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The map label for this gene is phoR [H]

Identifier: 116625338

GI number: 116625338

Start: 7891172

End: 7892641

Strand: Direct

Name: phoR [H]

Synonym: Acid_6283

Alternate gene names: 116625338

Gene position: 7891172-7892641 (Clockwise)

Preceding gene: 116625337

Following gene: 116625339

Centisome position: 79.18

GC content: 63.95

Gene sequence:

>1470_bases
ATGACCGGCCGGATTTTCCTCAAACTGATCGTTGGCGTCCTTGGCCTGCTTCTGATCGCGCTCCTGACCGTGGACTACTT
CGCCACCAACGTGGCGCAGGAGAACTACATCCAGAACCTGACCCAGCAGCTCACCGATAAGGGCCGCATGCTCGCCCTCA
CCTTCCCCTCGCCCGAAAGCCTGGATGCCGCCAGCGCGCGCCGCATGGCGCAGGCGGTCGGCGGTCGCATCACCGTCGTG
CGCTCGGATGGAAAGGTACTGGTCGATACCGAAGCCAACCCTTCGGAGATGGAGAACCACGGCTCCCGCAAGGAAATCCG
CGAGGCCTTTCAGCAGGGCGCCGGCTCGGAAATAAGGCAAAGCGCCACGATCGGTGTGTCATTCCTATACGTCGCGGTAC
CGGTCGCCGGAGGCGCTAGCGCGATCCGGATCGCGTTTCCGCTCTCGGAGATCAACCGTCAGATCGGGCAAATTCGAGGG
AAGATCCTGGTCAGCACGTCCGTGGCCTTCCTGCCGGCCGTTCTGATTGTCGCCATTCTGGCCCGCTTCATCTCGCGCCG
CCTGGCCGCTATCATGGCCCACGCCGGCGAGCTGGCCCGCGGCAACTTCCGCGCCCGCCTGCCGCAAACCGACTCCAGCG
AGTTCGGCCAGCTCGAGCAGACCCTCAATGAGACCGCCGAGAACCTGCAGCAGACCGTCTCGCAGCTCCAGCACGAGCAT
TCCGAGCTGGAGAAGCTGGAGCGCATCCGCAAGGATTTCGTGATCAACGTGTCGCACGAGCTGCGCACGCCGCTGGCTTC
CATCCAGGGCTATACCGAGACCCTGATCGATGGCGCGCTCACCGATCCCGACCACAACATGCGCTTCCTCGGCATCATCC
GCCACAACGCCGAGCGCCTGGCGCGGCTCACCGAAGATCTGCTCACGCTCTCGCGCGTGGAGCAGAAGCGCCAGAAGTTC
GAGTTCGACCTCCACTCCGCGAATGCGCTGATCCACGACGCCTTCGAGCTGGTGAGCCCCATTGCGCGCAAGAACTACAT
CGAGCTGGTGGAAGAGCGCGCCCCCGAAGACGCCGTCGTCTGCTGCGATAGCGAGGCTGTCTCGCAGATTCTCAGCAACC
TGCTGGATAACGCCATCAAGTACACGCCCGCGGACGGCAAGATCACCATGGGAGCCACGCCGGTAGGCTCCATGGTGGAG
TTCTTCGTGCGCGACACCGGCGCCGGCATTCCCGAAGAGGACCTGCCGCGGCTCTTCGAGCGCTTCTACCGCGTGGACAA
GGCGCGCTCGCGCGAGCTCGGCGGCACCGGACTCGGCCTTTCGATCGTCAAGCATATGGTGGCGGCCCACAGCGGCGCGA
CCCGCGTGGAGAGCGTGGTCCATCAGGGATCTACCTTCTATTTCACTCTGCCGGTGGACGAAGCGGCACTCGGGCACGAA
ACCCTTAATCCCGAATTCACCGCCTCTTAA

Upstream 100 bases:

>100_bases
TCCATGTCCGTCGCCTTCGCGAGCAGATCGAAGAACAGCCCGATGCGCCGCGCTACCTGACCACCGTCCGCGGTTTCGGG
TATCGTTTCGAAGAGGGCAC

Downstream 100 bases:

>100_bases
CGGTCCCGTAACGTTTGGCAGGGTACTGTGTGGCTGATAGTCATGAAGAAAATCTTACTAATCGAGGACGACGCAGACCT
CTTCTCGCTGCTGAAGTACA

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 489; Mature: 488

Protein sequence:

>489_residues
MTGRIFLKLIVGVLGLLLIALLTVDYFATNVAQENYIQNLTQQLTDKGRMLALTFPSPESLDAASARRMAQAVGGRITVV
RSDGKVLVDTEANPSEMENHGSRKEIREAFQQGAGSEIRQSATIGVSFLYVAVPVAGGASAIRIAFPLSEINRQIGQIRG
KILVSTSVAFLPAVLIVAILARFISRRLAAIMAHAGELARGNFRARLPQTDSSEFGQLEQTLNETAENLQQTVSQLQHEH
SELEKLERIRKDFVINVSHELRTPLASIQGYTETLIDGALTDPDHNMRFLGIIRHNAERLARLTEDLLTLSRVEQKRQKF
EFDLHSANALIHDAFELVSPIARKNYIELVEERAPEDAVVCCDSEAVSQILSNLLDNAIKYTPADGKITMGATPVGSMVE
FFVRDTGAGIPEEDLPRLFERFYRVDKARSRELGGTGLGLSIVKHMVAAHSGATRVESVVHQGSTFYFTLPVDEAALGHE
TLNPEFTAS

Sequences:

>Translated_489_residues
MTGRIFLKLIVGVLGLLLIALLTVDYFATNVAQENYIQNLTQQLTDKGRMLALTFPSPESLDAASARRMAQAVGGRITVV
RSDGKVLVDTEANPSEMENHGSRKEIREAFQQGAGSEIRQSATIGVSFLYVAVPVAGGASAIRIAFPLSEINRQIGQIRG
KILVSTSVAFLPAVLIVAILARFISRRLAAIMAHAGELARGNFRARLPQTDSSEFGQLEQTLNETAENLQQTVSQLQHEH
SELEKLERIRKDFVINVSHELRTPLASIQGYTETLIDGALTDPDHNMRFLGIIRHNAERLARLTEDLLTLSRVEQKRQKF
EFDLHSANALIHDAFELVSPIARKNYIELVEERAPEDAVVCCDSEAVSQILSNLLDNAIKYTPADGKITMGATPVGSMVE
FFVRDTGAGIPEEDLPRLFERFYRVDKARSRELGGTGLGLSIVKHMVAAHSGATRVESVVHQGSTFYFTLPVDEAALGHE
TLNPEFTAS
>Mature_488_residues
TGRIFLKLIVGVLGLLLIALLTVDYFATNVAQENYIQNLTQQLTDKGRMLALTFPSPESLDAASARRMAQAVGGRITVVR
SDGKVLVDTEANPSEMENHGSRKEIREAFQQGAGSEIRQSATIGVSFLYVAVPVAGGASAIRIAFPLSEINRQIGQIRGK
ILVSTSVAFLPAVLIVAILARFISRRLAAIMAHAGELARGNFRARLPQTDSSEFGQLEQTLNETAENLQQTVSQLQHEHS
ELEKLERIRKDFVINVSHELRTPLASIQGYTETLIDGALTDPDHNMRFLGIIRHNAERLARLTEDLLTLSRVEQKRQKFE
FDLHSANALIHDAFELVSPIARKNYIELVEERAPEDAVVCCDSEAVSQILSNLLDNAIKYTPADGKITMGATPVGSMVEF
FVRDTGAGIPEEDLPRLFERFYRVDKARSRELGGTGLGLSIVKHMVAAHSGATRVESVVHQGSTFYFTLPVDEAALGHET
LNPEFTAS

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=235, Percent_Identity=36.1702127659575, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1790861, Length=392, Percent_Identity=28.5714285714286, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1788393, Length=265, Percent_Identity=29.811320754717, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1789149, Length=274, Percent_Identity=30.2919708029197, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1786783, Length=342, Percent_Identity=27.7777777777778, Blast_Score=118, Evalue=8e-28,
Organism=Escherichia coli, GI145693157, Length=238, Percent_Identity=30.672268907563, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI48994928, Length=241, Percent_Identity=28.6307053941909, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788713, Length=276, Percent_Identity=26.4492753623188, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788549, Length=238, Percent_Identity=27.3109243697479, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790436, Length=241, Percent_Identity=31.5352697095436, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1790346, Length=230, Percent_Identity=30.4347826086957, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI87081816, Length=254, Percent_Identity=30.3149606299213, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1786912, Length=226, Percent_Identity=27.8761061946903, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1787894, Length=337, Percent_Identity=23.4421364985163, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788279, Length=233, Percent_Identity=27.0386266094421, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87082128, Length=233, Percent_Identity=29.6137339055794, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1789808, Length=476, Percent_Identity=22.8991596638655, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790300, Length=260, Percent_Identity=26.5384615384615, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790551, Length=205, Percent_Identity=28.780487804878, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789403, Length=286, Percent_Identity=26.9230769230769, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53726; Mature: 53595

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGRIFLKLIVGVLGLLLIALLTVDYFATNVAQENYIQNLTQQLTDKGRMLALTFPSPES
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
LDAASARRMAQAVGGRITVVRSDGKVLVDTEANPSEMENHGSRKEIREAFQQGAGSEIRQ
CCHHHHHHHHHHHCCEEEEEECCCCEEEECCCCHHHHHHCCCHHHHHHHHHCCCCHHHHH
SATIGVSFLYVAVPVAGGASAIRIAFPLSEINRQIGQIRGKILVSTSVAFLPAVLIVAIL
HHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHCHHEEHHHHHHHHHHHHHHHH
ARFISRRLAAIMAHAGELARGNFRARLPQTDSSEFGQLEQTLNETAENLQQTVSQLQHEH
HHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SELEKLERIRKDFVINVSHELRTPLASIQGYTETLIDGALTDPDHNMRFLGIIRHNAERL
HHHHHHHHHHHHHEEECHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHH
ARLTEDLLTLSRVEQKRQKFEFDLHSANALIHDAFELVSPIARKNYIELVEERAPEDAVV
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
CCDSEAVSQILSNLLDNAIKYTPADGKITMGATPVGSMVEFFVRDTGAGIPEEDLPRLFE
EECHHHHHHHHHHHHHHHHEECCCCCEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHH
RFYRVDKARSRELGGTGLGLSIVKHMVAAHSGATRVESVVHQGSTFYFTLPVDEAALGHE
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECCCHHHHCCC
TLNPEFTAS
CCCCCCCCC
>Mature Secondary Structure 
TGRIFLKLIVGVLGLLLIALLTVDYFATNVAQENYIQNLTQQLTDKGRMLALTFPSPES
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
LDAASARRMAQAVGGRITVVRSDGKVLVDTEANPSEMENHGSRKEIREAFQQGAGSEIRQ
CCHHHHHHHHHHHCCEEEEEECCCCEEEECCCCHHHHHHCCCHHHHHHHHHCCCCHHHHH
SATIGVSFLYVAVPVAGGASAIRIAFPLSEINRQIGQIRGKILVSTSVAFLPAVLIVAIL
HHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHCHHEEHHHHHHHHHHHHHHHH
ARFISRRLAAIMAHAGELARGNFRARLPQTDSSEFGQLEQTLNETAENLQQTVSQLQHEH
HHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SELEKLERIRKDFVINVSHELRTPLASIQGYTETLIDGALTDPDHNMRFLGIIRHNAERL
HHHHHHHHHHHHHEEECHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHH
ARLTEDLLTLSRVEQKRQKFEFDLHSANALIHDAFELVSPIARKNYIELVEERAPEDAVV
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
CCDSEAVSQILSNLLDNAIKYTPADGKITMGATPVGSMVEFFVRDTGAGIPEEDLPRLFE
EECHHHHHHHHHHHHHHHHEECCCCCEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHH
RFYRVDKARSRELGGTGLGLSIVKHMVAAHSGATRVESVVHQGSTFYFTLPVDEAALGHE
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECCCHHHHCCC
TLNPEFTAS
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]