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The map label for this gene is asd [H]

Identifier: 116626025

GI number: 116626025

Start: 8771108

End: 8772157

Strand: Reverse

Name: asd [H]

Synonym: Acid_6983

Alternate gene names: 116626025

Gene position: 8772157-8771108 (Counterclockwise)

Preceding gene: 116626026

Following gene: 116626024

Centisome position: 88.02

GC content: 63.05

Gene sequence:

>1050_bases
ATGCAAACGCGAATCGAAGTAGGCATTCTCGGCGCCACCGGGATGGTGGGCCAGCATTTCATCAAGTTCCTGCAGGGCCA
CCCGTGGTTCGACCTGAAGTGGCTCGGAGCCAGCGACCGCTCCGCCGGCAAGCAGTATAAGGACGCCATGACATGGCACC
TGGCGGGCGGCACTCCGGATTCGGTGGCGGGGCTCACGGTGGAAGAATGCAAACCGGGCAACGCGCCGCGCCTGCTTTTT
TCCGCGATGGATGCGGGAGTGGCTACGGACATCGAGCGGGCCTTCGCGCAGGCGGGGCATGTGGTGGTGTCGAATTCGCG
CAATCACCGTATGGAGCAGGACGTGCCGCTGATGGTGCCGGAGATCAATCCCGATCACCTGAAGCTGGTGCCGGGCCAGC
AGCGGGCGCGCGGTTGGAAGGGGCAGATTGTCACCAATCCGAACTGTTCCACCATCGGCCTGGTGATGGGGCTGGGCCCG
ATGAAGCAGTTCGGGATCACGAAGATTCTGGTGACCACGATGCAGGCAATTTCCGGCGCCGGATATCCCGGGGTTGCATC
CATGGACATTATGGGGAACGTGGTGCCCTATATCGGCAGCGAAGAAGAAAAGATGGAGATGGAGACGCAGAAGATCATGG
GCGATTTCGCCGGTGATCGGATTGTGCCGCTGGCGGCGAAGGTGAGCGCGCACTGCAATCGCGTTGGCGTGGTGGACGGC
CATACGGAAACGGTGTCGGTGGAGTTTTCCATGAAGCCCACCGAGGCCGACTTGCGGCATGCGATCGAGAGCTTCACGGC
GGTGCCGCAGGAGCGCAAACTGCCGAGCGCGCCGGGACGTCCGGTGATTTACATGAAAGAAGCCAACCGTCCGCAGCCGC
GCAAGGATGCGGAGCGCGAGCGCGGGATGGCGGCATTCGTAGGGCGGCTGCGGGCCTGCCCGGTGCTGGACTATAAGTTC
GTGGTGCTGAGCCACAACACGATTCGCGGAGCCGCGGGCGCGGCGGTGCTGAATGCCGAGCTGATGCATTCGGAAGGGAT
GCTGGACTGA

Upstream 100 bases:

>100_bases
GACCGGGGACTATTCACGTCGCGCACACGCTGGAAGAGCGGGTGCCGAAGACCCAGCTTCTGGAAGCTGTGGAACTTTAT
CAGCGCATCATAAAGGATTT

Downstream 100 bases:

>100_bases
TGATCGTCATGAAGTTCGGCGGCACCTCCGTGGAGAGCGCCGCGGCTATCGAACGGGTGGCGGGGATTGTGCGGGCGCGG
GAGGCGCGGCGACCGGTGGT

Product: aspartate-semialdehyde dehydrogenase

Products: NA

Alternate protein names: ASA dehydrogenase; ASADH [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MQTRIEVGILGATGMVGQHFIKFLQGHPWFDLKWLGASDRSAGKQYKDAMTWHLAGGTPDSVAGLTVEECKPGNAPRLLF
SAMDAGVATDIERAFAQAGHVVVSNSRNHRMEQDVPLMVPEINPDHLKLVPGQQRARGWKGQIVTNPNCSTIGLVMGLGP
MKQFGITKILVTTMQAISGAGYPGVASMDIMGNVVPYIGSEEEKMEMETQKIMGDFAGDRIVPLAAKVSAHCNRVGVVDG
HTETVSVEFSMKPTEADLRHAIESFTAVPQERKLPSAPGRPVIYMKEANRPQPRKDAERERGMAAFVGRLRACPVLDYKF
VVLSHNTIRGAAGAAVLNAELMHSEGMLD

Sequences:

>Translated_349_residues
MQTRIEVGILGATGMVGQHFIKFLQGHPWFDLKWLGASDRSAGKQYKDAMTWHLAGGTPDSVAGLTVEECKPGNAPRLLF
SAMDAGVATDIERAFAQAGHVVVSNSRNHRMEQDVPLMVPEINPDHLKLVPGQQRARGWKGQIVTNPNCSTIGLVMGLGP
MKQFGITKILVTTMQAISGAGYPGVASMDIMGNVVPYIGSEEEKMEMETQKIMGDFAGDRIVPLAAKVSAHCNRVGVVDG
HTETVSVEFSMKPTEADLRHAIESFTAVPQERKLPSAPGRPVIYMKEANRPQPRKDAERERGMAAFVGRLRACPVLDYKF
VVLSHNTIRGAAGAAVLNAELMHSEGMLD
>Mature_349_residues
MQTRIEVGILGATGMVGQHFIKFLQGHPWFDLKWLGASDRSAGKQYKDAMTWHLAGGTPDSVAGLTVEECKPGNAPRLLF
SAMDAGVATDIERAFAQAGHVVVSNSRNHRMEQDVPLMVPEINPDHLKLVPGQQRARGWKGQIVTNPNCSTIGLVMGLGP
MKQFGITKILVTTMQAISGAGYPGVASMDIMGNVVPYIGSEEEKMEMETQKIMGDFAGDRIVPLAAKVSAHCNRVGVVDG
HTETVSVEFSMKPTEADLRHAIESFTAVPQERKLPSAPGRPVIYMKEANRPQPRKDAERERGMAAFVGRLRACPVLDYKF
VVLSHNTIRGAAGAAVLNAELMHSEGMLD

Specific function: This enzyme catalyzes the second step in the common metabolic pathway to synthesize Thr and Met from Asp [H]

COG id: COG0136

COG function: function code E; Aspartate-semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aspartate-semialdehyde dehydrogenase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6320362, Length=358, Percent_Identity=45.2513966480447, Blast_Score=299, Evalue=5e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000319
- InterPro:   IPR005676
- InterPro:   IPR012080
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280 [H]

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC [H]

EC number: =1.2.1.11 [H]

Molecular weight: Translated: 37839; Mature: 37839

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: PS01103 ASD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTRIEVGILGATGMVGQHFIKFLQGHPWFDLKWLGASDRSAGKQYKDAMTWHLAGGTPD
CCCEEEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHCEEEEECCCCCC
SVAGLTVEECKPGNAPRLLFSAMDAGVATDIERAFAQAGHVVVSNSRNHRMEQDVPLMVP
CCCCCCHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEC
EINPDHLKLVPGQQRARGWKGQIVTNPNCSTIGLVMGLGPMKQFGITKILVTTMQAISGA
CCCCCCEEECCCHHHCCCCCCEEEECCCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHHCC
GYPGVASMDIMGNVVPYIGSEEEKMEMETQKIMGDFAGDRIVPLAAKVSAHCNRVGVVDG
CCCCCEEHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHCCCEEEEECC
HTETVSVEFSMKPTEADLRHAIESFTAVPQERKLPSAPGRPVIYMKEANRPQPRKDAERE
CCEEEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHH
RGMAAFVGRLRACPVLDYKFVVLSHNTIRGAAGAAVLNAELMHSEGMLD
CCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQTRIEVGILGATGMVGQHFIKFLQGHPWFDLKWLGASDRSAGKQYKDAMTWHLAGGTPD
CCCEEEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHCEEEEECCCCCC
SVAGLTVEECKPGNAPRLLFSAMDAGVATDIERAFAQAGHVVVSNSRNHRMEQDVPLMVP
CCCCCCHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEC
EINPDHLKLVPGQQRARGWKGQIVTNPNCSTIGLVMGLGPMKQFGITKILVTTMQAISGA
CCCCCCEEECCCHHHCCCCCCEEEECCCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHHCC
GYPGVASMDIMGNVVPYIGSEEEKMEMETQKIMGDFAGDRIVPLAAKVSAHCNRVGVVDG
CCCCCEEHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHCCCEEEEECC
HTETVSVEFSMKPTEADLRHAIESFTAVPQERKLPSAPGRPVIYMKEANRPQPRKDAERE
CCEEEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHH
RGMAAFVGRLRACPVLDYKFVVLSHNTIRGAAGAAVLNAELMHSEGMLD
CCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]