLMPASAYPFALLFLECD
AEEVDVNVHPSKTEVRFRHGSFLHDFIRDSIRERLMESRPAPTFSPVPMAAPPAQQGAQLPYSEFSQMLENEQQAASEMA
EPAIAGEPAMPEFNLRATAPPTPRLDFSAPPIEVAPGPPPSGKLSRRLDMHGEFPLEAIPAPEMSLSALSDLRPLGQIHE
SFIIAAGRDGLWIIDQHVAHERILFEQVLKQRAAGRVETQRLLMPMILQLSAEQQIDYARIADELHASGFETEPFGNRTI
AVKAAPAAVGPQDLERILFEILEIAENEMRTNSLDDLRRNICASIACRAAIKINMRLDLAKMEWLLRALAATDCPMSCPH
GRPIAMHYSTREILKAFHRI

Sequences:

>Translated_660_residues
MGRIRILPDQVANKIAAGEVVERPASVVKELLENSLDAGATEVRVEVEAGGRRLIRIVDDGFGMLRDDALLAFERHATSK
LRDVKDLLSIATLGFRGEALPSIASVSRLLLETRSMEEPTGTRIEIAGGKMLRCEEAALGGGTVITVRDLFYNVPARRKF
LRTEPTELAHIASLVTHYSLAHPDKSFRLSTGPTELLGVTPVASMKERVYQVFGSQILDELVEIGVRERDLFLPPPSVPP
SQAIAEYRSTEPEDPPFRRFRLTGFFSRPQIQKSNRNSIYIFVNGRLIRDRLVLHALSSAYHNLMPASAYPFALLFLECD
AEEVDVNVHPSKTEVRFRHGSFLHDFIRDSIRERLMESRPAPTFSPVPMAAPPAQQGAQLPYSEFSQMLENEQQAASEMA
EPAIAGEPAMPEFNLRATAPPTPRLDFSAPPIEVAPGPPPSGKLSRRLDMHGEFPLEAIPAPEMSLSALSDLRPLGQIHE
SFIIAAGRDGLWIIDQHVAHERILFEQVLKQRAAGRVETQRLLMPMILQLSAEQQIDYARIADELHASGFETEPFGNRTI
AVKAAPAAVGPQDLERILFEILEIAENEMRTNSLDDLRRNICASIACRAAIKINMRLDLAKMEWLLRALAATDCPMSCPH
GRPIAMHYSTREILKAFHRI
>Mature_659_residues
GRIRILPDQVANKIAAGEVVERPASVVKELLENSLDAGATEVRVEVEAGGRRLIRIVDDGFGMLRDDALLAFERHATSKL
RDVKDLLSIATLGFRGEALPSIASVSRLLLETRSMEEPTGTRIEIAGGKMLRCEEAALGGGTVITVRDLFYNVPARRKFL
RTEPTELAHIASLVTHYSLAHPDKSFRLSTGPTELLGVTPVASMKERVYQVFGSQILDELVEIGVRERDLFLPPPSVPPS
QAIAEYRSTEPEDPPFRRFRLTGFFSRPQIQKSNRNSIYIFVNGRLIRDRLVLHALSSAYHNLMPASAYPFALLFLECDA
EEVDVNVHPSKTEVRFRHGSFLHDFIRDSIRERLMESRPAPTFSPVPMAAPPAQQGAQLPYSEFSQMLENEQQAASEMAE
PAIAGEPAMPEFNLRATAPPTPRLDFSAPPIEVAPGPPPSGKLSRRLDMHGEFPLEAIPAPEMSLSALSDLRPLGQIHES
FIIAAGRDGLWIIDQHVAHERILFEQVLKQRAAGRVETQRLLMPMILQLSAEQQIDYARIADELHASGFETEPFGNRTIA
VKAAPAAVGPQDLERILFEILEIAENEMRTNSLDDLRRNICASIACRAAIKINMRLDLAKMEWLLRALAATDCPMSCPHG
RPIAMHYSTREILKAFHRI

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=367, Percent_Identity=34.0599455040872, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI4505913, Length=359, Percent_Identity=28.6908077994429, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI310128478, Length=359, Percent_Identity=28.6908077994429, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI4505911, Length=348, Percent_Identity=27.0114942528736, Blast_Score=126, Evalue=7e-29,
Organism=Homo sapiens, GI189458898, Length=348, Percent_Identity=27.0114942528736, Blast_Score=125, Evalue=2e-28,
Organism=Homo sapiens, GI189458896, Length=185, Percent_Identity=35.6756756756757, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI263191589, Length=271, Percent_Identity=28.0442804428044, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI91992160, Length=387, Percent_Identity=26.6149870801034, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI310128480, Length=312, Percent_Identity=27.2435897435897, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI91992162, Length=387, Percent_Identity=26.6149870801034, Blast_Score=109, Evalue=8e-24,
Organism=Homo sapiens, GI310128482, Length=220, Percent_Identity=25.9090909090909, Blast_Score=70, Evalue=8e-12,
Organism=Homo sapiens, GI310128484, Length=260, Percent_Identity=25, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI310128486, Length=220, Percent_Identity=25.9090909090909, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1790612, Length=590, Percent_Identity=35.2542372881356, Blast_Score=265, Evalue=5e-72,
Organism=Caenorhabditis elegans, GI71991825, Length=347, Percent_Identity=31.9884726224784, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17562796, Length=360, Percent_Identity=28.3333333333333, Blast_Score=128, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323819, Length=339, Percent_Identity=35.3982300884956, Blast_Score=190, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6324247, Length=345, Percent_Identity=25.7971014492754, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6325093, Length=740, Percent_Identity=22.027027027027, Blast_Score=108, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6323063, Length=383, Percent_Identity=25.065274151436, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17136968, Length=366, Percent_Identity=34.1530054644809, Blast_Score=207, Evalue=2e-53,
Organism=Drosophila melanogaster, GI17136970, Length=361, Percent_Identity=27.9778393351801, Blast_Score=122, Evalue=8e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_SOLUE (Q01QW7)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_828238.1
- ProteinModelPortal:   Q01QW7
- SMR:   Q01QW7
- STRING:   Q01QW7
- GeneID:   4426917
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_7040
- NMPDR:   fig|234267.9.peg.6675
- eggNOG:   COG0323
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- PhylomeDB:   Q01QW7
- ProtClustDB:   CLSK774931
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 73399; Mature: 73268

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRIRILPDQVANKIAAGEVVERPASVVKELLENSLDAGATEVRVEVEAGGRRLIRIVDD
CCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEEECC
GFGMLRDDALLAFERHATSKLRDVKDLLSIATLGFRGEALPSIASVSRLLLETRSMEEPT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCC
GTRIEIAGGKMLRCEEAALGGGTVITVRDLFYNVPARRKFLRTEPTELAHIASLVTHYSL
CCEEEECCCCEEEEHHHCCCCCCEEEEHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHH
AHPDKSFRLSTGPTELLGVTPVASMKERVYQVFGSQILDELVEIGVRERDLFLPPPSVPP
CCCCCCEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCH
SQAIAEYRSTEPEDPPFRRFRLTGFFSRPQIQKSNRNSIYIFVNGRLIRDRLVLHALSSA
HHHHHHHHCCCCCCCCHHEEEEEECCCCCCCCCCCCCEEEEEECCEEHHHHHHHHHHHHH
YHNLMPASAYPFALLFLECDAEEVDVNVHPSKTEVRFRHGSFLHDFIRDSIRERLMESRP
HHHCCCCCCCCEEEEEEECCCCCEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHCCC
APTFSPVPMAAPPAQQGAQLPYSEFSQMLENEQQAASEMAEPAIAGEPAMPEFNLRATAP
CCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCC
PTPRLDFSAPPIEVAPGPPPSGKLSRRLDMHGEFPLEAIPAPEMSLSALSDLRPLGQIHE
CCCCCCCCCCCEECCCCCCCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
SFIIAAGRDGLWIIDQHVAHERILFEQVLKQRAAGRVETQRLLMPMILQLSAEQQIDYAR
HEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHH
IADELHASGFETEPFGNRTIAVKAAPAAVGPQDLERILFEILEIAENEMRTNSLDDLRRN
HHHHHHCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
ICASIACRAAIKINMRLDLAKMEWLLRALAATDCPMSCPHGRPIAMHYSTREILKAFHRI
HHHHHHHHEEEEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHCC
>Mature Secondary Structure 
GRIRILPDQVANKIAAGEVVERPASVVKELLENSLDAGATEVRVEVEAGGRRLIRIVDD
CCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEEECC
GFGMLRDDALLAFERHATSKLRDVKDLLSIATLGFRGEALPSIASVSRLLLETRSMEEPT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCC
GTRIEIAGGKMLRCEEAALGGGTVITVRDLFYNVPARRKFLRTEPTELAHIASLVTHYSL
CCEEEECCCCEEEEHHHCCCCCCEEEEHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHH
AHPDKSFRLSTGPTELLGVTPVASMKERVYQVFGSQILDELVEIGVRERDLFLPPPSVPP
CCCCCCEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCH
SQAIAEYRSTEPEDPPFRRFRLTGFFSRPQIQKSNRNSIYIFVNGRLIRDRLVLHALSSA
HHHHHHHHCCCCCCCCHHEEEEEECCCCCCCCCCCCCEEEEEECCEEHHHHHHHHHHHHH
YHNLMPASAYPFALLFLECDAEEVDVNVHPSKTEVRFRHGSFLHDFIRDSIRERLMESRP
HHHCCCCCCCCEEEEEEECCCCCEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHCCC
APTFSPVPMAAPPAQQGAQLPYSEFSQMLENEQQAASEMAEPAIAGEPAMPEFNLRATAP
CCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCC
PTPRLDFSAPPIEVAPGPPPSGKLSRRLDMHGEFPLEAIPAPEMSLSALSDLRPLGQIHE
CCCCCCCCCCCEECCCCCCCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
SFIIAAGRDGLWIIDQHVAHERILFEQVLKQRAAGRVETQRLLMPMILQLSAEQQIDYAR
HEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHH
IADELHASGFETEPFGNRTIAVKAAPAAVGPQDLERILFEILEIAENEMRTNSLDDLRRN
HHHHHHCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
ICASIACRAAIKINMRLDLAKMEWLLRALAATDCPMSCPHGRPIAMHYSTREILKAFHRI
HHHHHHHHEEEEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA