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The map label for this gene is folE [H]

Identifier: 116620685

GI number: 116620685

Start: 1922111

End: 1922695

Strand: Direct

Name: folE [H]

Synonym: Acid_1565

Alternate gene names: 116620685

Gene position: 1922111-1922695 (Clockwise)

Preceding gene: 116620684

Following gene: 116620686

Centisome position: 19.29

GC content: 59.15

Gene sequence:

>585_bases
ATGAACCCCAAACCCGAAGAGGCGCCGATCGCTCCCCTGATCGAGGATCTGCTCGGCCGGCTCGGCGAGGACCCGAAGCG
CGACGGCCTGCTACGGACCCCGCAGCGCGTGGATAAGTCCCTCCGCTTCCTCACCAGCGGCTACCGCATGGATATCGACA
AAATCCTGAACGGCGCGCTGTACGAAGTGAAGTACGACGAGATGGTGGTCGTGAAGGACATCGAGTTCTTCAGCCTCTGC
GAGCACCACATGCTCCCTTTCTATGGCAAGATGCACGTGGCATACTTGCCGCAGAAAAAGGTGATCGGCCTGAGCAAGAT
CCCGCGGCTGGTGGACATGTTCGCGCGAAGGCTCCAAATCCAGGAGCGATTGACCCAGCAGGTGGCCCAAACCATTCAAG
AGGTAATCCGCCCCTTAGGCGTCGGCGTAATCTGCGAAGCGAAACATTTCTGCATGATGATGCGCGGCGTCGAGAAGCAG
CATTCCGGCGCGATGACCAGCGCCATGCTAGGTGCTTTCCGGGATCGCAAAGAAACGCGCGACGAGTTCCTGGCCCTCGT
GAATCATCGCAGCAACGGATTTTAG

Upstream 100 bases:

>100_bases
GGCGAATGGCCGAAGCTGGAGAAAATCCGCATCGGAGAGACCGCCCGAAACATCTTCGAAGTCGGTGCAGATGAAATCGA
ATAAAGCCGTAGTTAAGATC

Downstream 100 bases:

>100_bases
GATTCCTCGCAGAGACGCAGAGCCGCAGAGACCCGCAAAGAAGCAAAATGTGTTGGATTTTCTTTGCGTTACTCTGCGGC
TCTGCGTCTGCGAGAAATAG

Product: GTP cyclohydrolase

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MNPKPEEAPIAPLIEDLLGRLGEDPKRDGLLRTPQRVDKSLRFLTSGYRMDIDKILNGALYEVKYDEMVVVKDIEFFSLC
EHHMLPFYGKMHVAYLPQKKVIGLSKIPRLVDMFARRLQIQERLTQQVAQTIQEVIRPLGVGVICEAKHFCMMMRGVEKQ
HSGAMTSAMLGAFRDRKETRDEFLALVNHRSNGF

Sequences:

>Translated_194_residues
MNPKPEEAPIAPLIEDLLGRLGEDPKRDGLLRTPQRVDKSLRFLTSGYRMDIDKILNGALYEVKYDEMVVVKDIEFFSLC
EHHMLPFYGKMHVAYLPQKKVIGLSKIPRLVDMFARRLQIQERLTQQVAQTIQEVIRPLGVGVICEAKHFCMMMRGVEKQ
HSGAMTSAMLGAFRDRKETRDEFLALVNHRSNGF
>Mature_194_residues
MNPKPEEAPIAPLIEDLLGRLGEDPKRDGLLRTPQRVDKSLRFLTSGYRMDIDKILNGALYEVKYDEMVVVKDIEFFSLC
EHHMLPFYGKMHVAYLPQKKVIGLSKIPRLVDMFARRLQIQERLTQQVAQTIQEVIRPLGVGVICEAKHFCMMMRGVEKQ
HSGAMTSAMLGAFRDRKETRDEFLALVNHRSNGF

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=178, Percent_Identity=52.8089887640449, Blast_Score=218, Evalue=3e-57,
Organism=Homo sapiens, GI4503949, Length=178, Percent_Identity=52.8089887640449, Blast_Score=218, Evalue=3e-57,
Organism=Homo sapiens, GI66932970, Length=148, Percent_Identity=49.3243243243243, Blast_Score=170, Evalue=6e-43,
Organism=Homo sapiens, GI66932972, Length=138, Percent_Identity=52.1739130434783, Blast_Score=170, Evalue=7e-43,
Organism=Escherichia coli, GI1788476, Length=202, Percent_Identity=36.6336633663366, Blast_Score=124, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17560486, Length=176, Percent_Identity=52.8409090909091, Blast_Score=214, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6321706, Length=183, Percent_Identity=53.0054644808743, Blast_Score=213, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24656782, Length=174, Percent_Identity=54.0229885057471, Blast_Score=207, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24656791, Length=174, Percent_Identity=54.0229885057471, Blast_Score=206, Evalue=5e-54,
Organism=Drosophila melanogaster, GI24656796, Length=174, Percent_Identity=54.0229885057471, Blast_Score=206, Evalue=7e-54,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 22303; Mature: 22303

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPKPEEAPIAPLIEDLLGRLGEDPKRDGLLRTPQRVDKSLRFLTSGYRMDIDKILNGAL
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCHH
YEVKYDEMVVVKDIEFFSLCEHHMLPFYGKMHVAYLPQKKVIGLSKIPRLVDMFARRLQI
EEEECCCEEEEECCHHHHHHHHHCCCHHCCCHHEECCCHHHCCHHHHHHHHHHHHHHHHH
QERLTQQVAQTIQEVIRPLGVGVICEAKHFCMMMRGVEKQHSGAMTSAMLGAFRDRKETR
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
DEFLALVNHRSNGF
HHHHHHHHHCCCCC
>Mature Secondary Structure
MNPKPEEAPIAPLIEDLLGRLGEDPKRDGLLRTPQRVDKSLRFLTSGYRMDIDKILNGAL
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCHH
YEVKYDEMVVVKDIEFFSLCEHHMLPFYGKMHVAYLPQKKVIGLSKIPRLVDMFARRLQI
EEEECCCEEEEECCHHHHHHHHHCCCHHCCCHHEECCCHHHCCHHHHHHHHHHHHHHHHH
QERLTQQVAQTIQEVIRPLGVGVICEAKHFCMMMRGVEKQHSGAMTSAMLGAFRDRKETR
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
DEFLALVNHRSNGF
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA