Click here to switch to the map view.

The map label for this gene is mdmC [H]

Identifier: 116625511

GI number: 116625511

Start: 8094686

End: 8095348

Strand: Direct

Name: mdmC [H]

Synonym: Acid_6458

Alternate gene names: 116625511

Gene position: 8094686-8095348 (Clockwise)

Preceding gene: 116625510

Following gene: 116625512

Centisome position: 81.23

GC content: 63.05

Gene sequence:

>663_bases
ATGTCTAGATTCCACACCCCGATTACCGATGAGATGGCGGATTATGTCCGCGAGGTCAGCCTGCGCGAACCCGAGGTGCT
GCGCGCGCAGCGCGAGAGTACGGATGATCATCCGAAGGCCAGTATGCAGACGGCGCCCGAGCAGGGTCAGTTCTTGAACC
TGCTGGCACGGCTGGTGAACGCCAAGAAGACGCTCGAAGTCGGCGTGTTCCTGGGGTATAGCTCGACCTGCGTGGCGCTG
GCGCTGCCTGAGAACGGGAAAATTATAGCCTGCGATGTGAGCGAAGAATACACGGCGAGCGCACGGCAGACGTGGAAGGA
AGCGGGCGTGGAACGGAAGATCGACCTGCGGATCGCCCCGGCGCTGCAAACGCTCGACGCCCTGATCGCGGCGGGCGAGA
GCGGCACGTTCGATTTCGCGTTCATCGACGCCGACAAAGGCAACTACGCAAATTATTACGAGCGTGCGTTGGAGCTTGTG
CGGCGCGGCGGACTGATCGTGATCGACAACGTGCTCTGGCACGGCGCGGTAATCGACCCGGCGGAGCGCGACACCGACAC
GGAAGCCATCCGCGCGTTCAACCGGAAGCTCCACGCGGATGCACGCGTCGCGCTGAGCCTGGTCCCGCTCGGAGACGGAT
TGACGCTGGCGTGCAAGCTCTAA

Upstream 100 bases:

>100_bases
TCAAATGGCTGGGGTGGACGACAGCAGTGGTGATGACCGCAGCGGCAGTAGCGATGATGCTCGCAGGATAGAGGCCGGCG
CGGTAAAATTGACAGTTTGC

Downstream 100 bases:

>100_bases
CGGCGGCGACGGTTTTCCCGTGCTACGCGGCGGCCGACCGGCCACTGGCGGAGCGTCTGGCAGCCCTGCTGGAACGCGGC
GCGGACGTGCGCATTTTCCT

Product: caffeoyl-CoA O-methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MSRFHTPITDEMADYVREVSLREPEVLRAQRESTDDHPKASMQTAPEQGQFLNLLARLVNAKKTLEVGVFLGYSSTCVAL
ALPENGKIIACDVSEEYTASARQTWKEAGVERKIDLRIAPALQTLDALIAAGESGTFDFAFIDADKGNYANYYERALELV
RRGGLIVIDNVLWHGAVIDPAERDTDTEAIRAFNRKLHADARVALSLVPLGDGLTLACKL

Sequences:

>Translated_220_residues
MSRFHTPITDEMADYVREVSLREPEVLRAQRESTDDHPKASMQTAPEQGQFLNLLARLVNAKKTLEVGVFLGYSSTCVAL
ALPENGKIIACDVSEEYTASARQTWKEAGVERKIDLRIAPALQTLDALIAAGESGTFDFAFIDADKGNYANYYERALELV
RRGGLIVIDNVLWHGAVIDPAERDTDTEAIRAFNRKLHADARVALSLVPLGDGLTLACKL
>Mature_219_residues
SRFHTPITDEMADYVREVSLREPEVLRAQRESTDDHPKASMQTAPEQGQFLNLLARLVNAKKTLEVGVFLGYSSTCVALA
LPENGKIIACDVSEEYTASARQTWKEAGVERKIDLRIAPALQTLDALIAAGESGTFDFAFIDADKGNYANYYERALELVR
RGGLIVIDNVLWHGAVIDPAERDTDTEAIRAFNRKLHADARVALSLVPLGDGLTLACKL

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=214, Percent_Identity=46.2616822429907, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17565612, Length=221, Percent_Identity=39.3665158371041, Blast_Score=156, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI72001127, Length=222, Percent_Identity=38.2882882882883, Blast_Score=144, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI72001028, Length=216, Percent_Identity=37.962962962963, Blast_Score=130, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI25148771, Length=221, Percent_Identity=35.7466063348416, Blast_Score=128, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71991493, Length=187, Percent_Identity=30.4812834224599, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 24234; Mature: 24103

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRFHTPITDEMADYVREVSLREPEVLRAQRESTDDHPKASMQTAPEQGQFLNLLARLVN
CCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHCCCCCCCHHHHHHHHHHC
AKKTLEVGVFLGYSSTCVALALPENGKIIACDVSEEYTASARQTWKEAGVERKIDLRIAP
CHHHEEEEEEECCCCCEEEEEECCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEEEEEHH
ALQTLDALIAAGESGTFDFAFIDADKGNYANYYERALELVRRGGLIVIDNVLWHGAVIDP
HHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECHHHCCCEECC
AERDTDTEAIRAFNRKLHADARVALSLVPLGDGLTLACKL
CCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEEC
>Mature Secondary Structure 
SRFHTPITDEMADYVREVSLREPEVLRAQRESTDDHPKASMQTAPEQGQFLNLLARLVN
CCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHCCCCCCCHHHHHHHHHHC
AKKTLEVGVFLGYSSTCVALALPENGKIIACDVSEEYTASARQTWKEAGVERKIDLRIAP
CHHHEEEEEEECCCCCEEEEEECCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEEEEEHH
ALQTLDALIAAGESGTFDFAFIDADKGNYANYYERALELVRRGGLIVIDNVLWHGAVIDP
HHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECHHHCCCEECC
AERDTDTEAIRAFNRKLHADARVALSLVPLGDGLTLACKL
CCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]