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The map label for this gene is lepB [H]

Identifier: 116621326

GI number: 116621326

Start: 2828258

End: 2829070

Strand: Reverse

Name: lepB [H]

Synonym: Acid_2207

Alternate gene names: 116621326

Gene position: 2829070-2828258 (Counterclockwise)

Preceding gene: 116621329

Following gene: 116621322

Centisome position: 28.39

GC content: 59.9

Gene sequence:

>813_bases
ATGACAGATGTGGAGACATCGACTGACCTTAAGGCGCCGGGCTTTCGGACGCGGATCGCCGAACTGACCGACGACGTGCA
GCGCGGTTTTATCGCCGAGTGGGCGGTAACCATCATCCTGCTGCTTTTCGGCACCACCACACTCATCCAGGCCTTCGTCA
TTCCCAGTGCATCCATGGTCGGCACGCTGCTGATCGGCGATCACGTACTGGTGGACAAACTGGTCTACGCTCCCGGCGGA
GCTGTGAGCAGCAAGATCCTTCCCTATCGCGATGTGCGCCGCGGCGATATCATCGTCTTCCGCTACCCGCTCAACATTTC
GCAGGATTATGTGAAGCGCGCCATCGGCGTCCCCGGCGACCACATCCACTTCGACAACAAGCAACTCTTCCTCAATGGCA
AGATGGTCAACGAGCCCTACACTGTGCATTCGCAGCAGTACCCCGACGTCTACCGCGACAATTTTCCCTCCGGCGCGCAC
GCCATGCCGCTACGCCCCCGCGCCGCCGAAATGATCGAGAAAAACGTGGTCGACGGTGAACTCGTCGTCCCGCCCGGCTA
CATCTTCGCCATGGGAGACAACCGCGACGATTCCGATGACAGCCGCTACTGGGGCCTCGTCCCGCGCGAGAATATCGTCG
GCACCCCGGTCATCATCTACTGGAGTTTCGAAGCCCCGACCCAGGACCTCATCAATGGGAACGTGGGCGTTGACCACATC
ATCGACGTCATCACCCATTTCTTCACCAAGACCCGTTGGTCCCGGACTTTCAAGTTGATTCGCGGCTACCCGCTGGGCCG
CGCGTCGAATTAG

Upstream 100 bases:

>100_bases
GGCAATTCCGGAGTGGCTTGAGACAAGCGATCCCCCTTCTGTCCGTTATGGTAGCAAACCCGTCACACAATTCCGGTCCT
GCCACGTCTCATCCGATACA

Downstream 100 bases:

>100_bases
GTCTAGAGAACCTTCATCACGAAGATCGATTGATCGTCGAACGCCACCTTCGAAAACTTATCCAGCTCTTCGAATATCTT
GAGTATCAAGCCGTCCGCCG

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MTDVETSTDLKAPGFRTRIAELTDDVQRGFIAEWAVTIILLLFGTTTLIQAFVIPSASMVGTLLIGDHVLVDKLVYAPGG
AVSSKILPYRDVRRGDIIVFRYPLNISQDYVKRAIGVPGDHIHFDNKQLFLNGKMVNEPYTVHSQQYPDVYRDNFPSGAH
AMPLRPRAAEMIEKNVVDGELVVPPGYIFAMGDNRDDSDDSRYWGLVPRENIVGTPVIIYWSFEAPTQDLINGNVGVDHI
IDVITHFFTKTRWSRTFKLIRGYPLGRASN

Sequences:

>Translated_270_residues
MTDVETSTDLKAPGFRTRIAELTDDVQRGFIAEWAVTIILLLFGTTTLIQAFVIPSASMVGTLLIGDHVLVDKLVYAPGG
AVSSKILPYRDVRRGDIIVFRYPLNISQDYVKRAIGVPGDHIHFDNKQLFLNGKMVNEPYTVHSQQYPDVYRDNFPSGAH
AMPLRPRAAEMIEKNVVDGELVVPPGYIFAMGDNRDDSDDSRYWGLVPRENIVGTPVIIYWSFEAPTQDLINGNVGVDHI
IDVITHFFTKTRWSRTFKLIRGYPLGRASN
>Mature_269_residues
TDVETSTDLKAPGFRTRIAELTDDVQRGFIAEWAVTIILLLFGTTTLIQAFVIPSASMVGTLLIGDHVLVDKLVYAPGGA
VSSKILPYRDVRRGDIIVFRYPLNISQDYVKRAIGVPGDHIHFDNKQLFLNGKMVNEPYTVHSQQYPDVYRDNFPSGAHA
MPLRPRAAEMIEKNVVDGELVVPPGYIFAMGDNRDDSDDSRYWGLVPRENIVGTPVIIYWSFEAPTQDLINGNVGVDHII
DVITHFFTKTRWSRTFKLIRGYPLGRASN

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=235, Percent_Identity=31.9148936170213, Blast_Score=107, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR019533 [H]

Pfam domain/function: PF00717 Peptidase_S24; PF10502 Peptidase_S26 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 30310; Mature: 30179

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDVETSTDLKAPGFRTRIAELTDDVQRGFIAEWAVTIILLLFGTTTLIQAFVIPSASMV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
GTLLIGDHVLVDKLVYAPGGAVSSKILPYRDVRRGDIIVFRYPLNISQDYVKRAIGVPGD
HHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCC
HIHFDNKQLFLNGKMVNEPYTVHSQQYPDVYRDNFPSGAHAMPLRPRAAEMIEKNVVDGE
EEEECCCEEEEECEEECCCEEECCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCE
LVVPPGYIFAMGDNRDDSDDSRYWGLVPRENIVGTPVIIYWSFEAPTQDLINGNVGVDHI
EEECCCEEEEECCCCCCCCCCCEECCCCCCCCCCCCEEEEEECCCCHHHHHCCCCCHHHH
IDVITHFFTKTRWSRTFKLIRGYPLGRASN
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TDVETSTDLKAPGFRTRIAELTDDVQRGFIAEWAVTIILLLFGTTTLIQAFVIPSASMV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
GTLLIGDHVLVDKLVYAPGGAVSSKILPYRDVRRGDIIVFRYPLNISQDYVKRAIGVPGD
HHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCC
HIHFDNKQLFLNGKMVNEPYTVHSQQYPDVYRDNFPSGAHAMPLRPRAAEMIEKNVVDGE
EEEECCCEEEEECEEECCCEEECCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCE
LVVPPGYIFAMGDNRDDSDDSRYWGLVPRENIVGTPVIIYWSFEAPTQDLINGNVGVDHI
EEECCCEEEEECCCCCCCCCCCEECCCCCCCCCCCCEEEEEECCCCHHHHHCCCCCHHHH
IDVITHFFTKTRWSRTFKLIRGYPLGRASN
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]