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The map label for this gene is 116620684

Identifier: 116620684

GI number: 116620684

Start: 1921669

End: 1922094

Strand: Direct

Name: 116620684

Synonym: Acid_1564

Alternate gene names: NA

Gene position: 1921669-1922094 (Clockwise)

Preceding gene: 116620683

Following gene: 116620685

Centisome position: 19.28

GC content: 55.63

Gene sequence:

>426_bases
GTGACCCGCCGTTACCAGTTTGCCGCTTCTCATCGCCTGCATTCGGACCAATTGAGCGCGGAGGAGAACCGGAGCTTGTA
CGGCAAGTGCAACAATCCGTACGGCCACGGTCACAACTACGTCGTCGAAGTGAGTGTGCGCGGACCCGTGGATGAAGCCA
CGGGGCGCACTGTGGATATCGTCTTGCTCGATGAATTGGTGAGACGAGAGGTGGTACAGCCTTTCGACCATCGCAACCTG
AACGCAGAAGTGGATGCGTTCACTAAGGCGGTGGCAACCTCGGAAAATCTCGGTTTCGAGATTTGCCGGAGGCTGAAGCG
CAATTGGAAAGAAGTGTTTCCGGGCGAATGGCCGAAGCTGGAGAAAATCCGCATCGGAGAGACCGCCCGAAACATCTTCG
AAGTCGGTGCAGATGAAATCGAATAA

Upstream 100 bases:

>100_bases
AGCCGCGCTTGAGCGACCCGCGGCACAGATTGTTCTCGGTCCGCGTGTACGAGACCGCCGACCTGTACGTCGATTATTTC
GGAGAGCAGCCGTGTTCCGC

Downstream 100 bases:

>100_bases
AGCCGTAGTTAAGATCATGAACCCCAAACCCGAAGAGGCGCCGATCGCTCCCCTGATCGAGGATCTGCTCGGCCGGCTCG
GCGAGGACCCGAAGCGCGAC

Product: putative 6-pyruvoyl tetrahydropterin synthase

Products: 6-pyruvoyl-5,6,7,8-tetrahydropterin; triphosphate

Alternate protein names: 6-Pyruvoyl-Tetrahydropterin Synthase; 6-Pyruvoyltetrahydropterin Synthase; 6-Pyruvoyl-Tetrahydropterin Synthase-Like Protein; 6-Pyruvoyl Tetrahydropterin Synthase Family; 6-Pyruvoyl Tetrahydropterin Synthase Family Protein; Tetrahydrobiopterin Biosynthesis-Like Protein; 6-Pyruvoyl Tetrahydrobiopterin Synthase; 6-Pyruvoyltetrahydrobiopterin Synthase; 6-Pyruvoyltetrahydropterin Synthase Synthase

Number of amino acids: Translated: 141; Mature: 140

Protein sequence:

>141_residues
MTRRYQFAASHRLHSDQLSAEENRSLYGKCNNPYGHGHNYVVEVSVRGPVDEATGRTVDIVLLDELVRREVVQPFDHRNL
NAEVDAFTKAVATSENLGFEICRRLKRNWKEVFPGEWPKLEKIRIGETARNIFEVGADEIE

Sequences:

>Translated_141_residues
MTRRYQFAASHRLHSDQLSAEENRSLYGKCNNPYGHGHNYVVEVSVRGPVDEATGRTVDIVLLDELVRREVVQPFDHRNL
NAEVDAFTKAVATSENLGFEICRRLKRNWKEVFPGEWPKLEKIRIGETARNIFEVGADEIE
>Mature_140_residues
TRRYQFAASHRLHSDQLSAEENRSLYGKCNNPYGHGHNYVVEVSVRGPVDEATGRTVDIVLLDELVRREVVQPFDHRNLN
AEVDAFTKAVATSENLGFEICRRLKRNWKEVFPGEWPKLEKIRIGETARNIFEVGADEIE

Specific function: Unknown

COG id: COG0720

COG function: function code H; 6-pyruvoyl-tetrahydropterin synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506331, Length=132, Percent_Identity=43.9393939393939, Blast_Score=112, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI115532226, Length=133, Percent_Identity=42.1052631578947, Blast_Score=102, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI115532224, Length=133, Percent_Identity=42.1052631578947, Blast_Score=102, Evalue=7e-23,
Organism=Drosophila melanogaster, GI19550074, Length=134, Percent_Identity=42.5373134328358, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24585378, Length=134, Percent_Identity=42.5373134328358, Blast_Score=114, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.2.3.12

Molecular weight: Translated: 16225; Mature: 16094

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00987 PTPS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRRYQFAASHRLHSDQLSAEENRSLYGKCNNPYGHGHNYVVEVSVRGPVDEATGRTVDI
CCCCCCHHHHHCCCCHHCCCCCCCCEEECCCCCCCCCCCEEEEEEECCCCCCCCCCEEEE
VLLDELVRREVVQPFDHRNLNAEVDAFTKAVATSENLGFEICRRLKRNWKEVFPGEWPKL
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCC
EKIRIGETARNIFEVGADEIE
CEEECCHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TRRYQFAASHRLHSDQLSAEENRSLYGKCNNPYGHGHNYVVEVSVRGPVDEATGRTVDI
CCCCCHHHHHCCCCHHCCCCCCCCEEECCCCCCCCCCCEEEEEEECCCCCCCCCCEEEE
VLLDELVRREVVQPFDHRNLNAEVDAFTKAVATSENLGFEICRRLKRNWKEVFPGEWPKL
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCC
EKIRIGETARNIFEVGADEIE
CEEECCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin

Specific reaction: 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA