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The map label for this gene is purL [H]

Identifier: 116625014

GI number: 116625014

Start: 7451644

End: 7453872

Strand: Direct

Name: purL [H]

Synonym: Acid_5944

Alternate gene names: 116625014

Gene position: 7451644-7453872 (Clockwise)

Preceding gene: 116625013

Following gene: 116625015

Centisome position: 74.77

GC content: 63.93

Gene sequence:

>2229_bases
ATGAGCGGCACGGCCGCCTTCTCACCCGAAATCATCGCCCAGCATCAGTTGACTGACGGCGAGTATCAGAAGATCGTGGA
CATTCTGGGCCGCGAACCCAGCTACACCGAGCTCGGAATTTTCAGCGTGATGTGGAGCGAGCACTGCTCTTATAAGAGCT
CGCGGATTCACCTGAAGAAGCTGCCCACGCGCGGCAAGCTGGTGGTGCAAGGCCCCGGCGAGAACGCGGGCATCATCGAT
ATCGGGGGCGGCTACGTGATCGCCTTCAAAATCGAATCGCACAATCATCCCAGCTTCATCGAGCCGTTCCAAGGCGCCGC
GACCGGCGTCGGCGGCATCCTGCGCGACATCTTCACGATGGGGGCGCGGCCGATTGCGGTGCTGGATTCGCTGCGCTTCG
GGCGGCTGGACGATCCGGAAACCGGCGCGCGAAATCGCCGCATTCTCAGCGGGGTGGTGAGTGGGATCGCGCACTACGGC
AACTGCTTCGGCGTGCCGACGGTGGGCGGCGAATGCATCTTCGAGCCCTGCTACGACGGCAATCCGCTGGTCAACGTCTT
TGCGCTCGGCGTCTGCCGCAAGGAGGACGTGTTCTATGCGAAGGCCGCGGGCGTGGGCAACCCCGTGATCTACGTGGGCG
CGCGCACCGGGCGGGATGGGATTCACGGCGCGTCGATGGCCTCCGCCGAGTTCACCGAGGAATCCAAGCAGAAGCGGCCC
AACGTGCAGATGGGCGACCCGTTCATGGAGAAGCTGCTGCTGGAGGCCTGCCTGGAAGCCATGCAAACGGGCGCCATCGT
GGGAATTCAGGATATGGGCGCGGCCGGACTGACCTGCTCCACCTGCGAAATGGGCAGCCGCGGCGAGGTCGGGGTCGAAA
TCGAATTGGACCGTGTTCCGCAGCGCGCCACCGGCATGACTCCTTACGAGATCATGCTCAGCGAAAGCCAGGAGCGCATG
CTGCTGGTGGCCGATAAAGGGCGCGAGGACGAAGTCTTCCGCGTCTTCAAGAAATGGGGATTGGAAGCCGTCGAGATCGG
CATCGTGACCGATGACGGCAAGCTGCGGGTTCGCCATCACGGCGAGATCGTGGCCGAGATCCCCAATCGCGAGCTGGCCG
ACGAGGCCCCACTCTACGACCGTCCCCATACCGCGCCGCCTCCCGCGCCGCTGGCTCCCGCGCCTCGAACTTCCGACGTC
CCCACGGTGCAGGATGCGCTGCCCCTGCTGCTGGCTGCGCCGGACATCTGTTCCAAGCACTGGATTTGGGAACAGTACGA
TTATCAGGTGCGCACCAATACGCTCACCCGCCCCGAGCAGAGCGATGCCTCCATCGTGCGGATCAAAGAGACCGGGACGG
CAATCGCGATGTCGCTCGATGGCAACGGCCGCTACTGCCAGCTCTCGCCGCGCGAAGGCGCGATCCTCGCCGTGGCCGAA
AGCTGCCGCAATCTCTCGGTGGTCGGCGCGCAGCCGGTAGCCGCCACCAACTGTTTGAATTTTGGAAATCCGGAGCGGCC
AGAGATTATGGCGCAGTTGGTGGAGGCGATCGAGGGCATGTCGGATGCCTGCCGCTTCTTCGATACGCCGATCACCGGTG
GAAACGTCAGCCTGTACAACGAAACGTTGGGCGAGGGAATTTATCCGACGCCCGTGATCGGCATCGTCGGACTCATGAAG
ACGGCGGCTCCCGTCACGGTGCCGTTCCAACATGCCGGACGCAGTGTGCTGCTGCTGGGCGGAGTGGGCACATGCGAGGA
GACGCGCTTCGGCGGCACGCAGTACGCAAAGGAAATCGACCGGCAGCTCTGGGGACTGCCGCCCGCGCTCGACCTGGAGC
GCGAGAAGAATGTGCAGAGCGCGATTCGCGAAATCGTGGCGGCCGGACTGGCCGAATCGGCGCATGACCTGAGCGACGGC
GGCCTGGCGGTGGCGCTGGCCGAGTGCAGCTTCGGGAATGCGGGCATCGGCGCCCAAATCGACCTGGATAGCGATTTGCG
TCCGGAATGGCTGGCCTTTCACGAAGGACCGTCGCGGATTCTGATATCGACGGCGAACCCGAAAGAGGTGGTCGCGATCG
CACAAAGGCACGGCGTCGAGGCTCCGGTGGTCGGCGTTACAATTGAGTCAGGAATGGAAATCCGGCAGAGGGGCAATACG
CTGGGTTCCTGGGACATCGCGGCACTCAGGGCCGCTTACGAGGGGGCACTCGAGGCGCATGTTCGATAA

Upstream 100 bases:

>100_bases
TGGGCATGATGCCGCATCCCGAACGGGTCACGGAGCCCTTGATGGGCGGCACCGACGGGCTGCTGGTCTTCGAATCCATG
CTGCGCGCGGCGGTGCACGC

Downstream 100 bases:

>100_bases
ATTTCACGATGAATGCGGCGTGGTCGCCATTTACGGCCACCCCGAGGCTTCTAAACTTGCGTATCTCGGGCTCTACTCGC
TCCAGCATCGCGGGCAGGAG

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 742; Mature: 741

Protein sequence:

>742_residues
MSGTAAFSPEIIAQHQLTDGEYQKIVDILGREPSYTELGIFSVMWSEHCSYKSSRIHLKKLPTRGKLVVQGPGENAGIID
IGGGYVIAFKIESHNHPSFIEPFQGAATGVGGILRDIFTMGARPIAVLDSLRFGRLDDPETGARNRRILSGVVSGIAHYG
NCFGVPTVGGECIFEPCYDGNPLVNVFALGVCRKEDVFYAKAAGVGNPVIYVGARTGRDGIHGASMASAEFTEESKQKRP
NVQMGDPFMEKLLLEACLEAMQTGAIVGIQDMGAAGLTCSTCEMGSRGEVGVEIELDRVPQRATGMTPYEIMLSESQERM
LLVADKGREDEVFRVFKKWGLEAVEIGIVTDDGKLRVRHHGEIVAEIPNRELADEAPLYDRPHTAPPPAPLAPAPRTSDV
PTVQDALPLLLAAPDICSKHWIWEQYDYQVRTNTLTRPEQSDASIVRIKETGTAIAMSLDGNGRYCQLSPREGAILAVAE
SCRNLSVVGAQPVAATNCLNFGNPERPEIMAQLVEAIEGMSDACRFFDTPITGGNVSLYNETLGEGIYPTPVIGIVGLMK
TAAPVTVPFQHAGRSVLLLGGVGTCEETRFGGTQYAKEIDRQLWGLPPALDLEREKNVQSAIREIVAAGLAESAHDLSDG
GLAVALAECSFGNAGIGAQIDLDSDLRPEWLAFHEGPSRILISTANPKEVVAIAQRHGVEAPVVGVTIESGMEIRQRGNT
LGSWDIAALRAAYEGALEAHVR

Sequences:

>Translated_742_residues
MSGTAAFSPEIIAQHQLTDGEYQKIVDILGREPSYTELGIFSVMWSEHCSYKSSRIHLKKLPTRGKLVVQGPGENAGIID
IGGGYVIAFKIESHNHPSFIEPFQGAATGVGGILRDIFTMGARPIAVLDSLRFGRLDDPETGARNRRILSGVVSGIAHYG
NCFGVPTVGGECIFEPCYDGNPLVNVFALGVCRKEDVFYAKAAGVGNPVIYVGARTGRDGIHGASMASAEFTEESKQKRP
NVQMGDPFMEKLLLEACLEAMQTGAIVGIQDMGAAGLTCSTCEMGSRGEVGVEIELDRVPQRATGMTPYEIMLSESQERM
LLVADKGREDEVFRVFKKWGLEAVEIGIVTDDGKLRVRHHGEIVAEIPNRELADEAPLYDRPHTAPPPAPLAPAPRTSDV
PTVQDALPLLLAAPDICSKHWIWEQYDYQVRTNTLTRPEQSDASIVRIKETGTAIAMSLDGNGRYCQLSPREGAILAVAE
SCRNLSVVGAQPVAATNCLNFGNPERPEIMAQLVEAIEGMSDACRFFDTPITGGNVSLYNETLGEGIYPTPVIGIVGLMK
TAAPVTVPFQHAGRSVLLLGGVGTCEETRFGGTQYAKEIDRQLWGLPPALDLEREKNVQSAIREIVAAGLAESAHDLSDG
GLAVALAECSFGNAGIGAQIDLDSDLRPEWLAFHEGPSRILISTANPKEVVAIAQRHGVEAPVVGVTIESGMEIRQRGNT
LGSWDIAALRAAYEGALEAHVR
>Mature_741_residues
SGTAAFSPEIIAQHQLTDGEYQKIVDILGREPSYTELGIFSVMWSEHCSYKSSRIHLKKLPTRGKLVVQGPGENAGIIDI
GGGYVIAFKIESHNHPSFIEPFQGAATGVGGILRDIFTMGARPIAVLDSLRFGRLDDPETGARNRRILSGVVSGIAHYGN
CFGVPTVGGECIFEPCYDGNPLVNVFALGVCRKEDVFYAKAAGVGNPVIYVGARTGRDGIHGASMASAEFTEESKQKRPN
VQMGDPFMEKLLLEACLEAMQTGAIVGIQDMGAAGLTCSTCEMGSRGEVGVEIELDRVPQRATGMTPYEIMLSESQERML
LVADKGREDEVFRVFKKWGLEAVEIGIVTDDGKLRVRHHGEIVAEIPNRELADEAPLYDRPHTAPPPAPLAPAPRTSDVP
TVQDALPLLLAAPDICSKHWIWEQYDYQVRTNTLTRPEQSDASIVRIKETGTAIAMSLDGNGRYCQLSPREGAILAVAES
CRNLSVVGAQPVAATNCLNFGNPERPEIMAQLVEAIEGMSDACRFFDTPITGGNVSLYNETLGEGIYPTPVIGIVGLMKT
AAPVTVPFQHAGRSVLLLGGVGTCEETRFGGTQYAKEIDRQLWGLPPALDLEREKNVQSAIREIVAAGLAESAHDLSDGG
LAVALAECSFGNAGIGAQIDLDSDLRPEWLAFHEGPSRILISTANPKEVVAIAQRHGVEAPVVGVTIESGMEIRQRGNTL
GSWDIAALRAAYEGALEAHVR

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Homo sapiens, GI31657129, Length=646, Percent_Identity=26.9349845201238, Blast_Score=100, Evalue=9e-21,
Organism=Escherichia coli, GI48994899, Length=773, Percent_Identity=25.0970245795602, Blast_Score=107, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17553022, Length=701, Percent_Identity=23.39514978602, Blast_Score=101, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321498, Length=795, Percent_Identity=23.6477987421384, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 79735; Mature: 79603

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGTAAFSPEIIAQHQLTDGEYQKIVDILGREPSYTELGIFSVMWSEHCSYKSSRIHLKK
CCCCCCCCCHHHEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEE
LPTRGKLVVQGPGENAGIIDIGGGYVIAFKIESHNHPSFIEPFQGAATGVGGILRDIFTM
CCCCCEEEEECCCCCCCEEEECCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHC
GARPIAVLDSLRFGRLDDPETGARNRRILSGVVSGIAHYGNCFGVPTVGGECIFEPCYDG
CCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEECCCCCCCCEEEECCCCC
NPLVNVFALGVCRKEDVFYAKAAGVGNPVIYVGARTGRDGIHGASMASAEFTEESKQKRP
CCCEEEHEECCCCCCCEEEEECCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCC
NVQMGDPFMEKLLLEACLEAMQTGAIVGIQDMGAAGLTCSTCEMGSRGEVGVEIELDRVP
CCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEECCCCCCCCCEEEEEECCCCC
QRATGMTPYEIMLSESQERMLLVADKGREDEVFRVFKKWGLEAVEIGIVTDDGKLRVRHH
CHHCCCCCCEEEECCCCCCEEEEECCCCCHHHHHHHHHHCCEEEEEEEEECCCEEEEEEC
GEIVAEIPNRELADEAPLYDRPHTAPPPAPLAPAPRTSDVPTVQDALPLLLAAPDICSKH
CEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHCC
WIWEQYDYQVRTNTLTRPEQSDASIVRIKETGTAIAMSLDGNGRYCQLSPREGAILAVAE
CCCCCCCEEEEECCCCCCCCCCCCEEEEEECCCEEEEEECCCCCEEEECCCCCCEEEEEH
SCRNLSVVGAQPVAATNCLNFGNPERPEIMAQLVEAIEGMSDACRFFDTPITGGNVSLYN
HCCCEEEECCCCCHHHHCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCCCEEEEH
ETLGEGIYPTPVIGIVGLMKTAAPVTVPFQHAGRSVLLLGGVGTCEETRFGGTQYAKEID
HHHCCCCCCCHHHHHHHHHHHCCCEEEEHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHH
RQLWGLPPALDLEREKNVQSAIREIVAAGLAESAHDLSDGGLAVALAECSFGNAGIGAQI
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCEEE
DLDSDLRPEWLAFHEGPSRILISTANPKEVVAIAQRHGVEAPVVGVTIESGMEIRQRGNT
ECCCCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHCCCC
LGSWDIAALRAAYEGALEAHVR
CCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SGTAAFSPEIIAQHQLTDGEYQKIVDILGREPSYTELGIFSVMWSEHCSYKSSRIHLKK
CCCCCCCCHHHEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEE
LPTRGKLVVQGPGENAGIIDIGGGYVIAFKIESHNHPSFIEPFQGAATGVGGILRDIFTM
CCCCCEEEEECCCCCCCEEEECCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHC
GARPIAVLDSLRFGRLDDPETGARNRRILSGVVSGIAHYGNCFGVPTVGGECIFEPCYDG
CCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEECCCCCCCCEEEECCCCC
NPLVNVFALGVCRKEDVFYAKAAGVGNPVIYVGARTGRDGIHGASMASAEFTEESKQKRP
CCCEEEHEECCCCCCCEEEEECCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCC
NVQMGDPFMEKLLLEACLEAMQTGAIVGIQDMGAAGLTCSTCEMGSRGEVGVEIELDRVP
CCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEECCCCCCCCCEEEEEECCCCC
QRATGMTPYEIMLSESQERMLLVADKGREDEVFRVFKKWGLEAVEIGIVTDDGKLRVRHH
CHHCCCCCCEEEECCCCCCEEEEECCCCCHHHHHHHHHHCCEEEEEEEEECCCEEEEEEC
GEIVAEIPNRELADEAPLYDRPHTAPPPAPLAPAPRTSDVPTVQDALPLLLAAPDICSKH
CEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHCC
WIWEQYDYQVRTNTLTRPEQSDASIVRIKETGTAIAMSLDGNGRYCQLSPREGAILAVAE
CCCCCCCEEEEECCCCCCCCCCCCEEEEEECCCEEEEEECCCCCEEEECCCCCCEEEEEH
SCRNLSVVGAQPVAATNCLNFGNPERPEIMAQLVEAIEGMSDACRFFDTPITGGNVSLYN
HCCCEEEECCCCCHHHHCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCCCEEEEH
ETLGEGIYPTPVIGIVGLMKTAAPVTVPFQHAGRSVLLLGGVGTCEETRFGGTQYAKEID
HHHCCCCCCCHHHHHHHHHHHCCCEEEEHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHH
RQLWGLPPALDLEREKNVQSAIREIVAAGLAESAHDLSDGGLAVALAECSFGNAGIGAQI
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCEEE
DLDSDLRPEWLAFHEGPSRILISTANPKEVVAIAQRHGVEAPVVGVTIESGMEIRQRGNT
ECCCCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHCCCC
LGSWDIAALRAAYEGALEAHVR
CCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA