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The map label for this gene is srpA [H]

Identifier: 116622536

GI number: 116622536

Start: 4344341

End: 4345321

Strand: Direct

Name: srpA [H]

Synonym: Acid_3434

Alternate gene names: 116622536

Gene position: 4344341-4345321 (Clockwise)

Preceding gene: 116622532

Following gene: 116622537

Centisome position: 43.59

GC content: 62.49

Gene sequence:

>981_bases
ATGGTTTCATCAATACTGGTACAGCACAATTTGAGAAAGGACTTCACCATGACTCCCGCCAAGGAAAATCTATCCAGCCA
GGAAGTACTCCAGGCATTCGACGATGTATCCGGATTGCACCCGGGATACCGGCCGGTCCACGCGAAAGGCATCCTTCTTT
CCGGGAGATTCAGACCTTCGCCAAGCGGGATGTCACTGACCAAGGCTCCGCATCTGCACCGATCCTTCACGCCCGTCACG
GTGCGCTTCTCGGATTTCGCAGGCGTGCCGGCGGTGCCTGATAACGATCCGAATGCGAGCCCTCGCGGACTCGCCATCCG
GTTTCACCTCGCCGAACATGTGCATACCGACATCATTGCCCACTCGGTGGATGGATTTCCCGCGCGGACGGTGGAGGAAT
TCGTCGAGTTCCTGCGCGCGATAGCGGCCAGCCGTCCCGAGAGTCCCAAGCCGTCGCCGGTCGAAGTTTTCCTCGCGGCG
CATCCCGCGGCACTCGCGTTTGTCCAGGCGAATAAGCCGGTGCCATGCAGCTTCGCAAGGGAGAACTTCTTCTCTGTGAG
CGCCTACGAATTTACCGACGCGTCGGGAGTGAGCCGCTTCGGCCGCTATCGGATTCGCCCCGCGGACGGCGCCGAATACC
TGGACGCGGCAGCAGCCGCTTCCGCGCCGGCCAATTTCCTGTTCGACGAGATCCGGCAGAGGGTCGGCAAAGGGCCGCTG
GAGTTCCGCATCGAAGTGCAGCTTTCCGCCGCGGGCGACCGCGTGGACGATTCCACCGTCCACTGGCCCAAGGATCGCCC
GCAGATCGAGTTCGGTACGATTGAGCTCACGAGCGTGGTCGCGAACAATGACGCGGAGCAGCGGCAGATCATTTTCGACC
CGATCCCGCGGGTGGATGGGATTGGCTCCTCCGGGGACCCGCTGCTGGAACCGCGCGCCAATGTTTATCTGGCGAGCGGC
CGGCGGCGCCGCCAGGGTTAG

Upstream 100 bases:

>100_bases
CCAGGACGAGCGGGCAGAACACGGTTATGATCTTCACGTTAACGCTATATTAGCGCTTGCCGCAGCTCTTTGGGCGGTCA
AATAATCGCTCTTTCTAGTC

Downstream 100 bases:

>100_bases
TAATGCGGCTAACGTAACTAAACTGGAATCCGTGCGCTAATCGAACCTGTTGCGGACATCGTTCATCGGTCCGTAACAGG
GAGCATTCCACGATGCACGA

Product: catalase domain-containing protein

Products: H2O; O2 [C]

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MVSSILVQHNLRKDFTMTPAKENLSSQEVLQAFDDVSGLHPGYRPVHAKGILLSGRFRPSPSGMSLTKAPHLHRSFTPVT
VRFSDFAGVPAVPDNDPNASPRGLAIRFHLAEHVHTDIIAHSVDGFPARTVEEFVEFLRAIAASRPESPKPSPVEVFLAA
HPAALAFVQANKPVPCSFARENFFSVSAYEFTDASGVSRFGRYRIRPADGAEYLDAAAAASAPANFLFDEIRQRVGKGPL
EFRIEVQLSAAGDRVDDSTVHWPKDRPQIEFGTIELTSVVANNDAEQRQIIFDPIPRVDGIGSSGDPLLEPRANVYLASG
RRRRQG

Sequences:

>Translated_326_residues
MVSSILVQHNLRKDFTMTPAKENLSSQEVLQAFDDVSGLHPGYRPVHAKGILLSGRFRPSPSGMSLTKAPHLHRSFTPVT
VRFSDFAGVPAVPDNDPNASPRGLAIRFHLAEHVHTDIIAHSVDGFPARTVEEFVEFLRAIAASRPESPKPSPVEVFLAA
HPAALAFVQANKPVPCSFARENFFSVSAYEFTDASGVSRFGRYRIRPADGAEYLDAAAAASAPANFLFDEIRQRVGKGPL
EFRIEVQLSAAGDRVDDSTVHWPKDRPQIEFGTIELTSVVANNDAEQRQIIFDPIPRVDGIGSSGDPLLEPRANVYLASG
RRRRQG
>Mature_326_residues
MVSSILVQHNLRKDFTMTPAKENLSSQEVLQAFDDVSGLHPGYRPVHAKGILLSGRFRPSPSGMSLTKAPHLHRSFTPVT
VRFSDFAGVPAVPDNDPNASPRGLAIRFHLAEHVHTDIIAHSVDGFPARTVEEFVEFLRAIAASRPESPKPSPVEVFLAA
HPAALAFVQANKPVPCSFARENFFSVSAYEFTDASGVSRFGRYRIRPADGAEYLDAAAAASAPANFLFDEIRQRVGKGPL
EFRIEVQLSAAGDRVDDSTVHWPKDRPQIEFGTIELTSVVANNDAEQRQIIFDPIPRVDGIGSSGDPLLEPRANVYLASG
RRRRQG

Specific function: Decomposes Hydrogen Peroxide Into Water And Oxygen; Serves To Protect Cells From The Toxic Effects Of Hydrogen Peroxide. [C]

COG id: COG0753

COG function: function code P; Catalase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the catalase family [H]

Homologues:

Organism=Homo sapiens, GI4557014, Length=301, Percent_Identity=27.5747508305648, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020835
- InterPro:   IPR018028
- InterPro:   IPR011614 [H]

Pfam domain/function: PF00199 Catalase [H]

EC number: 1.11.1.6 [C]

Molecular weight: Translated: 35685; Mature: 35685

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSSILVQHNLRKDFTMTPAKENLSSQEVLQAFDDVSGLHPGYRPVHAKGILLSGRFRPS
CCCHHHHHHHCCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCCCCCEEECEEEEECCCCCC
PSGMSLTKAPHLHRSFTPVTVRFSDFAGVPAVPDNDPNASPRGLAIRFHLAEHVHTDIIA
CCCCEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHH
HSVDGFPARTVEEFVEFLRAIAASRPESPKPSPVEVFLAAHPAALAFVQANKPVPCSFAR
HCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCEEEEEEECCCCCCCCHHH
ENFFSVSAYEFTDASGVSRFGRYRIRPADGAEYLDAAAAASAPANFLFDEIRQRVGKGPL
CCCEEEEEEECCCCHHHHHHCCEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCE
EFRIEVQLSAAGDRVDDSTVHWPKDRPQIEFGTIELTSVVANNDAEQRQIIFDPIPRVDG
EEEEEEEEECCCCCCCCCCEECCCCCCCEEECEEEEEEEEECCCCHHCEEEECCCCCCCC
IGSSGDPLLEPRANVYLASGRRRRQG
CCCCCCCCCCCCCCEEEECCCCCCCC
>Mature Secondary Structure
MVSSILVQHNLRKDFTMTPAKENLSSQEVLQAFDDVSGLHPGYRPVHAKGILLSGRFRPS
CCCHHHHHHHCCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCCCCCEEECEEEEECCCCCC
PSGMSLTKAPHLHRSFTPVTVRFSDFAGVPAVPDNDPNASPRGLAIRFHLAEHVHTDIIA
CCCCEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHH
HSVDGFPARTVEEFVEFLRAIAASRPESPKPSPVEVFLAAHPAALAFVQANKPVPCSFAR
HCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCEEEEEEECCCCCCCCHHH
ENFFSVSAYEFTDASGVSRFGRYRIRPADGAEYLDAAAAASAPANFLFDEIRQRVGKGPL
CCCEEEEEEECCCCHHHHHHCCEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCE
EFRIEVQLSAAGDRVDDSTVHWPKDRPQIEFGTIELTSVVANNDAEQRQIIFDPIPRVDG
EEEEEEEEECCCCCCCCCCEECCCCCCCEEECEEEEEEEEECCCCHHCEEEECCCCCCCC
IGSSGDPLLEPRANVYLASGRRRRQG
CCCCCCCCCCCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Heme Group. [C]

Metal ions: NA

Kcat value (1/min): 980000 [C]

Specific activity: NA

Km value (mM): 18.2 {H2O2}} 10 {H2O2}} 3.7 {H2O2}} [C]

Substrates: Hydrogen peroxide [C]

Specific reaction: (2) Hydrogen peroxide --> (2) H2O + O2 [C]

General reaction: Redox reaction [C]

Inhibitor: 3-Amino-1-H-1, 2, 4-triazolecoli, Rhodopseudomonascapsulata; Dianisidine; H2O2 [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7536734 [H]