Click here to switch to the map view.

The map label for this gene is hldE [H]

Identifier: 116622655

GI number: 116622655

Start: 4500546

End: 4501520

Strand: Reverse

Name: hldE [H]

Synonym: Acid_3554

Alternate gene names: 116622655

Gene position: 4501520-4500546 (Counterclockwise)

Preceding gene: 116622656

Following gene: 116622652

Centisome position: 45.17

GC content: 67.08

Gene sequence:

>975_bases
ATGACGGCCGCGCAGATCCTCGCCGAATTCCGACGCCTGCGCGTGCTGGTGGTCGGCGACGTCTGCCTGGACCGCTGGTG
CCGCTACGACCCGGCGCTCGCCGATGAATCGCGAGAGACCGGTATTCCGCGGATCGCCGTCGTCTCCACCGAGGTGACGC
CTGGCGCCGCCGGGACTATCTGCAATAATCTGGCGGCGCTCGGCGCCGGCCGCATCGCCGTGCTCGGCATGGTCGGCGAC
GATGGCTTCGGCTATGAATTGCGCGGCTCGCTCACAGCGCGCGGCATCGGACACGAACTGCTGGTGGATGCACCGGGCAT
TCCGACGTTCACCTACACCAAGCTGATCAACGACGTGACCGGCGAAGAGGATCGTCCGCGCGTGGATTTCGTGTACACAC
GTCCCCTGCCCGACCGCGTAGAGCGCGAACTGGTTGCGCGCCTGGAGCGCGCCGCGCCGGAGTTCGACGTGATCCTGGTC
TCGGACCAGGCGGAGACCAGCGCGGGAGGAGTGGTGACTGCGGCCATGCGGCAGGCCATCGAACGCATCGCGCTCGCCCA
ACCCGAGACCGTTGTGTGGGTGGACTCGCGATTGCGCAGCGAACTCTTCCGCCATGCGGTGGTCAAGCCCAATCAGCAGG
AGGCCGAAGCCGCATCCCTGCGCGTGCTCGGAAGGATCGATTACGAGGAGATGCGCCGCCGCACCGGAGCGCGCTGCCTG
ATCGTGACGCATGGCGGGAAAGGCGCGCTGGTAGTGGATGAGGGCGGTGCGCAATGGGTGGAAGCCCGCCCGGTGGCGGA
CCCCGTGGATATTTGCGGTGCGGGAGACAGCTTCAGCGCAGGGGGTGCGCTGGCACTAAAAGTCACGGGCGACCCGTTGG
AAGCAGCGCGCTTCGGCAACCGGATCGCCTCCATCACCATCATGAAAAAGGGCACCGGGACCGCCTCGCCCGAGGAAGTC
CTGGCGCAACCTTGA

Upstream 100 bases:

>100_bases
CCCACAAGACGATTCTGGTGCGCACAATCGCCGACGGCGGCGAGAGCTTTTACTTTTGCGGCGAGCATCGCGCCACCGTG
CCCGCACTCTGGCGCCTGCT

Downstream 100 bases:

>100_bases
TCGGTCCCTGACGAGCCGCGACCGTTAGGGAGCGATCTCCAAATTTTCTACTGCCCAGGCGCGGCGGGCGGCGGCACTGT
CTCCGGCATGTTCTTGCCAC

Product: ribokinase-like domain-containing protein

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MTAAQILAEFRRLRVLVVGDVCLDRWCRYDPALADESRETGIPRIAVVSTEVTPGAAGTICNNLAALGAGRIAVLGMVGD
DGFGYELRGSLTARGIGHELLVDAPGIPTFTYTKLINDVTGEEDRPRVDFVYTRPLPDRVERELVARLERAAPEFDVILV
SDQAETSAGGVVTAAMRQAIERIALAQPETVVWVDSRLRSELFRHAVVKPNQQEAEAASLRVLGRIDYEEMRRRTGARCL
IVTHGGKGALVVDEGGAQWVEARPVADPVDICGAGDSFSAGGALALKVTGDPLEAARFGNRIASITIMKKGTGTASPEEV
LAQP

Sequences:

>Translated_324_residues
MTAAQILAEFRRLRVLVVGDVCLDRWCRYDPALADESRETGIPRIAVVSTEVTPGAAGTICNNLAALGAGRIAVLGMVGD
DGFGYELRGSLTARGIGHELLVDAPGIPTFTYTKLINDVTGEEDRPRVDFVYTRPLPDRVERELVARLERAAPEFDVILV
SDQAETSAGGVVTAAMRQAIERIALAQPETVVWVDSRLRSELFRHAVVKPNQQEAEAASLRVLGRIDYEEMRRRTGARCL
IVTHGGKGALVVDEGGAQWVEARPVADPVDICGAGDSFSAGGALALKVTGDPLEAARFGNRIASITIMKKGTGTASPEEV
LAQP
>Mature_323_residues
TAAQILAEFRRLRVLVVGDVCLDRWCRYDPALADESRETGIPRIAVVSTEVTPGAAGTICNNLAALGAGRIAVLGMVGDD
GFGYELRGSLTARGIGHELLVDAPGIPTFTYTKLINDVTGEEDRPRVDFVYTRPLPDRVERELVARLERAAPEFDVILVS
DQAETSAGGVVTAAMRQAIERIALAQPETVVWVDSRLRSELFRHAVVKPNQQEAEAASLRVLGRIDYEEMRRRTGARCLI
VTHGGKGALVVDEGGAQWVEARPVADPVDICGAGDSFSAGGALALKVTGDPLEAARFGNRIASITIMKKGTGTASPEEVL
AQP

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789432, Length=331, Percent_Identity=28.7009063444109, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.-.-

Molecular weight: Translated: 34685; Mature: 34554

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAAQILAEFRRLRVLVVGDVCLDRWCRYDPALADESRETGIPRIAVVSTEVTPGAAGTI
CCHHHHHHHHHHEEEEEECHHHHHHHHCCCCCCCCCCHHCCCCEEEEEEECCCCCCHHHH
CNNLAALGAGRIAVLGMVGDDGFGYELRGSLTARGIGHELLVDAPGIPTFTYTKLINDVT
HHHHHHCCCCCEEEEEEECCCCCCEEEECCEEECCCCCEEEEECCCCCCHHHHHHHHHHC
GEEDRPRVDFVYTRPLPDRVERELVARLERAAPEFDVILVSDQAETSAGGVVTAAMRQAI
CCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHH
ERIALAQPETVVWVDSRLRSELFRHAVVKPNQQEAEAASLRVLGRIDYEEMRRRTGARCL
HHHHHCCCCEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHEEECCCHHHHHHHCCCEEE
IVTHGGKGALVVDEGGAQWVEARPVADPVDICGAGDSFSAGGALALKVTGDPLEAARFGN
EEEECCCEEEEEECCCCCEEECCCCCCCHHHCCCCCCCCCCCEEEEEEECCCHHHHHHCC
RIASITIMKKGTGTASPEEVLAQP
CEEEEEEEECCCCCCCHHHHHCCC
>Mature Secondary Structure 
TAAQILAEFRRLRVLVVGDVCLDRWCRYDPALADESRETGIPRIAVVSTEVTPGAAGTI
CHHHHHHHHHHEEEEEECHHHHHHHHCCCCCCCCCCHHCCCCEEEEEEECCCCCCHHHH
CNNLAALGAGRIAVLGMVGDDGFGYELRGSLTARGIGHELLVDAPGIPTFTYTKLINDVT
HHHHHHCCCCCEEEEEEECCCCCCEEEECCEEECCCCCEEEEECCCCCCHHHHHHHHHHC
GEEDRPRVDFVYTRPLPDRVERELVARLERAAPEFDVILVSDQAETSAGGVVTAAMRQAI
CCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHH
ERIALAQPETVVWVDSRLRSELFRHAVVKPNQQEAEAASLRVLGRIDYEEMRRRTGARCL
HHHHHCCCCEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHEEECCCHHHHHHHCCCEEE
IVTHGGKGALVVDEGGAQWVEARPVADPVDICGAGDSFSAGGALALKVTGDPLEAARFGN
EEEECCCEEEEEECCCCCEEECCCCCCCHHHCCCCCCCCCCCEEEEEEECCCHHHHHHCC
RIASITIMKKGTGTASPEEVLAQP
CEEEEEEEECCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA