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The map label for this gene is guaB [H]

Identifier: 116625741

GI number: 116625741

Start: 8393817

End: 8395316

Strand: Reverse

Name: guaB [H]

Synonym: Acid_6691

Alternate gene names: 116625741

Gene position: 8395316-8393817 (Counterclockwise)

Preceding gene: 116625742

Following gene: 116625738

Centisome position: 84.24

GC content: 62.87

Gene sequence:

>1500_bases
ATGGCTGCCCGGATGATTGTCGCGCTATCATGGAAAGAATATCCTATGATCCAAGACATACTCCCTGAGGGCCTTACTTT
CGATGACGTCCTGCTCGAACCGGCTCGCAGCGAAGTGGTCCCCGCAGACGTGGATACTCGCACCTGTCTGACGCGCGAGA
TCGCACTGAATATTCCGATCGTGAGCGCCGCCATGGATACCGTGACGGAGTCGCACCTCGCGATCGCGCTGGCGCAGCAA
GGCGGCATCGGCATCGTCCATCGAAACATGACGATCGAGCGGCAGGCCGAAGAAGTGGACCGCGTGAAGCGCAGTGAGAG
CGGCATGATCGTGGACCCGATTACGATCGGGCCGGACGAGCCGATCTCGGCGGCGTTGACGCTGATGACGCGATATCGGA
TTTCGGGCGTGCCGGTCACCAAGAACAGCGTGTTGGTGGGGATTCTGACCAACCGCGACCTGCGCTTCGAGAATCGTTAC
GACCTGCCGATCTCCGAAGTGATGACCAAGGAAAACCTGGTCACGGTCCCGGTGGGCACTACGCTGGAGCAGGCCGAAGC
CATCCTGCACAAGCACCGCGTCGAAAAGCTGCTGGTGGTTGACGATCAGTTCGCGCTCAAGGGCCTCATCACCGTAAAGG
ACATTCAGAAAAAGTTGAAGTATCCGAACGCGGCCAAGGATAGCCAGGGCCGCCTGCGGGTGGGAGCGGCGATCGGCGCC
ACCGGAGATTTCTTCGAGCGCGCGCAGGAGCTGGTGAGGCGCAAGGTGGATGTGATCGCGATCGATACCGCGCACGGACA
CAGCCAGCGCGTGATGGACGCGGTGAAGACGCTCAAGAGCAAGCTGCCTGGAGTGCAGTTGATCACCGGCAACGTGGCCA
CCTACGAAGGCGCGCGCGAGTTGATCTCGCTGGGCGTGGACGGCATCAAGGTCGGGATCGGGCCGGGCTCGATCTGCACT
ACGCGCGTGGTGTCGGGCGCGGGCGTGCCGCAGATCACTGCCATCAGCGAGTGCGCGCGGGCCACCCGCGAAGCGCACGT
GCCGCTGATTGCCGACGGCGGCATCAAGTATTCGGGCGACATCAGCAAGGCGATTGCGGCCGGCGCCGATTGCGTCATGA
TCGGCAGCCTGCTGGCGGGCACGGACGAGAGCCCCGGCGAAACGATCCTCTTCCAGGGACGCACATTCAAAACCTATCGC
GGCATGGGCTCAATGGGTGCGATGGCGCAAGGCAGCTCCGACAGGTATTCGCAGGAAGCGGGCGGCAAGCTGGTGCCGGA
AGGCATCGAGGGGCGCGTGGCGGCGAAGGGTCCGCTGAGCGACCTGGTATATCAGCTGGTCGGCGGCTTGCGCAGCGGGA
TGGGCTATTGCGGAGCGCACGATATCCCGGTGTTCCAGCAGAAGGCGCGTTTCCTGCGCGTGTCTCCAGCCGGCTTGCGC
GAGAGCCACGTACACGACGTGATCATTACCAAGGAAGCGCCGAATTACCGAGTGGAGTGA

Upstream 100 bases:

>100_bases
GGAGCGGTCGGTAATTCGATTACCAACCGCTCCCTGACGGTCACGGCTCGGATGGGCGGCGCGTTCTTGCGGCGACGACG
GGGATGAGCGAGCCTGTCGC

Downstream 100 bases:

>100_bases
TCGCGGAAATCGGCGTAATCGGCGAGCACGGCTTTTTCCATGGCGCGTGCGGCTTTGAAGAGCCATCGGCGAGGACGCTT
CTTCAGATCCGTGAGCAGGG

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 499; Mature: 498

Protein sequence:

>499_residues
MAARMIVALSWKEYPMIQDILPEGLTFDDVLLEPARSEVVPADVDTRTCLTREIALNIPIVSAAMDTVTESHLAIALAQQ
GGIGIVHRNMTIERQAEEVDRVKRSESGMIVDPITIGPDEPISAALTLMTRYRISGVPVTKNSVLVGILTNRDLRFENRY
DLPISEVMTKENLVTVPVGTTLEQAEAILHKHRVEKLLVVDDQFALKGLITVKDIQKKLKYPNAAKDSQGRLRVGAAIGA
TGDFFERAQELVRRKVDVIAIDTAHGHSQRVMDAVKTLKSKLPGVQLITGNVATYEGARELISLGVDGIKVGIGPGSICT
TRVVSGAGVPQITAISECARATREAHVPLIADGGIKYSGDISKAIAAGADCVMIGSLLAGTDESPGETILFQGRTFKTYR
GMGSMGAMAQGSSDRYSQEAGGKLVPEGIEGRVAAKGPLSDLVYQLVGGLRSGMGYCGAHDIPVFQQKARFLRVSPAGLR
ESHVHDVIITKEAPNYRVE

Sequences:

>Translated_499_residues
MAARMIVALSWKEYPMIQDILPEGLTFDDVLLEPARSEVVPADVDTRTCLTREIALNIPIVSAAMDTVTESHLAIALAQQ
GGIGIVHRNMTIERQAEEVDRVKRSESGMIVDPITIGPDEPISAALTLMTRYRISGVPVTKNSVLVGILTNRDLRFENRY
DLPISEVMTKENLVTVPVGTTLEQAEAILHKHRVEKLLVVDDQFALKGLITVKDIQKKLKYPNAAKDSQGRLRVGAAIGA
TGDFFERAQELVRRKVDVIAIDTAHGHSQRVMDAVKTLKSKLPGVQLITGNVATYEGARELISLGVDGIKVGIGPGSICT
TRVVSGAGVPQITAISECARATREAHVPLIADGGIKYSGDISKAIAAGADCVMIGSLLAGTDESPGETILFQGRTFKTYR
GMGSMGAMAQGSSDRYSQEAGGKLVPEGIEGRVAAKGPLSDLVYQLVGGLRSGMGYCGAHDIPVFQQKARFLRVSPAGLR
ESHVHDVIITKEAPNYRVE
>Mature_498_residues
AARMIVALSWKEYPMIQDILPEGLTFDDVLLEPARSEVVPADVDTRTCLTREIALNIPIVSAAMDTVTESHLAIALAQQG
GIGIVHRNMTIERQAEEVDRVKRSESGMIVDPITIGPDEPISAALTLMTRYRISGVPVTKNSVLVGILTNRDLRFENRYD
LPISEVMTKENLVTVPVGTTLEQAEAILHKHRVEKLLVVDDQFALKGLITVKDIQKKLKYPNAAKDSQGRLRVGAAIGAT
GDFFERAQELVRRKVDVIAIDTAHGHSQRVMDAVKTLKSKLPGVQLITGNVATYEGARELISLGVDGIKVGIGPGSICTT
RVVSGAGVPQITAISECARATREAHVPLIADGGIKYSGDISKAIAAGADCVMIGSLLAGTDESPGETILFQGRTFKTYRG
MGSMGAMAQGSSDRYSQEAGGKLVPEGIEGRVAAKGPLSDLVYQLVGGLRSGMGYCGAHDIPVFQQKARFLRVSPAGLRE
SHVHDVIITKEAPNYRVE

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=453, Percent_Identity=41.9426048565121, Blast_Score=330, Evalue=3e-90,
Organism=Homo sapiens, GI156616279, Length=453, Percent_Identity=41.9426048565121, Blast_Score=328, Evalue=5e-90,
Organism=Homo sapiens, GI34328930, Length=453, Percent_Identity=41.9426048565121, Blast_Score=328, Evalue=5e-90,
Organism=Homo sapiens, GI34328928, Length=453, Percent_Identity=41.9426048565121, Blast_Score=328, Evalue=6e-90,
Organism=Homo sapiens, GI66933016, Length=479, Percent_Identity=39.2484342379958, Blast_Score=325, Evalue=6e-89,
Organism=Homo sapiens, GI217035152, Length=447, Percent_Identity=41.834451901566, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI217035148, Length=453, Percent_Identity=41.280353200883, Blast_Score=318, Evalue=6e-87,
Organism=Homo sapiens, GI217035150, Length=453, Percent_Identity=38.8520971302428, Blast_Score=289, Evalue=4e-78,
Organism=Homo sapiens, GI50541954, Length=245, Percent_Identity=37.1428571428571, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI50541952, Length=245, Percent_Identity=37.1428571428571, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI50541948, Length=245, Percent_Identity=37.1428571428571, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI156104880, Length=224, Percent_Identity=38.8392857142857, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI50541956, Length=245, Percent_Identity=37.1428571428571, Blast_Score=155, Evalue=9e-38,
Organism=Escherichia coli, GI1788855, Length=483, Percent_Identity=57.9710144927536, Blast_Score=494, Evalue=1e-141,
Organism=Escherichia coli, GI1786293, Length=234, Percent_Identity=36.7521367521368, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71994385, Length=496, Percent_Identity=35.2822580645161, Blast_Score=257, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI71994389, Length=419, Percent_Identity=37.708830548926, Blast_Score=244, Evalue=8e-65,
Organism=Caenorhabditis elegans, GI17560440, Length=242, Percent_Identity=35.9504132231405, Blast_Score=152, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6322012, Length=481, Percent_Identity=39.2931392931393, Blast_Score=320, Evalue=3e-88,
Organism=Saccharomyces cerevisiae, GI6323464, Length=481, Percent_Identity=39.7089397089397, Blast_Score=305, Evalue=9e-84,
Organism=Saccharomyces cerevisiae, GI6323585, Length=481, Percent_Identity=38.4615384615385, Blast_Score=305, Evalue=1e-83,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=39.9408284023669, Blast_Score=239, Evalue=7e-64,
Organism=Saccharomyces cerevisiae, GI6319353, Length=131, Percent_Identity=36.6412213740458, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24641071, Length=496, Percent_Identity=40.1209677419355, Blast_Score=323, Evalue=2e-88,
Organism=Drosophila melanogaster, GI24641073, Length=496, Percent_Identity=40.1209677419355, Blast_Score=323, Evalue=2e-88,
Organism=Drosophila melanogaster, GI28571163, Length=440, Percent_Identity=40.6818181818182, Blast_Score=292, Evalue=4e-79,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 53609; Mature: 53477

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAARMIVALSWKEYPMIQDILPEGLTFDDVLLEPARSEVVPADVDTRTCLTREIALNIPI
CCCEEEEEECCCCCCCHHHHCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHEECCCH
VSAAMDTVTESHLAIALAQQGGIGIVHRNMTIERQAEEVDRVKRSESGMIVDPITIGPDE
HHHHHHHHHHHHEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCC
PISAALTLMTRYRISGVPVTKNSVLVGILTNRDLRFENRYDLPISEVMTKENLVTVPVGT
HHHHHHHHHHHHEECCCCEECCCEEEEEEECCCEEECCCCCCCHHHHHCCCCEEEEECCC
TLEQAEAILHKHRVEKLLVVDDQFALKGLITVKDIQKKLKYPNAAKDSQGRLRVGAAIGA
CHHHHHHHHHHHHHCEEEEECCCHHHHHEEEHHHHHHHHCCCCCCCCCCCCEEEEEEECC
TGDFFERAQELVRRKVDVIAIDTAHGHSQRVMDAVKTLKSKLPGVQLITGNVATYEGARE
CHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHH
LISLGVDGIKVGIGPGSICTTRVVSGAGVPQITAISECARATREAHVPLIADGGIKYSGD
HHHHCCCCEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEECCC
ISKAIAAGADCVMIGSLLAGTDESPGETILFQGRTFKTYRGMGSMGAMAQGSSDRYSQEA
HHHHHHCCCCCEEHHHHHCCCCCCCCCEEEEECCEEHHHCCCCCCCCCCCCCCCCHHHHC
GGKLVPEGIEGRVAAKGPLSDLVYQLVGGLRSGMGYCGAHDIPVFQQKARFLRVSPAGLR
CCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCEEEECCCCCC
ESHVHDVIITKEAPNYRVE
CCCCCEEEEEECCCCCCCC
>Mature Secondary Structure 
AARMIVALSWKEYPMIQDILPEGLTFDDVLLEPARSEVVPADVDTRTCLTREIALNIPI
CCEEEEEECCCCCCCHHHHCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHEECCCH
VSAAMDTVTESHLAIALAQQGGIGIVHRNMTIERQAEEVDRVKRSESGMIVDPITIGPDE
HHHHHHHHHHHHEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCC
PISAALTLMTRYRISGVPVTKNSVLVGILTNRDLRFENRYDLPISEVMTKENLVTVPVGT
HHHHHHHHHHHHEECCCCEECCCEEEEEEECCCEEECCCCCCCHHHHHCCCCEEEEECCC
TLEQAEAILHKHRVEKLLVVDDQFALKGLITVKDIQKKLKYPNAAKDSQGRLRVGAAIGA
CHHHHHHHHHHHHHCEEEEECCCHHHHHEEEHHHHHHHHCCCCCCCCCCCCEEEEEEECC
TGDFFERAQELVRRKVDVIAIDTAHGHSQRVMDAVKTLKSKLPGVQLITGNVATYEGARE
CHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHH
LISLGVDGIKVGIGPGSICTTRVVSGAGVPQITAISECARATREAHVPLIADGGIKYSGD
HHHHCCCCEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEECCC
ISKAIAAGADCVMIGSLLAGTDESPGETILFQGRTFKTYRGMGSMGAMAQGSSDRYSQEA
HHHHHHCCCCCEEHHHHHCCCCCCCCCEEEEECCEEHHHCCCCCCCCCCCCCCCCHHHHC
GGKLVPEGIEGRVAAKGPLSDLVYQLVGGLRSGMGYCGAHDIPVFQQKARFLRVSPAGLR
CCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCEEEECCCCCC
ESHVHDVIITKEAPNYRVE
CCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]