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The map label for this gene is lysC [C]

Identifier: 116626024

GI number: 116626024

Start: 8769717

End: 8771108

Strand: Reverse

Name: lysC [C]

Synonym: Acid_6982

Alternate gene names: 116626024

Gene position: 8771108-8769717 (Counterclockwise)

Preceding gene: 116626025

Following gene: 116626023

Centisome position: 88.01

GC content: 62.93

Gene sequence:

>1392_bases
ATGATCGTCATGAAGTTCGGCGGCACCTCCGTGGAGAGCGCCGCGGCTATCGAACGGGTGGCGGGGATTGTGCGGGCGCG
GGAGGCGCGGCGACCGGTGGTGGTGGTCTCCGCGATGGGGAAGACCACGAACAAGCTGCTCGCGATCGCGTCGGCCGCGA
TTGCGGGCAAGCGTAATGAATACATTCCCCAGTTGCACGACCTGCGCGATTATCATTCGCGGGAGGCGCGGCTGGTGGTG
CCGCTCTCGGAGCGCGCGGAACTGGATCGCTTCCTGGATGAACATTTCCAGGAATTGACCGAGCTGGTGAAGGGCTTGGC
GGTGCTGGGCGAATTGACCCCGCGCTCGATCGACGCAATCTCGAGCTACGGGGAGCGGCTCTCGAGCTACATCGTGACGC
TCGCGTTCCGGCACTTCGGCATGGCGGCGGAGCACATCGATTCGCGCGACGTGATCATCACGGACCGGCGGCACACGCAG
GCTGCGCCGAATTTTCCGGAGACGTACGCGCGGCTGCAGAAGACGATTCCGCCGCTGGCCGCGCAGAGCGTGGTGGTGAT
GGGCGGGTTCATCGGTAGCACGGAAGACGGCGTGACCAGCACGCTGGGGCGCGGCGGCAGCGATTTCACGGCGGCGATCG
TGGGCGCGGGCATTCAGGCGGAAGAGATCCAGATCTGGACGGATGTGGATGGAATGCTTACGGCGGACCCGACGATCCTG
GCGGGCGGACACCGGGTGAAGACGATCTCGTTCGCGGAAGCGGCGGAGCTAGCGTACTTCGGCGCGAAGGTGCTGCACCC
GGCCACGGTGGTGCCGGCGATCGAGAAAAATATCCCGGTGATGATTCTGAATTCGCGACGGCCGGAGGTCCCCGGAACGC
ACATTACGGCGCACACGGTGCACTGCGAGAACGCGGTGAAATCGATCGCGTGCAAGCGCAAAATCACGACGGTGAGTATT
CACTCGACGCGCATGCTGATGGCGCACGGCTTCCTGCATCGCATTTTCGAGATTTTCGACCGCTACCAGACGCCGGTGGA
TATGGTGGCGACGAGTGAAGTGAGCGTATCGCTGACCATCGACAACACCACCCATATCGACCTGGTGCTCGGCGAGTTGC
GGCAGTTCGCGGAGGCCACGGTAGAGCACGATAGCGTGATCGTGTGCCTGGTAGGCGAGAATATCCGCCACACGCCGGGC
GTGGCGCGGCGCGTATTCAACTCGCTGGATGGCATCAATATCCGGATGATCAGCCAGGGGGCGTCGCTGCTGAATATCAG
CTTTGTGATCGCCGAGACCGATCTGGTGAACGCGGTGAGGCTGCTGCACGAGGAATTTTTCGCGACGCTCGATCCCAATG
TGTTCGAGCGCAAAGAGGCTGTGCATGCGTAA

Upstream 100 bases:

>100_bases
ACTATAAGTTCGTGGTGCTGAGCCACAACACGATTCGCGGAGCCGCGGGCGCGGCGGTGCTGAATGCCGAGCTGATGCAT
TCGGAAGGGATGCTGGACTG

Downstream 100 bases:

>100_bases
GCTGGCCATCGTAGGCTACGGGAAGATGGGCAGGTTGATTGAGCAGCTTGCGCCGCAGTACGGTTTCGAGGTCGCGCTTA
AGCTGGATGAATTCAACAAC

Product: aspartate kinase III

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MIVMKFGGTSVESAAAIERVAGIVRAREARRPVVVVSAMGKTTNKLLAIASAAIAGKRNEYIPQLHDLRDYHSREARLVV
PLSERAELDRFLDEHFQELTELVKGLAVLGELTPRSIDAISSYGERLSSYIVTLAFRHFGMAAEHIDSRDVIITDRRHTQ
AAPNFPETYARLQKTIPPLAAQSVVVMGGFIGSTEDGVTSTLGRGGSDFTAAIVGAGIQAEEIQIWTDVDGMLTADPTIL
AGGHRVKTISFAEAAELAYFGAKVLHPATVVPAIEKNIPVMILNSRRPEVPGTHITAHTVHCENAVKSIACKRKITTVSI
HSTRMLMAHGFLHRIFEIFDRYQTPVDMVATSEVSVSLTIDNTTHIDLVLGELRQFAEATVEHDSVIVCLVGENIRHTPG
VARRVFNSLDGINIRMISQGASLLNISFVIAETDLVNAVRLLHEEFFATLDPNVFERKEAVHA

Sequences:

>Translated_463_residues
MIVMKFGGTSVESAAAIERVAGIVRAREARRPVVVVSAMGKTTNKLLAIASAAIAGKRNEYIPQLHDLRDYHSREARLVV
PLSERAELDRFLDEHFQELTELVKGLAVLGELTPRSIDAISSYGERLSSYIVTLAFRHFGMAAEHIDSRDVIITDRRHTQ
AAPNFPETYARLQKTIPPLAAQSVVVMGGFIGSTEDGVTSTLGRGGSDFTAAIVGAGIQAEEIQIWTDVDGMLTADPTIL
AGGHRVKTISFAEAAELAYFGAKVLHPATVVPAIEKNIPVMILNSRRPEVPGTHITAHTVHCENAVKSIACKRKITTVSI
HSTRMLMAHGFLHRIFEIFDRYQTPVDMVATSEVSVSLTIDNTTHIDLVLGELRQFAEATVEHDSVIVCLVGENIRHTPG
VARRVFNSLDGINIRMISQGASLLNISFVIAETDLVNAVRLLHEEFFATLDPNVFERKEAVHA
>Mature_463_residues
MIVMKFGGTSVESAAAIERVAGIVRAREARRPVVVVSAMGKTTNKLLAIASAAIAGKRNEYIPQLHDLRDYHSREARLVV
PLSERAELDRFLDEHFQELTELVKGLAVLGELTPRSIDAISSYGERLSSYIVTLAFRHFGMAAEHIDSRDVIITDRRHTQ
AAPNFPETYARLQKTIPPLAAQSVVVMGGFIGSTEDGVTSTLGRGGSDFTAAIVGAGIQAEEIQIWTDVDGMLTADPTIL
AGGHRVKTISFAEAAELAYFGAKVLHPATVVPAIEKNIPVMILNSRRPEVPGTHITAHTVHCENAVKSIACKRKITTVSI
HSTRMLMAHGFLHRIFEIFDRYQTPVDMVATSEVSVSLTIDNTTHIDLVLGELRQFAEATVEHDSVIVCLVGENIRHTPG
VARRVFNSLDGINIRMISQGASLLNISFVIAETDLVNAVRLLHEEFFATLDPNVFERKEAVHA

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=457, Percent_Identity=36.1050328227571, Blast_Score=248, Evalue=4e-67,
Organism=Escherichia coli, GI1786183, Length=473, Percent_Identity=31.5010570824524, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1790376, Length=466, Percent_Identity=25.1072961373391, Blast_Score=101, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320893, Length=508, Percent_Identity=32.0866141732283, Blast_Score=206, Evalue=5e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 50606; Mature: 50606

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVMKFGGTSVESAAAIERVAGIVRAREARRPVVVVSAMGKTTNKLLAIASAAIAGKRNE
CEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCC
YIPQLHDLRDYHSREARLVVPLSERAELDRFLDEHFQELTELVKGLAVLGELTPRSIDAI
CCCHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
SSYGERLSSYIVTLAFRHFGMAAEHIDSRDVIITDRRHTQAAPNFPETYARLQKTIPPLA
HHHHHHHHHHHHHHHHHHHCCHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCHH
AQSVVVMGGFIGSTEDGVTSTLGRGGSDFTAAIVGAGIQAEEIQIWTDVDGMLTADPTIL
HCCEEEEECCCCCCCCCHHHHHCCCCCCHHHHHHCCCCEECEEEEEECCCCCEECCCEEE
AGGHRVKTISFAEAAELAYFGAKVLHPATVVPAIEKNIPVMILNSRRPEVPGTHITAHTV
ECCCEEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEEE
HCENAVKSIACKRKITTVSIHSTRMLMAHGFLHRIFEIFDRYQTPVDMVATSEVSVSLTI
EHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHEEECCEEEEEEE
DNTTHIDLVLGELRQFAEATVEHDSVIVCLVGENIRHTPGVARRVFNSLDGINIRMISQG
CCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECC
ASLLNISFVIAETDLVNAVRLLHEEFFATLDPNVFERKEAVHA
CCEEEEEEEEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCC
>Mature Secondary Structure
MIVMKFGGTSVESAAAIERVAGIVRAREARRPVVVVSAMGKTTNKLLAIASAAIAGKRNE
CEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCC
YIPQLHDLRDYHSREARLVVPLSERAELDRFLDEHFQELTELVKGLAVLGELTPRSIDAI
CCCHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
SSYGERLSSYIVTLAFRHFGMAAEHIDSRDVIITDRRHTQAAPNFPETYARLQKTIPPLA
HHHHHHHHHHHHHHHHHHHCCHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCHH
AQSVVVMGGFIGSTEDGVTSTLGRGGSDFTAAIVGAGIQAEEIQIWTDVDGMLTADPTIL
HCCEEEEECCCCCCCCCHHHHHCCCCCCHHHHHHCCCCEECEEEEEECCCCCEECCCEEE
AGGHRVKTISFAEAAELAYFGAKVLHPATVVPAIEKNIPVMILNSRRPEVPGTHITAHTV
ECCCEEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEEE
HCENAVKSIACKRKITTVSIHSTRMLMAHGFLHRIFEIFDRYQTPVDMVATSEVSVSLTI
EHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHEEECCEEEEEEE
DNTTHIDLVLGELRQFAEATVEHDSVIVCLVGENIRHTPGVARRVFNSLDGINIRMISQG
CCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECC
ASLLNISFVIAETDLVNAVRLLHEEFFATLDPNVFERKEAVHA
CCEEEEEEEEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]