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The map label for this gene is phoP [H]

Identifier: 116625337

GI number: 116625337

Start: 7890483

End: 7891175

Strand: Direct

Name: phoP [H]

Synonym: Acid_6282

Alternate gene names: 116625337

Gene position: 7890483-7891175 (Clockwise)

Preceding gene: 116625334

Following gene: 116625338

Centisome position: 79.18

GC content: 66.09

Gene sequence:

>693_bases
ATGCCGAAGAAGATCGCCATAGTCGAGGACGAAGCGGAGCTTGCATCCTTGATTGAGTACAACTTGACCCGTCACGGTTA
CGAGACCCAGATCCTCGGCGGCGGTACCGGGACCATGCGCGCCCTGGAGCAGGCCAAGCCCGACCTGATCCTCCTGGACG
TCATGCTGCCCGACGCCGATGGCTTCGAGCTCTGCCGCCAGATCCGCCACTCTTCGGCGCTCTCCCGCACCCCGGTCCTC
TTCCTGACCGCCCGCTCCGATGAGGTGGACCGCGTCCTCGGCCTCGAGATCGGCGGCGACGACTACATGACCAAGCCTTT
CAGCCCCCGCGAGCTGATCGCGCGCGTCAAGGCCCACCTGCGCCGCGAGGAGATGGATGCCGAGCCCGGTGCGGTCGGCA
TCGGCCCCTTCCGGCTCGATCGCACCGCCCGCCGCGTCTACCTGAACGGCCGCGAGATCTCCCTGACTTCCACCGAGTTC
AACCTCCTCGAGTACTTCCTCACTCATCCCGGTCGCGCCTACAGCCGCGACCAGCTGCTCGAGGCGGTGTGGGGCGAACA
GCGCTACGTCACCCCGCGCACCGTGGATGTCCATGTCCGTCGCCTTCGCGAGCAGATCGAAGAACAGCCCGATGCGCCGC
GCTACCTGACCACCGTCCGCGGTTTCGGGTATCGTTTCGAAGAGGGCACATGA

Upstream 100 bases:

>100_bases
CGGGAAATAGTTCACCCCTGGCAAATCCTGAGTCTAGCAGAACAGACCCGGTGGAAGGCTACAATGGAACGTACTGCACC
CGTTACGCTAAGCACTTTCC

Downstream 100 bases:

>100_bases
CCGGCCGGATTTTCCTCAAACTGATCGTTGGCGTCCTTGGCCTGCTTCTGATCGCGCTCCTGACCGTGGACTACTTCGCC
ACCAACGTGGCGCAGGAGAA

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 229

Protein sequence:

>230_residues
MPKKIAIVEDEAELASLIEYNLTRHGYETQILGGGTGTMRALEQAKPDLILLDVMLPDADGFELCRQIRHSSALSRTPVL
FLTARSDEVDRVLGLEIGGDDYMTKPFSPRELIARVKAHLRREEMDAEPGAVGIGPFRLDRTARRVYLNGREISLTSTEF
NLLEYFLTHPGRAYSRDQLLEAVWGEQRYVTPRTVDVHVRRLREQIEEQPDAPRYLTTVRGFGYRFEEGT

Sequences:

>Translated_230_residues
MPKKIAIVEDEAELASLIEYNLTRHGYETQILGGGTGTMRALEQAKPDLILLDVMLPDADGFELCRQIRHSSALSRTPVL
FLTARSDEVDRVLGLEIGGDDYMTKPFSPRELIARVKAHLRREEMDAEPGAVGIGPFRLDRTARRVYLNGREISLTSTEF
NLLEYFLTHPGRAYSRDQLLEAVWGEQRYVTPRTVDVHVRRLREQIEEQPDAPRYLTTVRGFGYRFEEGT
>Mature_229_residues
PKKIAIVEDEAELASLIEYNLTRHGYETQILGGGTGTMRALEQAKPDLILLDVMLPDADGFELCRQIRHSSALSRTPVLF
LTARSDEVDRVLGLEIGGDDYMTKPFSPRELIARVKAHLRREEMDAEPGAVGIGPFRLDRTARRVYLNGREISLTSTEFN
LLEYFLTHPGRAYSRDQLLEAVWGEQRYVTPRTVDVHVRRLREQIEEQPDAPRYLTTVRGFGYRFEEGT

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=44.2477876106195, Blast_Score=186, Evalue=1e-48,
Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=39.1304347826087, Blast_Score=173, Evalue=9e-45,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=43.4977578475336, Blast_Score=170, Evalue=8e-44,
Organism=Escherichia coli, GI1788394, Length=231, Percent_Identity=40.2597402597403, Blast_Score=168, Evalue=2e-43,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=37.5, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1786911, Length=229, Percent_Identity=37.117903930131, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1790863, Length=238, Percent_Identity=33.6134453781513, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI1787229, Length=232, Percent_Identity=36.2068965517241, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=34.0807174887892, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=34.061135371179, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=32.5892857142857, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=33.0316742081448, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=33.4763948497854, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=33.7777777777778, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1788550, Length=126, Percent_Identity=30.1587301587302, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1790299, Length=165, Percent_Identity=26.6666666666667, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26236; Mature: 26105

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKKIAIVEDEAELASLIEYNLTRHGYETQILGGGTGTMRALEQAKPDLILLDVMLPDAD
CCCEEEEEECHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCEEEEEEECCCCC
GFELCRQIRHSSALSRTPVLFLTARSDEVDRVLGLEIGGDDYMTKPFSPRELIARVKAHL
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHH
RREEMDAEPGAVGIGPFRLDRTARRVYLNGREISLTSTEFNLLEYFLTHPGRAYSRDQLL
HHHHCCCCCCCCCCCHHHHCCHHEEEEECCCEEEEECHHHHHHHHHHHCCCCCCCHHHHH
EAVWGEQRYVTPRTVDVHVRRLREQIEEQPDAPRYLTTVRGFGYRFEEGT
HHHHCCCEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEEECCCC
>Mature Secondary Structure 
PKKIAIVEDEAELASLIEYNLTRHGYETQILGGGTGTMRALEQAKPDLILLDVMLPDAD
CCEEEEEECHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCEEEEEEECCCCC
GFELCRQIRHSSALSRTPVLFLTARSDEVDRVLGLEIGGDDYMTKPFSPRELIARVKAHL
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHH
RREEMDAEPGAVGIGPFRLDRTARRVYLNGREISLTSTEFNLLEYFLTHPGRAYSRDQLL
HHHHCCCCCCCCCCCHHHHCCHHEEEEECCCEEEEECHHHHHHHHHHHCCCCCCCHHHHH
EAVWGEQRYVTPRTVDVHVRRLREQIEEQPDAPRYLTTVRGFGYRFEEGT
HHHHCCCEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]