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The map label for this gene is rnz [H]

Identifier: 116624769

GI number: 116624769

Start: 7130870

End: 7131742

Strand: Direct

Name: rnz [H]

Synonym: Acid_5693

Alternate gene names: 116624769

Gene position: 7130870-7131742 (Clockwise)

Preceding gene: 116624767

Following gene: 116624774

Centisome position: 71.55

GC content: 64.26

Gene sequence:

>873_bases
GTGATTCTTGTACGGATCTCCCTCTTTTTATTCCTCGCCGCGGCCGCCCTCGCGCAGGATACCCGCGTCGTCCTGCTCGG
CACGGGCAACCCCAACCCCGACCCCGACCGCATGGGTCCCGCGCTTGCGATCCTCTCCGGGAATCGCGCCTACCTGGTGG
ATTGTGGTCCCGGGGTGGTGCGCCGCGCGGCCCAGGCCGGCATCAGTATGGCGCGGCTCACGCGCGTCTTCATCACCCAC
CTTCACTCCGACCACACCGCCGGCTACCCCGATCTCATCCTGACGCCGCCGAACGCCGGCCGCGAAGTTGCGCTCGAGGC
GTACGGGCCGCCGGGTCTCCGTTCCATGACTTCGCACATCCTCAAGGCATGGTCAGAGGATTTCGACATCCGGCTGCACG
GCACGCAGCCTCATACCGCCGCCGCCTACACGGTCAATGCCCACGACGTCCGGCCCGGCGAAATTTACCGCGACGATACG
GTGCGCGTGATCGCCTTCGCGGTCCCGCACGGGGCCTGGAAATATGCCTATGGGTACCGCTTCGAGGCCAAGGACAAAGT
GATCGTGGTCAGCGGCGATACGACTTATAGCCCAGGACTGATCGCCGCCGCCAAGGGCGCCGACATCCTGGTTCACGAGG
TCTATTCGCAGAAGGGCTGGGAGGAGCGCACGGCGGACTGGCGGAAATACCACGCGGCGTATCACACCTCAGGGCCCGAC
GTTGGGCGTGTCGCTGCGCAGGTCCAACCGCGGATACTCGTGCTTTATCATTTGCTCCCGATGGGGCAATCAGCCGAGCA
GATTCTTGCGGAGATCCGGCAAAACTGGGCCGGGGAAGTGATTTACGGCAAGGATCTCGAGGTTATAAGGTGA

Upstream 100 bases:

>100_bases
GGTCAACTGATTGTCGGCGGCGTGGCCGGCCAGCGCGGCGGCGCAGGCGACCAGGGCGATGCGGAAAACTTTGGGCATGG
CTTCAATCTACAATGTCCTG

Downstream 100 bases:

>100_bases
GGGGCGGGGGCAGTGCGAGTCCGGGGAAGCCGCCTGAAAGGCGGCTGGCAGGATTGCCTGCCCCACATTGCGGCGAGCCG
CAAATTGAGGTCGTGGTTTG

Product: RNAse Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MILVRISLFLFLAAAALAQDTRVVLLGTGNPNPDPDRMGPALAILSGNRAYLVDCGPGVVRRAAQAGISMARLTRVFITH
LHSDHTAGYPDLILTPPNAGREVALEAYGPPGLRSMTSHILKAWSEDFDIRLHGTQPHTAAAYTVNAHDVRPGEIYRDDT
VRVIAFAVPHGAWKYAYGYRFEAKDKVIVVSGDTTYSPGLIAAAKGADILVHEVYSQKGWEERTADWRKYHAAYHTSGPD
VGRVAAQVQPRILVLYHLLPMGQSAEQILAEIRQNWAGEVIYGKDLEVIR

Sequences:

>Translated_290_residues
MILVRISLFLFLAAAALAQDTRVVLLGTGNPNPDPDRMGPALAILSGNRAYLVDCGPGVVRRAAQAGISMARLTRVFITH
LHSDHTAGYPDLILTPPNAGREVALEAYGPPGLRSMTSHILKAWSEDFDIRLHGTQPHTAAAYTVNAHDVRPGEIYRDDT
VRVIAFAVPHGAWKYAYGYRFEAKDKVIVVSGDTTYSPGLIAAAKGADILVHEVYSQKGWEERTADWRKYHAAYHTSGPD
VGRVAAQVQPRILVLYHLLPMGQSAEQILAEIRQNWAGEVIYGKDLEVIR
>Mature_290_residues
MILVRISLFLFLAAAALAQDTRVVLLGTGNPNPDPDRMGPALAILSGNRAYLVDCGPGVVRRAAQAGISMARLTRVFITH
LHSDHTAGYPDLILTPPNAGREVALEAYGPPGLRSMTSHILKAWSEDFDIRLHGTQPHTAAAYTVNAHDVRPGEIYRDDT
VRVIAFAVPHGAWKYAYGYRFEAKDKVIVVSGDTTYSPGLIAAAKGADILVHEVYSQKGWEERTADWRKYHAAYHTSGPD
VGRVAAQVQPRILVLYHLLPMGQSAEQILAEIRQNWAGEVIYGKDLEVIR

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [H]

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family [H]

Homologues:

Organism=Homo sapiens, GI8922122, Length=98, Percent_Identity=37.7551020408163, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI87082078, Length=139, Percent_Identity=28.7769784172662, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR013471 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.26.11 [H]

Molecular weight: Translated: 31812; Mature: 31812

Theoretical pI: Translated: 7.90; Mature: 7.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILVRISLFLFLAAAALAQDTRVVLLGTGNPNPDPDRMGPALAILSGNRAYLVDCGPGVV
CEEEHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHCCCEEEEEECCEEEEEECCHHHH
RRAAQAGISMARLTRVFITHLHSDHTAGYPDLILTPPNAGREVALEAYGPPGLRSMTSHI
HHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCEEEEEECCCCCHHHHHHHH
LKAWSEDFDIRLHGTQPHTAAAYTVNAHDVRPGEIYRDDTVRVIAFAVPHGAWKYAYGYR
HHHCCCCCEEEEECCCCCCEEEEEEECCCCCCCCEECCCCEEEEEEEECCCCEEEEEEEE
FEAKDKVIVVSGDTTYSPGLIAAAKGADILVHEVYSQKGWEERTADWRKYHAAYHTSGPD
EECCCEEEEEECCCCCCCCEEEECCCCEEHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC
VGRVAAQVQPRILVLYHLLPMGQSAEQILAEIRQNWAGEVIYGKDLEVIR
HHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCC
>Mature Secondary Structure
MILVRISLFLFLAAAALAQDTRVVLLGTGNPNPDPDRMGPALAILSGNRAYLVDCGPGVV
CEEEHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHCCCEEEEEECCEEEEEECCHHHH
RRAAQAGISMARLTRVFITHLHSDHTAGYPDLILTPPNAGREVALEAYGPPGLRSMTSHI
HHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCEEEEEECCCCCHHHHHHHH
LKAWSEDFDIRLHGTQPHTAAAYTVNAHDVRPGEIYRDDTVRVIAFAVPHGAWKYAYGYR
HHHCCCCCEEEEECCCCCCEEEEEEECCCCCCCCEECCCCEEEEEEEECCCCEEEEEEEE
FEAKDKVIVVSGDTTYSPGLIAAAKGADILVHEVYSQKGWEERTADWRKYHAAYHTSGPD
EECCCEEEEEECCCCCCCCEEEECCCCEEHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC
VGRVAAQVQPRILVLYHLLPMGQSAEQILAEIRQNWAGEVIYGKDLEVIR
HHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]