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The map label for this gene is nuoH2

Identifier: 116624767

GI number: 116624767

Start: 7128851

End: 7130032

Strand: Direct

Name: nuoH2

Synonym: Acid_5691

Alternate gene names: 116624767

Gene position: 7128851-7130032 (Clockwise)

Preceding gene: 116624766

Following gene: 116624769

Centisome position: 71.53

GC content: 62.35

Gene sequence:

>1182_bases
ATGGAGACCGTTCTCAACCATCCGCTGTTCATGCCCGTCCTGGTGACGCTGGTCATCATTGCGGCCTTCCCGCTGGTCGC
CGGCTATATCGTGCTGGTGGAGCGCAAGGTGCTCGCGGATTTCCAGGTGCGGCTGGGGCCGATGCGCTGCGGTCCGCACG
GCCTGCTGCAGCCCATCGCCGACGCGTTGAAGCTGCTGCTCAAGGAAGACATCATCCCGACCGATTCCGACAAGGCGATC
TTCTGGTTCGCGCCCTGCATTTCCACGATCACCGGCCTGGTGGCCTTCGCCGTAATTCCCTTCGCCCGCAAGATCTACGT
CGCCGATGTCAACGTGGGACTGCTGGTGATCTCCGCGACTTCGGCCGTCGGCATCCTCGGCATCATCCTCGGCGGCTGGT
CGTCGAACAGCCACTATTCGCTGCTCGGCGCACTGCGCAGCGCGGCCCAGCTGGTGAGTTACGAAGTGGCGCTCGCCTTC
GCGCTCCTCTCCGGAGTGATGGTGGCCGGCACGCTCAGCATGCAGGGCATCGTGCAATCGCAGGCGGATCGCGGCGTGTG
GGGCATCTTCGCCAATTACGGATTCATGGTCGTCCCGTTCGTCCTTTACATCATCGCTGCCACCGCGGAAACCAATCGCG
CGCCGTTCGATCTGCCGGAGGCCGAATCGGAACTGGTCGCGGGCTTCCATACCGAGTACAGCGGCTTCCGCTGGGCGCTC
TATTTCCTGGCCGAGTATGCCAACATCTTCGTGATCTCGAGCGTCGCGGTGACGCTCTTCTGGGGCGGCTGGCTGCGCCC
CTTCTCGAGCGTCGCGTGGCTCGAAAAGCCGCTGAACTACGGCGTCCCGGTGATCCTTTTCGTCGGCTCCGGATTACTGA
CCTTCACGCTGATCCGCAAAGTGGTGGACCCGATGCAGCAGAAAGTCCTGCTCGGCGTGGTCGTGCTGCTGGTCCTGATC
GGCGCCATCATGGCGATCCCGATGGTCAACGACGCGATGATCGGCCTCTTCTGGTTCCTGGTAAAAGTCAGCGTCATCAT
TTACACGATGATCTGGTTCCGCGGCACGTTCCCCCGCTACCGCTACGACCAGCTGATGAACATTGGCTGGAAGATCGCGA
TCCCGGTCGGCATGGCCTCCGTGATGGTCAACGCCGTGTTGGGGATGTTGGGAAAGCACTAG

Upstream 100 bases:

>100_bases
CTGCGCGCTCGCCCTGACGGGCATCGCGACGCTGGCGATCGGCATTTATCCCGAGCCGTTTCTCCGGCTCGCGCAGACTT
CGTTGTTCCGGTAGACATAT

Downstream 100 bases:

>100_bases
CCAGCGACCGTTTACAGCTTGCGGATCTTGATGTTCTTGAACCACGCATCGCTATTGTGGTTCTGCACTGAGATCTGGCA
TTCCTTGCGCGGCTGATTGA

Product: respiratory-chain NADH dehydrogenase subunit 1

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H 2; NDH-1 subunit H 2

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
METVLNHPLFMPVLVTLVIIAAFPLVAGYIVLVERKVLADFQVRLGPMRCGPHGLLQPIADALKLLLKEDIIPTDSDKAI
FWFAPCISTITGLVAFAVIPFARKIYVADVNVGLLVISATSAVGILGIILGGWSSNSHYSLLGALRSAAQLVSYEVALAF
ALLSGVMVAGTLSMQGIVQSQADRGVWGIFANYGFMVVPFVLYIIAATAETNRAPFDLPEAESELVAGFHTEYSGFRWAL
YFLAEYANIFVISSVAVTLFWGGWLRPFSSVAWLEKPLNYGVPVILFVGSGLLTFTLIRKVVDPMQQKVLLGVVVLLVLI
GAIMAIPMVNDAMIGLFWFLVKVSVIIYTMIWFRGTFPRYRYDQLMNIGWKIAIPVGMASVMVNAVLGMLGKH

Sequences:

>Translated_393_residues
METVLNHPLFMPVLVTLVIIAAFPLVAGYIVLVERKVLADFQVRLGPMRCGPHGLLQPIADALKLLLKEDIIPTDSDKAI
FWFAPCISTITGLVAFAVIPFARKIYVADVNVGLLVISATSAVGILGIILGGWSSNSHYSLLGALRSAAQLVSYEVALAF
ALLSGVMVAGTLSMQGIVQSQADRGVWGIFANYGFMVVPFVLYIIAATAETNRAPFDLPEAESELVAGFHTEYSGFRWAL
YFLAEYANIFVISSVAVTLFWGGWLRPFSSVAWLEKPLNYGVPVILFVGSGLLTFTLIRKVVDPMQQKVLLGVVVLLVLI
GAIMAIPMVNDAMIGLFWFLVKVSVIIYTMIWFRGTFPRYRYDQLMNIGWKIAIPVGMASVMVNAVLGMLGKH
>Mature_393_residues
METVLNHPLFMPVLVTLVIIAAFPLVAGYIVLVERKVLADFQVRLGPMRCGPHGLLQPIADALKLLLKEDIIPTDSDKAI
FWFAPCISTITGLVAFAVIPFARKIYVADVNVGLLVISATSAVGILGIILGGWSSNSHYSLLGALRSAAQLVSYEVALAF
ALLSGVMVAGTLSMQGIVQSQADRGVWGIFANYGFMVVPFVLYIIAATAETNRAPFDLPEAESELVAGFHTEYSGFRWAL
YFLAEYANIFVISSVAVTLFWGGWLRPFSSVAWLEKPLNYGVPVILFVGSGLLTFTLIRKVVDPMQQKVLLGVVVLLVLI
GAIMAIPMVNDAMIGLFWFLVKVSVIIYTMIWFRGTFPRYRYDQLMNIGWKIAIPVGMASVMVNAVLGMLGKH

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=235, Percent_Identity=40, Blast_Score=181, Evalue=9e-46,
Organism=Escherichia coli, GI1788618, Length=259, Percent_Identity=41.6988416988417, Blast_Score=201, Evalue=7e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH2_SOLUE (Q01UN2)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_826923.1
- STRING:   Q01UN2
- GeneID:   4426101
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_5691
- NMPDR:   fig|234267.9.peg.5414
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   NMCWKIM
- PhylomeDB:   Q01UN2
- ProtClustDB:   CLSK774498
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 42912; Mature: 42912

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1d1844c4)-; HASH(0x1de4c1e8)-; HASH(0x1e51abcc)-; HASH(0x1db1385c)-; HASH(0x1dda5fd4)-; HASH(0x1e053ec0)-; HASH(0x1e4c13ec)-; HASH(0x1d807fe8)-; HASH(0x1e0e9e34)-; HASH(0x1dcdfcd8)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METVLNHPLFMPVLVTLVIIAAFPLVAGYIVLVERKVLADFQVRLGPMRCGPHGLLQPIA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
DALKLLLKEDIIPTDSDKAIFWFAPCISTITGLVAFAVIPFARKIYVADVNVGLLVISAT
HHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHEEEEEECCEEEEEEEHH
SAVGILGIILGGWSSNSHYSLLGALRSAAQLVSYEVALAFALLSGVMVAGTLSMQGIVQS
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QADRGVWGIFANYGFMVVPFVLYIIAATAETNRAPFDLPEAESELVAGFHTEYSGFRWAL
HCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHH
YFLAEYANIFVISSVAVTLFWGGWLRPFSSVAWLEKPLNYGVPVILFVGSGLLTFTLIRK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHH
VVDPMQQKVLLGVVVLLVLIGAIMAIPMVNDAMIGLFWFLVKVSVIIYTMIWFRGTFPRY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
RYDQLMNIGWKIAIPVGMASVMVNAVLGMLGKH
HHHHHHCCCCEEEEHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure
METVLNHPLFMPVLVTLVIIAAFPLVAGYIVLVERKVLADFQVRLGPMRCGPHGLLQPIA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
DALKLLLKEDIIPTDSDKAIFWFAPCISTITGLVAFAVIPFARKIYVADVNVGLLVISAT
HHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHEEEEEECCEEEEEEEHH
SAVGILGIILGGWSSNSHYSLLGALRSAAQLVSYEVALAFALLSGVMVAGTLSMQGIVQS
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QADRGVWGIFANYGFMVVPFVLYIIAATAETNRAPFDLPEAESELVAGFHTEYSGFRWAL
HCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHH
YFLAEYANIFVISSVAVTLFWGGWLRPFSSVAWLEKPLNYGVPVILFVGSGLLTFTLIRK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHH
VVDPMQQKVLLGVVVLLVLIGAIMAIPMVNDAMIGLFWFLVKVSVIIYTMIWFRGTFPRY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
RYDQLMNIGWKIAIPVGMASVMVNAVLGMLGKH
HHHHHHCCCCEEEEHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA