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The map label for this gene is fabH

Identifier: 116626090

GI number: 116626090

Start: 8864703

End: 8865698

Strand: Reverse

Name: fabH

Synonym: Acid_7048

Alternate gene names: 116626090

Gene position: 8865698-8864703 (Counterclockwise)

Preceding gene: 116626092

Following gene: 116626082

Centisome position: 88.96

GC content: 63.55

Gene sequence:

>996_bases
TTGCCAAAGGCCAAGATCAGCGCGCTCGGCTGCTACACGCCACCACGCGTGCTCACCAACCAGGACCTGGAGAAACTGGT
CGATACCAATGATCAATGGATCATGGAGCGCACCGGAATCCGCGAGCGCCACATCGCTGCACCGGAGATGGCAACCTCCG
ACATGGCAATCGAAGCCGCGCGCTGCGCTCTGCTGCAGCGCGGCATCGACGCGTGCGAAATCGACGCGATCATTCTCTGC
ACGGTGACGCCTGATCACCTCTTCCCCTCCACGGCCTGTCTGGTACAGAACGCCATTGGGGCCAAAGGCGCGTGGGGCTT
CGACCTGATCGCCGCCTGTTCCGGATTCCTCTACGGCCTCACCACCGGCGCCCATTTCGTTATGGCCGGTACCCACAAGA
AAGTCCTCGTGATCGGTTCCGACACCATGAGCCGCATCATTGACTATACGGACCGCGCCACCTGTGTCCTCTTCGGCGAT
GGCGCCGGCGCCATGTTGATCGAGGCGACCGACGAGGCCGATGACGGCACAGGCTTCATCGATTTCCTCGGCGAAATCGA
TGGCTCCGGCGGCGAGTTCCTGCGCATGCCCGCCGGCGGCAGCCGCCGCCCCGCGTCGCACGAAACCGTGGATCAGCGCA
TGCACTACGTGCACCAGGAAGGCAGCCAGGTATTCAAGTACGCCTCGCGCAAAATGTACGAGGTCTGCCGCGACCTGCTG
GAGCGCAATCACTTCAAGGTGGAGGACGTCGGGCTGATGATTCCGCACCAGGCCAATAAGCGCATCATCAAGGCCGCCGG
CGATCGCCTCGGAATCGCGCCAGAGCGCGTCATGATCAACATCGAGCGCTACGGGAATACTACCGCCGGAACCCTGCCGC
TGGCCACGCGCGACGCCATCTCCGAGGGCCGCCTGAAGAAGGGCGACCTGGTCCTCTTCGCAGCCGTCGGCGCCGGCTAC
ACCGTGGGTGCCAGCCTTTGGCGCTGGGCCTTTTAA

Upstream 100 bases:

>100_bases
ACCGCGAAGCGCTTTCCGCCGCCCGATTTCACAACCCGCGACCCCCGGCCCGACGCTTCTGAGTTAACCTAAATCTTTAT
ACCTCACTAAGGATACTCTA

Downstream 100 bases:

>100_bases
GGCGTAACTTCTTTCAATCGCAAGCCGGTCGCCTTCCCGCGCGGTACATCGAGCTCCAGAATTCCGCCGGCATCGGCTTG
CGTCTCAAAAATCTCTTCGT

Product: 3-oxoacyl-[acyl-carrier-protein] synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MPKAKISALGCYTPPRVLTNQDLEKLVDTNDQWIMERTGIRERHIAAPEMATSDMAIEAARCALLQRGIDACEIDAIILC
TVTPDHLFPSTACLVQNAIGAKGAWGFDLIAACSGFLYGLTTGAHFVMAGTHKKVLVIGSDTMSRIIDYTDRATCVLFGD
GAGAMLIEATDEADDGTGFIDFLGEIDGSGGEFLRMPAGGSRRPASHETVDQRMHYVHQEGSQVFKYASRKMYEVCRDLL
ERNHFKVEDVGLMIPHQANKRIIKAAGDRLGIAPERVMINIERYGNTTAGTLPLATRDAISEGRLKKGDLVLFAAVGAGY
TVGASLWRWAF

Sequences:

>Translated_331_residues
MPKAKISALGCYTPPRVLTNQDLEKLVDTNDQWIMERTGIRERHIAAPEMATSDMAIEAARCALLQRGIDACEIDAIILC
TVTPDHLFPSTACLVQNAIGAKGAWGFDLIAACSGFLYGLTTGAHFVMAGTHKKVLVIGSDTMSRIIDYTDRATCVLFGD
GAGAMLIEATDEADDGTGFIDFLGEIDGSGGEFLRMPAGGSRRPASHETVDQRMHYVHQEGSQVFKYASRKMYEVCRDLL
ERNHFKVEDVGLMIPHQANKRIIKAAGDRLGIAPERVMINIERYGNTTAGTLPLATRDAISEGRLKKGDLVLFAAVGAGY
TVGASLWRWAF
>Mature_330_residues
PKAKISALGCYTPPRVLTNQDLEKLVDTNDQWIMERTGIRERHIAAPEMATSDMAIEAARCALLQRGIDACEIDAIILCT
VTPDHLFPSTACLVQNAIGAKGAWGFDLIAACSGFLYGLTTGAHFVMAGTHKKVLVIGSDTMSRIIDYTDRATCVLFGDG
AGAMLIEATDEADDGTGFIDFLGEIDGSGGEFLRMPAGGSRRPASHETVDQRMHYVHQEGSQVFKYASRKMYEVCRDLLE
RNHFKVEDVGLMIPHQANKRIIKAAGDRLGIAPERVMINIERYGNTTAGTLPLATRDAISEGRLKKGDLVLFAAVGAGYT
VGASLWRWAF

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=325, Percent_Identity=41.5384615384615, Blast_Score=259, Evalue=1e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_SOLUE (Q01QV9)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_828246.1
- ProteinModelPortal:   Q01QV9
- SMR:   Q01QV9
- STRING:   Q01QV9
- GeneID:   4424891
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_7048
- NMPDR:   fig|234267.9.peg.6682
- eggNOG:   COG0332
- HOGENOM:   HBG649927
- OMA:   QWIMERT
- PhylomeDB:   Q01QV9
- ProtClustDB:   CLSK774671
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 36001; Mature: 35870

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: ACT_SITE 113-113 ACT_SITE 256-256 ACT_SITE 286-286

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKAKISALGCYTPPRVLTNQDLEKLVDTNDQWIMERTGIRERHIAAPEMATSDMAIEAA
CCCCCEEEEECCCCCCCCCHHHHHHHHCCCCCEEHHHCCCCHHHCCCCCCCCCHHHHHHH
RCALLQRGIDACEIDAIILCTVTPDHLFPSTACLVQNAIGAKGAWGFDLIAACSGFLYGL
HHHHHHCCCCCEEECEEEEEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
TTGAHFVMAGTHKKVLVIGSDTMSRIIDYTDRATCVLFGDGAGAMLIEATDEADDGTGFI
CCCCEEEEECCCCEEEEECCHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCCCHH
DFLGEIDGSGGEFLRMPAGGSRRPASHETVDQRMHYVHQEGSQVFKYASRKMYEVCRDLL
HHHHCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERNHFKVEDVGLMIPHQANKRIIKAAGDRLGIAPERVMINIERYGNTTAGTLPLATRDAI
HCCCCEEEEEEEECCCCCCCHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHH
SEGRLKKGDLVLFAAVGAGYTVGASLWRWAF
HCCCCCCCCEEEEEECCCCCHHHHHHHHCCC
>Mature Secondary Structure 
PKAKISALGCYTPPRVLTNQDLEKLVDTNDQWIMERTGIRERHIAAPEMATSDMAIEAA
CCCCEEEEECCCCCCCCCHHHHHHHHCCCCCEEHHHCCCCHHHCCCCCCCCCHHHHHHH
RCALLQRGIDACEIDAIILCTVTPDHLFPSTACLVQNAIGAKGAWGFDLIAACSGFLYGL
HHHHHHCCCCCEEECEEEEEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
TTGAHFVMAGTHKKVLVIGSDTMSRIIDYTDRATCVLFGDGAGAMLIEATDEADDGTGFI
CCCCEEEEECCCCEEEEECCHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCCCHH
DFLGEIDGSGGEFLRMPAGGSRRPASHETVDQRMHYVHQEGSQVFKYASRKMYEVCRDLL
HHHHCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERNHFKVEDVGLMIPHQANKRIIKAAGDRLGIAPERVMINIERYGNTTAGTLPLATRDAI
HCCCCEEEEEEEECCCCCCCHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHH
SEGRLKKGDLVLFAAVGAGYTVGASLWRWAF
HCCCCCCCCEEEEEECCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA