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The map label for this gene is exuT [H]

Identifier: 116624722

GI number: 116624722

Start: 7078520

End: 7079785

Strand: Direct

Name: exuT [H]

Synonym: Acid_5646

Alternate gene names: 116624722

Gene position: 7078520-7079785 (Clockwise)

Preceding gene: 116624721

Following gene: 116624723

Centisome position: 71.03

GC content: 63.11

Gene sequence:

>1266_bases
ATGATCTTCGACATGCCGAAGATCAGAGGACTTCGTTGGTGGATGATCGGGCTGATCATGCTCGGCTCGGTGATCAACTA
CCTGACGCGCAGCACGCTCGCCGTCGCCGCACCGACCGTCTTAAAAGATCTCCACATCACCACGCAGCAATACTCGTGGA
TCGTCGGCGCCTTCCAGGGCGCGATCATGACCCAGCCAATCTGCGGTTATGTGCTCGACGTGCTTGGCCTCAAGGTTGGC
TTCGCGATCTTCGCCATTGCCTGGTCACTGGTCAACATGTCGCATGGCCTGGCCAACAGCTGGCAGGCGCTCGCCGCGTT
ACGCGGCCTCCTGGGATTTAGCGAGGGCTCGGCCAATCCCGCGGGTATGAAAGCGACCTCGGAGTGGTTCCCCGCCCGCG
AGCGCGGCCTCGCCGGCGGCGTTTACAACATCGGCGCTTCGGTGGGTTCCATGCTCGCGCCGCCGCTGGTTGCCTGGGCC
ATCCTGAGCTACAACTGGCGAGTGTCCTTCGTGATCACCGGGAGCCTGGGACTGATTTGGGTAGCCCTGTGGCTGCTGTT
CTACGAGTCGCCCGCGAAACACTCCGCGCTCTCGAAGGAGGAGCGGGAGTACATCGCGTCGGGGCAGGAGAAACACTTGC
AAGGCGATGGCACACGCCCGTCGCTCGTGAAGATTCTCAAGCAGCGCAACTTCTGGGGAATCGCAGTGCCCCGATTTCTC
GCCGACCCCACGTGGGGCACGCTCAGCTTCTGGCTGCCGCTCTATCTGAGCAGCGTCCGCCATATGGATTTGAAGCACAT
CGCGATGTTCGCGTGGATCCCGTTTCTGGCCGCCGATTTCGGTTGCGTGTTCGGCGGCCTGATCGCCATGACGCTGCAGA
AGCGCGCCGGGCTGAGCGTGATTAACGCGCGCCGCTGCGCCTTCACGGTGGGCGCGGTCCTGATGGTCGGCGTGGGCTTT
GTTGGCTTCGTGCAGAGCCCGTATGCCGCGATCGCGCTGTTGAGTCTCGGCGGCTTCGCGCACCAGACGCTCTCCGTCAC
CGTGATCACGATGGCCTCCGACCTCTTCAAGAAAAACGAGGTCGCGACCGCCGCCGGGATGGCCGGGACGTTCGGCAACG
CTGGACTGCTCATCTTCTCGCTGCTGATCGGCGGCCTGGTCGCAACCGTTGGCTATACGCCGTTCTTCGTCTGCCTGGGC
GTGCTCGATCTGTTCGGCGCCGTGGTGCTTTGGACCGTGGTCCGCGAGCGCAACTTCTCGATATGA

Upstream 100 bases:

>100_bases
TGCTGGTAACGCCCGGCCAGCAGGTGGAGGCGAAGGATCTGCTGCTAGTCATCGAGTAGGACGGGCCTGCGGCCTGTCGC
GCTAATCGGCTTTTGCTAAC

Downstream 100 bases:

>100_bases
CGATCCGCAATCCGATCCTGCCGGGATTCAATCCCGACCCGTCGATTCTTCGCGTCGGCGACGACTACTACATCGCCACT
TCCACGTTCGAGTGGTTCCC

Product: major facilitator transporter

Products: galacturonate [Cytoplasm]; Proton [Cytoplasm]; glucuronate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MIFDMPKIRGLRWWMIGLIMLGSVINYLTRSTLAVAAPTVLKDLHITTQQYSWIVGAFQGAIMTQPICGYVLDVLGLKVG
FAIFAIAWSLVNMSHGLANSWQALAALRGLLGFSEGSANPAGMKATSEWFPARERGLAGGVYNIGASVGSMLAPPLVAWA
ILSYNWRVSFVITGSLGLIWVALWLLFYESPAKHSALSKEEREYIASGQEKHLQGDGTRPSLVKILKQRNFWGIAVPRFL
ADPTWGTLSFWLPLYLSSVRHMDLKHIAMFAWIPFLAADFGCVFGGLIAMTLQKRAGLSVINARRCAFTVGAVLMVGVGF
VGFVQSPYAAIALLSLGGFAHQTLSVTVITMASDLFKKNEVATAAGMAGTFGNAGLLIFSLLIGGLVATVGYTPFFVCLG
VLDLFGAVVLWTVVRERNFSI

Sequences:

>Translated_421_residues
MIFDMPKIRGLRWWMIGLIMLGSVINYLTRSTLAVAAPTVLKDLHITTQQYSWIVGAFQGAIMTQPICGYVLDVLGLKVG
FAIFAIAWSLVNMSHGLANSWQALAALRGLLGFSEGSANPAGMKATSEWFPARERGLAGGVYNIGASVGSMLAPPLVAWA
ILSYNWRVSFVITGSLGLIWVALWLLFYESPAKHSALSKEEREYIASGQEKHLQGDGTRPSLVKILKQRNFWGIAVPRFL
ADPTWGTLSFWLPLYLSSVRHMDLKHIAMFAWIPFLAADFGCVFGGLIAMTLQKRAGLSVINARRCAFTVGAVLMVGVGF
VGFVQSPYAAIALLSLGGFAHQTLSVTVITMASDLFKKNEVATAAGMAGTFGNAGLLIFSLLIGGLVATVGYTPFFVCLG
VLDLFGAVVLWTVVRERNFSI
>Mature_421_residues
MIFDMPKIRGLRWWMIGLIMLGSVINYLTRSTLAVAAPTVLKDLHITTQQYSWIVGAFQGAIMTQPICGYVLDVLGLKVG
FAIFAIAWSLVNMSHGLANSWQALAALRGLLGFSEGSANPAGMKATSEWFPARERGLAGGVYNIGASVGSMLAPPLVAWA
ILSYNWRVSFVITGSLGLIWVALWLLFYESPAKHSALSKEEREYIASGQEKHLQGDGTRPSLVKILKQRNFWGIAVPRFL
ADPTWGTLSFWLPLYLSSVRHMDLKHIAMFAWIPFLAADFGCVFGGLIAMTLQKRAGLSVINARRCAFTVGAVLMVGVGF
VGFVQSPYAAIALLSLGGFAHQTLSVTVITMASDLFKKNEVATAAGMAGTFGNAGLLIFSLLIGGLVATVGYTPFFVCLG
VLDLFGAVVLWTVVRERNFSI

Specific function: Aldohexuronate transport system [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI6912666, Length=347, Percent_Identity=29.6829971181556, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI9945322, Length=393, Percent_Identity=27.9898218829517, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI9966811, Length=330, Percent_Identity=28.1818181818182, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI21322234, Length=389, Percent_Identity=27.5064267352185, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI148743791, Length=261, Percent_Identity=26.0536398467433, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI154800443, Length=286, Percent_Identity=24.1258741258741, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI223718438, Length=206, Percent_Identity=30.5825242718447, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4885441, Length=194, Percent_Identity=27.8350515463918, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI5031955, Length=249, Percent_Identity=23.6947791164659, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI2367193, Length=419, Percent_Identity=49.4033412887828, Blast_Score=428, Evalue=1e-121,
Organism=Escherichia coli, GI1789515, Length=414, Percent_Identity=27.7777777777778, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI87082320, Length=407, Percent_Identity=27.027027027027, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1789152, Length=405, Percent_Identity=25.679012345679, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI2367379, Length=306, Percent_Identity=27.1241830065359, Blast_Score=127, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17552542, Length=285, Percent_Identity=30.5263157894737, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17554148, Length=355, Percent_Identity=23.943661971831, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17566884, Length=193, Percent_Identity=25.9067357512953, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24658658, Length=400, Percent_Identity=25.5, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28573708, Length=330, Percent_Identity=28.1818181818182, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28573707, Length=330, Percent_Identity=28.1818181818182, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24658666, Length=364, Percent_Identity=27.4725274725275, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24584153, Length=351, Percent_Identity=24.7863247863248, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI28573299, Length=413, Percent_Identity=26.1501210653753, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI45550495, Length=368, Percent_Identity=25.8152173913043, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI20130167, Length=408, Percent_Identity=24.5098039215686, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24639764, Length=351, Percent_Identity=24.7863247863248, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24658674, Length=364, Percent_Identity=26.0989010989011, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24641682, Length=296, Percent_Identity=25, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24655271, Length=438, Percent_Identity=24.6575342465753, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI20130135, Length=426, Percent_Identity=24.6478873239437, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24648416, Length=384, Percent_Identity=23.9583333333333, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21356189, Length=384, Percent_Identity=23.9583333333333, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI20129235, Length=352, Percent_Identity=26.7045454545455, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24583789, Length=225, Percent_Identity=26.6666666666667, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24580790, Length=278, Percent_Identity=24.4604316546763, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45550364, Length=415, Percent_Identity=25.3012048192771, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45550460, Length=342, Percent_Identity=25.1461988304094, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24653727, Length=296, Percent_Identity=25, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24658696, Length=276, Percent_Identity=24.6376811594203, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24655255, Length=299, Percent_Identity=25.752508361204, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24658689, Length=407, Percent_Identity=24.0786240786241, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45552797, Length=407, Percent_Identity=24.0786240786241, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24651789, Length=424, Percent_Identity=24.5283018867925, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24651787, Length=424, Percent_Identity=24.5283018867925, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19922400, Length=312, Percent_Identity=24.6794871794872, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24654215, Length=312, Percent_Identity=24.6794871794872, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45554; Mature: 45554

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFDMPKIRGLRWWMIGLIMLGSVINYLTRSTLAVAAPTVLKDLHITTQQYSWIVGAFQG
CCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIMTQPICGYVLDVLGLKVGFAIFAIAWSLVNMSHGLANSWQALAALRGLLGFSEGSANP
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCC
AGMKATSEWFPARERGLAGGVYNIGASVGSMLAPPLVAWAILSYNWRVSFVITGSLGLIW
CCCCCCHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCHHHHH
VALWLLFYESPAKHSALSKEEREYIASGQEKHLQGDGTRPSLVKILKQRNFWGIAVPRFL
HHHHHHHHCCCHHHHHCCHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHCCCCCEECHHHH
ADPTWGTLSFWLPLYLSSVRHMDLKHIAMFAWIPFLAADFGCVFGGLIAMTLQKRAGLSV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
INARRCAFTVGAVLMVGVGFVGFVQSPYAAIALLSLGGFAHQTLSVTVITMASDLFKKNE
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
VATAAGMAGTFGNAGLLIFSLLIGGLVATVGYTPFFVCLGVLDLFGAVVLWTVVRERNFS
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
I
C
>Mature Secondary Structure
MIFDMPKIRGLRWWMIGLIMLGSVINYLTRSTLAVAAPTVLKDLHITTQQYSWIVGAFQG
CCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIMTQPICGYVLDVLGLKVGFAIFAIAWSLVNMSHGLANSWQALAALRGLLGFSEGSANP
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCC
AGMKATSEWFPARERGLAGGVYNIGASVGSMLAPPLVAWAILSYNWRVSFVITGSLGLIW
CCCCCCHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCHHHHH
VALWLLFYESPAKHSALSKEEREYIASGQEKHLQGDGTRPSLVKILKQRNFWGIAVPRFL
HHHHHHHHCCCHHHHHCCHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHCCCCCEECHHHH
ADPTWGTLSFWLPLYLSSVRHMDLKHIAMFAWIPFLAADFGCVFGGLIAMTLQKRAGLSV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
INARRCAFTVGAVLMVGVGFVGFVQSPYAAIALLSLGGFAHQTLSVTVITMASDLFKKNE
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
VATAAGMAGTFGNAGLLIFSLLIGGLVATVGYTPFFVCLGVLDLFGAVVLWTVVRERNFS
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
I
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: galacturonate [Periplasm]; Proton [Periplasm]; glucuronate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + galacturonate [Periplasm] = galacturonate [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + glucuronate [Periplasm] = Proton [Cytoplasm] + glucuronate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]